LOCUS       NM_001244944            6984 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens STEAP2 metalloreductase (STEAP2), transcript variant
            4, mRNA.
ACCESSION   NM_001244944
VERSION     NM_001244944.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6984)
  AUTHORS   Torrez,C.Z., Easley,A., Bouamar,H., Zheng,G., Gu,X., Yang,J.,
            Chiu,Y.C., Chen,Y., Halff,G.A., Cigarroa,F.G. and Sun,L.Z.
  TITLE     STEAP2 promotes hepatocellular carcinoma progression via increased
            copper levels and stress-activated MAP kinase activity
  JOURNAL   Sci Rep 14 (1), 12753 (2024)
   PUBMED   38830975
  REMARK    GeneRIF: STEAP2 promotes hepatocellular carcinoma progression via
            increased copper levels and stress-activated MAP kinase activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6984)
  AUTHORS   Wang,Y., Chen,S., Chen,S. and Jiang,J.
  TITLE     Unveiling the role of copper metabolism and STEAP2 in idiopathic
            pulmonary fibrosis molecular landscape
  JOURNAL   J Cell Mol Med 28 (11), e18414 (2024)
   PUBMED   38872435
  REMARK    GeneRIF: Unveiling the role of copper metabolism and STEAP2 in
            idiopathic pulmonary fibrosis molecular landscape.
REFERENCE   3  (bases 1 to 6984)
  AUTHORS   Zhang,D., Liu,H., Wang,W., Xu,G., Yin,C. and Wang,S.
  TITLE     STEAP2 promotes osteosarcoma progression by inducing
            epithelial-mesenchymal transition via the PI3K/AKT/mTOR signaling
            pathway and is regulated by EFEMP2
  JOURNAL   Cancer Biol Ther 23 (1), 1-16 (2022)
   PUBMED   36316642
  REMARK    GeneRIF: STEAP2 promotes osteosarcoma progression by inducing
            epithelial-mesenchymal transition via the PI3K/AKT/mTOR signaling
            pathway and is regulated by EFEMP2.
REFERENCE   4  (bases 1 to 6984)
  AUTHORS   Zhu,Y., Peng,X., Zhou,Q., Tan,L., Zhang,C., Lin,S. and Long,M.
  TITLE     METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary
            thyroid cancer progress by blocking the Hedgehog signaling pathway
            and epithelial-to-mesenchymal transition
  JOURNAL   Cell Death Dis 13 (4), 358 (2022)
   PUBMED   35436987
  REMARK    GeneRIF: METTL3-mediated m6A modification of STEAP2 mRNA inhibits
            papillary thyroid cancer progress by blocking the Hedgehog
            signaling pathway and epithelial-to-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6984)
  AUTHORS   Zhao,Z., Wang,Z., Song,Z., Wu,Y., Jin,Q. and Zhao,Z.
  TITLE     Predictive potential of STEAP family for survival, immune
            microenvironment and therapy response in glioma
  JOURNAL   Int Immunopharmacol 101 (Pt A), 108183 (2021)
   PUBMED   34649092
  REMARK    GeneRIF: Predictive potential of STEAP family for survival, immune
            microenvironment and therapy response in glioma.
REFERENCE   6  (bases 1 to 6984)
  AUTHORS   Korkmaz,C.G., Korkmaz,K.S., Kurys,P., Elbi,C., Wang,L., Klokk,T.I.,
            Hammarstrom,C., Troen,G., Svindland,A., Hager,G.L. and
            Saatcioglu,F.
  TITLE     Molecular cloning and characterization of STAMP2, an
            androgen-regulated six transmembrane protein that is overexpressed
            in prostate cancer
  JOURNAL   Oncogene 24 (31), 4934-4945 (2005)
   PUBMED   15897894
  REMARK    GeneRIF: Expression of STAMP2, a gene highly similar to STAMP1
            (STEAP2), in prostate cancer cells significantly increases cell
            growth and colony formation suggesting that STAMP2 may have a role
            in cell proliferation.
REFERENCE   7  (bases 1 to 6984)
  AUTHORS   Sanchez-Pulido,L., Rojas,A.M., Valencia,A., Martinez-A,C. and
            Andrade,M.A.
