LOCUS       NM_003155               3868 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens stanniocalcin 1 (STC1), mRNA.
ACCESSION   NM_003155
VERSION     NM_003155.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3868)
  AUTHORS   Kim,J.H., Kim,K., Kim,I., Seong,S., Koh,J.T. and Kim,N.
  TITLE     Stanniocalcin 1 and 1,25-dihydroxyvitamin D3 cooperatively regulate
            bone mineralization by osteoblasts
  JOURNAL   Exp Mol Med 56 (9), 1991-2001 (2024)
   PUBMED   39218976
  REMARK    GeneRIF: Stanniocalcin 1 and 1,25-dihydroxyvitamin D3 cooperatively
            regulate bone mineralization by osteoblasts.
REFERENCE   2  (bases 1 to 3868)
  AUTHORS   Duan,C., He,B., Wang,Y., Liu,W., Bao,W., Yu,L., Xin,J., Gui,H.,
            Lei,J., Yang,Z., Liu,J., Tao,W., Qin,J., Luo,J. and Dong,Z.
  TITLE     Stanniocalcin-1 promotes temozolomide resistance of glioblastoma
            through regulation of MGMT
  JOURNAL   Sci Rep 14 (1), 20199 (2024)
   PUBMED   39215105
  REMARK    GeneRIF: Stanniocalcin-1 promotes temozolomide resistance of
            glioblastoma through regulation of MGMT.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3868)
  AUTHORS   Ren,Z., Xu,Z., Chang,X., Liu,J. and Xiao,W.
  TITLE     STC1 competitively binding betaPIX enhances melanoma progression
            via YAP nuclear translocation and M2 macrophage recruitment through
            the YAP/CCL2/VEGFA/AKT feedback loop
  JOURNAL   Pharmacol Res 204, 107218 (2024)
   PUBMED   38768671
  REMARK    GeneRIF: STC1 competitively binding betaPIX enhances melanoma
            progression via YAP nuclear translocation and M2 macrophage
            recruitment through the YAP/CCL2/VEGFA/AKT feedback loop.
REFERENCE   4  (bases 1 to 3868)
  AUTHORS   Choi,S., An,H.J., Yeo,H.J., Sung,M.J., Oh,J., Lee,K., Lee,S.A.,
            Kim,S.K., Kim,J., Kim,I. and Lee,S.
  TITLE     MicroRNA-606 inhibits the growth and metastasis of triple-negative
            breast cancer by targeting Stanniocalcin 1
  JOURNAL   Oncol Rep 51 (1) (2024)
   PUBMED   37975233
  REMARK    GeneRIF: MicroRNA-606 inhibits the growth and metastasis of
            triple-negative breast cancer by targeting Stanniocalcin 1.
REFERENCE   5  (bases 1 to 3868)
  AUTHORS   Luo,M., Wang,X., Wu,S., Yang,C., Su,Q., Huang,L., Fu,K., An,S.,
            Xie,F., To,K.K.W., Wang,F. and Fu,L.
  TITLE     A20 promotes colorectal cancer immune evasion by upregulating STC1
            expression to block 'eat-me' signal
  JOURNAL   Signal Transduct Target Ther 8 (1), 312 (2023)
   PUBMED   37607946
  REMARK    GeneRIF: A20 promotes colorectal cancer immune evasion by
            upregulating STC1 expression to block 'eat-me' signal.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3868)
  AUTHORS   Chang,A.C., Jeffrey,K.J., Tokutake,Y., Shimamoto,A., Neumann,A.A.,
            Dunham,M.A., Cha,J., Sugawara,M., Furuichi,Y. and Reddel,R.R.
  TITLE     Human stanniocalcin (STC): genomic structure, chromosomal
            localization, and the presence of CAG trinucleotide repeats
  JOURNAL   Genomics 47 (3), 393-398 (1998)
   PUBMED   9480753
REFERENCE   7  (bases 1 to 3868)
  AUTHORS   Olsen,H.S., Cepeda,M.A., Zhang,Q.Q., Rosen,C.A., Vozzolo,B.L. and
            Wagner,G.F.
