LOCUS       NM_003153               3963 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens signal transducer and activator of transcription 6
            (STAT6), transcript variant 2, mRNA.
ACCESSION   NM_003153
VERSION     NM_003153.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3963)
  AUTHORS   Eschbacher,K.L., Tran,Q.T., Moskalev,E.A., Jenkins,S., Fritchie,K.,
            Stoehr,R., Caron,A., Link,M.J., Brown,P.D., Guajardo,A., Brat,D.J.,
            Wu,A., Santagata,S., Louis,D.N., Brastianos,P.K., Kaplan,A.B.,
            Alexander,B., Rossi,S., Ferrarese,F., Raleigh,D.R., Nguyen,M.P.,
            Gross,J., Velazquez Vega,J., Rodriguez,F., Perry,A.,
            Martinez-Lage,M., Orr,B.A., Haller,F. and Giannini,C.
  TITLE     NAB2::STAT6 fusions and genome-wide DNA methylation profiling:
            Predictors of patient outcomes in meningeal solitary fibrous tumors
  JOURNAL   Brain Pathol 34 (6), e13256 (2024)
   PUBMED   38523251
  REMARK    GeneRIF: NAB2::STAT6 fusions and genome-wide DNA methylation
            profiling: Predictors of patient outcomes in meningeal solitary
            fibrous tumors.
REFERENCE   2  (bases 1 to 3963)
  AUTHORS   de Juan,A., Tabtim-On,D., Coillard,A., Becher,B., Goudot,C. and
            Segura,E.
  TITLE     The aryl hydrocarbon receptor shapes monocyte transcriptional
            responses to interleukin-4 by prolonging STAT6 binding to promoters
  JOURNAL   Sci Signal 17 (858), eadn6324 (2024)
   PUBMED   39405377
  REMARK    GeneRIF: The aryl hydrocarbon receptor shapes monocyte
            transcriptional responses to interleukin-4 by prolonging STAT6
            binding to promoters.
REFERENCE   3  (bases 1 to 3963)
  AUTHORS   Deng,C., Huo,M., Chu,H., Zhuang,X., Deng,G., Li,W., Wei,H.,
            Zeng,L., He,Y., Liu,H., Li,J., Zhang,C. and Chen,H.
  TITLE     Exosome circATP8A1 induces macrophage M2 polarization by regulating
            the miR-1-3p/STAT6 axis to promote gastric cancer progression
  JOURNAL   Mol Cancer 23 (1), 49 (2024)
   PUBMED   38459596
  REMARK    GeneRIF: Exosome circATP8A1 induces macrophage M2 polarization by
            regulating the miR-1-3p/STAT6 axis to promote gastric cancer
            progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3963)
  AUTHORS   Benoit,A., Abraham,M.J., Li,S., Kim,J., Estrada-Tejedor,R.,
            Bakadlag,R., Subramaniam,N., Makhani,K., Guilbert,C., Tu,R.,
            Salaciak,M., Klein,K.O., Coyle,K.M., Hilton,L.K., Santiago,R.,
            Dmitrienko,S., Assouline,S., Morin,R.D., Del Rincon,S.V.,
            Johnson,N.A. and Mann,K.K.
  TITLE     STAT6 mutations enriched at diffuse large B-cell lymphoma relapse
            reshape the tumor microenvironment
  JOURNAL   Int J Hematol 119 (3), 275-290 (2024)
   PUBMED   38285120
  REMARK    GeneRIF: STAT6 mutations enriched at diffuse large B-cell lymphoma
            relapse reshape the tumor microenvironment.
REFERENCE   5  (bases 1 to 3963)
  AUTHORS   Tolomeo,M. and Cascio,A.
  TITLE     STAT4 and STAT6, their role in cellular and humoral immunity and in
            diverse human diseases
  JOURNAL   Int Rev Immunol 43 (6), 394-418 (2024)
   PUBMED   39188021
  REMARK    GeneRIF: STAT4 and STAT6, their role in cellular and humoral
            immunity and in diverse human diseases.
