LOCUS       NM_003151               2560 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens signal transducer and activator of transcription 4
            (STAT4), transcript variant 1, mRNA.
ACCESSION   NM_003151
VERSION     NM_003151.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Pileckaite,E., Vilkeviciute,A., Kriauciuniene,L., Liutkevicius,V.
            and Liutkeviciene,R.
  TITLE     Investigating the Link between STAT4 Genetic Variants, STAT4
            Protein Concentrations, and Laryngeal Squamous Cell Carcinoma: A
            Comprehensive Analysis of Clinical Manifestations
  JOURNAL   Int J Mol Sci 25 (18), 10180 (2024)
   PUBMED   39337665
  REMARK    GeneRIF: Investigating the Link between STAT4 Genetic Variants,
            STAT4 Protein Concentrations, and Laryngeal Squamous Cell
            Carcinoma: A Comprehensive Analysis of Clinical Manifestations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Varzari,A., Tudor,E., Corloteanu,A., Axentii,E., Vladei,I. and
            Deyneko,I.V.
  TITLE     Association between STAT4 gene polymorphism and susceptibility to
            pulmonary tuberculosis in the Moldavian population
  JOURNAL   Int J Immunogenet 51 (4), 228-234 (2024)
   PUBMED   38654468
  REMARK    GeneRIF: Association between STAT4 gene polymorphism and
            susceptibility to pulmonary tuberculosis in the Moldavian
            population.
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Xu,D.M., Chen,L.X., Zhuang,X.Y., Han,H. and Mo,M.
  TITLE     The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant
            Progression and Lymphatic Metastasis of Penile Cancer
  JOURNAL   Int J Med Sci 21 (6), 1176-1186 (2024)
   PUBMED   38774752
  REMARK    GeneRIF: The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis,
            Malignant Progression and Lymphatic Metastasis of Penile Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Tolomeo,M. and Cascio,A.
  TITLE     STAT4 and STAT6, their role in cellular and humoral immunity and in
            diverse human diseases
  JOURNAL   Int Rev Immunol 43 (6), 394-418 (2024)
   PUBMED   39188021
  REMARK    GeneRIF: STAT4 and STAT6, their role in cellular and humoral
            immunity and in diverse human diseases.
            Review article
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Yao,B.B., Niu,P., Surowy,C.S. and Faltynek,C.R.
  TITLE     Direct interaction of STAT4 with the IL-12 receptor
  JOURNAL   Arch Biochem Biophys 368 (1), 147-155 (1999)
   PUBMED   10415122
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Naeger,L.K., McKinney,J., Salvekar,A. and Hoey,T.
  TITLE     Identification of a STAT4 binding site in the interleukin-12
            receptor required for signaling
  JOURNAL   J Biol Chem 274 (4), 1875-1878 (1999)
   PUBMED   9890938
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Yamamoto,K., Kobayashi,H., Arai,A., Miura,O., Hirosawa,S. and
            Miyasaka,N.
  TITLE     cDNA cloning, expression and chromosome mapping of the human STAT4
            gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 207-210 (1997)
   PUBMED   9284918
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Thierfelder,W.E., van Deursen,J.M., Yamamoto,K., Tripp,R.A.,
            Sarawar,S.R., Carson,R.T., Sangster,M.Y., Vignali,D.A.,
            Doherty,P.C., Grosveld,G.C. and Ihle,J.N.
  TITLE     Requirement for Stat4 in interleukin-12-mediated responses of
            natural killer and T cells
  JOURNAL   Nature 382 (6587), 171-174 (1996)
   PUBMED   8700208
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Bacon,C.M., Petricoin,E.F. 3rd, Ortaldo,J.R., Rees,R.C.,
            Larner,A.C., Johnston,J.A. and O'Shea,J.J.
  TITLE     Interleukin 12 induces tyrosine phosphorylation and activation of
            STAT4 in human lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7307-7311 (1995)
   PUBMED   7638186
REFERENCE   10 (bases 1 to 2560)
  AUTHORS   Yamamoto,K., Quelle,F.W., Thierfelder,W.E., Kreider,B.L.,
            Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Silvennoinen,O. and
            Ihle,J.N.
