LOCUS       NM_003154                679 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens statherin (STATH), transcript variant 1, mRNA.
ACCESSION   NM_003154
VERSION     NM_003154.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 679)
  AUTHORS   Parlak,H.M., Buber,E., Gur,A.T., Karabulut,E. and Akalin,F.A.
  TITLE     Statherin and alpha-amylase levels in saliva from patients with
            gingivitis and periodontitis
  JOURNAL   Arch Oral Biol 145, 105574 (2023)
   PUBMED   36395562
  REMARK    GeneRIF: Statherin and alpha-amylase levels in saliva from patients
            with gingivitis and periodontitis.
REFERENCE   2  (bases 1 to 679)
  AUTHORS   Coutinho,C.A.A.C., Marson,F.A.L., Ribeiro,J.D. and Bertuzzo,C.S.
  TITLE     A negative screening of rare genetic variants in the ADIPOQ and
            STATH genes in cystic fibrosis
  JOURNAL   Pulmonology 26 (3), 138-144 (2020)
   PUBMED   31606405
  REMARK    GeneRIF: A negative screening of rare genetic variants in the
            ADIPOQ and STATH genes in cystic fibrosis.
REFERENCE   3  (bases 1 to 679)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 679)
  AUTHORS   Mutahar,M., O'Toole,S., Carpenter,G., Bartlett,D., Andiappan,M. and
            Moazzez,R.
  TITLE     Reduced statherin in acquired enamel pellicle on eroded teeth
            compared to healthy teeth in the same subjects: An in-vivo study
  JOURNAL   PLoS One 12 (8), e0183660 (2017)
   PUBMED   28837608
  REMARK    GeneRIF: The total protein and statherin in the in-vivo AEP were
            different between eroded and non-eroded tooth surfaces of the same
            patient
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 679)
  AUTHORS   Sarode,S.C., Sarode,G.S. and Patil,S.
  TITLE     Role of statherin in oral carcinogenesis
  JOURNAL   Oral Oncol 50 (10), e55-e56 (2014)
   PUBMED   25128293
  REMARK    GeneRIF: effects of statherin on intracellular calcium level and
            its subsequent related molecular alterations would give us new
            pathogenic aspect in oral carcinogenesis
REFERENCE   6  (bases 1 to 679)
  AUTHORS   Raj,P.A., Johnsson,M., Levine,M.J. and Nancollas,G.H.
  TITLE     Salivary statherin. Dependence on sequence, charge, hydrogen
            bonding potency, and helical conformation for adsorption to
            hydroxyapatite and inhibition of mineralization
  JOURNAL   J Biol Chem 267 (9), 5968-5976 (1992)
   PUBMED   1313424
REFERENCE   7  (bases 1 to 679)
  AUTHORS   Ramasubbu,N., Reddy,M.S., Bergey,E.J., Haraszthy,G.G., Soni,S.D.
            and Levine,M.J.
  TITLE     Large-scale purification and characterization of the major
            phosphoproteins and mucins of human submandibular-sublingual saliva
  JOURNAL   Biochem J 280 (Pt 2) (Pt 2), 341-352 (1991)
   PUBMED   1747107
REFERENCE   8  (bases 1 to 679)
  AUTHORS   Douglas,W.H., Reeh,E.S., Ramasubbu,N., Raj,P.A., Bhandary,K.K. and
            Levine,M.J.
  TITLE     Statherin: a major boundary lubricant of human saliva
  JOURNAL   Biochem Biophys Res Commun 180 (1), 91-97 (1991)
   PUBMED   1718282
REFERENCE   9  (bases 1 to 679)
  AUTHORS   Johnsson,M., Richardson,C.F., Bergey,E.J., Levine,M.J. and
            Nancollas,G.H.
  TITLE     The effects of human salivary cystatins and statherin on
            hydroxyapatite crystallization
  JOURNAL   Arch Oral Biol 36 (9), 631-636 (1991)
   PUBMED   1741693
REFERENCE   10 (bases 1 to 679)
  AUTHORS   Schlesinger,D.H. and Hay,D.I.
  TITLE     Complete covalent structure of statherin, a tyrosine-rich acidic
            peptide which inhibits calcium phosphate precipitation from human
            parotid saliva
  JOURNAL   J Biol Chem 252 (5), 1689-1695 (1977)
   PUBMED   838735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB986973.1, BC067219.1, CB958641.1 and AC063956.7.
            
            On May 17, 2019 this sequence version replaced NM_003154.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB230546.1, DB234727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246895.9/ ENSP00000246895.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CB986973.1         40-42
            4-560               BC067219.1         5-561
            561-565             CB958641.1         563-567
            566-679             AC063956.7         44586-44699
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..679
                     /gene="STATH"
                     /gene_synonym="STR"
                     /note="statherin"
                     /db_xref="GeneID:6779"
                     /db_xref="HGNC:HGNC:11369"
                     /db_xref="MIM:184470"
     exon            1..60
                     /gene="STATH"
                     /gene_synonym="STR"
                     /inference="alignment:Splign:2.1.0"
     exon            61..126
                     /gene="STATH"
                     /gene_synonym="STR"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..264
                     /gene="STATH"
                     /gene_synonym="STR"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="statherin isoform a precursor"
                     /protein_id="NP_003145.1"
                     /db_xref="CCDS:CCDS3533.1"
                     /db_xref="GeneID:6779"
                     /db_xref="HGNC:HGNC:11369"
                     /db_xref="MIM:184470"
                     /translation="MKFLVFAFILALMVSMIGADSSEEKFLRRIGRFGYGYGPYQPVP
                     EQPLYPQPYQPQYQQYTF"
     exon            127..147
                     /gene="STATH"
                     /gene_synonym="STR"
                     /inference="alignment:Splign:2.1.0"
     exon            148..177
                     /gene="STATH"
                     /gene_synonym="STR"
                     /inference="alignment:Splign:2.1.0"
     exon            178..297
                     /gene="STATH"
                     /gene_synonym="STR"
                     /inference="alignment:Splign:2.1.0"
     exon            298..679
                     /gene="STATH"
                     /gene_synonym="STR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      540..545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STATH"
                     /gene_synonym="STR"
                     /note="hexamer: AATAAA"
     polyA_site      562
                     /gene="STATH"
                     /gene_synonym="STR"
                     /note="major polyA site"
ORIGIN      
        1 atcatctctt gaagcttcac ttcaacttca ctacttctgt agtctcatct tgagtaaaag
       61 agaacccagc caactatgaa gttccttgtc tttgccttca tcttggctct catggtttcc
      121 atgattggag ctgattcatc tgaagagaaa tttttgcgta gaattggaag attcggttat
      181 gggtatggcc cttatcagcc agttccagaa caaccactat acccacaacc ataccaacca
      241 caataccaac aatatacctt ttaatatcat cagtaactgc aggacatgat tattgaggct
      301 tgattggcaa atacgacttc tacatccata ttctcatctt tcataccata tcacactact
      361 accacttttt gaagaatcat caaagagcaa tgcaaatgaa aaacactata atttactgta
      421 tactctttgt ttcaggatac ttgccttttc aattgtcact tgatgatata attgcaattt
      481 aaactgttaa gctgtgttca gtactgtttc tgaataatag aaatcacttc tctaaaagca
      541 ataaatttca agcacatttt tacatgtatg ctccttattt ttctcttttc tatttatagg
      601 aataatgatt tctttcatca tcttctttcc cagtttgact agcacagatt gaagcccata
      661 atgtcagagg tccttattt
//