  TITLE     Human stanniocalcin: a possible hormonal regulator of mineral
            metabolism
  JOURNAL   Proc Natl Acad Sci U S A 93 (5), 1792-1796 (1996)
   PUBMED   8700837
REFERENCE   8  (bases 1 to 3868)
  AUTHORS   Chang,A.C., Janosi,J., Hulsbeek,M., de Jong,D., Jeffrey,K.J.,
            Noble,J.R. and Reddel,R.R.
  TITLE     A novel human cDNA highly homologous to the fish hormone
            stanniocalcin
  JOURNAL   Mol Cell Endocrinol 112 (2), 241-247 (1995)
   PUBMED   7489828
REFERENCE   9  (bases 1 to 3868)
  AUTHORS   Wagner,G.F., Guiraudon,C.C., Milliken,C. and Copp,D.H.
  TITLE     Immunological and biological evidence for a stanniocalcin-like
            hormone in human kidney
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 1871-1875 (1995)
   PUBMED   7892193
REFERENCE   10 (bases 1 to 3868)
  AUTHORS   Liang,P., Averboukh,L., Keyomarsi,K., Sager,R. and Pardee,A.B.
  TITLE     Differential display and cloning of messenger RNAs from human
            breast cancer versus mammary epithelial cells
  JOURNAL   Cancer Res 52 (24), 6966-6968 (1992)
   PUBMED   1458489
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U25997.1, BC029044.1 and
            AC012119.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_003155.2.
            
            Summary: This gene encodes a secreted, homodimeric glycoprotein
            that is expressed in a wide variety of tissues and may have
            autocrine or paracrine functions. The gene contains a 5' UTR rich
            in CAG trinucleotide repeats. The encoded protein contains 11
            conserved cysteine residues and is phosphorylated by protein kinase
            C exclusively on its serine residues. The protein may play a role
            in the regulation of renal and intestinal calcium and phosphate
            transport, cell metabolism, or cellular calcium/phosphate
            homeostasis. Overexpression of human stanniocalcin 1 in mice
            produces high serum phosphate levels, dwarfism, and increased
            metabolic rate. This gene has altered expression in hepatocellular,
            ovarian, and breast cancers. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.180030.1, U25997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465411 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290271.7/ ENSP00000290271.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1089              U25997.1           2-1090
            1090-2477           BC029044.1         1069-2456
            2478-3785           AC012119.8         55933-57240
            3786-3868           U25997.1           3791-3873
FEATURES             Location/Qualifiers
     source          1..3868
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..3868
                     /gene="STC1"
                     /gene_synonym="STC"
                     /note="stanniocalcin 1"
                     /db_xref="GeneID:6781"
                     /db_xref="HGNC:HGNC:11373"
                     /db_xref="MIM:601185"
     exon            1..401
                     /gene="STC1"
                     /gene_synonym="STC"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1027
                     /gene="STC1"
                     /gene_synonym="STC"
                     /codon_start=1
