LOCUS       NM_182915               4259 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens STEAP3 metalloreductase (STEAP3), transcript variant
            1, mRNA.
ACCESSION   NM_182915
VERSION     NM_182915.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4259)
  AUTHORS   Lv,J., Liu,X., Sun,Z., Gao,J., Yu,X., Zhang,M., Zhang,Z., Ren,S.
            and Zuo,Y.
  TITLE     STEAP3 promotes colon cancer cell proliferation and migration via
            regulating histone acetylation
  JOURNAL   Hum Genet 143 (3), 343-355 (2024)
   PUBMED   38480539
  REMARK    GeneRIF: STEAP3 promotes colon cancer cell proliferation and
            migration via regulating histone acetylation.
REFERENCE   2  (bases 1 to 4259)
  AUTHORS   Han,Y., Fu,L., Kong,Y., Jiang,C., Huang,L. and Zhang,H.
  TITLE     STEAP3 Affects Ovarian Cancer Progression by Regulating Ferroptosis
            through the p53/SLC7A11 Pathway
  JOURNAL   Mediators Inflamm 2024, 4048527 (2024)
   PUBMED   38440354
  REMARK    GeneRIF: STEAP3 Affects Ovarian Cancer Progression by Regulating
            Ferroptosis through the p53/SLC7A11 Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4259)
  AUTHORS   Ding,T., Chen,S., Xiao,W., Liu,Z., Tu,J., Yu,Y., Dong,B., Chen,W.
            and Zeng,Y.
  TITLE     Six-Transmembrane Epithelial Antigen of Prostate 3 Promotes Hepatic
            Insulin Resistance and Steatosis
  JOURNAL   J Lipid Res 64 (1), 100318 (2023)
   PUBMED   36495944
  REMARK    GeneRIF: Six-Transmembrane Epithelial Antigen of Prostate 3
            Promotes Hepatic Insulin Resistance and Steatosis.
REFERENCE   4  (bases 1 to 4259)
  AUTHORS   Ye,C.L., Du,Y., Yu,X., Chen,Z.Y., Wang,L., Zheng,Y.F. and Liu,X.H.
  TITLE     STEAP3 Affects Ferroptosis and Progression of Renal Cell Carcinoma
            Through the p53/xCT Pathway
  JOURNAL   Technol Cancer Res Treat 21, 15330338221078728 (2022)
   PUBMED   35275508
  REMARK    GeneRIF: STEAP3 Affects Ferroptosis and Progression of Renal Cell
            Carcinoma Through the p53/xCT Pathway.
REFERENCE   5  (bases 1 to 4259)
  AUTHORS   Grunewald,T.G., Bach,H., Cossarizza,A. and Matsumoto,I.
  TITLE     The STEAP protein family: versatile oxidoreductases and targets for
            cancer immunotherapy with overlapping and distinct cellular
            functions
  JOURNAL   Biol Cell 104 (11), 641-657 (2012)
   PUBMED   22804687
REFERENCE   6  (bases 1 to 4259)
  AUTHORS   Lu,Y., Zhang,X., Beheshti,B. and Zhang,J.
  TITLE     Adenoviral-mediated pHyde gene transfer and cisplatin additively
            inhibit human prostate cancer growth by enhancing apoptosis
  JOURNAL   Prostate 69 (3), 234-248 (2009)
   PUBMED   19016247
REFERENCE   7  (bases 1 to 4259)
  AUTHORS   Passer,B.J., Nancy-Portebois,V., Amzallag,N., Prieur,S., Cans,C.,
            Roborel de Climens,A., Fiucci,G., Bouvard,V., Tuynder,M.,
            Susini,L., Morchoisne,S., Crible,V., Lespagnol,A., Dausset,J.,
            Oren,M., Amson,R. and Telerman,A.
  TITLE     The p53-inducible TSAP6 gene product regulates apoptosis and the
            cell cycle and interacts with Nix and the Myt1 kinase
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2284-2289 (2003)
   PUBMED   12606722
  REMARK    GeneRIF: TSAP6 may augment Myt1 activity and act downstream to p53
            to interface apoptosis and cell-cycle progression
REFERENCE   8  (bases 1 to 4259)
  AUTHORS   Korkmaz,K.S., Elbi,C., Korkmaz,C.G., Loda,M., Hager,G.L. and
            Saatcioglu,F.