  TITLE     ACRATA: a novel electron transfer domain associated to apoptosis
            and cancer
  JOURNAL   BMC Cancer 4, 98 (2004)
   PUBMED   15623366
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6984)
  AUTHORS   Porkka,K.P., Helenius,M.A. and Visakorpi,T.
  TITLE     Cloning and characterization of a novel six-transmembrane protein
            STEAP2, expressed in normal and malignant prostate
  JOURNAL   Lab Invest 82 (11), 1573-1582 (2002)
   PUBMED   12429817
  REMARK    GeneRIF: STEAP2 is involved in the development of prostate cancer.
            As a cell-surface antigen, it is a potential diagnostic or
            therapeutic target in prostate cancer.
REFERENCE   9  (bases 1 to 6984)
  AUTHORS   Korkmaz,K.S., Elbi,C., Korkmaz,C.G., Loda,M., Hager,G.L. and
            Saatcioglu,F.
  TITLE     Molecular cloning and characterization of STAMP1, a highly
            prostate-specific six transmembrane protein that is overexpressed
            in prostate cancer
  JOURNAL   J Biol Chem 277 (39), 36689-36696 (2002)
   PUBMED   12095985
  REMARK    GeneRIF: cloning and characterization of STAMP1, which is expressed
            in both normal prostate and prostate neoplasms
REFERENCE   10 (bases 1 to 6984)
  AUTHORS   Walker,M.G., Volkmuth,W., Sprinzak,E., Hodgson,D. and Klingler,T.
  TITLE     Prediction of gene function by genome-scale expression analysis:
            prostate cancer-associated genes
  JOURNAL   Genome Res 9 (12), 1198-1203 (1999)
   PUBMED   10613842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002064.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001244944.1.
            
            Summary: This gene is a member of the STEAP family and encodes a
            multi-pass membrane protein that localizes to the Golgi complex,
            the plasma membrane, and the vesicular tubular structures in the
            cytosol. A highly similar protein in mouse has both ferrireductase
            and cupric reductase activity, and stimulates the cellular uptake
            of both iron and copper in vitro. Increased transcriptional
            expression of the human gene is associated with prostate cancer
            progression. Alternate transcriptional splice variants, encoding
            different isoforms, have been characterized. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 4 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.264780.1,
                                           SRR1660809.98168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394621.7/ ENSP00000378119.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC002064.1         4013-4318
            307-419             AC002064.1         8764-8876
            420-944             AC002064.1         17323-17847
            945-1472            AC002064.1         19244-19771
            1473-1637           AC002064.1         22145-22309
            1638-6984           AC002064.1         24610-29956
FEATURES             Location/Qualifiers
     source          1..6984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.13"
     gene            1..6984
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /note="STEAP2 metalloreductase"
                     /db_xref="GeneID:261729"
                     /db_xref="HGNC:HGNC:17885"
                     /db_xref="MIM:605094"
     exon            1..306
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     exon            307..419
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     exon            420..944
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1925
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /EC_number="1.16.1.-"
