LOCUS       NM_003714               4254 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens stanniocalcin 2 (STC2), mRNA.
ACCESSION   NM_003714
VERSION     NM_003714.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4254)
  AUTHORS   Zhong,R., Zhan,J. and Zhang,S.
  TITLE     Integrative Analysis Reveals STC2 as a Prognostic Biomarker of
            Laryngeal Squamous Cell Carcinoma
  JOURNAL   Appl Biochem Biotechnol 196 (7), 3891-3913 (2024)
   PUBMED   37792175
  REMARK    GeneRIF: Integrative Analysis Reveals STC2 as a Prognostic
            Biomarker of Laryngeal Squamous Cell Carcinoma.
REFERENCE   2  (bases 1 to 4254)
  AUTHORS   Hu,Y., Han,L., Zhang,H., Li,W., Wu,T., Ma,J., Zhang,D., Ma,K.,
            Xiao,B., Yu,Y., Xu,H., Tian,L., Liao,X. and Chen,L.
  TITLE     The down-regulation of STC2 mRNA may serve as a biomarker for death
            from mechanical asphyxia
  JOURNAL   Leg Med (Tokyo) 67, 102382 (2024)
   PUBMED   38159418
  REMARK    GeneRIF: The down-regulation of STC2 mRNA may serve as a biomarker
            for death from mechanical asphyxia.
REFERENCE   3  (bases 1 to 4254)
  AUTHORS   Qiu,J., Chen,X. and Zheng,Z.
  TITLE     Evaluating STC2 gene RNA in peripheral blood serum of gastric
            cancer patients
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 72-75 (2023)
   PUBMED   38063115
  REMARK    GeneRIF: Evaluating STC2 gene RNA in peripheral blood serum of
            gastric cancer patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4254)
  AUTHORS   Yang,J.M., Kim,S.J., Park,S., Son,W., Kim,A. and Lee,J.
  TITLE     Exosomal miR-184 in the aqueous humor of patients with central
            serous chorioretinopathy: a potential diagnostic and prognostic
            biomarker
  JOURNAL   J Nanobiotechnology 21 (1), 242 (2023)
   PUBMED   37507708
  REMARK    GeneRIF: Exosomal miR-184 in the aqueous humor of patients with
            central serous chorioretinopathy: a potential diagnostic and
            prognostic biomarker.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4254)
  AUTHORS   Xiong,L., Li,X., Hua,X. and Qian,Z.
  TITLE     Circ-STC2 promotes the ferroptosis of nucleus pulposus cells via
            targeting miR-486-3p/TFR2 axis
  JOURNAL   J Orthop Surg Res 18 (1), 518 (2023)
   PUBMED   37480032
  REMARK    GeneRIF: Circ-STC2 promotes the ferroptosis of nucleus pulposus
            cells via targeting miR-486-3p/TFR2 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4254)
  AUTHORS   Jellinek,D.A., Chang,A.C., Larsen,M.R., Wang,X., Robinson,P.J. and
            Reddel,R.R.
  TITLE     Stanniocalcin 1 and 2 are secreted as phosphoproteins from human
            fibrosarcoma cells
  JOURNAL   Biochem J 350 Pt 2 (Pt 2), 453-461 (2000)
   PUBMED   10947959
REFERENCE   7  (bases 1 to 4254)
  AUTHORS   Moore,E.E., Kuestner,R.E., Conklin,D.C., Whitmore,T.E., Downey,W.,
            Buddle,M.M., Adams,R.L., Bell,L.A., Thompson,D.L., Wolf,A.,
            Chen,L., Stamm,M.R., Grant,F.J., Lok,S., Ren,H. and De Jongh,K.S.
  TITLE     Stanniocalcin 2: characterization of the protein and its
            localization to human pancreatic alpha cells
  JOURNAL   Horm Metab Res 31 (7), 406-414 (1999)
   PUBMED   10450831
REFERENCE   8  (bases 1 to 4254)
  AUTHORS   DiMattia,G.E., Varghese,R. and Wagner,G.F.
