LOCUS       NM_012448               5079 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens signal transducer and activator of transcription 5B
            (STAT5B), mRNA.
ACCESSION   NM_012448
VERSION     NM_012448.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5079)
  AUTHORS   Bhattarai,P.Y., Kim,G., Lim,S.C. and Choi,H.S.
  TITLE     METTL3-STAT5B interaction facilitates the co-transcriptional m6A
            modification of mRNA to promote breast tumorigenesis
  JOURNAL   Cancer Lett 603, 217215 (2024)
   PUBMED   39218290
  REMARK    GeneRIF: METTL3-STAT5B interaction facilitates the
            co-transcriptional m[6]A modification of mRNA to promote breast
            tumorigenesis.
REFERENCE   2  (bases 1 to 5079)
  AUTHORS   Suske,T., Sorger,H., Manhart,G., Ruge,F., Prutsch,N.,
            Zimmerman,M.W., Eder,T., Abdallah,D.I., Maurer,B., Wagner,C.,
            Schonefeldt,S., Spirk,K., Pichler,A., Pemovska,T., Schweicker,C.,
            Poloske,D., Hubanic,E., Jungherz,D., Muller,T.A., Aung,M.M.K.,
            Orlova,A., Pham,H.T.T., Zimmel,K., Krausgruber,T., Bock,C.,
            Muller,M., Dahlhoff,M., Boersma,A., Rulicke,T., Fleck,R., de
            Araujo,E.D., Gunning,P.T., Aittokallio,T., Mustjoki,S., Sanda,T.,
            Hartmann,S., Grebien,F., Hoermann,G., Haferlach,T., Staber,P.B.,
            Neubauer,H.A., Look,A.T., Herling,M. and Moriggl,R.
  TITLE     Hyperactive STAT5 hijacks T cell receptor signaling and drives
            immature T cell acute lymphoblastic leukemia
  JOURNAL   J Clin Invest 134 (8), e168536 (2024)
   PUBMED   38618957
  REMARK    GeneRIF: Hyperactive STAT5 hijacks T cell receptor signaling and
            drives immature T cell acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5079)
  AUTHORS   Li,C.F., Chan,T.C., Fang,F.M., Yu,S.C. and Huang,H.Y.
  TITLE     PAK1 overexpression promotes myxofibrosarcoma angiogenesis through
            STAT5B-mediated CSF2 transactivation: clinical and therapeutic
            relevance of amplification and nuclear entry
  JOURNAL   Int J Biol Sci 19 (12), 3920-3936 (2023)
   PUBMED   37564209
  REMARK    GeneRIF: PAK1 overexpression promotes myxofibrosarcoma angiogenesis
            through STAT5B-mediated CSF2 transactivation: clinical and
            therapeutic relevance of amplification and nuclear entry.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5079)
  AUTHORS   Li,J., Li,L., Mahesutihan,G., Meng,J., Chen,Y. and Lv,J.
  TITLE     Identification of STAT5B as a biomarker associated with prognosis
            and immune infiltration in breast cancer
  JOURNAL   Medicine (Baltimore) 102 (9), e32972 (2023)
   PUBMED   36862902
  REMARK    GeneRIF: Identification of STAT5B as a biomarker associated with
            prognosis and immune infiltration in breast cancer.
REFERENCE   5  (bases 1 to 5079)
  AUTHORS   Smith,M.R., Satter,L.R.F. and Vargas-Hernandez,A.
  TITLE     STAT5b: A master regulator of key biological pathways
  JOURNAL   Front Immunol 13, 1025373 (2023)
   PUBMED   36755813
  REMARK    GeneRIF: STAT5b: A master regulator of key biological pathways.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5079)
  AUTHORS   Stocklin,E., Wissler,M., Gouilleux,F. and Groner,B.
  TITLE     Functional interactions between Stat5 and the glucocorticoid
            receptor
  JOURNAL   Nature 383 (6602), 726-728 (1996)
   PUBMED   8878484
REFERENCE   7  (bases 1 to 5079)
  AUTHORS   Novak,U., Mui,A., Miyajima,A. and Paradiso,L.
  TITLE     Formation of STAT5-containing DNA binding complexes in response to
            colony-stimulating factor-1 and platelet-derived growth factor
  JOURNAL   J Biol Chem 271 (31), 18350-18354 (1996)
   PUBMED   8702476
REFERENCE   8  (bases 1 to 5079)
  AUTHORS   Lin,J.X., Mietz,J., Modi,W.S., John,S. and Leonard,W.J.