            Review article
REFERENCE   6  (bases 1 to 3963)
  AUTHORS   Shimoda,K., van Deursen,J., Sangster,M.Y., Sarawar,S.R.,
            Carson,R.T., Tripp,R.A., Chu,C., Quelle,F.W., Nosaka,T.,
            Vignali,D.A., Doherty,P.C., Grosveld,G., Paul,W.E. and Ihle,J.N.
  TITLE     Lack of IL-4-induced Th2 response and IgE class switching in mice
            with disrupted Stat6 gene
  JOURNAL   Nature 380 (6575), 630-633 (1996)
   PUBMED   8602264
REFERENCE   7  (bases 1 to 3963)
  AUTHORS   Takeda,K., Tanaka,T., Shi,W., Matsumoto,M., Minami,M.,
            Kashiwamura,S., Nakanishi,K., Yoshida,N., Kishimoto,T. and Akira,S.
  TITLE     Essential role of Stat6 in IL-4 signalling
  JOURNAL   Nature 380 (6575), 627-630 (1996)
   PUBMED   8602263
REFERENCE   8  (bases 1 to 3963)
  AUTHORS   Quelle,F.W., Shimoda,K., Thierfelder,W., Fischer,C., Kim,A.,
            Ruben,S.M., Cleveland,J.L., Pierce,J.H., Keegan,A.D., Nelms,K. et
            al.
  TITLE     Cloning of murine Stat6 and human Stat6, Stat proteins that are
            tyrosine phosphorylated in responses to IL-4 and IL-3 but are not
            required for mitogenesis
  JOURNAL   Mol Cell Biol 15 (6), 3336-3343 (1995)
   PUBMED   7760829
REFERENCE   9  (bases 1 to 3963)
  AUTHORS   Hou,J., Schindler,U., Henzel,W.J., Ho,T.C., Brasseur,M. and
            McKnight,S.L.
  TITLE     An interleukin-4-induced transcription factor: IL-4 Stat
  JOURNAL   Science 265 (5179), 1701-1706 (1994)
   PUBMED   8085155
REFERENCE   10 (bases 1 to 3963)
  AUTHORS   Kotanides,H. and Reich,N.C.
  TITLE     Requirement of tyrosine phosphorylation for rapid activation of a
            DNA binding factor by IL-4
  JOURNAL   Science 262 (5137), 1265-1267 (1993)
   PUBMED   7694370
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005823.2, AC023237.34 and
            AI082533.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003153.4.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. This protein plays a central role in
            exerting IL4 mediated biological responses. It is found to induce
            the expression of BCL2L1/BCL-X(L), which is responsible for the
            anti-apoptotic activity of IL4. Knockout studies in mice suggested
            the roles of this gene in differentiation of T helper 2 (Th2)
            cells, expression of cell surface markers, and class switch of
            immunoglobulins. Alternative splicing results in multiple
            transcript variants.[provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the
            same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075852.1, U16031.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300134.8/ ENSP00000300134.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1539              BC005823.2         17-1555
            1540-1540           AC023237.34        43507-43507
            1541-2281           BC005823.2         1557-2297
            2282-2282           AC023237.34        47525-47525
            2283-3053           BC005823.2         2298-3068
            3054-3054           AC023237.34        50039-50039
            3055-3929           BC005823.2         3070-3944
            3930-3963           AI082533.1         18-51               c
FEATURES             Location/Qualifiers
     source          1..3963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..3963
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /note="signal transducer and activator of transcription 6"
                     /db_xref="GeneID:6778"
                     /db_xref="HGNC:HGNC:11368"
                     /db_xref="MIM:601512"
     exon            1..234
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            235..371
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2799
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /note="isoform 1 is encoded by transcript variant 2; STAT,
                     interleukin4-induced; transcription factor IL-4 STAT;
                     signal transducer and activator of transcription 6,
                     interleukin-4 induced"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     6 isoform 1"
