LOCUS       NM_017453               3651 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens staufen double-stranded RNA binding protein 1 (STAU1),
            transcript variant T3, mRNA.
ACCESSION   NM_017453
VERSION     NM_017453.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3651)
  AUTHORS   Lv,Z., Ren,Y., Li,Y., Niu,F., Li,Z., Li,M., Li,X., Li,Q., Huang,D.,
            Yu,Y., Xiong,Y. and Qian,L.
  TITLE     RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance
            through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling
            cascade
  JOURNAL   Mol Med 30 (1), 124 (2024)
   PUBMED   39138413
  REMARK    GeneRIF: RNA-binding protein GIGYF2 orchestrates hepatic insulin
            resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT
            signaling cascade.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3651)
  AUTHORS   Zhao,R., Huang,S., Li,J., Gu,A., Fu,M., Hua,W., Mao,Y., Lei,Q.Y.,
            Lu,B. and Wen,W.
  TITLE     Excessive STAU1 condensate drives mTOR translation and autophagy
            dysfunction in neurodegeneration
  JOURNAL   J Cell Biol 223 (8) (2024)
   PUBMED   38913026
  REMARK    GeneRIF: Excessive STAU1 condensate drives mTOR translation and
            autophagy dysfunction in neurodegeneration.
REFERENCE   3  (bases 1 to 3651)
  AUTHORS   Liu,X., Chen,Y., Li,Y., Bai,J., Zeng,Z., Wang,M., Dong,Y. and
            Zhou,Y.
  TITLE     STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell
            characteristics in ovarian cancer
  JOURNAL   Biol Direct 19 (1), 59 (2024)
   PUBMED   39080743
  REMARK    GeneRIF: STAU1-mediated CNBP mRNA degradation by LINC00665 alters
            stem cell characteristics in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3651)
  AUTHORS   Pasterczyk,K.R., Li,X.L., Singh,R., Zibitt,M.S., Hartford,C.C.R.,
            Pongor,L., Jenkins,L.M., Hu,Y., Zhao,P.X., Muys,B.R., Kumar,S.,
            Roper,N., Aladjem,M.I., Pommier,Y., Grammatikakis,I. and Lal,A.
  TITLE     Staufen1 Represses the FOXA1-Regulated Transcriptome by
            Destabilizing FOXA1 mRNA in Colorectal Cancer Cells
  JOURNAL   Mol Cell Biol 44 (2), 43-56 (2024)
   PUBMED   38347726
  REMARK    GeneRIF: Staufen1 Represses the FOXA1-Regulated Transcriptome by
            Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.
REFERENCE   5  (bases 1 to 3651)
  AUTHORS   Gonzalez Quesada,Y. and DesGroseillers,L.
  TITLE     A Degradation Motif in STAU1 Defines a Novel Family of Proteins
            Involved in Inflammation
  JOURNAL   Int J Mol Sci 23 (19), 11588 (2022)
   PUBMED   36232890
  REMARK    GeneRIF: A Degradation Motif in STAU1 Defines a Novel Family of
            Proteins Involved in Inflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3651)
  AUTHORS   Kiebler,M.A. and DesGroseillers,L.
  TITLE     Molecular insights into mRNA transport and local translation in the
            mammalian nervous system
  JOURNAL   Neuron 25 (1), 19-28 (2000)
   PUBMED   10707969
  REMARK    Review article
REFERENCE   7  (bases 1 to 3651)
  AUTHORS   Falcon,A.M., Fortes,P., Marion,R.M., Beloso,A. and Ortin,J.
  TITLE     Interaction of influenza virus NS1 protein and the human homologue
            of Staufen in vivo and in vitro
  JOURNAL   Nucleic Acids Res 27 (11), 2241-2247 (1999)
   PUBMED   10325410
REFERENCE   8  (bases 1 to 3651)
  AUTHORS   Wickham,L., Duchaine,T., Luo,M., Nabi,I.R. and DesGroseillers,L.