                     /note="isoform a is encoded by transcript variant 4;
                     metalloreductase STEAP2; six transmembrane epithelial
                     antigen of the prostate 2; protein up-regulated in
                     metastatic prostate cancer; protein upregulated in
                     metastatic prostate cancer; SixTransMembrane Protein of
                     Prostate 1; prostate cancer-associated protein 1;
                     six-transmembrane epithelial antigen of prostate 2; STEAP
                     family member 2, metalloreductase"
                     /codon_start=1
                     /product="metalloreductase STEAP2 isoform a"
                     /protein_id="NP_001231873.1"
                     /db_xref="CCDS:CCDS5615.1"
                     /db_xref="GeneID:261729"
                     /db_xref="HGNC:HGNC:17885"
                     /db_xref="MIM:605094"
                     /translation="MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKS
                     LTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLW
                     DLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKD
                     ASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVV
                     AISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLL
                     AAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFL
                     NMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFS
                     FIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILF
                     LPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM"
     exon            945..1472
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1637
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..6984
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6892..6897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /note="hexamer: AATAAA"
     polyA_site      6918
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /note="major polyA site"
     regulatory      6960..6965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
                     /note="hexamer: ATTAAA"
     polyA_site      6984
                     /gene="STEAP2"
                     /gene_synonym="IPCA1; PCANAP1; PUMPCn; STAMP1; STMP"
ORIGIN      
        1 agtcagcgtt cctcgggccc tcggcgccac gagctgtccg ggcacgcagc ccctagcggc
       61 gcgtcgctgc caagccggcc tccgcgcgcc tccctccttc cttctcccct ggctgttcgc
      121 gatccagctt gggtaggcgg ggaagcagct ggagtgcgac cgccgcggca gccaccctgc
      181 aaccgccagt cggaggtgca gtccgtaggc cctggccccc gggtgggccc ttggggagtc
      241 ggcgccgctc ccggggagct gcaaggctcg cccctgcccg gcgtggaggg cgcggggggc
      301 gcggagaaag tgaagagagg aaattggaaa attgtgagtg gaccttctga tactgctcct
      361 ccttgcgtgg aaaaggggaa agaactgcat gcatattatt cagcgtccta tattcaaagg
      421 atattcttgg tgatcttgga agtgtccgta tcatggaatc aatctctatg atgggaagcc
      481 ctaagagcct tagtgaaact tttttaccta atggcataaa tggtatcaaa gatgcaagga
      541 aggtcactgt aggtgtgatt ggaagtggag attttgccaa atccttgacc attcgactta
      601 ttagatgcgg ctatcatgtg gtcataggaa gtagaaatcc taagtttgct tctgaatttt
      661 ttcctcatgt ggtagatgtc actcatcatg aagatgctct cacaaaaaca aatataatat
      721 ttgttgctat acacagagaa cattatacct ccctgtggga cctgagacat ctgcttgtgg
      781 gtaaaatcct gattgatgtg agcaataaca tgaggataaa ccagtaccca gaatccaatg
      841 ctgaatattt ggcttcatta ttcccagatt ctttgattgt caaaggattt aatgttgtct
      901 cagcttgggc acttcagtta ggacctaagg atgccagccg gcaggtttat atatgcagca
      961 acaatattca agcgcgacaa caggttattg aacttgcccg ccagttgaat ttcattccca
     1021 ttgacttggg atccttatca tcagccagag agattgaaaa tttaccccta cgactcttta
     1081 ctctctggag agggccagtg gtggtagcta taagcttggc cacatttttt ttcctttatt
