LOCUS       NM_001382447            1261 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens STEAP family member 1B (STEAP1B), transcript variant
            3, mRNA.
ACCESSION   NM_001382447
VERSION     NM_001382447.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1261)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1261)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1261)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1261)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1261)
  AUTHORS   Gomes,I.M., Santos,C.R. and Maia,C.J.
  TITLE     Expression of STEAP1 and STEAP1B in prostate cell lines, and the
            putative regulation of STEAP1 by post-transcriptional and
            post-translational mechanisms
  JOURNAL   Genes Cancer 5 (3-4), 142-151 (2014)
   PUBMED   25053991
  REMARK    GeneRIF: STEAP1B transcripts have similar structural features to
            STEAP1, but may encode proteins with less transmembrane domains.
            STEAP1B2 transcript is also overexpressed on neoplastic prostate,
            making it worth to evaluate its potential as cancer biomarker
REFERENCE   6  (bases 1 to 1261)
  AUTHORS   Murea,M., Lu,L., Ma,L., Hicks,P.J., Divers,J., McDonough,C.W.,
            Langefeld,C.D., Bowden,D.W. and Freedman,B.I.
  TITLE     Genome-wide association scan for survival on dialysis in
            African-Americans with type 2 diabetes
  JOURNAL   Am J Nephrol 33 (6), 502-509 (2011)
   PUBMED   21546767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002480.1, AC005061.2 and AC099759.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.668499.1,
                                           SRR18074967.1272139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000678116.1/ ENSP00000503251.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC002480.1         4593-4667           c
            76-190              AC005061.2         113879-113993       c
            191-703             AC005061.2         112431-112943       c
            704-868             AC005061.2         111672-111836       c
            869-1261            AC099759.4         56209-56601         c
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..1261
                     /gene="STEAP1B"
                     /note="STEAP family member 1B"
                     /db_xref="GeneID:256227"
                     /db_xref="HGNC:HGNC:41907"
     exon            1..75
                     /gene="STEAP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            76..190
                     /gene="STEAP1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..901
                     /gene="STEAP1B"
                     /note="isoform 3 is encoded by transcript variant 3; STEAP
                     family protein MGC87042"
                     /codon_start=1
                     /product="STEAP family member 1B isoform 3"
                     /protein_id="NP_001369376.1"
                     /db_xref="CCDS:CCDS94065.1"
                     /db_xref="GeneID:256227"
                     /db_xref="HGNC:HGNC:41907"
                     /translation="MESRKDITNQEEIWKMKPRRNLEDNDYLHEDTGETSMLKRPVLL
                     HLQQTAHADEFDCPSELQHAQELFPQWHLPIKIAAVMASLTFLYTLLREVIHPLATSH
                     QQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQVHNGTKYKKFPHWLDKWMLT
                     RKQFGLLSLFFAVLHAIYTLSYAMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEI
                     YVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQVHGRINFLTL"
     exon            191..703
                     /gene="STEAP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            704..868
                     /gene="STEAP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1261
                     /gene="STEAP1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STEAP1B"
                     /note="hexamer: ATTAAA"
     polyA_site      1261
                     /gene="STEAP1B"
                     /note="major polyA site"
ORIGIN      
        1 aggcgccgcg tggggccggc acctcccggc agcagcggca gctgagactc acggtcaagc
       61 tacggcgagg agtgggtggc tgaagccata ctattttata gaattaatgg aaagcagaaa
      121 agacatcaca aaccaagaag aaatttggaa aatgaagcct aggagaaatt tagaagacaa
      181 cgattatttg catgaggaca cgggagagac cagcatgcta aaaagacctg tgcttttgca
      241 tttgcagcaa acagcccatg ctgatgaatt tgactgccct tcagaacttc agcacgcaca
      301 ggaactcttt ccacagtggc acttgccaat taaaatagct gctgttatgg catctctgac
      361 ttttctttac actcttctga gggaagtaat tcacccttta gcaacttccc atcaacaata
      421 tttttataaa attccaatcc tggtcatcaa caaagtcttg ccaatggttt ccatcactct
      481 cttggcattg gtttacctac caggtgtgat agcagcaatt gtccaagttc ataatggaac
      541 caagtataag aagtttccac attggttgga taagtggatg ttaacaagaa agcagtttgg
      601 gcttctcagt ttgttttttg ctgtactgca tgcaatttat actctgtctt acgcaatgag
      661 gcgatcctac agatacaagt tgctaaactg ggcatatcaa caggtccaac aaaataaaga
      721 agatgcctgg attgagcatg atgtttggag aatggagatt tatgtgtctc tgggaattgt
      781 gggactggca atactggctc tgttggctgt gacatctatt ccatctgtga gtgactcttt
      841 gacatggaga gaatttcact atattcaggt acatggtagg atcaacttcc tgaccttgtg
      901 acagatcctg ccagtaacat gagaggaaat gagaacgagg ctttggagca cagcattgga
      961 ttgctcatgc agaacaccac ccagtgccct ttccctctgc cacaatgaac agccatgctg
     1021 caggtgacgg ctgctctgtc aacatggatc cggcagggca gatgagtgga tcccccagcg
     1081 gactcatgag agagcaaaca aaaagtccat atgtgttgtg ctaatccact gagattgtgt
     1141 tggttgttac ggagcctaac ctagcctatc ccgacacgag gatcagacat gataatcaaa
     1201 tgtgtttata aagtgttgga tggaaatatt ctgacaacat taaaagactc tacccaagga
     1261 a
//
