LOCUS       NM_001288718            3770 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens signal transducer and activator of transcription 5A
            (STAT5A), transcript variant 1, mRNA.
ACCESSION   NM_001288718
VERSION     NM_001288718.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Jing,N., Du,X., Liang,Y., Tao,Z., Bao,S., Xiao,H., Dong,B.,
            Gao,W.Q. and Fang,Y.X.
  TITLE     PAX6 promotes neuroendocrine phenotypes of prostate cancer via
            enhancing MET/STAT5A-mediated chromatin accessibility
  JOURNAL   J Exp Clin Cancer Res 43 (1), 144 (2024)
   PUBMED   38745318
  REMARK    GeneRIF: PAX6 promotes neuroendocrine phenotypes of prostate cancer
            via enhancing MET/STAT5A-mediated chromatin accessibility.
            Erratum:[J Exp Clin Cancer Res. 2024 Jun 15;43(1):167. doi:
            10.1186/s13046-024-03084-x.. PMID: 38877572]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3770)
  AUTHORS   Suske,T., Sorger,H., Manhart,G., Ruge,F., Prutsch,N.,
            Zimmerman,M.W., Eder,T., Abdallah,D.I., Maurer,B., Wagner,C.,
            Schonefeldt,S., Spirk,K., Pichler,A., Pemovska,T., Schweicker,C.,
            Poloske,D., Hubanic,E., Jungherz,D., Muller,T.A., Aung,M.M.K.,
            Orlova,A., Pham,H.T.T., Zimmel,K., Krausgruber,T., Bock,C.,
            Muller,M., Dahlhoff,M., Boersma,A., Rulicke,T., Fleck,R., de
            Araujo,E.D., Gunning,P.T., Aittokallio,T., Mustjoki,S., Sanda,T.,
            Hartmann,S., Grebien,F., Hoermann,G., Haferlach,T., Staber,P.B.,
            Neubauer,H.A., Look,A.T., Herling,M. and Moriggl,R.
  TITLE     Hyperactive STAT5 hijacks T cell receptor signaling and drives
            immature T cell acute lymphoblastic leukemia
  JOURNAL   J Clin Invest 134 (8), e168536 (2024)
   PUBMED   38618957
  REMARK    GeneRIF: Hyperactive STAT5 hijacks T cell receptor signaling and
            drives immature T cell acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3770)
  AUTHORS   Cheng,C., Liang,S., Yue,K., Wu,N., Li,Z., Dong,T., Dong,X.,
            Ling,M., Jiang,Q., Liu,J. and Huang,X.J.
  TITLE     STAT5 is essential for inducing the suppressive subset and
            attenuate cytotoxicity of Vdelta2+ T cells in acute myeloid
            leukemia
  JOURNAL   Cancer Lett 587, 216730 (2024)
   PUBMED   38360140
  REMARK    GeneRIF: STAT5 is essential for inducing the suppressive subset and
            attenuate cytotoxicity of Vdelta2[+] T cells in acute myeloid
            leukemia.
REFERENCE   4  (bases 1 to 3770)
  AUTHORS   Yang,J., Chen,J., Chang,J., Sun,X., Wei,Q., Cai,X. and Cao,P.
  TITLE     IDH2/R140Q mutation confers cytokine-independent proliferation of
            TF-1 cells by activating constitutive STAT3/5 phosphorylation
  JOURNAL   Cell Commun Signal 22 (1), 116 (2024)
   PUBMED   38347540
  REMARK    GeneRIF: IDH2/R140Q mutation confers cytokine-independent
            proliferation of TF-1 cells by activating constitutive STAT3/5
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3770)
  AUTHORS   Zhang,Y., Zhao,L., Wu,A., Lin,P., Fan,J., Chen,J., Wang,X. and
            Zeng,X.
