LOCUS       NM_003152               4301 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens signal transducer and activator of transcription 5A
            (STAT5A), transcript variant 2, mRNA.
ACCESSION   NM_003152 XM_005257621
VERSION     NM_003152.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4301)
  AUTHORS   Jing,N., Du,X., Liang,Y., Tao,Z., Bao,S., Xiao,H., Dong,B.,
            Gao,W.Q. and Fang,Y.X.
  TITLE     PAX6 promotes neuroendocrine phenotypes of prostate cancer via
            enhancing MET/STAT5A-mediated chromatin accessibility
  JOURNAL   J Exp Clin Cancer Res 43 (1), 144 (2024)
   PUBMED   38745318
  REMARK    GeneRIF: PAX6 promotes neuroendocrine phenotypes of prostate cancer
            via enhancing MET/STAT5A-mediated chromatin accessibility.
            Erratum:[J Exp Clin Cancer Res. 2024 Jun 15;43(1):167. doi:
            10.1186/s13046-024-03084-x.. PMID: 38877572]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4301)
  AUTHORS   Suske,T., Sorger,H., Manhart,G., Ruge,F., Prutsch,N.,
            Zimmerman,M.W., Eder,T., Abdallah,D.I., Maurer,B., Wagner,C.,
            Schonefeldt,S., Spirk,K., Pichler,A., Pemovska,T., Schweicker,C.,
            Poloske,D., Hubanic,E., Jungherz,D., Muller,T.A., Aung,M.M.K.,
            Orlova,A., Pham,H.T.T., Zimmel,K., Krausgruber,T., Bock,C.,
            Muller,M., Dahlhoff,M., Boersma,A., Rulicke,T., Fleck,R., de
            Araujo,E.D., Gunning,P.T., Aittokallio,T., Mustjoki,S., Sanda,T.,
            Hartmann,S., Grebien,F., Hoermann,G., Haferlach,T., Staber,P.B.,
            Neubauer,H.A., Look,A.T., Herling,M. and Moriggl,R.
  TITLE     Hyperactive STAT5 hijacks T cell receptor signaling and drives
            immature T cell acute lymphoblastic leukemia
  JOURNAL   J Clin Invest 134 (8), e168536 (2024)
   PUBMED   38618957
  REMARK    GeneRIF: Hyperactive STAT5 hijacks T cell receptor signaling and
            drives immature T cell acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4301)
  AUTHORS   Cheng,C., Liang,S., Yue,K., Wu,N., Li,Z., Dong,T., Dong,X.,
            Ling,M., Jiang,Q., Liu,J. and Huang,X.J.
  TITLE     STAT5 is essential for inducing the suppressive subset and
            attenuate cytotoxicity of Vdelta2+ T cells in acute myeloid
            leukemia
  JOURNAL   Cancer Lett 587, 216730 (2024)
   PUBMED   38360140
  REMARK    GeneRIF: STAT5 is essential for inducing the suppressive subset and
            attenuate cytotoxicity of Vdelta2[+] T cells in acute myeloid
            leukemia.
REFERENCE   4  (bases 1 to 4301)
  AUTHORS   Yang,J., Chen,J., Chang,J., Sun,X., Wei,Q., Cai,X. and Cao,P.
  TITLE     IDH2/R140Q mutation confers cytokine-independent proliferation of
            TF-1 cells by activating constitutive STAT3/5 phosphorylation
  JOURNAL   Cell Commun Signal 22 (1), 116 (2024)
   PUBMED   38347540
  REMARK    GeneRIF: IDH2/R140Q mutation confers cytokine-independent
            proliferation of TF-1 cells by activating constitutive STAT3/5
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4301)
  AUTHORS   Zhang,Y., Zhao,L., Wu,A., Lin,P., Fan,J., Chen,J., Wang,X. and
            Zeng,X.
  TITLE     Abnormal M1 polarization of placental macrophage induced by
            IL-15/STAT5 activation in VVC may lead to adverse pregnancy
            outcomes
  JOURNAL   Microbes Infect 26 (1-2), 105232 (2024)
   PUBMED   37802467
  REMARK    GeneRIF: Abnormal M1 polarization of placental macrophage induced
            by IL-15/STAT5 activation in VVC may lead to adverse pregnancy
            outcomes.
