LOCUS       NM_012449               1219 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens STEAP family member 1 (STEAP1), mRNA.
ACCESSION   NM_012449 XM_940149
VERSION     NM_012449.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1219)
  AUTHORS   Zhao,S., Chen,H., Zhou,Y., Wang,Q., Liang,X., Yang,N., Yan,L. and
            Yang,J.
  TITLE     Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in
            Carcinomas: A Meta-Analysis
  JOURNAL   Front Biosci (Landmark Ed) 28 (11), 280 (2023)
   PUBMED   38062846
  REMARK    GeneRIF: Six Transmembrane Epithelial Antigen 1 as a Prognostic
            Biomarker in Carcinomas: A Meta-Analysis.
REFERENCE   2  (bases 1 to 1219)
  AUTHORS   Rocha,S.M., Santos,F.M., Socorro,S., Passarinha,L.A. and Maia,C.J.
  TITLE     Proteomic analysis of STEAP1 knockdown in human LNCaP prostate
            cancer cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (7), 119522 (2023)
   PUBMED   37315586
  REMARK    GeneRIF: Proteomic analysis of STEAP1 knockdown in human LNCaP
            prostate cancer cells.
REFERENCE   3  (bases 1 to 1219)
  AUTHORS   Zou,X., Liu,C., Huang,Z., Xiang,S., Li,K., Yuan,Y., Hao,Y. and
            Zhou,F.
  TITLE     Inhibition of STEAP1 ameliorates inflammation and ferroptosis of
            acute lung injury caused by sepsis in LPS-induced human pulmonary
            microvascular endothelial cells
  JOURNAL   Mol Biol Rep 50 (7), 5667-5674 (2023)
   PUBMED   37209327
  REMARK    GeneRIF: Inhibition of STEAP1 ameliorates inflammation and
            ferroptosis of acute lung injury caused by sepsis in LPS-induced
            human pulmonary microvascular endothelial cells.
REFERENCE   4  (bases 1 to 1219)
  AUTHORS   Rocha,S.M., Nascimento,D., Cardoso,A.M., Passarinha,L., Socorro,S.
            and Maia,C.J.
  TITLE     STEAP1 regulation and its influence modulating the response of
            LNCaP prostate cancer cells to bicalutamide, enzalutamide and
            apalutamide
  JOURNAL   Mol Med Rep 27 (2) (2023)
   PUBMED   36660947
  REMARK    GeneRIF: STEAP1 regulation and its influence modulating the
            response of LNCaP prostate cancer cells to bicalutamide,
            enzalutamide and apalutamide.
REFERENCE   5  (bases 1 to 1219)
  AUTHORS   Zhao,C., Xiong,K., Ji,Z., Liu,F. and Li,X.
  TITLE     The Prognostic Value and Immunological Role of STEAP1 in
            Pan-Cancer: A Result of Data-Based Analysis
  JOURNAL   Oxid Med Cell Longev 2022, 8297011 (2022)
   PUBMED   35313641
  REMARK    GeneRIF: The Prognostic Value and Immunological Role of STEAP1 in
            Pan-Cancer: A Result of Data-Based Analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1219)
  AUTHORS   Valenti,M.T., Dalle Carbonare,L., Donatelli,L., Bertoldo,F.,
            Giovanazzi,B., Caliari,F. and Lo Cascio,V.
  TITLE     STEAP mRNA detection in serum of patients with solid tumours
  JOURNAL   Cancer Lett 273 (1), 122-126 (2009)
   PUBMED   18793824
  REMARK    GeneRIF: STEAP mRNA is used here as a marker to evaluate biological
            samples from individuals suspected of having cancers, and may
            provide prognostic information useful in defining appropriate
            therapeutic options.
REFERENCE   7  (bases 1 to 1219)
  AUTHORS   Rodeberg,D.A., Nuss,R.A., Elsawa,S.F. and Celis,E.
  TITLE     Recognition of six-transmembrane epithelial antigen of the
            prostate-expressing tumor cells by peptide antigen-induced
            cytotoxic T lymphocytes
  JOURNAL   Clin Cancer Res 11 (12), 4545-4552 (2005)
   PUBMED   15958640
  REMARK    GeneRIF: Peptide STEAP-292.2L (MLAVFLPIV) may have potential as an
            antitumor peptide vaccine.
REFERENCE   8  (bases 1 to 1219)
  AUTHORS   Korkmaz,K.S., Elbi,C., Korkmaz,C.G., Loda,M., Hager,G.L. and
            Saatcioglu,F.
  TITLE     Molecular cloning and characterization of STAMP1, a highly
            prostate-specific six transmembrane protein that is overexpressed
            in prostate cancer
  JOURNAL   J Biol Chem 277 (39), 36689-36696 (2002)
   PUBMED   12095985
REFERENCE   9  (bases 1 to 1219)
  AUTHORS   Yang,D., Holt,G.E., Velders,M.P., Kwon,E.D. and Kast,W.M.