  TITLE     Abnormal M1 polarization of placental macrophage induced by
            IL-15/STAT5 activation in VVC may lead to adverse pregnancy
            outcomes
  JOURNAL   Microbes Infect 26 (1-2), 105232 (2024)
   PUBMED   37802467
  REMARK    GeneRIF: Abnormal M1 polarization of placental macrophage induced
            by IL-15/STAT5 activation in VVC may lead to adverse pregnancy
            outcomes.
REFERENCE   6  (bases 1 to 3770)
  AUTHORS   Kirken,R.A., Rui,H., Malabarba,M.G., Howard,O.M., Kawamura,M.,
            O'Shea,J.J. and Farrar,W.L.
  TITLE     Activation of JAK3, but not JAK1, is critical for IL-2-induced
            proliferation and STAT5 recruitment by a COOH-terminal region of
            the IL-2 receptor beta-chain
  JOURNAL   Cytokine 7 (7), 689-700 (1995)
   PUBMED   8580378
REFERENCE   7  (bases 1 to 3770)
  AUTHORS   Johnston,J.A., Bacon,C.M., Finbloom,D.S., Rees,R.C., Kaplan,D.,
            Shibuya,K., Ortaldo,J.R., Gupta,S., Chen,Y.Q., Giri,J.D. et al.
  TITLE     Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus
            kinases by interleukins 2 and 15
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8705-8709 (1995)
   PUBMED   7568001
REFERENCE   8  (bases 1 to 3770)
  AUTHORS   Lin,J.X., Migone,T.S., Tsang,M., Friedmann,M., Weatherbee,J.A.,
            Zhou,L., Yamauchi,A., Bloom,E.T., Mietz,J., John,S. et al.
  TITLE     The role of shared receptor motifs and common Stat proteins in the
            generation of cytokine pleiotropy and redundancy by IL-2, IL-4,
            IL-7, IL-13, and IL-15
  JOURNAL   Immunity 2 (4), 331-339 (1995)
   PUBMED   7719938
REFERENCE   9  (bases 1 to 3770)
  AUTHORS   Hou,J., Schindler,U., Henzel,W.J., Wong,S.C. and McKnight,S.L.
  TITLE     Identification and purification of human Stat proteins activated in
            response to interleukin-2
  JOURNAL   Immunity 2 (4), 321-329 (1995)
   PUBMED   7719937
REFERENCE   10 (bases 1 to 3770)
  AUTHORS   Gouilleux,F., Wakao,H., Mundt,M. and Groner,B.
  TITLE     Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a
            prerequisite for DNA binding and induction of transcription
  JOURNAL   EMBO J 13 (18), 4361-4369 (1994)
   PUBMED   7925280
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291650.1, L41142.1,
            AB208972.1 and BC027036.1.
            
            On Aug 11, 2020 this sequence version replaced NM_001288718.1.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. This protein is activated by, and
            mediates the responses of many cell ligands, such as IL2, IL3, IL7
            GM-CSF, erythropoietin, thrombopoietin, and different growth
            hormones. Activation of this protein in myeloma and lymphoma
            associated with a TEL/JAK2 gene fusion is independent of cell
            stimulus and has been shown to be essential for tumorigenesis. The
            mouse counterpart of this gene is found to induce the expression of
            BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this
            gene in cells. Alternatively spliced transcript variants have been
            found for this gene. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 2
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027036.1, L41142.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590949.6/ ENSP00000468749.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               AK291650.1         632-1231
            601-2568            L41142.1           547-2514
            2569-3767           AB208972.1         2431-3629
            3768-3770           BC027036.1         3763-3765
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..3770
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /note="signal transducer and activator of transcription
                     5A"
                     /db_xref="GeneID:6776"