REFERENCE   6  (bases 1 to 4301)
  AUTHORS   Kirken,R.A., Rui,H., Malabarba,M.G., Howard,O.M., Kawamura,M.,
            O'Shea,J.J. and Farrar,W.L.
  TITLE     Activation of JAK3, but not JAK1, is critical for IL-2-induced
            proliferation and STAT5 recruitment by a COOH-terminal region of
            the IL-2 receptor beta-chain
  JOURNAL   Cytokine 7 (7), 689-700 (1995)
   PUBMED   8580378
REFERENCE   7  (bases 1 to 4301)
  AUTHORS   Johnston,J.A., Bacon,C.M., Finbloom,D.S., Rees,R.C., Kaplan,D.,
            Shibuya,K., Ortaldo,J.R., Gupta,S., Chen,Y.Q., Giri,J.D. et al.
  TITLE     Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus
            kinases by interleukins 2 and 15
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8705-8709 (1995)
   PUBMED   7568001
REFERENCE   8  (bases 1 to 4301)
  AUTHORS   Lin,J.X., Migone,T.S., Tsang,M., Friedmann,M., Weatherbee,J.A.,
            Zhou,L., Yamauchi,A., Bloom,E.T., Mietz,J., John,S. et al.
  TITLE     The role of shared receptor motifs and common Stat proteins in the
            generation of cytokine pleiotropy and redundancy by IL-2, IL-4,
            IL-7, IL-13, and IL-15
  JOURNAL   Immunity 2 (4), 331-339 (1995)
   PUBMED   7719938
REFERENCE   9  (bases 1 to 4301)
  AUTHORS   Hou,J., Schindler,U., Henzel,W.J., Wong,S.C. and McKnight,S.L.
  TITLE     Identification and purification of human Stat proteins activated in
            response to interleukin-2
  JOURNAL   Immunity 2 (4), 321-329 (1995)
   PUBMED   7719937
REFERENCE   10 (bases 1 to 4301)
  AUTHORS   Gouilleux,F., Wakao,H., Mundt,M. and Groner,B.
  TITLE     Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a
            prerequisite for DNA binding and induction of transcription
  JOURNAL   EMBO J 13 (18), 4361-4369 (1994)
   PUBMED   7925280
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U43185.1, AK291650.1, L41142.1,
            AB208972.1 and BC027036.1.
            
            On Aug 11, 2020 this sequence version replaced NM_003152.3.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. This protein is activated by, and
            mediates the responses of many cell ligands, such as IL2, IL3, IL7
            GM-CSF, erythropoietin, thrombopoietin, and different growth
            hormones. Activation of this protein in myeloma and lymphoma
            associated with a TEL/JAK2 gene fusion is independent of cell
            stimulus and has been shown to be essential for tumorigenesis. The
            mouse counterpart of this gene is found to induce the expression of
            BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this
            gene in cells. Alternatively spliced transcript variants have been
            found for this gene. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U43185.1, SRR14038194.3001216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               U43185.1           2-142
            142-585             AK291650.1         242-685
            586-3099            L41142.1           1-2514
            3100-4298           AB208972.1         2431-3629
            4299-4301           BC027036.1         3763-3765
FEATURES             Location/Qualifiers
     source          1..4301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..4301
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /note="signal transducer and activator of transcription
                     5A"
                     /db_xref="GeneID:6776"
                     /db_xref="HGNC:HGNC:11366"
                     /db_xref="MIM:601511"
     exon            1..89
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            90..632
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            633..770
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             643..3027
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /note="isoform 1 is encoded by transcript variant 2;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     5A isoform 1"