  TITLE     Mammalian staufen is a double-stranded-RNA- and tubulin-binding
            protein which localizes to the rough endoplasmic reticulum
  JOURNAL   Mol Cell Biol 19 (3), 2220-2230 (1999)
   PUBMED   10022909
REFERENCE   9  (bases 1 to 3651)
  AUTHORS   Marion,R.M., Fortes,P., Beloso,A., Dotti,C. and Ortin,J.
  TITLE     A human sequence homologue of Staufen is an RNA-binding protein
            that is associated with polysomes and localizes to the rough
            endoplasmic reticulum
  JOURNAL   Mol Cell Biol 19 (3), 2212-2219 (1999)
   PUBMED   10022908
REFERENCE   10 (bases 1 to 3651)
  AUTHORS   DesGroseillers,L. and Lemieux,N.
  TITLE     Localization of a human double-stranded RNA-binding protein gene
            (STAU) to band 20q13.1 by fluorescence in situ hybridization
  JOURNAL   Genomics 36 (3), 527-529 (1996)
   PUBMED   8884277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133174.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 16, 2020 this sequence version replaced NM_017453.3.
            
            Summary: Staufen is a member of the family of double-stranded RNA
            (dsRNA)-binding proteins involved in the transport and/or
            localization of mRNAs to different subcellular compartments and/or
            organelles. These proteins are characterized by the presence of
            multiple dsRNA-binding domains which are required to bind RNAs
            having double-stranded secondary structures. The human homologue of
            staufen encoded by STAU, in addition contains a microtubule-
            binding domain similar to that of microtubule-associated protein
            1B, and binds tubulin. The STAU gene product has been shown to be
            present in the cytoplasm in association with the rough endoplasmic
            reticulum (RER), implicating this protein in the transport of mRNA
            via the microtubule network to the RER, the site of translation.
            [provided by RefSeq, Apr 2020].
            
            Transcript Variant: This variant (T3) differs in the 5' UTR and the
            5' coding region, and uses an upstream translation start site
            compared to variant T2. The encoded isoform (b) has a longer and
            distinct N-terminus compared to isoform a. Both variants T3 and T7
            encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF061939.1, SRR14038193.516231.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371856.7/ ENSP00000360922.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AL133174.15        108188-108406       c
            220-294             AL133174.15        94267-94341         c
            295-583             AL133174.15        86069-86357         c
            584-722             AL133174.15        74005-74143         c
            723-888             AL133174.15        71654-71819         c
            889-987             AL133174.15        55905-56003         c
            988-1200            AL133174.15        44447-44659         c
            1201-1344           AL133174.15        43164-43307         c
            1345-1491           AL133174.15        40054-40200         c
            1492-1567           AL133174.15        38405-38480         c
            1568-1887           AL133174.15        37849-38168         c
            1888-2010           AL133174.15        37198-37320         c
            2011-2096           AL133174.15        35854-35939         c
            2097-3651           AL133174.15        33411-34965         c
FEATURES             Location/Qualifiers
     source          1..3651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..3651
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /note="staufen double-stranded RNA binding protein 1"