                     /db_xref="HGNC:HGNC:11366"
                     /db_xref="MIM:601511"
     exon            1..101
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            102..239
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2496
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     5A isoform 1"
                     /protein_id="NP_001275647.1"
                     /db_xref="CCDS:CCDS11424.1"
                     /db_xref="GeneID:6776"
                     /db_xref="HGNC:HGNC:11366"
                     /db_xref="MIM:601511"
                     /translation="MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWD
                     AIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCP
                     LELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTEN
                     ELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQRE
                     AQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQ
                     SWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFII
                     EKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNEC
                     SGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSV
                     GSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLC
                     EALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGW
                     NYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEI
                     GGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKY
                     YTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQ
                     NPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS"
     exon            240..396
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            397..486
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            487..661
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            662..792
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            793..944
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1100
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1280
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1368
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1491
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1584
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1791
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1886
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2017
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2173
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2225
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2333
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..3770
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3749..3754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /note="hexamer: AATAAA"
     polyA_site      3770
                     /gene="STAT5A"
                     /gene_synonym="MGF; STAT5"
                     /note="major polyA site"
ORIGIN      
        1 agtaacagcc gccgctgccg ccgccgccag gaaccccggc cgggagcgag agccgcgggg
       61 cgcagagccg gcccggctgc cggacggtgc ggccccacca ggtgaacggc catggcgggc
      121 tggatccagg cccagcagct gcagggagac gcgctgcgcc agatgcaggt gctgtacggc
      181 cagcacttcc ccatcgaggt ccggcactac ttggcccagt ggattgagag ccagccatgg
      241 gatgccattg acttggacaa tccccaggac agagcccaag ccacccagct cctggagggc
      301 ctggtgcagg agctgcagaa gaaggcggag caccaggtgg gggaagatgg gtttttactg
      361 aagatcaagc tggggcacta cgccacgcag ctccagaaaa catatgaccg ctgccccctg
      421 gagctggtcc gctgcatccg gcacattctg tacaatgaac agaggctggt ccgagaagcc
      481 aacaattgca gctctccggc tgggatcctg gttgacgcca tgtcccagaa gcaccttcag
      541 atcaaccaga catttgagga gctgcgactg gtcacgcagg acacagagaa tgagctgaag
      601 aaactgcagc agactcagga gtacttcatc atccagtacc aggagagcct gaggatccaa
      661 gctcagtttg cccagctggc ccagctgagc ccccaggagc gtctgagccg ggagacggcc