                     /protein_id="NP_003144.3"
                     /db_xref="CCDS:CCDS8931.1"
                     /db_xref="GeneID:6778"
                     /db_xref="HGNC:HGNC:11368"
                     /db_xref="MIM:601512"
                     /translation="MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVG
                     SDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQI
                     LQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQV
                     SLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFE
                     ESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVE
                     KQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGA
                     ESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASF
                     TLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEK
                     MCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILL
                     GRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDS
                     EIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEA
                     FRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSM
                     QLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPH
                     PQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPT
                     EQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW"
     exon            372..510
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            511..594
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            595..733
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            734..786
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            787..935
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1067
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1256
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1344
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1467
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1560
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1767
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1862
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1999
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2146
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2210
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2321
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2414
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2480
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2609
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..3963
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3908..3913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /note="hexamer: AATAAA"
     polyA_site      3934
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /note="major polyA site"
     regulatory      3937..3942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /note="hexamer: AATAAT"
     polyA_site      3963
                     /gene="STAT6"
                     /gene_synonym="D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C"
                     /note="major polyA site"
ORIGIN      
        1 ggggcagcca ctgcttacac tgaagaggga ggacgggaga ggagtgtgtg tgtgtgtgtg
       61 tgtgtgtgtg tgtatgtatg tgtgtgcttt atcttatttt tctttttggt ggtggtggtg
      121 gaagggggga ggtgctagca gggccagcct tgaactcgct ggacagagct acagacctat
      181 ggggcctgga agtgcccgct gagaaaggga gaagacagca gaggggttgc cgaggcaacc
      241 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg
      301 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag
      361 agccagccct gggagttcct ggtcggctcc gacgccttct gctgcaactt ggctagtgcc
      421 ctactttcag acactgtcca gcaccttcag gcctcggtgg gagagcaggg ggaggggagc
      481 accatcttgc aacacatcag cacccttgag agcatatatc agagggaccc cctgaagctg
      541 gtggccactt tcagacaaat acttcaagga gagaaaaaag ctgttatgga acagttccgc
      601 cacttgccaa tgcctttcca ctggaagcag gaagaactca agtttaagac aggcttgcgg
      661 aggctgcagc accgagtagg ggagatccac cttctccgag aagccctgca gaagggggct