  TITLE     Stat4, a novel gamma interferon activation site-binding protein
            expressed in early myeloid differentiation
  JOURNAL   Mol Cell Biol 14 (7), 4342-4349 (1994)
   PUBMED   8007943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L78440.1 and BC031212.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003151.3.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. This protein is essential for mediating
            responses to IL12 in lymphocytes, and regulating the
            differentiation of T helper cells. Mutations in this gene may be
            associated with systemic lupus erythematosus and rheumatoid
            arthritis. Alternate splicing results in multiple transcript
            variants that encode the same protein. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L78440.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392320.7/ ENSP00000376134.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2556              L78440.1           33-2588
            2557-2560           BC031212.1         2744-2747
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2-q32.3"
     gene            1..2560
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /note="signal transducer and activator of transcription 4"
                     /db_xref="GeneID:6775"
                     /db_xref="HGNC:HGNC:11365"
                     /db_xref="MIM:600558"
     exon            1..48
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            49..177
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2296
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     4"
                     /protein_id="NP_003142.1"
                     /db_xref="CCDS:CCDS2310.1"
                     /db_xref="GeneID:6775"
                     /db_xref="HGNC:HGNC:11365"
                     /db_xref="MIM:600558"
                     /translation="MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWE
                     AASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVA
                     VVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQD
                     TKYLEDLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQ
                     IIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQL
                     EKLEEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVL
                     KTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSN
                     GSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYGLTIDLETSSLP
                     VVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGR
                     GLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHIL
                     PLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHS
                     VEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEV
                     SRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPMSPSVYAVLRENLSPTTIETA
                     MKSPYSAE"
     exon            178..322
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            323..421
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            422..514
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            515..593
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            594..679
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            680..831
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            832..990
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1083
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1143
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1161
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1255
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1300
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1384
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1483
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1619
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1669
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1764
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1901
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2093
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2160
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2269
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2560
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2526..2531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /note="hexamer: AAGAAA"
     polyA_site      2560
                     /gene="STAT4"
                     /gene_synonym="DPMC; SLEB11"
                     /note="major polyA site"
ORIGIN      
        1 gactttggac ttgagcactg cctgggacct gtgctgagag agcgctagca tgtctcagtg
       61 gaatcaagtc caacagttag aaatcaagtt tttggagcag gtggatcaat tctatgatga
      121 caactttccc atggaaattc ggcatctgtt ggcccaatgg attgaaaatc aagactggga
      181 ggcagcttct aacaatgaaa ccatggcaac gattcttctt caaaacttgt taatacaact
      241 ggatgaacag ttaggtcgtg tttccaaaga gaaaaaccta ctcttgatac acaatctaaa
      301 aagaattagg aaggtccttc agggaaaatt tcatggaaat ccaatgcatg tagctgtggt
      361 tatttcaaac tgtttaaggg aagagaggag aatattggct gcagccaaca tgcctgtcca
      421 ggggcctcta gagaaatcct tacaaagttc ttcagtttca gaaagacaga ggaatgtgga
      481 gcacaaagtg gctgccatta aaaacagtgt gcagatgaca gaacaagata ccaaatactt
      541 agaagatctg caagacgaat ttgactacag gtataaaaca attcagacaa tggatcagag
      601 tgacaagaat agtgccatgg tgaatcagga agttttgaca ctgcaggaaa tgcttaacag
      661 cctcgatttc aagagaaagg aggctctcag taaaatgacc caaatcatcc atgagacaga
      721 cctgttaatg aacaccatgc tcatagaaga gctgcaagac tggaagcggc ggcagcaaat
      781 cgcctgcatc gggggtccac tccacaatgg gctcgaccag cttcagaact gctttacact
      841 attggcagaa agtcttttcc aactgagaag gcaattggag aaactagagg agcaatctac
      901 caaaatgaca tatgaaggtg atcccattcc aatgcaaaga actcacatgc tagaaagagt
      961 caccttcttg atctacaacc ttttcaagaa ctcatttgtg gttgagcgac agccatgtat
     1021 gccaacccac cctcagaggc cgttggtact taaaacccta attcagttca ctgtaaaact
     1081 aaggctacta ataaaattgc cagaactaaa ctatcaggta aaggttaagg catcaattga
     1141 caagaatgtt tcaactctaa gcaaccgaag atttgtactt tgtggaacta atgtcaaagc
     1201 catgtctatt gaagaatctt ccaatgggag tctctcagta gaatttcgac atttgcaacc
     1261 aaaggaaatg aagtccagtg ctggaggtaa aggaaatgag ggctgtcaca tggtgactga
     1321 agaacttcat tccataacgt ttgaaacaca gatctgcctc tatggcctga ccatagattt
     1381 ggagaccagc tcattgcctg tggtgatgat ttccaatgtc agtcagttac ctaatgcttg
     1441 ggcatccatc atttggtaca acgtgtcaac caacgattcc cagaacttgg ttttctttaa
     1501 taatcctcca cctgccacat tgagtcaact actggaggtg atgagctggc agttttcatc
     1561 gtacgttggt cgtggtctta actcagatca actccatatg ctggcagaga agcttacagt
     1621 ccaatctagc tacagtgatg gtcacctcac ctgggccaag ttctgcaagg aacatttacc
     1681 tggtaaatca tttacctttt ggacatggct tgaagcaata ttggatctaa ttaagaaaca
     1741 cattcttccc ctttggattg atgggtatgt catgggcttt gttagcaaag agaaggaacg
     1801 gctgttgcta aaggataaaa tgcctggcac ctttttatta agattcagtg aaagccatct
     1861 cggaggaata actttcacct gggtggacca ttctgaaagt ggggaagtga gattccactc
     1921 tgtagaaccc tacaataaag gccggttgtc tgctctgcca ttcgctgaca tcctgcgaga
     1981 ctacaaagtt attatggctg aaaacattcc tgaaaaccct ctgaagtacc tatatcctga
     2041 cattcccaaa gacaaagcct tcggtaaaca ctacagctct cagccttgcg aagtttcaag
     2101 accaacagaa aggggtgaca aaggttatgt tccttctgtt tttatcccca tctcaacaat
     2161 ccgaagtgat tcaacagagc cacattctcc atcagacctt cttcccatgt ctccaagtgt
     2221 gtatgcggtg ttgagagaaa acctgagtcc cacaacaatt gaaactgcaa tgaagtctcc
     2281 ttattctgct gaatgacagg ataaactctg acgcaccaag aaaggaagca aatgaaaaag
     2341 tttaaagact gttctttgcc caataaccac attttatttc ttcagctttg taaataccag
     2401 gttctaggaa atgtttgaca tctgaagctc tcttcacact cccgtggcac tcctcaattg
     2461 ggagtgttgt gactgaaatg cttgaaacca aagcttcaga taaacttgca agataagaca
     2521 actttaagaa accagtgtta ataacaatat taacagaaga
//