  TITLE     Cloning of human Stat5B. Reconstitution of interleukin-2-induced
            Stat5A and Stat5B DNA binding activity in COS-7 cells
  JOURNAL   J Biol Chem 271 (18), 10738-10744 (1996)
   PUBMED   8631883
REFERENCE   9  (bases 1 to 5079)
  AUTHORS   Silva,C.M., Lu,H. and Day,R.N.
  TITLE     Characterization and cloning of STAT5 from IM-9 cells and its
            activation by growth hormone
  JOURNAL   Mol Endocrinol 10 (5), 508-518 (1996)
   PUBMED   8732682
REFERENCE   10 (bases 1 to 5079)
  AUTHORS   Lin,J.X., Migone,T.S., Tsang,M., Friedmann,M., Weatherbee,J.A.,
            Zhou,L., Yamauchi,A., Bloom,E.T., Mietz,J., John,S. et al.
  TITLE     The role of shared receptor motifs and common Stat proteins in the
            generation of cytokine pleiotropy and redundancy by IL-2, IL-4,
            IL-7, IL-13, and IL-15
  JOURNAL   Immunity 2 (4), 331-339 (1995)
   PUBMED   7719938
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC065227.1 and U47686.1.
            
            On Aug 31, 2019 this sequence version replaced NM_012448.3.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. This protein mediates the signal
            transduction triggered by various cell ligands, such as IL2, IL4,
            CSF1, and different growth hormones. It has been shown to be
            involved in diverse biological processes, such as TCR signaling,
            apoptosis, adult mammary gland development, and sexual dimorphism
            of liver gene expression. This gene was found to fuse to retinoic
            acid receptor-alpha (RARA) gene in a small subset of acute
            promyelocytic leukemias (APLL). The dysregulation of the signaling
            pathways mediated by this protein may be the cause of the APLL.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065227.1, AB208920.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293328.8/ ENSP00000293328.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2551              BC065227.1         16-2566
            2552-2734           U47686.1           2544-2726
            2735-5079           BC065227.1         2746-5090
FEATURES             Location/Qualifiers
     source          1..5079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..5079
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /note="signal transducer and activator of transcription
                     5B"
                     /db_xref="GeneID:6777"
                     /db_xref="HGNC:HGNC:11367"
                     /db_xref="MIM:604260"
     exon            1..144
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            145..282
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2518
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /note="transcription factor STAT5B"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     5B"
                     /protein_id="NP_036580.2"
                     /db_xref="CCDS:CCDS11423.1"
                     /db_xref="GeneID:6777"
                     /db_xref="HGNC:HGNC:11367"
                     /db_xref="MIM:604260"
                     /translation="MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWD
                     SVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCP
                     MELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTEN
                     ELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQRE
                     AQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQ
                     SWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFII
                     EKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDY
                     SGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSV
                     GGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLC
                     EALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGR
                     NYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEI
                     GGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKY
                     YTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHY
                     NMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS"
     exon            283..439
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            440..529
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            530..704
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..835
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            836..987
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1143
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1323
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1411
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1534
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1627
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1834
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1929
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2060
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2231
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2283
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2391
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..5079
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5057..5062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /note="hexamer: AATAAA"
     polyA_site      5079
                     /gene="STAT5B"
                     /gene_synonym="GHISID2; STAT5"
                     /note="major polyA site"
ORIGIN      
        1 ggcggccgga gccgtcaccc cgggcgggga cccagcgcag gcaactccgc gcggcggccc
       61 ggccgaggga gggagcgagc gggcgggcgg gcaagccaga cagctgggcc ggagcagccg
      121 cgggcgcccg aggggccgag cgagattgta aaccatggct gtgtggatac aagctcagca
      181 gctccaagga gaagcccttc atcagatgca agcgttatat ggccagcatt ttcccattga
      241 ggtgcggcat tatttatccc agtggattga aagccaagca tgggactcag tagatcttga
      301 taatccacag gagaacatta aggccaccca gctcctggag ggcctggtgc aggagctgca
      361 gaagaaggca gagcaccagg tgggggaaga tgggttttta ctgaagatca agctggggca
      421 ctatgccaca cagctccaga acacgtatga ccgctgcccc atggagctgg tccgctgcat
      481 ccgccatata ttgtacaatg aacagaggtt ggtccgagaa gccaacaatg gtagctctcc
      541 agctggaagc cttgctgatg ccatgtccca gaaacacctc cagatcaacc agacgtttga
      601 ggagctgcga ctggtcacgc aggacacaga gaatgagtta aaaaagctgc agcagactca
      661 ggagtacttc atcatccagt accaggagag cctgaggatc caagctcagt ttggcccgct
      721 ggcccagctg agcccccagg agcgtctgag ccgggagacg gccctccagc agaagcaggt
      781 gtctctggag gcctggttgc agcgtgaggc acagacactg cagcagtacc gcgtggagct
      841 ggccgagaag caccagaaga ccctgcagct gctgcggaag cagcagacca tcatcctgga
      901 tgacgagctg atccagtgga agcggcggca gcagctggcc gggaacggcg ggccccccga
      961 gggcagcctg gacgtgctac agtcctggtg tgagaagttg gccgagatca tctggcagaa
     1021 ccggcagcag atccgcaggg ctgagcacct ctgccagcag ctgcccatcc ccggcccagt
     1081 ggaggagatg ctggccgagg tcaacgccac catcacggac attatctcag ccctggtgac
     1141 cagcacgttc atcattgaga agcagcctcc tcaggtcctg aagacccaga ccaagtttgc
     1201 agccactgtg cgcctgctgg tgggcgggaa gctgaacgtg cacatgaacc ccccccaggt
     1261 gaaggccacc atcatcagtg agcagcaggc caagtctctg ctcaagaacg agaacacccg
     1321 caatgattac agtggcgaga tcttgaacaa ctgctgcgtc atggagtacc accaagccac
     1381 aggcaccctt agtgcccact tcaggaatat gtccctgaaa cgaattaaga ggtcagaccg
     1441 tcgtggggca gagtcggtga cagaagaaaa atttacaatc ctgtttgaat cccagttcag
     1501 tgttggtgga aatgagctgg tttttcaagt caagaccctg tccctgccag tggtggtgat
     1561 cgttcatggc agccaggaca acaatgcgac ggccactgtt ctctgggaca atgcttttgc
     1621 agagcctggc agggtgccat ttgccgtgcc tgacaaagtg ctgtggccac agctgtgtga
     1681 ggcgctcaac atgaaattca aggccgaagt gcagagcaac cggggcctga ccaaggagaa
     1741 cctcgtgttc ctggcgcaga aactgttcaa caacagcagc agccacctgg aggactacag
     1801 tggcctgtct gtgtcctggt cccagttcaa cagggagaat ttaccaggac ggaattacac
     1861 tttctggcaa tggtttgacg gtgtgatgga agtgttaaaa aaacatctca agcctcattg