      721 gaggctggcc aagtgtctct gcacagcttg atagaaactc ctgctaatgg gactgggcca
      781 agtgaggccc tggccatgct actgcaggag accactggag agctagaggc agccaaagcc
      841 ctagtgctga agaggatcca gatttggaaa cggcagcagc agctggcagg gaatggcgca
      901 ccgtttgagg agagcctggc cccactccag gagaggtgtg aaagcctggt ggacatttat
      961 tcccagctac agcaggaggt aggggcggct ggtggggagc ttgagcccaa gacccgggca
     1021 tcgctgactg gccggctgga tgaagtcctg agaaccctcg tcaccagttg cttcctggtg
     1081 gagaagcagc ccccccaggt actgaagact cagaccaagt tccaggctgg agttcgattc
     1141 ctgttgggct tgaggttcct gggggcccca gccaagcctc cgctggtcag ggccgacatg
     1201 gtgacagaga agcaggcgcg ggagctgagt gtgcctcagg gtcctggggc tggagcagaa
     1261 agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc
     1321 tgctctgccc tgttcaagaa cctgcttctc aagaagatca agcggtgtga gcggaagggc
     1381 actgagtctg tcacagagga gaagtgcgct gtgctcttct ctgccagctt cacacttggc
     1441 cccggcaaac tccccatcca gctccaggcc ctgtctctgc ccctggtggt catcgtccat
     1501 ggcaaccaag acaacaatgc caaagccact atcctgtggg acaatgcctt ctctgagatg
     1561 gaccgcgtgc cctttgtggt ggctgagcgg gtgccctggg agaagatgtg tgaaactctg
     1621 aacctgaagt tcatggctga ggtggggacc aaccgggggc tgctcccaga gcacttcctc
     1681 ttcctggccc agaagatctt caatgacaac agcctcagta tggaggcctt ccagcaccgt
     1741 tctgtgtcct ggtcgcagtt caacaaggag atcctgctgg gccgtggctt caccttttgg
     1801 cagtggtttg atggtgtcct ggacctcacc aaacgctgtc tccggagcta ctggtctgac
     1861 cggctgatca ttggcttcat cagcaaacag tacgttacta gccttcttct caatgagccc
     1921 gacggaacct ttctcctccg cttcagcgac tcagagattg ggggcatcac cattgcccat
     1981 gtcatccggg gccaggatgg ctctccacag atagagaaca tccagccatt ctctgccaaa
     2041 gacctgtcca ttcgctcact gggggaccga atccgggatc ttgctcagct caaaaatctc
     2101 tatcccaaga agcccaagga tgaggctttc cggagccact acaagcctga acagatgggt
     2161 aaggatggca ggggttatgt cccagctacc atcaagatga ccgtggaaag ggaccaacca
     2221 cttcctaccc cagagctcca gatgcctacc atggtgcctt cttatgacct tggaatggcc
     2281 cctgattcct ccatgagcat gcagcttggc ccagatatgg tgccccaggt gtacccacca
     2341 cactctcact ccatcccccc gtatcaaggc ctctccccag aagaatcagt caacgtgttg
     2401 tcagccttcc aggagcctca cctgcagatg ccccccagcc tgggccagat gagcctgccc
     2461 tttgaccagc ctcaccccca gggcctgctg ccgtgccagc ctcaggagca tgctgtgtcc
     2521 agccctgacc ccctgctctg ctcagatgtg accatggtgg aagacagctg cctgagccag
     2581 ccagtgacag cgtttcctca gggcacttgg attggtgaag acatattccc tcctctgctg
     2641 cctcccactg aacaggacct cactaagctt ctcctggagg ggcaagggga gtcgggggga
     2701 gggtccttgg gggcacagcc cctcctgcag ccctcccact atgggcaatc tgggatctca
     2761 atgtcccaca tggacctaag ggccaacccc agttggtgat cccagctgga gggagaaccc
     2821 aaagagacag ctcttctact acccccacag acctgctctg gacacttgct catgccctgc
     2881 caagcagcag atggggaggg tgccctccta tccccaccta ctcctgggtc aggaggaaaa
     2941 gactaacagg agaatgcaca gtgggtggag ccaatccact ccttcctttc tatcattccc
     3001 ctgcccacct ccttccagca ctgactggaa gggaagttca ggctctgaga cacaccccaa
     3061 catgcctgca cctgcagcgc gcacacgcac gcacacacac atacagagct ctctgagggt
     3121 gatggggctg agcaggaggg gggctgggta agagcacagg ttagggcatg gaaggcttct
     3181 ccgcccattc tgacccaggg cctaggacgg ataggcagga acatacagac acatttacac
     3241 tagaggccag ggatagagga tattgggtct cagccctagg ggaatgggaa gcagctcaag
     3301 ggaccctggg tgggagcata ggaggggtct ggacatgtgg ttactagtac aggttttgcc
     3361 ctgattaaaa aatctcccaa agccccaaat tcctgttagc caggtggagg cttctgatac
     3421 gtgtatgaga ctatgcaaaa gtacaagggc tgagattctt cgtgtatagc tgtgtgaacg
     3481 tgtatgtacc taggatatgt taaatgtata gctggcacct tagttgcatg accacataga
     3541 acatgtgtct atctgctttt gcctacgtga caacacaaat ttgggagggt gagacactgc
     3601 acagaagaca gcagcaagtg tgctggcctc tctgacatat gctaaccccc aaatactctg
     3661 aatttggagt ctgactgtgc ccaagtgggt ccaagtggct gtgacatcta cgtatggctc
     3721 cacacctcca atgctgcctg ggagccaggg tgagagtctg ggtccaggcc tggccatgtg
     3781 gccctccagt gtatgagagg gccctgcctg ctgcatcttt tctgttgccc catccaccgc
     3841 cagcttccct tcactcccct atcccattct ccctctcaag gcaggggtca tagatcctaa
     3901 gccataaaat aaattttatt ccaaaataac aaaataaata atctactgta cacaatctga
     3961 aaa
//