                     /protein_id="NP_003143.2"
                     /db_xref="CCDS:CCDS11424.1"
                     /db_xref="GeneID:6776"
                     /db_xref="HGNC:HGNC:11366"
                     /db_xref="MIM:601511"
                     /translation="MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWD
                     AIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCP
                     LELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTEN
                     ELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQRE
                     AQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQ
                     SWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFII
                     EKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNEC
                     SGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSV
                     GSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLC
                     EALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGW
                     NYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEI
                     GGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKY
                     YTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQ
                     NPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS"
     exon            771..927
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1017
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1192
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1323
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1475
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1631
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1811
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1899
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2022
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2115
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2322
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2417
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2548
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2704
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2756
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2864
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..4301
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4280..4285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /note="hexamer: AATAAA"
     polyA_site      4301
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /note="major polyA site"
ORIGIN      
        1 agacaggata ttcactgctg tggcaaggcc tgtagagagt ttcgaagtta ggaggactca
       61 agacggtccc tccctggact tttctgaagg ggctcaaaag atgacacgcg ccagagctgg
      121 aaggcgtcgc caattggtcc acttttccct cctccctttt tgcggatgag aaaactgagg
      181 cccaggtttg ggatttccag agcccgggat ttcccggcaa cgcccgacaa ccacattccc
      241 ccggctattc tgacccgccc cggttccggg acgctccctg ggagccgccg ccgagggcct
      301 gctgggactc ccgggggacc ccgccgtcgg ggcagccccc acgcccggcg ccgcccgccg
      361 ggaacggccg ccgctgttgc gcacttgcag gggagccggc gactgagggc gaggcaggga
      421 gggagcaagc ggggctggga gggctgctgg cgcgggctcg cgcgctgtgt atggtctatc
      481 gcaggcagct gacctttgag gaggaaatcg ctgctctccg ctccttcctg tagtaacagc
      541 cgccgctgcc gccgccgcca ggaaccccgg ccgggagcga gagccgcggg gcgcagagcc
      601 ggcccggctg ccggacggtg cggccccacc aggtgaacgg ccatggcggg ctggatccag
      661 gcccagcagc tgcagggaga cgcgctgcgc cagatgcagg tgctgtacgg ccagcacttc
      721 cccatcgagg tccggcacta cttggcccag tggattgaga gccagccatg ggatgccatt
      781 gacttggaca atccccagga cagagcccaa gccacccagc tcctggaggg cctggtgcag
      841 gagctgcaga agaaggcgga gcaccaggtg ggggaagatg ggtttttact gaagatcaag
      901 ctggggcact acgccacgca gctccagaaa acatatgacc gctgccccct ggagctggtc
      961 cgctgcatcc ggcacattct gtacaatgaa cagaggctgg tccgagaagc caacaattgc
     1021 agctctccgg ctgggatcct ggttgacgcc atgtcccaga agcaccttca gatcaaccag
     1081 acatttgagg agctgcgact ggtcacgcag gacacagaga atgagctgaa gaaactgcag