                     /db_xref="GeneID:6780"
                     /db_xref="HGNC:HGNC:11370"
                     /db_xref="MIM:601716"
     exon            1..219
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            220..294
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            295..583
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..2112
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /note="isoform b is encoded by transcript variant T3;
                     staufen, RNA binding protein, homolog 1; protein
                     phosphatase 1, regulatory subunit 150"
                     /codon_start=1
                     /product="double-stranded RNA-binding protein Staufen
                     homolog 1 isoform b"
                     /protein_id="NP_059347.2"
                     /db_xref="CCDS:CCDS13414.1"
                     /db_xref="GeneID:6780"
                     /db_xref="HGNC:HGNC:11370"
                     /db_xref="MIM:601716"
                     /translation="MSQVQVQVQNPSAALSGSQILNKNQSLLSQPLMSIPSTTSSLPS
                     ENAGRPIQNSALPSASITSTSAAAESITPTVELNALCMKLGKKPMYKPVDPYSRMQST
                     YNYNMRGGAYPPRYFYPFPVPPLLYQVELSVGGQQFNGKGKTRQAAKHDAAAKALRIL
                     QNEPLPERLEVNGRESEEENLNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVT
                     KVSVGEFVGEGEGKSKKISKKNAAIAVLEELKKLPPLPAVERVKPRIKKKTKPIVKPQ
                     TSPEYGQGINPISRLAQIQQAKKEKEPEYTLLTERGLPRRREFVMQVKVGNHTAEGTG
                     TNKKVAKRNAAENMLEILGFKVPQAQPTKPALKSEEKTPIKKPGDGRKVTFFEPGSGD
                     ENGTSNKEDEFRMPYLSHQQLPAGILPMVPEVAQAVGVSQGHHTKDFTRAAPNPAKAT
                     VTAMIARELLYGGTSPTAETILKNNISSGHVPHGPLTRPSEQLDYLSRVQGFQVEYKD
                     FPKNNKNEFVSLINCSSQPPLISHGIGKDVESCHDMAALNILKLLSELDQQSTEMPRT
                     GNGPMSVCGRC"
     exon            584..722
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            723..888
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            889..987
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1200
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1344
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1491
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1567
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1887
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2010
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2096
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..3651
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3449..3454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /note="hexamer: AATAAA"
     polyA_site      3467
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /note="major polyA site"
     regulatory      3632..3637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /note="hexamer: AATAAA"
     polyA_site      3651
                     /gene="STAU1"
                     /gene_synonym="PPP1R150; STAU"
                     /note="major polyA site"
ORIGIN      
        1 cttcagcgtt tgcgccggcg gctgccgcgt ctctctcggc tcccgcttcc tttgaccgcc
       61 tccccccccc ggcccggcgg cgcccgcctc ctccacggcc actccgcctc ttccctccct
      121 tcgtcccttc ttcctctccc ttttttcctt cttccttccc ctcctcgccg ccaccgccca
      181 ggaccgccgg ccgggggacg agctcggagc agcagccaga gtttattaac cacttaacct
      241 ctcagaactg aacaaagaca acattgttcc tggaacgccc tctttttaaa aaaggtagaa
      301 ctttagactt catagcactg aattaacctg cactgaaagc tgtttacctg catttgttca
      361 cttttgttga aagtgaccat gtctcaagtt caagtgcaag ttcagaaccc atctgctgct
      421 ctctcaggga gccaaatact gaacaagaac cagtctcttc tctcacagcc tttgatgagt
      481 attccttcta ctactagctc tctgccctct gaaaatgcag gtagacccat tcaaaactct
      541 gctttaccct ctgcatctat tacatccacc agtgcagctg cagaaagcat aacccctact
      601 gtagaactaa atgcactgtg catgaaactt ggaaaaaaac caatgtataa gcctgttgac