  TITLE     Molecular cloning and characterization of stanniocalcin-related
            protein
  JOURNAL   Mol Cell Endocrinol 146 (1-2), 137-140 (1998)
   PUBMED   10022771
REFERENCE   9  (bases 1 to 4254)
  AUTHORS   Ishibashi,K., Miyamoto,K., Taketani,Y., Morita,K., Takeda,E.,
            Sasaki,S. and Imai,M.
  TITLE     Molecular cloning of a second human stanniocalcin homologue (STC2)
  JOURNAL   Biochem Biophys Res Commun 250 (2), 252-258 (1998)
   PUBMED   9753616
REFERENCE   10 (bases 1 to 4254)
  AUTHORS   Chang,A.C. and Reddel,R.R.
  TITLE     Identification of a second stanniocalcin cDNA in mouse and human:
            stanniocalcin 2
  JOURNAL   Mol Cell Endocrinol 141 (1-2), 95-99 (1998)
   PUBMED   9723890
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK095891.1, AC106731.3,
            AK027663.1 and BQ181336.1.
            
            On Aug 11, 2020 this sequence version replaced NM_003714.2.
            
            Summary: This gene encodes a secreted, homodimeric glycoprotein
            that is expressed in a wide variety of tissues and may have
            autocrine or paracrine functions. The encoded protein has 10 of its
            15 cysteine residues conserved among stanniocalcin family members
            and is phosphorylated by casein kinase 2 exclusively on its serine
            residues. Its C-terminus contains a cluster of histidine residues
            which may interact with metal ions. The protein may play a role in
            the regulation of renal and intestinal calcium and phosphate
            transport, cell metabolism, or cellular calcium/phosphate
            homeostasis. Constitutive overexpression of human stanniocalcin 2
            in mice resulted in pre- and postnatal growth restriction, reduced
            bone and skeletal muscle growth, and organomegaly. Expression of
            this gene is induced by estrogen and altered in some breast
            cancers. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027663.1, SRR11853559.27028.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265087.9/ ENSP00000265087.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1948              AK095891.1         1091-3038
            1949-3160           AC106731.3         57987-59198         c
            3161-4247           AK027663.1         3212-4298
            4248-4254           BQ181336.1         19-25               c
FEATURES             Location/Qualifiers
     source          1..4254
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4254
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /note="stanniocalcin 2"
                     /db_xref="GeneID:8614"
                     /db_xref="HGNC:HGNC:11374"
                     /db_xref="MIM:603665"
     exon            1..372
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1130
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /note="stanniocalcin-related protein; STC-related protein"
                     /codon_start=1
                     /product="stanniocalcin-2 precursor"
                     /protein_id="NP_003705.1"
                     /db_xref="CCDS:CCDS4388.1"
                     /db_xref="GeneID:8614"
                     /db_xref="HGNC:HGNC:11374"
                     /db_xref="MIM:603665"
                     /translation="MCAERLGQFMTLALVLATFDPARGTDATNPPEGPQDRSSQQKGR
