LOCUS       NP_878919                498 aa            linear   PRI 07-MAY-2024
DEFINITION  metalloreductase STEAP3 isoform a [Homo sapiens].
ACCESSION   NP_878919
VERSION     NP_878919.2
DBSOURCE    REFSEQ: accession NM_182915.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 498)
  AUTHORS   Lv,J., Liu,X., Sun,Z., Gao,J., Yu,X., Zhang,M., Zhang,Z., Ren,S.
            and Zuo,Y.
  TITLE     STEAP3 promotes colon cancer cell proliferation and migration via
            regulating histone acetylation
  JOURNAL   Hum Genet 143 (3), 343-355 (2024)
   PUBMED   38480539
  REMARK    GeneRIF: STEAP3 promotes colon cancer cell proliferation and
            migration via regulating histone acetylation.
REFERENCE   2  (residues 1 to 498)
  AUTHORS   Han,Y., Fu,L., Kong,Y., Jiang,C., Huang,L. and Zhang,H.
  TITLE     STEAP3 Affects Ovarian Cancer Progression by Regulating Ferroptosis
            through the p53/SLC7A11 Pathway
  JOURNAL   Mediators Inflamm 2024, 4048527 (2024)
   PUBMED   38440354
  REMARK    GeneRIF: STEAP3 Affects Ovarian Cancer Progression by Regulating
            Ferroptosis through the p53/SLC7A11 Pathway.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 498)
  AUTHORS   Ding,T., Chen,S., Xiao,W., Liu,Z., Tu,J., Yu,Y., Dong,B., Chen,W.
            and Zeng,Y.
  TITLE     Six-Transmembrane Epithelial Antigen of Prostate 3 Promotes Hepatic
            Insulin Resistance and Steatosis
  JOURNAL   J Lipid Res 64 (1), 100318 (2023)
   PUBMED   36495944
  REMARK    GeneRIF: Six-Transmembrane Epithelial Antigen of Prostate 3
            Promotes Hepatic Insulin Resistance and Steatosis.
REFERENCE   4  (residues 1 to 498)
  AUTHORS   Ye,C.L., Du,Y., Yu,X., Chen,Z.Y., Wang,L., Zheng,Y.F. and Liu,X.H.
  TITLE     STEAP3 Affects Ferroptosis and Progression of Renal Cell Carcinoma
            Through the p53/xCT Pathway
  JOURNAL   Technol Cancer Res Treat 21, 15330338221078728 (2022)
   PUBMED   35275508
  REMARK    GeneRIF: STEAP3 Affects Ferroptosis and Progression of Renal Cell
            Carcinoma Through the p53/xCT Pathway.
REFERENCE   5  (residues 1 to 498)
  AUTHORS   Grunewald,T.G., Bach,H., Cossarizza,A. and Matsumoto,I.
  TITLE     The STEAP protein family: versatile oxidoreductases and targets for
            cancer immunotherapy with overlapping and distinct cellular
            functions
  JOURNAL   Biol Cell 104 (11), 641-657 (2012)
   PUBMED   22804687
REFERENCE   6  (residues 1 to 498)
  AUTHORS   Lu,Y., Zhang,X., Beheshti,B. and Zhang,J.
  TITLE     Adenoviral-mediated pHyde gene transfer and cisplatin additively
            inhibit human prostate cancer growth by enhancing apoptosis
  JOURNAL   Prostate 69 (3), 234-248 (2009)
   PUBMED   19016247
REFERENCE   7  (residues 1 to 498)
  AUTHORS   Passer,B.J., Nancy-Portebois,V., Amzallag,N., Prieur,S., Cans,C.,
            Roborel de Climens,A., Fiucci,G., Bouvard,V., Tuynder,M.,
            Susini,L., Morchoisne,S., Crible,V., Lespagnol,A., Dausset,J.,
            Oren,M., Amson,R. and Telerman,A.