     1141 cctttgtcag agatgtgatt catccatatg ctagaaacca acagagtgac ttttacaaaa
     1201 ttcctataga gattgtgaat aaaaccttac ctatagttgc cattactttg ctctccctag
     1261 tatacctcgc aggtcttctg gcagctgctt atcaacttta ttacggcacc aagtatagga
     1321 gatttccacc ttggttggaa acctggttac agtgtagaaa acagcttgga ttactaagtt
     1381 ttttcttcgc tatggtccat gttgcctaca gcctctgctt accgatgaga aggtcagaga
     1441 gatatttgtt tctcaacatg gcttatcagc aggttcatgc aaatattgaa aactcttgga
     1501 atgaggaaga agtttggaga attgaaatgt atatctcctt tggcataatg agccttggct
     1561 tactttccct cctggcagtc acttctatcc cttcagtgag caatgcttta aactggagag
     1621 aattcagttt tattcagtct acacttggat atgtcgctct gctcataagt actttccatg
     1681 ttttaattta tggatggaaa cgagcttttg aggaagagta ctacagattt tatacaccac
     1741 caaactttgt tcttgctctt gttttgccct caattgtaat tctgggtaag attattttat
     1801 tccttccatg tataagccga aagctaaaac gaattaaaaa aggctgggaa aagagccaat
     1861 ttctggaaga aggtatggga ggaacaattc ctcatgtctc cccggagagg gtcacagtaa
     1921 tgtgatgaca aatggtgttc acagctgcca tataaagttc tactcatgcc attattttta
     1981 tgacttctac gttcagttac aagtatgctg tcaaattatc gtgggttgaa acttgttaaa
     2041 tgagatttca actgacttag tgatagagtt ttcttcaagt taattttcac aaatgtcatg
     2101 tttgccaata tgaatttttc tagtcaacat attattgtaa tttaggtatg ttttgttttg
     2161 ttttgcacaa ctgtaaccct gttgttactt tatatttcat aatcaggcaa aaatacttac
     2221 agttaataat atagatataa tgttaaaaac aatttgcaaa ccagcagaat tttaagcttt
     2281 taaaataatt caatggatat acattttttt ctgaagatta agattttaat tattcaactt
     2341 aaaaagtaga aatgcattat tatacatttt tttaagaaag gacacgttat gttagcatct
     2401 aggtaaggct gcatgatagc attcctatat ttctctcata aaataggatt tgaaggatga
     2461 aattaattgt atgaagcaat gtgattatat gaagagacac aaattaaaaa gacaaattaa
     2521 acctgaaatt atatttaaaa tatatttgag acatgaaata catactgata atacatacct
     2581 catgaaagat tttattcttt attgtgttac agagcagttt cattttcata ttaatatact
     2641 gatcaggaag aggattcagt aacatttggc ttccaaaact gctatctcta atacggtacc
     2701 aatcctagga actgtatact agttcctact tagaacaaaa gtatcaagtt tgcacacaag
     2761 taatctgcca gctgaccttt gtcgcacctt aaccagtcac cacttgctat ggtataggat
     2821 tatactgatg ttctttgagg gattctgatg tgctaggcat ggttctaagt actttacttg
     2881 tattatccca tttaatactt agaacaaccc cgtgagataa gtagttatta tcctcatttt
     2941 acacatgagg gaccgaagga tagaaaagtt atttttcaaa ggtcttgcag ttaataaatg
     3001 gcagagtgag cattcaagtc caggtagtca tattccagag gccacggttt taaccactag
     3061 gctctagagc tcccgccgcg cccctatgca ttatgttcac aatgccaatc tagatgcttc
     3121 ctcttttgta taaagtcact gacattcttt agagtgggtt gggtgcatcc aaaaatgtat
     3181 aaaaatatta ttataataaa cttattactg cttgtagggt aattcacagt tacttaccct
     3241 attcttgctt ggaacatgag cctggagacc catggcagtc catatgcctc cctatgcagt
     3301 gaagggccct agcagtgtta acaaattgct gagatcccac ggagtctttc aaaaatctct
     3361 gtagagttag tcttctcctt ttctcttcct gagaagttct cctgcctgca taaccattca
     3421 ttagggagta ctttacaagc atgaaggata ttagggtaag tggctaatta taaatctact
     3481 ctagagacat ataatcatac agattattca taaaattttt cagtgctgtc cttccacatt
     3541 taattgcatt ttgctcaaac tgtagaatgc cctacattcc ccccacccca atttgctatt
     3601 tccttattaa aatagaaaat tataggcaag atacaattat atgcgttcct cttcctgaaa
     3661 ttataacatt tctaaactta cccacgtagg tactactgaa tccaactgcc aacaataaaa
     3721 agacttttat ttagtagagg ctacctttcc caccagtgac tctttttcta caactgcctt
     3781 gtcagtttgg taattcactt atgattttct aatgttctct tggtgaattt tattatcttg
     3841 taccctcttt tttttttttt ttttttttaa agacagagtc ttgctctgtc acccaggctg
     3901 gagtgcagtg gcacgatctc ggctcactgc aagctctgcc tcccgggttc acgccattct
     3961 cctgcctcag cctcccgagt agctgggact acaggtgccc gccaccatgc ccggctgatt
     4021 tctttttgta tttttagtag agacggagtt tcaccgtgtt agccaggatg gtctcgatct
