LOCUS       NM_003943               2244 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens starch binding domain 1 (STBD1), mRNA.
ACCESSION   NM_003943
VERSION     NM_003943.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2244)
  AUTHORS   Zhang,Y., Sun,Y., Shi,J., Xu,P., Wang,Y., Liu,J., Gong,X., Wang,Y.,
            Tang,Y., Liu,H., Zhou,X., Lin,Z., Baba,O., Morita,T., Yu,B. and
            Pan,L.
  TITLE     Decoding the molecular mechanism of selective autophagy of glycogen
            mediated by autophagy receptor STBD1
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2402817121 (2024)
   PUBMED   39236246
  REMARK    GeneRIF: Decoding the molecular mechanism of selective autophagy of
            glycogen mediated by autophagy receptor STBD1.
REFERENCE   2  (bases 1 to 2244)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   3  (bases 1 to 2244)
  AUTHORS   Han,Z., Zhang,W., Ning,W., Wang,C., Deng,W., Li,Z., Shang,Z.,
            Shen,X., Liu,X., Baba,O., Morita,T., Chen,L., Xue,Y. and Jia,D.
  TITLE     Model-based analysis uncovers mutations altering autophagy
            selectivity in human cancer
  JOURNAL   Nat Commun 12 (1), 3258 (2021)
   PUBMED   34059679
  REMARK    GeneRIF: Model-based analysis uncovers mutations altering autophagy
            selectivity in human cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2244)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2244)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2244)
  AUTHORS   Jiang,S., Wells,C.D. and Roach,P.J.
  TITLE     Starch-binding domain-containing protein 1 (Stbd1) and glycogen
            metabolism: Identification of the Atg8 family interacting motif
            (AIM) in Stbd1 required for interaction with GABARAPL1
  JOURNAL   Biochem Biophys Res Commun 413 (3), 420-425 (2011)
   PUBMED   21893048
  REMARK    GeneRIF: Atg8 interacting motif (AIM) in Stbd1 is necessary for
            GABARAPL1 binding.
REFERENCE   7  (bases 1 to 2244)
  AUTHORS   Jiang,S., Heller,B., Tagliabracci,V.S., Zhai,L., Irimia,J.M.,
            DePaoli-Roach,A.A., Wells,C.D., Skurat,A.V. and Roach,P.J.
  TITLE     Starch binding domain-containing protein 1/genethonin 1 is a novel
            participant in glycogen metabolism
  JOURNAL   J Biol Chem 285 (45), 34960-34971 (2010)
   PUBMED   20810658
  REMARK    Erratum:[J Biol Chem. 2011 Nov 11;286(45):39673]
REFERENCE   8  (bases 1 to 2244)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   9  (bases 1 to 2244)
  AUTHORS   Bouju,S., Lignon,M.F., Pietu,G., Le Cunff,M., Leger,J.J.,
            Auffray,C. and Dechesne,C.A.
  TITLE     Molecular cloning and functional expression of a novel human gene
            encoding two 41-43 kDa skeletal muscle internal membrane proteins
  JOURNAL   Biochem J 335 (Pt 3) (Pt 3), 549-556 (1998)
   PUBMED   9794794
REFERENCE   10 (bases 1 to 2244)
  AUTHORS   Pietu,G., Alibert,O., Guichard,V., Lamy,B., Bois,F., Leroy,E.,
            Mariage-Sampson,R., Houlgatte,R., Soularue,P. and Auffray,C.
  TITLE     Novel gene transcripts preferentially expressed in human muscles
            revealed by quantitative hybridization of a high density cDNA array
  JOURNAL   Genome Res 6 (6), 492-503 (1996)
   PUBMED   8828038
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK123795.1 and BC022301.1.