  TITLE     The p53-inducible TSAP6 gene product regulates apoptosis and the
            cell cycle and interacts with Nix and the Myt1 kinase
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2284-2289 (2003)
   PUBMED   12606722
  REMARK    GeneRIF: TSAP6 may augment Myt1 activity and act downstream to p53
            to interface apoptosis and cell-cycle progression
REFERENCE   8  (residues 1 to 498)
  AUTHORS   Korkmaz,K.S., Elbi,C., Korkmaz,C.G., Loda,M., Hager,G.L. and
            Saatcioglu,F.
  TITLE     Molecular cloning and characterization of STAMP1, a highly
            prostate-specific six transmembrane protein that is overexpressed
            in prostate cancer
  JOURNAL   J Biol Chem 277 (39), 36689-36696 (2002)
   PUBMED   12095985
REFERENCE   9  (residues 1 to 498)
  AUTHORS   Zhang,X., Steiner,M.S., Rinaldy,A. and Lu,Y.
  TITLE     Apoptosis induction in prostate cancer cells by a novel gene
            product, pHyde, involves caspase-3
  JOURNAL   Oncogene 20 (42), 5982-5990 (2001)
   PUBMED   11593405
REFERENCE   10 (residues 1 to 498)
  AUTHORS   Steiner,M.S., Zhang,X., Wang,Y. and Lu,Y.
  TITLE     Growth inhibition of prostate cancer by an adenovirus expressing a
            novel tumor suppressor gene, pHyde
  JOURNAL   Cancer Res 60 (16), 4419-4425 (2000)
   PUBMED   10969787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL833624.1, BX538047.1 and
            AC016736.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 10, 2004 this sequence version replaced NP_878919.1.
            
            Summary: This gene encodes a multipass membrane protein that
            functions as an iron transporter. The encoded protein can reduce
            both iron (Fe3+) and copper (Cu2+) cations. This protein may
            mediate downstream responses to p53, including promoting apoptosis.
            Deficiency in this gene can cause anemia. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833624.1, BX538047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393110.7/ ENSP00000376822.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     Protein         1..498
                     /product="metalloreductase STEAP3 isoform a"
                     /EC_number="1.16.1.-"
                     /note="metalloreductase STEAP3; tumor suppressor pHyde;
                     STEAP family member 3, metalloreductase; tumor
                     suppressor-activated pathway protein 6; six-transmembrane
                     epithelial antigen of prostate 3; ferrireductase"
                     /calculated_mol_wt=55521
     Region          41..232
                     /region_name="COG2085"
                     /note="Predicted dinucleotide-binding enzyme [General
                     function prediction only]"
                     /db_xref="CDD:441688"
     Region          272..415
                     /region_name="Ferric_reduct"
                     /note="Ferric reductase like transmembrane component;
                     pfam01794"
                     /db_xref="CDD:426438"
     CDS             1..498
                     /gene="STEAP3"
                     /gene_synonym="AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3;
                     TSAP6"
                     /coded_by="NM_182915.3:449..1945"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS42738.1"
                     /db_xref="GeneID:55240"
                     /db_xref="HGNC:HGNC:24592"
                     /db_xref="MIM:609671"
ORIGIN      
        1 mshqpavatk mpeemdkpli slhlvdsdss lakvpdeapk vgilgsgdfa rslatrlvgs
       61 gfkvvvgsrn pkrtarlfps aaqvtfqeea vsspevifva vfrehysslc slsdqlagki
      121 lvdvsnpteq ehlqhresna eylaslfptc tvvkafnvis awtlqagprd gnrqvpicgd
      181 qpeakravse malamgfmpv dmgslasawe veamplrllp awkvptllal glfvcfyayn
      241 fvrdvlqpyv qesqnkffkl pvsvvnttlp cvayvllslv ylpgvlaaal qlrrgtkyqr
      301 fpdwldhwlq hrkqigllsf fcaalhalys fclplrrahr ydlvnlavkq vlankshlwv
      361 eeevwrmeiy lslgvlalgt lsllavtslp sianslnwre fsfvqsslgf valvlstlht
      421 ltygwtrafe esrykfylpp tftltllvpc vvilakalfl lpcisrrlar irrgwerest
      481 ikftlptdha laektshv
//