     4081 cctgacctcg tgatccgccc gccttggcct ccaaagtgct gggattacag gtgtgagcta
     4141 ccgcgcccgg cctattatct tgtactttct aactgagccc tctattttct ttattttaat
     4201 aatatttctc cccacttgag aatcacttgt tagttcttgg taggaattca gttgggcaat
     4261 gataactttt atgggcaaaa acattctatt atagtgaact aatgaaaata acagcgtatt
     4321 ttcaatattt tcttattcct taaattccac tcttttaaca ctatgcttaa ccacttaatg
     4381 tgatgaaata ttcctaaaag ttaaatgact attaaagcat atattgttgc atgtatatat
     4441 taagtagccg atactctaaa taaaaatacc actgttacag ataaatgggg cctttaaaaa
     4501 tatgaaaaac aaacttgtga aaatgtataa aagatgcatc tgttgtttca aatggcacta
     4561 tcttcttttc agtactacaa aaacagaata attttgaagt tttagaataa atgtaatata
     4621 tttactataa ttctaaatgt ttaaatgctt ttctaaaaat gcaaaactat gatgtttagt
     4681 tgctttattt tacctctatg tgattatttt tcttaattgt tattttttat aatcattatt
     4741 tttctgaacc attcttctgg cctcagaagt aggactgaat tctactattg ctaggtgtga
     4801 gaaagtggtg gtgagaacct tagagcagtg gagatttgct acctggtctg tgttttgaga
     4861 agtgcccctt agaaagttaa aagaatgtag aaaagatact cagtcttaat cctatgcaaa
     4921 aaaaaaaatc aagtaattgt tttcctatga ggaaaataac catgagctgt atcatgctac
     4981 ttagctttta tgtaaatatt tcttatgtct cctctattaa gagtatttaa aatcatattt
     5041 aaatatgaat ctattcatgc taacattatt tttcaaaaca tacatggaaa tttagcccag
     5101 attgtctaca tataaggttt ttatttgaat tgtaaaatat ttaaaagtat gaataaaata
     5161 tatttatagg tatttatcag agatgattat tttgtgctac atacaggttg gctaatgagc
     5221 tctagtgtta aactacctga ttaatttctt ataaagcagc ataaccttgg cttgattaag
     5281 gaattctact ttcaaaaatt aatctgataa tagtaacaag gtatattata ctttcattac
     5341 aatcaaatta tagaaattac ttgtgtaaaa gggcttcaag aatatatcca atttttaaat
     5401 attttaatat atctcctatc tgataactta attcttctaa attaccactt gccattaagc
     5461 tatttcataa taaattctgt acagtttccc cccaaaaaag agatttattt atgaaatatt
     5521 taaagtttct aatgtggtat tttaaataaa gtatcataaa tgtaataagt aaatatttat
     5581 ttaggaatac tgtgaacact gaactaatta ttcctgtgtc agtctatgaa atccctgttt
     5641 tgaaatacgt aaacagccta aaatgtgttg aaattatttt gtaaatccat gacttaaaac
     5701 aagatacata catagtataa cacacctcac agtgttaaga tttatattgt gaaatgagac
     5761 accctacctt caattgttca tcagtgggta aaacaaattc tgatgtacat tcaggacaaa
     5821 tgattagccc taaatgaaac tgtaataatt tcagtggaaa ctcaatctgt ttttaccttt
     5881 aaacagtgaa ttttacatga atgaatgggt tcttcacttt ttttttagta tgagaaaatt
     5941 atacagtgct taattttcag agattctttc catatgttac taaaaaatgt tttgttcagc
     6001 ctaacatact gagttttttt taactttcta aattattgaa tttccatcat gcattcatcc
     6061 aaaattaagg cagactgttt ggattcttcc agtggccaga tgagctaaat taaatcacaa
     6121 aagcagatgc ttttgtatga tctccaaatt gccaacttta aggaaatatt ctcttgaaat
     6181 tgtctttaaa gatcttttgc agctttgcag atacccagac tgagctggaa ctggaatttg
     6241 tcttcctatt gactctactt ctttaaaagc ggctgcccat tacattcctc agctgtcctt
     6301 gcagttaggt gtacatgtga ctgagtgttg gccagtgaga tgaagtctcc tcaaaggaag
     6361 gcagcatgtg tcctttttca tcccttcatc ttgctgctgg gattgtggat ataacaggag
     6421 ccctggcagc tgtctccaga ggatcaaagc cacacccaaa gagtaaggca gattagagac
     6481 cagaaagacc ttgactactt ccctacttcc actgcttttt cctgcattta agccattgta
     6541 aatctgggtg tgttacatga agtgaaaatt aattctttct gcccttcagt tctttatcct
     6601 gataccattt aacactgtct gaattaacta gactgcaata attctttctt ttgaaagctt
     6661 ttaaaggata atgtgcaatt cacattaaaa ttgattttcc attgtcaatt agttatactc
     6721 attttcctgc cttgatcttt cattagatat tttgtatctg cttggaatat attatcttct
     6781 ttttaactgt gtaattggta attactaaaa ctctgtaatc tccaaaatat tgctatcaaa
     6841 ttacacacca tgttttctat cattctcata gatctgcctt ataaacattt aaataaaaag
     6901 tactatttaa tgatttaact tctgttttga aatgttgtat acacgtggat ttttttctca
     6961 ttaaataata attctagtat ttga
//