                     LSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIRGLHGICMTFLHNAGKFDAQGKSF
                     IKDALKCKAHALRHRFGCISRKCPAIREMVSQLQRECYLKHDLCAAAQENTRVIVEMI
                     HFKDLLLHEPYVDLVNLLLTCGEEVKEAITHSVQVQCEQNWGSLCSILSFCTSAIQKP
                     PTAPPERQPQVDRTKLSRAHHGEAGHHLPEPSSRETGRGAKGERGSKSHPNAHARGRV
                     GGLGAQGPSGSSEWEDEQSEYSDIRR"
     exon            373..515
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /inference="alignment:Splign:2.1.0"
     exon            516..727
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /inference="alignment:Splign:2.1.0"
     exon            728..4254
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1892..1897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /note="hexamer: AATAAA"
     polyA_site      1912
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /note="major polyA site"
     regulatory      3506..3511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /note="hexamer: CATAAA"
     polyA_site      3538
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
     regulatory      4232..4237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
                     /note="hexamer: AATAAA"
     polyA_site      4254
                     /gene="STC2"
                     /gene_synonym="STC-2; STCRP"
ORIGIN      
        1 actcgcggcg ctgctaacgg cctggtcaca tgctctccgg agagctacgg gagggcgctg
       61 ggtaacctct atccgagccg cggccgcgag gaggagggaa aaggcgagca aaaaggaaga
      121 gtgggaggag gaggggaagc ggcgaaggag gaagaggagg aggaggaaga ggggagcaca
      181 aaggatccag gtctcccgac gggaggttaa taccaagaac catgtgtgcc gagcggctgg
      241 gccagttcat gaccctggct ttggtgttgg ccacctttga cccggcgcgg gggaccgacg
      301 ccaccaaccc acccgagggt ccccaagaca ggagctccca gcagaaaggc cgcctgtccc
      361 tgcagaatac agcggagatc cagcactgtt tggtcaacgc tggcgatgtg gggtgtggcg
      421 tgtttgaatg tttcgagaac aactcttgtg agattcgggg cttacatggg atttgcatga
      481 cttttctgca caacgctgga aaatttgatg cccagggcaa gtcattcatc aaagacgcct
      541 tgaaatgtaa ggcccacgct ctgcggcaca ggttcggctg cataagccgg aagtgcccgg
      601 ccatcaggga aatggtgtcc cagttgcagc gggaatgcta cctcaagcac gacctgtgcg
      661 cggctgccca ggagaacacc cgggtgatag tggagatgat ccatttcaag gacttgctgc
      721 tgcacgaacc ctacgtggac ctcgtgaact tgctgctgac ctgtggggag gaggtgaagg
      781 aggccatcac ccacagcgtg caggttcagt gtgagcagaa ctggggaagc ctgtgctcca
      841 tcttgagctt ctgcacctcg gccatccaga agcctcccac ggcgcccccc gagcgccagc
      901 cccaggtgga cagaaccaag ctctccaggg cccaccacgg ggaagcagga catcacctcc
      961 cagagcccag cagtagggag actggccgag gtgccaaggg tgagcgaggt agcaagagcc
     1021 acccaaacgc ccatgcccga ggcagagtcg ggggccttgg ggctcaggga ccttccggaa
     1081 gcagcgagtg ggaagacgaa cagtctgagt attctgatat ccggaggtga aatgaaaggc
     1141 ctggccacga aatctttcct ccacgccgtc cattttctta tctatggaca ttccaaaaca
     1201 tttaccatta gagagggggg atgtcacacg caggattctg tggggactgt ggacttcatc
     1261 gaggtgtgtg ttcgcggaac ggacaggtga gatggagacc cctggggccg tggggtctca
     1321 ggggtgcctg gtgaattctg cacttacacg tactcaaggg agcgcgcccg cgttatcctc
     1381 gtacctttgt cttctttcca tctgtggagt cagtgggtgt cggccgctct gttgtggggg
     1441 aggtgaacca gggaggggca gggcaaggca gggcccccag agctgggcca cacagtgggt
     1501 gctgggcctc gccccgaagc ttctggtgca gcagcctctg gtgctgtctc cgcggaagtc
     1561 agggcggctg gattccagga caggagtgaa tgtaaaaata aatatcgctt agaatgcagg
