LOCUS       NM_001164380            2970 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2),
            transcript variant 1, mRNA.
ACCESSION   NM_001164380
VERSION     NM_001164380.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Yang,H., Zhu,Y., Li,X., Jiang,Z. and Dai,W.
  TITLE     RNF216 affects the stability of STAU2 in the hypothalamus
  JOURNAL   Dev Growth Differ 65 (7), 408-417 (2023)
   PUBMED   37439148
  REMARK    GeneRIF: RNF216 affects the stability of STAU2 in the hypothalamus.
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Zhang,C., Wei,G., Zhu,X., Chen,X., Ma,X., Hu,P., Liu,W., Yang,W.,
            Ruan,T., Zhang,W., Wu,C. and Tao,K.
  TITLE     Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric
            Cancer by Targeting the miR-589/CAPZA1 Axis
  JOURNAL   Int J Nanomedicine 18, 127-142 (2023)
   PUBMED   36643863
  REMARK    GeneRIF: Exosome-Delivered circSTAU2 Inhibits the Progression of
            Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Balakrishnan,K., Jaguva Vasudevan,A.A., Mohareer,K., Luedde,T.,
            Munk,C. and Banerjee,S.
  TITLE     Encapsidation of Staufen-2 Enhances Infectivity of HIV-1
  JOURNAL   Viruses 13 (12), 2459 (2021)
   PUBMED   34960728
  REMARK    GeneRIF: Encapsidation of Staufen-2 Enhances Infectivity of HIV-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Zheng,Y.X., Wang,L., Kong,W.S., Chen,H., Wang,X.N., Meng,Q.,
            Zhang,H.N., Guo,S.J., Jiang,H.W. and Tao,S.C.
  TITLE     Nsp2 has the potential to be a drug target revealed by global
            identification of SARS-CoV-2 Nsp2-interacting proteins
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (9), 1134-1141 (2021)
   PUBMED   34159380
REFERENCE   5  (bases 1 to 2970)
  AUTHORS   Conde,L., Gonzalez Quesada,Y., Bonnet-Magnaval,F., Beaujois,R. and
            DesGroseillers,L.
  TITLE     STAU2 protein level is controlled by caspases and the CHK1 pathway
            and regulates cell cycle progression in the non-transformed
            hTERT-RPE1 cells
  JOURNAL   BMC Mol Cell Biol 22 (1), 16 (2021)
   PUBMED   33663378
  REMARK    GeneRIF: STAU2 protein level is controlled by caspases and the CHK1
            pathway and regulates cell cycle progression in the non-transformed
            hTERT-RPE1 cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2970)
  AUTHORS   Furic,L., Maher-Laporte,M. and DesGroseillers,L.
  TITLE     A genome-wide approach identifies distinct but overlapping subsets
            of cellular mRNAs associated with Staufen1- and Staufen2-containing
            ribonucleoprotein complexes
  JOURNAL   RNA 14 (2), 324-335 (2008)
   PUBMED   18094122
  REMARK    GeneRIF: Stau1- and Stau2-mRNPs associate with distinct but
            overlapping sets of cellular mRNAs.
REFERENCE   7  (bases 1 to 2970)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 2970)
  AUTHORS   Duchaine,T.F., Hemraj,I., Furic,L., Deitinghoff,A., Kiebler,M.A.
            and DesGroseillers,L.
  TITLE     Staufen2 isoforms localize to the somatodendritic domain of neurons
            and interact with different organelles
  JOURNAL   J Cell Sci 115 (Pt 16), 3285-3295 (2002)
   PUBMED   12140260
  REMARK    GeneRIF: Data show that Stau2 is localized to the neuronal soma and
            dendrites, but it does not colocalize with Stau1-containing
            particles.
REFERENCE   9  (bases 1 to 2970)
  AUTHORS   Kiebler,M.A. and DesGroseillers,L.
  TITLE     Molecular insights into mRNA transport and local translation in the
            mammalian nervous system
  JOURNAL   Neuron 25 (1), 19-28 (2000)
   PUBMED   10707969
  REMARK    Review article
REFERENCE   10 (bases 1 to 2970)
  AUTHORS   Buchner,G., Bassi,M.T., Andolfi,G., Ballabio,A. and Franco,B.
  TITLE     Identification of a novel homolog of the Drosophila staufen protein
            in the chromosome 8q13-q21.1 region
  JOURNAL   Genomics 62 (1), 113-118 (1999)
   PUBMED   10585778
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK002152.1, AC100784.2 and
            AF459097.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001164380.1.