  TITLE     Murine six-transmembrane epithelial antigen of the prostate,
            prostate stem cell antigen, and prostate-specific membrane antigen:
            prostate-specific cell-surface antigens highly expressed in
            prostate cancer of transgenic adenocarcinoma mouse prostate mice
  JOURNAL   Cancer Res 61 (15), 5857-5860 (2001)
   PUBMED   11479226
REFERENCE   10 (bases 1 to 1219)
  AUTHORS   Hubert,R.S., Vivanco,I., Chen,E., Rastegar,S., Leong,K.,
            Mitchell,S.C., Madraswala,R., Zhou,Y., Kuo,J., Raitano,A.B.,
            Jakobovits,A., Saffran,D.C. and Afar,D.E.
  TITLE     STEAP: a prostate-specific cell-surface antigen highly expressed in
            human prostate tumors
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14523-14528 (1999)
   PUBMED   10588738
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004969.1.
            
            On Nov 26, 2018 this sequence version replaced NM_012449.2.
            
            Summary: This gene is predominantly expressed in prostate tissue,
            and is found to be upregulated in multiple cancer cell lines. The
            gene product is predicted to be a six-transmembrane protein, and
            was shown to be a cell surface antigen significantly expressed at
            cell-cell junctions. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.78951.1,
                                           SRR5189664.91736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297205.7/ ENSP00000297205.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC004969.1         51789-51863
            76-190              AC004969.1         57078-57192
            191-703             AC004969.1         58125-58637
            704-868             AC004969.1         59234-59398
            869-1219            AC004969.1         61797-62147
FEATURES             Location/Qualifiers
     source          1..1219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.13"
     gene            1..1219
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /note="STEAP family member 1"
                     /db_xref="GeneID:26872"
                     /db_xref="HGNC:HGNC:11378"
                     /db_xref="MIM:604415"
     exon            1..75
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            76..190
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1126
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /EC_number="1.16.1.-"
                     /note="metalloreductase STEAP1; six-transmembrane
                     epithelial antigen of prostate 1; six transmembrane
                     epithelial antigen of the prostate 1; STEAP1
                     metalloreductase"
                     /codon_start=1
                     /product="STEAP1 protein"
                     /protein_id="NP_036581.1"
                     /db_xref="CCDS:CCDS5614.1"
                     /db_xref="GeneID:26872"
                     /db_xref="HGNC:HGNC:11378"
                     /db_xref="MIM:604415"
                     /translation="MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLL
                     HLHQTAHADEFDCPSELQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSH
                     QQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLT
                     RKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEI
                     YVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNK
                     WIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLPCLRKKILKIRHGWEDVTKINKTE
                     ICSQL"
     exon            191..703
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            704..868
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1219
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1199..1204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /note="hexamer: AATAAA"
     polyA_site      1219
                     /gene="STEAP1"
                     /gene_synonym="PRSS24; STEAP"
                     /note="major polyA site"
ORIGIN      
        1 aggcgccgcg tggggcccgc acctctgggc agcagcggca gccgagactc acggtcaagc
       61 taaggcgaag agtgggtggc tgaagccata ctattttata gaattaatgg aaagcagaaa
      121 agacatcaca aaccaagaag aactttggaa aatgaagcct aggagaaatt tagaagaaga
      181 cgattatttg cataaggaca cgggagagac cagcatgcta aaaagacctg tgcttttgca
      241 tttgcaccaa acagcccatg ctgatgaatt tgactgccct tcagaacttc agcacacaca
      301 ggaactcttt ccacagtggc acttgccaat taaaatagct gctattatag catctctgac
      361 ttttctttac actcttctga gggaagtaat tcacccttta gcaacttccc atcaacaata
      421 tttttataaa attccaatcc tggtcatcaa caaagtcttg ccaatggttt ccatcactct
      481 cttggcattg gtttacctgc caggtgtgat agcagcaatt gtccaacttc ataatggaac
      541 caagtataag aagtttccac attggttgga taagtggatg ttaacaagaa agcagtttgg
      601 gcttctcagt ttcttttttg ctgtactgca tgcaatttat agtctgtctt acccaatgag
      661 gcgatcctac agatacaagt tgctaaactg ggcatatcaa caggtccaac aaaataaaga
      721 agatgcctgg attgagcatg atgtttggag aatggagatt tatgtgtctc tgggaattgt
      781 gggattggca atactggctc tgttggctgt gacatctatt ccatctgtga gtgactcttt
      841 gacatggaga gaatttcact atattcagag caagctagga attgtttccc ttctactggg
      901 cacaatacac gcattgattt ttgcctggaa taagtggata gatataaaac aatttgtatg
      961 gtatacacct ccaactttta tgatagctgt tttccttcca attgttgtcc tgatatttaa
     1021 aagcatacta ttcctgccat gcttgaggaa gaagatactg aagattagac atggttggga
     1081 agacgtcacc aaaattaaca aaactgagat atgttcccag ttgtagaatt actgtttaca
     1141 cacatttttg ttcaatattg atatatttta tcaccaacat ttcaagtttg tatttgttaa
     1201 taaaatgatt attcaagga
//