            
            On Aug 11, 2020 this sequence version replaced NM_003943.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022301.1, AF062534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237642.7/ ENSP00000237642.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1700              AK123795.1         708-2407
            1701-2244           BC022301.1         1734-2277
FEATURES             Location/Qualifiers
     source          1..2244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..2244
                     /gene="STBD1"
                     /gene_synonym="GENEX3414; GENX-3414"
                     /note="starch binding domain 1"
                     /db_xref="GeneID:8987"
                     /db_xref="HGNC:HGNC:24854"
                     /db_xref="MIM:607406"
     exon            1..257
                     /gene="STBD1"
                     /gene_synonym="GENEX3414; GENX-3414"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1114
                     /gene="STBD1"
                     /gene_synonym="GENEX3414; GENX-3414"
                     /note="genethonin 1; glycophagy cargo receptor STBD1"
                     /codon_start=1
                     /product="starch-binding domain-containing protein 1"
                     /protein_id="NP_003934.1"
                     /db_xref="CCDS:CCDS3578.1"
                     /db_xref="GeneID:8987"
                     /db_xref="HGNC:HGNC:24854"
                     /db_xref="MIM:607406"
                     /translation="MGAVWSALLVGGGLAGALFVWLLRGGPGDTGKDGDAEQEKDAPL
                     GGAAIPGGHQSGSSGLSPGPSGQELVTKPEHLQESNGHLISKTKDLGKLQAASWRLQN
                     PSREVCDNSREHVPSGQFPDTEAPATSETSNSRSYSEVSRNESLESPMGEWGFQKGQE
                     ISAKAATCFAEKLPSSNLLKNRAKEEMSLSDLNSQDRVDHEEWEMVPRHSSWGDVGVG
                     GSLKAPVLNLNQGMDNGRSTLVEARGQQVHGKMERVAVMPAGSQQVSVRFQVHYVTST
                     DVQFIAVTGDHECLGRWNTYIPLHYNKDGFWSHSIFLPADTVVEWKFVLVENGGVTRW
                     EECSNRFLETGHEDKVVHAWWGIH"
     exon            258..2244
                     /gene="STBD1"
                     /gene_synonym="GENEX3414; GENX-3414"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2218..2223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STBD1"
                     /gene_synonym="GENEX3414; GENX-3414"
                     /note="hexamer: AATAAA"
     polyA_site      2244
                     /gene="STBD1"
                     /gene_synonym="GENEX3414; GENX-3414"
                     /note="major polyA site"
ORIGIN      
        1 agtccctgta gtctcctgcg gccgcggcct ctcagccatg ggcgccgtct ggtccgccct
       61 gctggttgga gggggtctgg ccggagcact tttcgtttgg ctgctgcggg gcggccctgg
      121 cgacaccggg aaggacgggg atgcggagca ggagaaagac gcccctcttg ggggagctgc
      181 gattccggga ggccatcaga gtggcagcag cggactgagc cctggacctt ccgggcagga
      241 gctggtcacc aaaccagagc atcttcaaga aagcaatgga catttgattt ctaagaccaa
      301 agaccttggt aaactgcaag cagcatcatg gagattgcag aatccttcca gggaagtctg
      361 tgacaattca agagaacatg ttccttctgg acagtttcca gacacagaag ctccagctac
      421 ctctgagacc agtaactcta ggagttactc tgaagtttca agaaatgaaa gccttgaatc
      481 tcctatggga gaatggggat tccaaaaagg acaagagata tctgctaaag cagctacatg
      541 ttttgcagag aagttgcctt ctagcaacct gctcaagaac agagctaaag aagaaatgag
      601 cctctctgat ttgaacagtc aggaccgggt tgaccacgag gagtgggaaa tggtgcctag
      661 gcactcatct tggggggatg ttggtgtggg tggcagtctt aaggctccag tgttaaacct
      721 aaaccaggga atggacaatg gaagaagcac tttggtggaa gcaagaggtc agcaagtgca
      781 tgggaaaatg gaaagggtag cagtgatgcc tgcagggtct cagcaagtta gtgtcaggtt
      841 ccaggtccat tatgtcacaa gcactgatgt gcaattcatt gcagtaactg gagaccatga
      901 gtgtcttggg agatggaaca cttacatccc actccactat aacaaggatg ggttctggtc
      961 tcattccatt ttcctgcctg cagatacagt ggtggagtgg aagtttgtgt tggtagagaa
     1021 tgggggagtt acccgctggg aagaatgcag caatagattc ctagaaactg gccatgagga
     1081 taaagtggtt cacgcatggt gggggattca ctgattcagt ttgcaaagta atggagaagc
     1141 tgtagaacaa tgtggaagag gctgaggttg tggaacacac tgaataaaat aaaggcagtg
     1201 tgactccaaa ttcagccatc tgaattgttt aaatttgcta gtggattttg tctaatgtgc
     1261 agaaatatat atgtctaatg tgcagaaata tatatgtgtg tatgtgtgta tatatatgca
     1321 cacacacaca gataatgctt ccagtgaatg tgaacttctt ttccctgtgg cactgattga
     1381 cagacttgtg ctgatccatt attactttag ggcttgattc tcttggggag tgacttggct
     1441 aagcttcagg tgtaaactgt ggtcacggag caaaaacatt aaccagctgc ccagggttca
     1501 agcttgagcc tttaggtgat ctttaaacta tggtagtaaa ataagcctca ctcaaacata
     1561 gctgacttcc tattggtaca gcttgaaaag cactttttac tacatacaca ttttatgctt
     1621 aaaaagttaa catgatacga aactgtgatt agaaaatatc tggtctggat gtgattagta
     1681 aggatacaag ataatgttct aagactgcct aatgcttttt gtttgatttt catctgccag
     1741 gcgttgttat gtgctatgag ggtagcaagt acgtctttgt cttaatgatc taaggctggt
     1801 gtagaaacaa agggcctaat gagaaccaat catcatggaa gtcagttgcg ggggcagccc
     1861 ataaggaaag ggaaagtgag tggggttggg cataggctga gtgaggtggc ctgaatgaca
     1921 cctcttagag gactgtgaag tacaggcaca gcccgactgc agggagggat gcacccatca
     1981 tttacccatg ggagcatctg taggaccatc tctctcccac ttcttctccc ctcccccacc
     2041 gcatctggcc agatggactg tcctacagca atcgtttcca tctgtcaccc tcttccctct
     2101 cctttcatac cagtcactat cttgggtaac aaatttatac aggacagtgg tacagaaata
     2161 catctttgct ctgagaatac agcaaatatt aacttaaatt attataactg aacaaataat
     2221 aaaacctgaa ttttaatatc ttca
//