                     /product="stanniocalcin-1 precursor"
                     /protein_id="NP_003146.1"
                     /db_xref="CCDS:CCDS6043.1"
                     /db_xref="GeneID:6781"
                     /db_xref="HGNC:HGNC:11373"
                     /db_xref="MIM:601185"
                     /translation="MLQNSAVLLVLVISASATHEAEQNDSVSPRKSRVAAQNSAEVVR
                     CLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANG
                     VTSKVFLAIRRCSTFQRMIAEVQEECYSKLNVCSIAKRNPEAITEVVQLPNHFSNRYY
                     NRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNE
                     PQKLKVLLRNLRGEEDSPSHIKRTSHESA"
     exon            402..544
                     /gene="STC1"
                     /gene_synonym="STC"
                     /inference="alignment:Splign:2.1.0"
     exon            545..756
                     /gene="STC1"
                     /gene_synonym="STC"
                     /inference="alignment:Splign:2.1.0"
     exon            757..3868
                     /gene="STC1"
                     /gene_synonym="STC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3789..3794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STC1"
                     /gene_synonym="STC"
                     /note="hexamer: ATTAAA"
     polyA_site      3809
                     /gene="STC1"
                     /gene_synonym="STC"
                     /note="major polyA site"
     regulatory      3850..3855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STC1"
                     /gene_synonym="STC"
                     /note="hexamer: AATAAA"
     polyA_site      3868
                     /gene="STC1"
                     /gene_synonym="STC"
                     /note="major polyA site"
ORIGIN      
        1 agtttgcaaa agccagaggt gcaagaagca gcgactgcag cagcagcagc agcagcggcg
       61 gtggcagcag cagcagcagc ggcggcagca gcagcagcag cggaggcacc ggtggcagca
      121 gcagcatcac cagcaacaac aacaaaaaaa aatcctcatc aaatcctcac ctaagctttc
      181 agtgtatcca gatccacatc ttcactcaag ccaggagagg gaaagaggaa aggggggcag
      241 gaaaaaaaaa aaacccaaca acttagcgga aacttctcag agaatgctcc aaaactcagc
      301 agtgcttctg gtgctggtga tcagtgcttc tgcaacccat gaggcggagc agaatgactc
      361 tgtgagcccc aggaaatccc gagtggcggc tcaaaactca gctgaagtgg ttcgttgcct
      421 caacagtgct ctacaggtcg gctgcggggc ttttgcatgc ctggaaaact ccacctgtga
      481 cacagatggg atgtatgaca tctgtaaatc cttcttgtac agcgctgcta aatttgacac
      541 tcagggaaaa gcattcgtca aagagagctt aaaatgcatc gccaacgggg tcacctccaa
      601 ggtcttcctc gccattcgga ggtgctccac tttccaaagg atgattgctg aggtgcagga
      661 agagtgctac agcaagctga atgtgtgcag catcgccaag cggaaccctg aagccatcac
      721 tgaggtcgtc cagctgccca atcacttctc caacagatac tataacagac ttgtccgaag
      781 cctgctggaa tgtgatgaag acacagtcag cacaatcaga gacagcctga tggagaaaat
      841 tgggcctaac atggccagcc tcttccacat cctgcagaca gaccactgtg cccaaacaca
      901 cccacgagct gacttcaaca ggagacgcac caatgagccg cagaagctga aagtcctcct
      961 caggaacctc cgaggtgagg aggactctcc ctcccacatc aaacgcacat cccatgagag
     1021 tgcataacca gggagaggtt attcacaacc tcaccaaact agtatcattt taggggtgtt
     1081 gacacaccag ttttgagtgt actgtgcctg gtttgatttt tttaaagtag ttcctatttt
     1141 ctatccccct taaagaaaat tgcatgaaac taggcttctg taatcaatat cccaacattc
     1201 tgcaatggca gcattcccac caacaaaatc catgtgacca ttctgcctct cctcaggaga