            
            Summary: Staufen homolog 2 is a member of the family of
            double-stranded RNA (dsRNA)-binding proteins involved in the
            transport and/or localization of mRNAs to different subcellular
            compartments and/or organelles. These proteins are characterized by
            the presence of multiple dsRNA-binding domains which are required
            to bind RNAs having double-stranded secondary structures. Staufen
            homolog 2 shares 48.5% and 59.9% similarity with drosophila and
            human staufen, respectively. The exact function of Staufen homolog
            2 is not known, but since it contains 3 copies of conserved dsRNA
            binding domain, it could be involved in double-stranded RNA binding
            events. Several transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) represents the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002152.1, SRR1803611.77250.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524300.6/ ENSP00000428756.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-845               AK002152.1         1-845
            846-846             AC100784.2         53879-53879
            847-2951            AK002152.1         847-2951
            2952-2970           AF459097.1         2758-2776
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..2970
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /note="staufen double-stranded RNA binding protein 2"
                     /db_xref="GeneID:27067"
                     /db_xref="HGNC:HGNC:11371"
                     /db_xref="MIM:605920"
     exon            1..58
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            59..171
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            172..237
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            238..368
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1967
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /note="isoform a is encoded by transcript variant 1;
                     double-stranded RNA-binding protein Staufen homolog 2;
                     staufen homolog 2; staufen, RNA binding protein, homolog
                     2"
                     /codon_start=1
                     /product="double-stranded RNA-binding protein Staufen
                     homolog 2 isoform a"
                     /protein_id="NP_001157852.1"
                     /db_xref="CCDS:CCDS55247.1"
                     /db_xref="GeneID:27067"
                     /db_xref="HGNC:HGNC:11371"
                     /db_xref="MIM:605920"
                     /translation="MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSKMFSVQL
                     SLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNG
                     LAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPVPKIFYVQLTVGNNEFFGE
                     GKTRQAARHNAAMKALQALQNEPIPERSPQNGESGKDVDDDKDANKSEISLVFEIALK
                     RNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLP
                     PLPVVEKPKLFFKKRPKTIVKAGPEYGQGMNPISRLAQIQQAKKEKEPDYVLLSERGM
                     PRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTNLQDQLEKTGENK
                     GWSGPKPGFPEPTNNTPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPKDMNQPSSS
                     FFSISPTSNSSATIARELLMNGTSSTAEAIGLKGSSPTPPCSPVQPSKQLEYLARIQG
                     FQAALSALKQFSEQGLDPIDGAMNIEKGSLEKQAKHLREKADNNQAPPGSIAQDCKKS
                     NSAV"
     exon            369..528
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..664
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            665..824
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            825..932
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1145
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1283
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1415
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1476
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1784
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1873