     1141 cagactcagg agtacttcat catccagtac caggagagcc tgaggatcca agctcagttt
     1201 gcccagctgg cccagctgag cccccaggag cgtctgagcc gggagacggc cctccagcag
     1261 aagcaggtgt ctctggaggc ctggttgcag cgtgaggcac agacactgca gcagtaccgc
     1321 gtggagctgg ccgagaagca ccagaagacc ctgcagctgc tgcggaagca gcagaccatc
     1381 atcctggatg acgagctgat ccagtggaag cggcggcagc agctggccgg gaacggcggg
     1441 ccccccgagg gcagcctgga cgtgctacag tcctggtgtg agaagttggc cgagatcatc
     1501 tggcagaacc ggcagcagat ccgcagggct gagcacctct gccagcagct gcccatcccc
     1561 ggcccagtgg aggagatgct ggccgaggtc aacgccacca tcacggacat tatctcagcc
     1621 ctggtgacca gcacattcat cattgagaag cagcctcctc aggtcctgaa gacccagacc
     1681 aagtttgcag ccaccgtacg cctgctggtg ggcgggaagc tgaacgtgca catgaatccc
     1741 ccccaggtga aggccaccat catcagtgag cagcaggcca agtctctgct taaaaatgag
     1801 aacacccgca acgagtgcag tggtgagatc ctgaacaact gctgcgtgat ggagtaccac
     1861 caagccacgg gcaccctcag tgcccacttc aggaacatgt cactgaagag gatcaagcgt
     1921 gctgaccggc ggggtgcaga gtccgtgaca gaggagaagt tcacagtcct gtttgagtct
     1981 cagttcagtg ttggcagcaa tgagcttgtg ttccaggtga agactctgtc cctacctgtg
     2041 gttgtcatcg tccacggcag ccaggaccac aatgccacgg ctactgtgct gtgggacaat
     2101 gcctttgctg agccgggcag ggtgccattt gccgtgcctg acaaagtgct gtggccgcag
     2161 ctgtgtgagg cgctcaacat gaaattcaag gccgaagtgc agagcaaccg gggcctgacc
     2221 aaggagaacc tcgtgttcct ggcgcagaaa ctgttcaaca acagcagcag ccacctggag
     2281 gactacagtg gcctgtccgt gtcctggtcc cagttcaaca gggagaactt gccgggctgg
     2341 aactacacct tctggcagtg gtttgacggg gtgatggagg tgttgaagaa gcaccacaag
     2401 ccccactgga atgatggggc catcctaggt tttgtgaata agcaacaggc ccacgacctg
     2461 ctcatcaaca agcccgacgg gaccttcttg ttgcgcttta gtgactcaga aatcgggggc
     2521 atcaccatcg cctggaagtt tgactccccg gaacgcaacc tgtggaacct gaaaccattc
     2581 accacgcggg atttctccat caggtccctg gctgaccggc tgggggacct gagctatctc
     2641 atctatgtgt ttcctgaccg ccccaaggat gaggtcttct ccaagtacta cactcctgtg
     2701 ctggctaaag ctgttgatgg atatgtgaaa ccacagatca agcaagtggt ccctgagttt
     2761 gtgaatgcat ctgcagatgc tgggggcagc agcgccacgt acatggacca ggccccctcc
     2821 ccagctgtgt gcccccaggc tccctataac atgtacccac agaaccctga ccatgtactc
     2881 gatcaggatg gagaattcga cctggatgag accatggatg tggccaggca cgtggaggaa
     2941 ctcttacgcc gaccaatgga cagtcttgac tcccgcctct cgccccctgc cggtcttttc
     3001 acctctgcca gaggctccct ctcatgaatg tttgaatccc acgcttctct ttggaaacaa
     3061 tatgcaatgt gaagcggtcg tgttgtgagt ttagtaaggc tgtgtacact gacacctttg
     3121 caggcatgca tgtgcttgtg tgtgtgtgtg tgtgtgtgtc cttgtgcatg agctacgcct
     3181 gcctcccctg tgcagtcctg ggatgtggct gcagcagcgg tggcctcttt tcagatcatg
     3241 gcatccaaga gtgcgccgag tctgtctctg tcatggtaga gaccgagcct ctgtcactgc
     3301 aggcactcaa tgcagccaga cctattcctc ctgggcccct catctgctca gcagctattt
     3361 gaatgagatg attcagaagg ggaggggaga caggtaacgt ctgtaagctg aagtttcact
     3421 ccggagtgag aagctttgcc ctcctaagag agagagacag agagacagag agagagaaag
     3481 agagagtgtg tgggtctatg taaatgcatc tgtcctcatg tgttgatgta accgattcat
     3541 ctctcagaag ggaggctggg gttcattttc gagtagtatt ttatacttta gtgaacgtgg
     3601 actccagact ctctgtgaac cctatgagag cgcgtctggg cccggccatg tccttagcac
     3661 aggggggccg ccggtttgag tgagggtttc tgagctgctc tgaattagtc cttgcttggc
     3721 tgcttggcct tgggcttcat tcaagtctat gatgctgttg cccacgtttc ccgggatata
     3781 tattctctcc cctccgttgg gccccagcct tctttgcttg cctctctgtt tgtaaccttg
     3841 tcgacaaaga ggtagaaaag attgggtcta ggatatggtg ggtggacagg ggccccggga
     3901 cttggagggt tggtcctctt gcctcctgga aaaaacaaaa acaaaaaact gcagtgaaag
     3961 acaagctgca aatcagccat gtgctgcgtg cctgtggaat ctggagtgag gggtaaaagc
     4021 tgatctggtt tgactccgct ggaggtgggg cctggagcag gccttgcgct gttgcgtaac
     4081 tggctgtgtt ctggtgaggc cttgctccca accccacacg ctcctccctc tgaggctgta
     4141 ggactcgcag tcaggggcag ctgaccatgg aagattgaga gcccaaggtt taaacttctc
     4201 tgaagggagg tggggatgag aagaggggtt tttttgtact ttgtacaaag accacacatt
     4261 tgtgtaaaca gtgttttgga ataaaatatt tttttcataa a
//