     1621 agaagggtgg agaggaggca ggggccgagg gggtgcttgg tgccaaactg aaattcagtt
     1681 tcttgtgtgg ggccttgcgg ttcagagctc ttggcgaggg tggagggagg agtgtcattt
     1741 ctatgtgtaa tttctgagcc attgtactgt ctgggctggg ggggacactg tccaagggag
     1801 tggcccctat gagtttatat tttaaccact gcttcaaatc tcgatttcac tttttttatt
     1861 tatccagtta tatctacata tctgtcatct aaataaatgg ctttcaaaca aagcaactgg
     1921 gtcattaaaa ccagctcaaa gggggtttaa aaaaaaaaaa ccagcccatc ctttgaggct
     1981 gatttttctt ttttttaagt tctattttaa aagctatcaa acagcgacat agccatacat
     2041 ctgactgcct gacatggact cctgcccact tgggggaaac cttataccca gaggaaaata
     2101 cacacctggg gagtacattt gacaaatttc ccttaggatt tcgttatctc accttgaccc
     2161 tcagccaaga ttggtaaagc tgcgtcctgg cgattccagg agacccagct ggaaacctgg
     2221 cttctccatg tgaggggatg ggaaaggaaa gaagagaatg aagactactt agtaattccc
     2281 atcaggaaat gctgaccttt tacataaaat caaggagact gctgaaaatc tctaagggac
     2341 aggattttcc agatcctaat tggaaattta gcaataagga gaggagtcca aggggacaaa
     2401 taaaggcaga gagaagagac agaactaaaa atacgaggaa aggagagtga ggattttcat
     2461 taaaagtctc agcagtgggt ttcttgggtt atttaaaaca tcacctaaat aggccttttc
     2521 ttcctaattg gccatcaaat taaagcctat cctttctcaa gcaggagctg gtattgtagg
     2581 gagtggccgg gtattctggg ctgggctctt ctggagtagg gggtcagcaa acattgtctg
     2641 caaagggcca gatactgaat ccagtacttt cagtttggcg agccgtgagg tctctgtcga
     2701 aactactcaa ctctgccgtc ctagcacaaa agcagccata gacaacacac aaacgagagg
     2761 gcttggctcc cttccaggaa gatttattta acaggctccc agctgaattt cactcacagg
     2821 acacagttta ctgatctctg ttctagtgag tgggtcaaaa agcatatgca tccttatccg
     2881 tcaactcatc agctcttcct caaggcaacc tgaggccaga caccaagaaa ccaagcgtat
     2941 ctgctctaaa atgacttgtt cctggggaat gccttcaacc aaaacacagc tagtatttct
     3001 atgccccaaa tccaatccca gtctttcatg atccatgccg gcggttgggt ggggagggga
     3061 atcattggtt gggggaaggg aggaaacccc acctccagcc cccgccaccg ggctccctgg
     3121 gcacccagca agatctgggg ctgcagagaa cagaagagct ggtgcactta atccagctct
     3181 gcccttgggg ggaggaggac ctgtgtgtca ggctctgcca tgggaacgag tgtaaaccgt
     3241 ggctgtctcc tgcagtgagc caccgcggca ggcacgttga ctgttttact gacatcactc
     3301 aaaagctaaa gcaataacat tctcctgcgt tgctgagtca gctgttcatt tgtccgccag
     3361 ctcctggact ggatgtgtga aaggcatcac atttccattt tcctccgtgt aaatgtttta
     3421 tgtgttcgcc tactgatccc attcgttgct tctattgtaa atatttgtca tttgtattta
     3481 ttatctctgt gttttccccc taaggcataa aatggtttac tgtgttcatt tgaacccatt
     3541 tactgatctc tgttgtatat ttttcatgcc actgctttgt tttctcctca gaagtcgggt
     3601 agatagcatt tctatcccat ccctcacgtt attggaagca tgcaacagta tttattgctc
     3661 agggtcttct gcttaaaact gaggaaggtc cacattcctg caagcattga ttgagacatt
     3721 tgcacaatct aaaatgtaag caaagtagtc attaaaaata caccctctac ttgggcttta
     3781 tactgcatac aaatttactc atgagccttc ctttgaggaa ggatgtggat ctccaaataa
     3841 agatttagtg tttattttga gctctgcatc ttaacaagat gatctgaaca cctctccttt
     3901 gtatcaataa atagccctgt tattctgaag tgagaggacc aagtatagta aaatgctgac
     3961 atctaaaact aaataaatag aaaacaccag gccagaacta tagtcatact cacacaaagg
     4021 gagaaattta aactcgaacc aagcaaaagg cttcacggaa atagcatgga aaaacaatgc
     4081 ttccagtggc cacttcctaa ggaggaacaa ccccgtctga tctcagaatt ggcaccacgt
     4141 gagcttgcta agtgataata tctgtttcta ctacggattt aggcaacagg acctgtacat
     4201 tgtcacattg cattattttt cttcaagcgt taataaaagt tttaaataaa tggc
//