  TITLE     Molecular cloning and characterization of STAMP1, a highly
            prostate-specific six transmembrane protein that is overexpressed
            in prostate cancer
  JOURNAL   J Biol Chem 277 (39), 36689-36696 (2002)
   PUBMED   12095985
REFERENCE   9  (bases 1 to 4259)
  AUTHORS   Zhang,X., Steiner,M.S., Rinaldy,A. and Lu,Y.
  TITLE     Apoptosis induction in prostate cancer cells by a novel gene
            product, pHyde, involves caspase-3
  JOURNAL   Oncogene 20 (42), 5982-5990 (2001)
   PUBMED   11593405
REFERENCE   10 (bases 1 to 4259)
  AUTHORS   Steiner,M.S., Zhang,X., Wang,Y. and Lu,Y.
  TITLE     Growth inhibition of prostate cancer by an adenovirus expressing a
            novel tumor suppressor gene, pHyde
  JOURNAL   Cancer Res 60 (16), 4419-4425 (2000)
   PUBMED   10969787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL833624.1, BX538047.1 and
            AC016736.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_182915.2.
            
            Summary: This gene encodes a multipass membrane protein that
            functions as an iron transporter. The encoded protein can reduce
            both iron (Fe3+) and copper (Cu2+) cations. This protein may
            mediate downstream responses to p53, including promoting apoptosis.
            Deficiency in this gene can cause anemia. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833624.1, BX538047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393110.7/ ENSP00000376822.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL833624.1         27-32
            7-1910              BX538047.1         2-1905
            1911-4259           AC016736.6         4492-6840
FEATURES             Location/Qualifiers
     source          1..4259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..4259
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /note="STEAP3 metalloreductase"
                     /db_xref="GeneID:55240"
                     /db_xref="HGNC:HGNC:24592"
                     /db_xref="MIM:609671"
     exon            1..55
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /inference="alignment:Splign:2.1.0"
     exon            56..470
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..1945
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /EC_number="1.16.1.-"
                     /note="isoform a is encoded by transcript variant 1;
                     metalloreductase STEAP3; tumor suppressor pHyde; STEAP
                     family member 3, metalloreductase; tumor
                     suppressor-activated pathway protein 6; six-transmembrane
                     epithelial antigen of prostate 3; ferrireductase"
                     /codon_start=1
                     /product="metalloreductase STEAP3 isoform a"
                     /protein_id="NP_878919.2"
                     /db_xref="CCDS:CCDS42738.1"
                     /db_xref="GeneID:55240"
                     /db_xref="HGNC:HGNC:24592"
                     /db_xref="MIM:609671"
                     /translation="MSHQPAVATKMPEEMDKPLISLHLVDSDSSLAKVPDEAPKVGIL
                     GSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVTFQEEAVSSPEVIFVAVF
                     REHYSSLCSLSDQLAGKILVDVSNPTEQEHLQHRESNAEYLASLFPTCTVVKAFNVIS
                     AWTLQAGPRDGNRQVPICGDQPEAKRAVSEMALAMGFMPVDMGSLASAWEVEAMPLRL
                     LPAWKVPTLLALGLFVCFYAYNFVRDVLQPYVQESQNKFFKLPVSVVNTTLPCVAYVL
                     LSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFCAALHALYSFCLP
                     LRRAHRYDLVNLAVKQVLANKSHLWVEEEVWRMEIYLSLGVLALGTLSLLAVTSLPSI
                     ANSLNWREFSFVQSSLGFVALVLSTLHTLTYGWTRAFEESRYKFYLPPTFTLTLLVPC
                     VVILAKALFLLPCISRRLARIRRGWERESTIKFTLPTDHALAEKTSHV"
     exon            471..970
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1498
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1663
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..4259
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4236..4241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /note="hexamer: AATAAA"
     polyA_site      4259
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /note="major polyA site"
ORIGIN      
        1 gccttcgccg cggaccttca gctgccgcgg tcgctccgag cggcgggccg cagagatgac
       61 atttattcat tttatgcatc ctgggttcta ctggtcgtcc cacctcagtt cctgtagcaa
      121 agagacttga gtctgagcca ctaattatca cccgtgaggt ttcctccccg agcaggaagc
      181 agcaggccag agctgcgctc tctcagtgca ctctccaacc aagcatcagt caccactccc
      241 ggtccagccc ctgtggccaa gagctggcgt gcaggctgcg ggaggcagct ggctgtgcaa
      301 gaccctggca gggccctcgc ctcctgagaa accgagagtc agaaccaaag ccaggctgtc
      361 ctggttggag actgagccag aaagggtggc tcacctcacg gtgaggctgt cgagtgacct
      421 gagagcctca gaccctcacg tcagccggat gtcgcaccag cctgctgttg ccaccaaaat
      481 gccagaagag atggacaagc cactgatcag cctccacctg gtggacagcg atagtagcct
      541 tgccaaggtc cccgatgagg cccccaaagt gggcatcctg ggtagcgggg actttgcccg
      601 ctccctggcc acacgcctgg tgggctctgg cttcaaagtg gtggtgggga gccgcaaccc
      661 caaacgcaca gccaggctgt ttccctcagc ggcccaagtg actttccaag aggaggcagt
      721 gagctccccg gaggtcatct ttgtggctgt gttccgggag cactactctt cactgtgcag
      781 tctcagtgac cagctggcgg gcaagatcct ggtggatgtg agcaacccta cagagcaaga
      841 gcaccttcag catcgtgagt ccaatgctga gtacctggcc tccctcttcc ccacttgcac
      901 agtggtcaag gccttcaatg tcatctctgc ctggaccctg caggctggcc caagggatgg
      961 taacaggcag gtgcccatct gcggtgacca gccagaagcc aagcgtgctg tctcggagat
     1021 ggcgctcgcc atgggcttca tgcccgtgga catgggatcc ctggcgtcag cctgggaggt
     1081 ggaggccatg cccctgcgcc tcctcccggc ctggaaggtg cccaccctgc tggccctggg
     1141 gctcttcgtc tgcttctatg cctacaactt cgtccgggac gttctgcagc cctatgtgca
     1201 ggaaagccag aacaagttct tcaagctgcc cgtgtccgtg gtcaacacca cactgccgtg
     1261 cgtggcctac gtgctgctgt cactcgtgta cttgcccggc gtgctggcgg ctgccctgca
     1321 gctgcggcgc ggcaccaagt accagcgctt ccccgactgg ctggaccact ggctacagca
     1381 ccgcaagcag atcgggctgc tcagcttctt ctgcgccgcc ctgcacgccc tctacagctt
     1441 ctgcttgccg ctgcgccgcg cccaccgcta cgacctggtc aacctggcag tcaagcaggt
     1501 cttggccaac aagagccacc tctgggtgga ggaggaggtc tggcggatgg agatctacct
     1561 ctccctggga gtgctggccc tcggcacgtt gtccctgctg gccgtgacct cactgccgtc
     1621 cattgcaaac tcgctcaact ggagggagtt cagcttcgtt cagtcctcac tgggctttgt
     1681 ggccctcgtg ctgagcacac tgcacacgct cacctacggc tggacccgcg ccttcgagga