     1261 aagtaccctc ttttaccaac ttcctctgcc atgtttttcc cctgctcccc tgagaccacc
     1321 cccaaacaca aaacattcat gtaactctcc agccattgta atttgaagat gtggatccct
     1381 ttagaacggt tgccccagta gagttagctg ataaggaaac tttatttaaa tgcatgtctt
     1441 aaatgctcat aaagatgtta aatggaattc gtgttatgaa tctgtgctgg ccatggacga
     1501 atatgaatgt cacatttgaa ttcttgatct ctaatgagct agtgtcttat ggtcttgatc
     1561 ctccaatgtc taattttctt tccgacacat ttaccaaatt gcttgagcct ggctgtccaa
     1621 ccagactttg agcctgcatc ttcttgcatc taatgaaaaa caaaaagcta acatctttac
     1681 gtactgtaac tgctcagagc tttaaaagta tctttaacaa ttgtcttaaa accagagaat
     1741 cttaaggtct aactgtggaa tataaatagc tgaaaactaa tgtactgtac ataaattcca
     1801 gaggactctg cttaaacaaa gcagtatata ataactttat tgcatataga tttagttttg
     1861 taacttagct ttatttttct tttcctggga atggaataac tatctcactt ccagatatcc
     1921 acataaatgc tccttgtggc cttttttata actaaggggg tagaagtagt tttaattcaa
     1981 catcaaaact taagatgggc ctgtatgaga caggaaaaac caacaggttt atctgaagga
     2041 ccccaggtaa gatgttaatc tcccagccca cctcaaccca gaggctactc ttgacttaga
     2101 cctatactga aagatctctg tcacatccaa ctggaaattc caggaaccaa aaagagcatc
     2161 cctatgggct tggaccactt acagtgtgat aaggcctact atacattagg aagtggcagt
     2221 tctttactcg tcccctttca tcggtgcctg gtactctggc aaatgatgat ggggtgggag
     2281 actttccatt aaatcaatca ggaatgagtc aatcagcctt taggtcttta gtccggggga
     2341 cttggggctg agagagtata aataaccctg ggctgtccag ccttaataga cttctcttac
     2401 attttcgtcc tgtagcacgc tgcctgccaa agtagtcctg gcagctggac catctctgta
     2461 ggatcgtaaa aaaatagaaa aaaagaaaaa aaaaagaaag aaagagggaa aaagagctgg
     2521 tggtttgatc atttctgcca tgatgtttac aagatggcga ccaccaaagt caaacgacta
     2581 acctatctat gaacaacagt agtttctcag ggtcactgtc cttgaaccca acagtccctt
     2641 atgagcgtca ctgcccacca aaggtcaatg tcaagagagg aagagaggga ggaggggtag
     2701 gactgcaggg gccactccaa actcgcttag gtagaaacta ttggtgcttg actctcacta
     2761 ggctaaactc aagatttgac caaatcgagt gatagggatc ctggtgggag gagagagggc
     2821 acatctccag aaaaatgaaa agcaatacaa ctttaccata aagcctttaa aaccagtaac
     2881 gtgctgctca aggaccaaga gcaattgcag cagacccagc agcagcagca gcagcacaaa
     2941 cattgctgcc tttgtcccca cacagcctct aagcgtgctg acatcagatt gttaagggca
     3001 tttttatact cagaactgtc ccatccccag gtccccaaac ttatggacac tgccttagcc
     3061 tcttggaaat caggtagacc atattctaag ttagactctt cccctccctc ccacacttcc
     3121 cacccccagg caaggctgac ttctctgaat cagaaaagct attaaagttt gtgtgttgtg
     3181 tccattttgc aaacccaact aagccaggac cccaatgcga caagtagttc atgagtattc
     3241 ctagcaaatt tctctctttc ttcagttcag tagatttcct tttttctttt cttttttttt
     3301 tttttttttt ttggctgtga cctcttcaaa ccgtggtacc cccccttttc tccccacgat
     3361 gatatctata tatgtatcta caatacatat atctacacat acagaaagaa gcagttctca
     3421 caatgttgct agttttttgc ttctctttcc cccaccctac tccctccaat tcccccttaa
     3481 acttccaaag cttcgtcttg tgtttgctgc agagtgattc gggggctgac ctagaccagt
     3541 ttgcatgatt cttctcttgt gatttggttg cactttagac atttttgtgc cattatattt
     3601 gcattatgta tttataattt aaatgatatt taggtttttg gctgagtact ggaataaaca
     3661 gtgagcatat ctggtatatg tcattattta ttgttaaatt acatttttaa gctccatgtg
     3721 catataaagg ttatgaaaca tatcatggta atgacagatg caagttattt tatttgctta
     3781 tttttataat taaagatgcc atagcataat atgaagcctt tggtgaattc cttctaagat
     3841 aaaaataata ataaagtgtt acgtttta
//