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2970
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2942..2947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /note="hexamer: AGTAAA"
     polyA_site      2970
                     /gene="STAU2"
                     /gene_synonym="39K2; 39K3"
                     /note="major polyA site"
ORIGIN      
        1 agttctctgt agtgtttgcc aatgttggag ccgtctgcaa agtgtccccg gcaagaagag
       61 gctgcctacc acaaggactt tagcttactt tttaaagatt gaagaaaaaa aagaagacag
      121 aaaaagaaga actcaaagat acacaaagta atttgaacca aggctcagaa gtttttggag
      181 ccgtgaggga tacagcagtt tggtcaatat tgtcttaaca tgcttcaaat aaatcagctt
      241 ctctccaaga taaaatggca aacccaaaag agaaaactgc aatgtgtctg gtaaatgagt
      301 tagcccgttt caatagagtc caaccccagt ataaacttct gaatgaaaga gggcctgctc
      361 attcaaagat gttctcagtg cagctgagtc ttggtgagca gacatgggaa tccgaaggca
      421 gcagtataaa gaaggctcag caggctgttg ccaataaagc tttgactgaa tctacgcttc
      481 ccaaaccagt tcagaagcca cccaaaagta atgttaacaa taacccaggc agtataactc
      541 caactgtgga actgaatggg cttgctatga aaaggggaga gcctgccatc tacaggccat
      601 tagatccaaa gccattccca aattatagag ctaattacaa ctttcggggc atgtacaatc
      661 agaggtatca ttgcccagtg cctaagatct tttatgttca gctcactgta ggaaataatg
      721 aattttttgg ggaaggaaag actcgacaag ctgctagaca caatgctgca atgaaagccc
      781 tccaagcact gcagaatgaa cctattccag aaagatctcc tcagaatggt gaatcaggaa
      841 aggatgtgga tgatgacaaa gatgcaaata agtctgagat cagcttagtg tttgaaattg
      901 ctctgaagcg aaatatgcct gtcagttttg aggttattaa agaaagtgga ccaccacata
      961 tgaaaagctt tgttactcga gtgtcagtag gagagttctc tgcagaagga gaaggaaata
     1021 gcaaaaaact ctccaagaag cgcgctgcga ccaccgtctt acaggagctt aaaaaacttc
     1081 cacctcttcc tgtggtggaa aagccaaaac tattttttaa aaaacgccct aaaacaatag
     1141 taaaggccgg accagaatat ggccaaggga tgaaccctat tagccgcctg gcgcaaattc
     1201 aacaggccaa aaaggaaaag gagccggatt atgttttgct ttcagaaaga ggaatgcctc
     1261 gacgtcgaga atttgtgatg caggtgaagg taggcaatga agttgctaca ggaacaggac
     1321 ctaataaaaa gatagccaaa aaaaatgctg cagaagcaat gctgttacaa cttggttata
     1381 aagcatccac taatcttcag gatcaacttg agaagacagg ggaaaacaaa ggatggagtg
     1441 gtccaaagcc tgggtttcct gaaccaacaa ataatactcc aaaaggaatt cttcatttgt
     1501 ctcctgatgt ttatcaagag atggaagcca gccgccacaa agtaatctct ggcactactc
     1561 taggctattt gtcacccaaa gatatgaacc aaccttcaag ctctttcttc agtatatctc
     1621 ccacatcgaa tagttcagct acaattgcca gggaactcct tatgaatgga acatcttcta
     1681 cagctgaagc cataggttta aaaggaagtt ctcctactcc cccttgttct ccagtacaac
     1741 cttcaaaaca actggaatat ttagcaagga ttcaaggctt tcaggcagcc ttaagtgcct
     1801 tgaaacaatt ttctgaacaa ggactggatc caatcgatgg agcaatgaat atcgaaaaag
     1861 gttctcttga aaaacaagcc aagcatctga gagagaaagc ggacaataac caggcacccc
     1921 cgggctccat cgctcaggac tgcaagaaat caaactcggc cgtctagcag ctcccagaac
     1981 ccgcggctgc caccgcatcc ttataaacct gtcagcacgc atgagggtgt ctgtgttcag
     2041 ggaaatgaat gactaatacc attatttgag tcttatgtga agacaacact attctaacac
     2101 gagagataat atacatggta ctgtttattc aactggggaa aaataaaact ttgagcattt
     2161 cccttggaac tcgagatcag atcataactc atttgcctag aggcagcaga aatctgatcc
     2221 tgctactgga gcttaaaata acaagtaaag aaaagtgtta gaaacaaagc taaaatttta
     2281 acatgattaa taatagagaa gttgggtttg gttctgttgt tatgattgtt ttgtcgtggt
     2341 gcttgtgttc agttatattc tctctctctc tcatttcaaa tactgcttga caattcgaaa
     2401 atgaaccaat gatgtgctgt ggaatgtgat ggttgtcttc atatagagtc acatggtttc
     2461 tctttttatg cagatattta taatcttcat cctatatcag taggaataac tataaggtgc
     2521 actacaaaaa gatgtatgca aacaaacatg ttttaaatca ggtcagatat ctgatgaaaa
     2581 atacgaacta atgttaagag caagtagttt caacatactc caggaactga gaaacaaaac
     2641 aaagcaattg tgggttttga gctccatata ctcttagcaa gtaagggggc gtcttgcccc
     2701 tatatatcat cttcccggat tccactccct gttgtgggaa tcgcgcccac ccccatccgt
     2761 gtgttgtagc cactcacggt ttgcatcaag agtgtttttt gtaactgcct ctggacttgg
     2821 gacagtgagt aggatcaaaa ataaataatg tacatgacgg ggaagggaaa aacctgttgg
     2881 agttgcttcc agccagccac gctccgggcc agcatgttgg aatccagcgt ggagcagatg
     2941 cagtaaaaat gtggttggtt tctgtgtgaa
//