     1921 gaatgatggg gccattttgg ggtttgtaaa caagcaacag gcccatgacc tactcattaa
     1981 caagccagat gggaccttcc tcctgagatt cagtgactca gaaattggcg gcatcaccat
     2041 tgcttggaag tttgattctc aggaaagaat gttttggaat ctgatgcctt ttaccaccag
     2101 agacttctcc attcggtccc tagccgaccg cttgggagac ttgaattacc ttatctacgt
     2161 gtttcctgat cggccaaaag atgaagtata ctccaaatac tacacaccag ttccctgcga
     2221 gtctgctact gctaaagctg ttgatggata cgtgaagcca cagatcaagc aagtggtccc
     2281 tgagtttgtg aacgcatctg cagatgccgg gggcggcagc gccacgtaca tggaccaggc
     2341 cccctcccca gctgtgtgtc cccaggctca ctataacatg tacccacaga accctgactc
     2401 agtccttgac accgatgggg acttcgatct ggaggacaca atggacgtag cgcggcgtgt
     2461 ggaggagctc ctgggccggc caatggacag tcagtggatc ccgcacgcac aatcgtgacc
     2521 ccgcgacctc tccatcttca gcttcttcat cttcaccaga ggaatcactc ttgtggatgt
     2581 tttaattcca tgaatcgctt ctcttttgaa acaatactca taatgtgaag tgttaatact
     2641 agttgtgacc ttagtgtttc tgtgcatggt ggcaccagcg aagggagtgc gagtatgtgt
     2701 ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt gcgtgtttgc acgttatggt gtttctccct
     2761 ctcactgtct gagagtttag ttgtagcaga ggggccacag acagaagctg tggtggtttt
     2821 tactttgtgc aaaaaggcag tgagtttcgt gaagcctgga agttggccat gtgtcttaag
     2881 agtggctgga ctttgacatg tggctgtttg aataagagaa ggacaaaggg aggagaaagc
     2941 acatgtgctc cagtgagtct tcgtcactct gtctgccaag caattgatat ataaccgtga
     3001 ttgtctctgc ttttcttctg aaatgtagat aactgctttt tgacaaagag agccttccct
     3061 ctcccccacc cctgtgttct tgggtaggaa tgggaaaagg ggcaacctac aaagattgtt
     3121 ggggcaaggg aagtcacaag ctttcggatg ggcggtggct tttcacaaaa catttagctc
     3181 atcttattct ctctttgtcc tctctcccct cctgcccgcc cgcaccctgg aattgccact
     3241 cagttcctct gggtgtgcac atatgtttgg agaaatagag gagagaaaag agggccacgt
     3301 aactgagagc ttacagtgcc aatgccgttt gtgttctggc cagagtggag tgcgcagccc
     3361 tgactcccag gcgctgagat tgttgcctgg ttacccagga agctgctgtt ccggctgccc
     3421 agcctttctc tgagccagcg gatgcacagt ccgtggcctt cttcaggctt attgatgatg
     3481 ctttttgcaa atgttgaatc atggttctgt ttctaagttg gatctttttt gttttctcct
     3541 tgccacccta atttgacatc aaaattctct cttgtgcatt gggccctggg tcattcaaac
     3601 ccaggtcacc tcattcccct tctctgttca cacctaatgt cttgaagagt aggtagcagc
     3661 agtgtgggct gaacctaggc cagcttgctt agcgggtcac cctgctgtga agtcctggca
     3721 ggtgttggta atgtgtggaa atgcagtcag caagtttgct ggggagtttg ataaaagtat
     3781 aaaacaaaac aaaaaaagcc tcggtataat tttgttccac gacttcttct gtagctttac
     3841 accagaagga aggaatgggc tacagcaggt agtggaggaa gaggggggtg agcaggtgta
     3901 ttaaaatagc ttacgggtaa ggcctaaaag gtcacccctc ggccccctct ccaaaagaag
     3961 ggcatgggca cccccaggag aggatggccc caaaaacctt atttttatac atgagagtaa
     4021 ataaacatat tttttttaca aaaataactt ctgaatttat cagtgttttg ccgttaaaaa
     4081 tattcctcta tagtaaatta tttattggaa gatgactttt ttaaagctgc cgtttgcctt
     4141 ggcttggttt catacactga tttatttttc tatgccaggc agtagagtct ctctgcctct
     4201 gaggagcagg ctacccgcat cccactcagc ccctccctac ccctcaagat ttgatgaaaa
     4261 ttccaaccat gaggatgggt gcatcgggga agggtgagaa ggagagcctg cctgctcagg
     4321 gatccaggct cgtagagtca ctccctgccc gtctcccaga gatgcttcac cagcacctgc
     4381 ctctgagacc tcgctctctg ttccagcaac cctggttggg gggtcagact tgatacactt
     4441 tcaggttggg agtggaccca ccccagggcc tgctgaggac agagcagcca ggccgtcctg
     4501 gctcactttg cagttggcac tgggttgggg aggaagagag ctgatgagtg tggcttccct
     4561 gagctggggt ttccctgctt gtccagttgt gagctgtcct cggtgttacc gaggctgtgc
     4621 ctagagagtg gagatttttg atgaaaggtg tgctcgctct ctgcgttcta tcttctctct
     4681 cctccttgtt cctgcaaacc acaagataaa ggtagtggtg tgtctcgacc ccatcagcct
     4741 ctcacccact cccagacaca cacaagtcct caaaagtttc agctccgtgt gtgagatgtg
     4801 caggtttttt ctagggggta gggggagact aaaatcgaat ataacttaaa atgaaagtat
     4861 actttttata atttttcttt ttaaaacttg gtgaaattat ttcagataca tattttagtg
     4921 tcaaggcaga ttagttattt agccaccaaa aaaaagtatt gtgtacaatt tggggcctca
     4981 aatttgactc tgcctcaaaa aaaagaaata tatcctatgc agagttacag tcacaaagtt
     5041 gtgtatttta tgttacaata aagccttcct ctgaaggga
//