      721 ctccagcaga agcaggtgtc tctggaggcc tggttgcagc gtgaggcaca gacactgcag
      781 cagtaccgcg tggagctggc cgagaagcac cagaagaccc tgcagctgct gcggaagcag
      841 cagaccatca tcctggatga cgagctgatc cagtggaagc ggcggcagca gctggccggg
      901 aacggcgggc cccccgaggg cagcctggac gtgctacagt cctggtgtga gaagttggcc
      961 gagatcatct ggcagaaccg gcagcagatc cgcagggctg agcacctctg ccagcagctg
     1021 cccatccccg gcccagtgga ggagatgctg gccgaggtca acgccaccat cacggacatt
     1081 atctcagccc tggtgaccag cacattcatc attgagaagc agcctcctca ggtcctgaag
     1141 acccagacca agtttgcagc caccgtacgc ctgctggtgg gcgggaagct gaacgtgcac
     1201 atgaatcccc cccaggtgaa ggccaccatc atcagtgagc agcaggccaa gtctctgctt
     1261 aaaaatgaga acacccgcaa cgagtgcagt ggtgagatcc tgaacaactg ctgcgtgatg
     1321 gagtaccacc aagccacggg caccctcagt gcccacttca ggaacatgtc actgaagagg
     1381 atcaagcgtg ctgaccggcg gggtgcagag tccgtgacag aggagaagtt cacagtcctg
     1441 tttgagtctc agttcagtgt tggcagcaat gagcttgtgt tccaggtgaa gactctgtcc
     1501 ctacctgtgg ttgtcatcgt ccacggcagc caggaccaca atgccacggc tactgtgctg
     1561 tgggacaatg cctttgctga gccgggcagg gtgccatttg ccgtgcctga caaagtgctg
     1621 tggccgcagc tgtgtgaggc gctcaacatg aaattcaagg ccgaagtgca gagcaaccgg
     1681 ggcctgacca aggagaacct cgtgttcctg gcgcagaaac tgttcaacaa cagcagcagc
     1741 cacctggagg actacagtgg cctgtccgtg tcctggtccc agttcaacag ggagaacttg
     1801 ccgggctgga actacacctt ctggcagtgg tttgacgggg tgatggaggt gttgaagaag
     1861 caccacaagc cccactggaa tgatggggcc atcctaggtt ttgtgaataa gcaacaggcc
     1921 cacgacctgc tcatcaacaa gcccgacggg accttcttgt tgcgctttag tgactcagaa
     1981 atcgggggca tcaccatcgc ctggaagttt gactccccgg aacgcaacct gtggaacctg
     2041 aaaccattca ccacgcggga tttctccatc aggtccctgg ctgaccggct gggggacctg
     2101 agctatctca tctatgtgtt tcctgaccgc cccaaggatg aggtcttctc caagtactac
     2161 actcctgtgc tggctaaagc tgttgatgga tatgtgaaac cacagatcaa gcaagtggtc
     2221 cctgagtttg tgaatgcatc tgcagatgct gggggcagca gcgccacgta catggaccag
     2281 gccccctccc cagctgtgtg cccccaggct ccctataaca tgtacccaca gaaccctgac
     2341 catgtactcg atcaggatgg agaattcgac ctggatgaga ccatggatgt ggccaggcac
     2401 gtggaggaac tcttacgccg accaatggac agtcttgact cccgcctctc gccccctgcc
     2461 ggtcttttca cctctgccag aggctccctc tcatgaatgt ttgaatccca cgcttctctt
     2521 tggaaacaat atgcaatgtg aagcggtcgt gttgtgagtt tagtaaggct gtgtacactg
     2581 acacctttgc aggcatgcat gtgcttgtgt gtgtgtgtgt gtgtgtgtcc ttgtgcatga
     2641 gctacgcctg cctcccctgt gcagtcctgg gatgtggctg cagcagcggt ggcctctttt
     2701 cagatcatgg catccaagag tgcgccgagt ctgtctctgt catggtagag accgagcctc
     2761 tgtcactgca ggcactcaat gcagccagac ctattcctcc tgggcccctc atctgctcag
     2821 cagctatttg aatgagatga ttcagaaggg gaggggagac aggtaacgtc tgtaagctga
     2881 agtttcactc cggagtgaga agctttgccc tcctaagaga gagagacaga gagacagaga
     2941 gagagaaaga gagagtgtgt gggtctatgt aaatgcatct gtcctcatgt gttgatgtaa
     3001 ccgattcatc tctcagaagg gaggctgggg ttcattttcg agtagtattt tatactttag
     3061 tgaacgtgga ctccagactc tctgtgaacc ctatgagagc gcgtctgggc ccggccatgt
     3121 ccttagcaca ggggggccgc cggtttgagt gagggtttct gagctgctct gaattagtcc
     3181 ttgcttggct gcttggcctt gggcttcatt caagtctatg atgctgttgc ccacgtttcc
     3241 cgggatatat attctctccc ctccgttggg ccccagcctt ctttgcttgc ctctctgttt
     3301 gtaaccttgt cgacaaagag gtagaaaaga ttgggtctag gatatggtgg gtggacaggg
     3361 gccccgggac ttggagggtt ggtcctcttg cctcctggaa aaaacaaaaa caaaaaactg
     3421 cagtgaaaga caagctgcaa atcagccatg tgctgcgtgc ctgtggaatc tggagtgagg
     3481 ggtaaaagct gatctggttt gactccgctg gaggtggggc ctggagcagg ccttgcgctg
     3541 ttgcgtaact ggctgtgttc tggtgaggcc ttgctcccaa ccccacacgc tcctccctct
     3601 gaggctgtag gactcgcagt caggggcagc tgaccatgga agattgagag cccaaggttt
     3661 aaacttctct gaagggaggt ggggatgaga agaggggttt ttttgtactt tgtacaaaga
     3721 ccacacattt gtgtaaacag tgttttggaa taaaatattt ttttcataaa
//