      661 ccttactctc ggatgcagtc cacctataac tacaacatga gaggaggtgc ttatcccccg
      721 aggtactttt acccatttcc agttccacct ttactttatc aagtggaact ttctgtggga
      781 ggacagcaat ttaatggcaa aggaaagaca agacaggctg cgaaacacga tgctgctgcc
      841 aaagcgttga ggatcctgca gaatgagccc ctgccagaga ggctggaggt gaatggaaga
      901 gaatccgaag aagaaaatct caataaatct gaaataagtc aagtgtttga gattgcactt
      961 aaacggaact tgcctgtgaa tttcgaggtg gcccgggaga gtggcccacc ccacatgaag
     1021 aactttgtga ccaaggtttc ggttggggag tttgtggggg aaggtgaagg gaaaagcaag
     1081 aagatttcaa agaaaaatgc cgccatagct gttcttgagg agctgaagaa gttaccgccc
     1141 ctgcctgcag ttgaacgagt aaagcctaga atcaaaaaga aaacaaaacc catagtcaag
     1201 ccacagacaa gcccagaata tggccagggg atcaatccga ttagccgact ggcccagatc
     1261 cagcaggcaa aaaaggagaa ggagccagag tacacgctcc tcacagagcg aggcctcccg
     1321 cgccgcaggg agtttgtgat gcaggtgaag gttggaaacc acactgcaga aggaacgggc
     1381 accaacaaga aggtggccaa gcgcaatgca gccgagaaca tgctggagat ccttggtttc
     1441 aaagtcccgc aggcgcagcc caccaaaccc gcactcaagt cagaggagaa gacacccata
     1501 aagaaaccag gggatggaag aaaagtaacc ttttttgaac ctggctctgg ggatgaaaat
     1561 gggactagta ataaagagga tgagttcagg atgccttatc taagtcatca gcagctgcct
     1621 gctggaattc ttcccatggt gcccgaggtc gcccaggctg taggagttag tcaaggacat
     1681 cacaccaaag attttaccag ggcagctccg aatcctgcca aggccacggt aactgccatg
     1741 atagcccgag agttgttgta tgggggcacc tcgcccacag ccgagaccat tttaaagaat
     1801 aacatctctt caggccacgt accccatgga cctctcacga gaccctctga gcaactggac
     1861 tatctttcca gagtccaggg attccaggtt gaatacaaag acttccccaa aaacaacaag
     1921 aacgaatttg tatctcttat caattgctcc tctcagccac ctctgatcag ccatggtatc
     1981 ggcaaggatg tggagtcctg ccatgatatg gctgcgctga acatcttaaa gttgctgtct
     2041 gagttggacc aacaaagtac agagatgcca agaacaggaa acggaccaat gtctgtgtgt
     2101 gggaggtgct gaaccttttc tggccatgaa ccattataaa atcccaacat atatactgaa
     2161 aatactgaaa ctgctttgaa aatttggaat ttctgatacc tccagtgggc cgagagacac
     2221 ggtgggtaaa ggatgtgggc agcagcaggg aagacaacag aaacacaagg aggcggctgt
     2281 ggccgggctg gactgtgctg gggtttgttg tgatggccac tcggtgacct ggcggtccct
     2341 acgcaatagc agctgcctgt ggggaagaag ggctgcccag ccagctggtt ctcccgggac
     2401 accagcagat ccacaccctg ggcacctccg tgtttggtct tttttttccc ctgtgtgaaa
     2461 gaagaaacgg cacgacccct tctcaagctg gctcactcag acacattggg acaaaccctg
     2521 gacagccatg ccagagagag gcctttgacc ggccccagag ctaaaagcac cagagaaaat
     2581 caaatgcttc ctactcagcg tgacccaact tttctagtgt gccacggccc caccacctcc
     2641 tgcagtaccc acaccatcac cactgctttc tcttccaaca gtgatctgta ttcttagttt
     2701 cattattttc ttttgattga tatgacacta tataaaattt tcatttgaga atttctcaat
     2761 tgtatctagt taaatagcac agtttggaaa cttgtctgag actgacttta tcaataatct
     2821 aaccgacaaa gatcatatcc atgtgtatgt ggttagacat ttttatttca ttgactaacc
     2881 caggacagtt tcagtgatgc aaattgtgtg ccctctggtt cagctgaaac agtcctggac
     2941 tttcaaaaac cttgaataag tctcccacag ttgtataaat tggacaattt aggaatttta
     3001 aactttagat gatcatttgg ttccattttt atttcatttt tatttttgtt aatgcaaaca
     3061 ggacttaaat gaactttgat ctctgtttta aagattatta aaaaacattg tgtatctata
     3121 catatggctc ttgaggactt agctttcact acactacagg atatgatctc catgtagtcc
     3181 atataaacct gcagagtgat tttccagagt gctcgatact gttaattaca tctccattag
     3241 ggctgaaaag aatgacctac gtttctgtat acagctgtgt tgcttttgat gttgtgttac
     3301 tgtacacaga agtgtgtgca ctgaggctct gcgtgtggtc cgtatggaaa gcctggtagc
     3361 cctgcgagtt aagtactgct tccattcatt gtttacgctg gaatttttct ccccatggaa
     3421 tgtaagtaaa acttaagtgt ttgtcatcaa taaatggtaa tactaaattt ttttgttaat
     3481 ttattctcaa atgccactac tgctaggttg gtcccctccc aacttgcccc tatccttttt
     3541 ttatttttaa gaaaaaaact ttgtaatgct tgtgattcca tctgggcaaa agtctgaaga
     3601 tctgaaataa ctttatatca aaccattgat caataaacag ctactaatga a
//