     1741 gagccgctac aagttctacc tgcctcccac cttcacgctc acgctgctgg tgccctgcgt
     1801 cgtcatcctg gccaaagccc tgtttctcct gccctgcatc agccgcagac tcgccaggat
     1861 ccggagaggc tgggagaggg agagcaccat caagttcacg ctgcccacag accacgccct
     1921 ggccgagaag acgagccacg tatgaggtgc ctgccctggg ctctggaccc cgggcacacg
     1981 agggacggtg ccctgagccc gttaggtttt cttttcttgg tggtgcaaag tggtataact
     2041 gtgtgcaaat aggaggtttg aggtccaaat tcctgggact caaatgtatg cagtactatt
     2101 cagaatgata tacacacata tgtgtatatg tatttacata tattccacat atataacagg
     2161 atttgcaatt atacatagct agctaaaaag ttgggtctct gagatttcaa cttgtagatt
     2221 taaaaacaag tgccgtacgt taagagaaga gcagatcatg ctattgtgac atttgcagag
     2281 atatacacac actttttgta cagaagaggc ttgtgctgtg gtgggttcga tttatccctg
     2341 cccaccccac ccccacaact tcccttttgc tacttcccca aggctcttgc agagctaggg
     2401 ctctgaaggg gagggaaggc aacggctctg cccagagcca tccctggagc atgtgagcag
     2461 cggctggtct cttccctcca cctggggcag cagcaggagg cctggggagg aggaaaatca
     2521 ggcagtcggc ctggagtctg tgcctggtcc tttgcccggt ggtgggagga tggagggatt
     2581 gggctgaagc tgctccacct catccttgct gagtggggga gacattttcc ctgaaagtca
     2641 gaagtcacca tagagcctgc aaatggatcc tcctgtgaga gtgacgtcac ctcctttcca
     2701 gagccattag tgagcctggc ttgggaacaa gtgtaatttc cttccctcct ttaacctggc
     2761 gatgagcgtc ctttaaacca ctgtgccttc tcaccctttc catcttcagt ttgaatgact
     2821 cccaggaagg cctagagcag accctttaga aatcagccca agggggagag caagagaaaa
     2881 cactctaggg agtaaagctc cccgggcgtc agagttgagc cctgcctggg ctgaaggact
     2941 gtcttcacga agtcagtcct gaggaaaaat attggggact ccaaatgtcc tctggcagag
     3001 gacccagaaa accacactgg ctccaacttc ctcctcatgg ggcattacac ttcaaaacag
     3061 tggggagcaa cttttccacc aaagctacaa acctaaaatg ctgctgcccc aaagcacaag
     3121 agggaagagc accgccgggg ccacaggacg tctgtcctcc agtcacaggc catccttgct
     3181 gctccctact gactctagct tacttcccct gtgaagaaac aggtgttctc ggctgagccc
     3241 ccaaccctct gcagaaccag gttgatctgc cacagaaaaa gcatctttga agacaaagag
     3301 ggtgaggtct tcatgagtct cctgggccca aagccatctt ctgatggaag gaagagagta
     3361 gggccagtga aggctgccca gagagaatgt cacagatgag gctgcccctg cccccccccc
     3421 gccagggagg tttcatgagc tcatgtctat gcagcacata agggttcttc agtgaaaagc
     3481 aggagaagag cccactgcaa ggatagctca ttaggcacat gaccgatgca gggaaggcca
     3541 tgccggggaa gctcttcctg caggtatttt ccatctgctg tgccaaggct gagcggcaga
     3601 aacttgtctc ataaattggc actgatggag catcagctgt ggcccacaga gagccttgct
     3661 gagaaggggg caggtaaagc agagatttta gcattgcctt ggcataacaa gggcccatcg
     3721 attccctact aatgagaggc agggagagca tgggcaatgg agacccacca atgatcccca
     3781 accccggtgg gtactggctg cctgccctgg gccagggaat ggctccttat accaaagatg
     3841 ctggcacata gcagaaccca gtgcacgtcc tccccttccc acccacctct ggctgaaggt
     3901 gctcaagagg gaagcaatta taaggtgggt ggcaggaggg aacaggtgcc acctgctgga
     3961 caatcacacg aaaggcaggc gggctgtgta ctgggccctg actgtgcgtc cactgctgtc
     4021 ttccctacct caccaggcta ctggcagcag catcccgaga gcacatcatc tccacagcct
     4081 ggtaaattcc atgtgcctct gggtacaaaa gtgcctcaac gacatgctct ggaaatccca
     4141 aatgccacag tctgaggttg atatctaaaa tctatgcctt caaaagagtc tctgtttttt
     4201 ttttttaacc tggtagacag tataaaagca gtgcaaataa acacctaacc ttctgcaaa
//
