LOCUS       NM_139276               4921 bp    mRNA    linear   PRI 22-MAR-2025
DEFINITION  Homo sapiens signal transducer and activator of transcription 3
            (STAT3), transcript variant 1, mRNA.
ACCESSION   NM_139276
VERSION     NM_139276.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4921)
  AUTHORS   Chen,Z., Xu,L., Lin,S., Huang,H., Long,Q. and Liu,J.
  TITLE     GdX inhibits the occurrence and progression of breast cancer by
            negatively modulating the activity of STAT3
  JOURNAL   Cancer Biol Ther 25 (1), 2420383 (2024)
   PUBMED   39487760
  REMARK    GeneRIF: GdX inhibits the occurrence and progression of breast
            cancer by negatively modulating the activity of STAT3.
REFERENCE   2  (bases 1 to 4921)
  AUTHORS   Olbrich,P. and Freeman,A.F.
  TITLE     STAT1 and STAT3 gain of function: clinically heterogenous immune
            regulatory disorders
  JOURNAL   Curr Opin Allergy Clin Immunol 24 (6), 440-447 (2024)
   PUBMED   39475850
  REMARK    GeneRIF: STAT1 and STAT3 gain of function: clinically heterogenous
            immune regulatory disorders.
            Review article
REFERENCE   3  (bases 1 to 4921)
  AUTHORS   Shin,J.J., Suk,K. and Lee,W.H.
  TITLE     LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory
            activation via the miR-30b-5p/SOC3 axis in THP-1 cells
  JOURNAL   Sci Rep 14 (1), 25726 (2024)
   PUBMED   39468152
  REMARK    GeneRIF: LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated
            inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4921)
  AUTHORS   Mangum,K.D., denDekker,A., Li,Q., Tsoi,L.C., Joshi,A.D.,
            Melvin,W.J., Wolf,S.J., Moon,J.Y., Audu,C.O., Shadiow,J., Obi,A.T.,
            Wasikowski,R., Barrett,E.C., Bauer,T.M., Boyer,K., Ahmed,Z.,
            Davis,F.M., Gudjonsson,J. and Gallagher,K.A.
  TITLE     The STAT3/SETDB2 axis dictates NF-kappaB-mediated inflammation in
            macrophages during wound repair
  JOURNAL   JCI Insight 9 (20), e179017 (2024)
   PUBMED   39435663
  REMARK    GeneRIF: The STAT3/SETDB2 axis dictates NF-kappaB-mediated
            inflammation in macrophages during wound repair.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4921)
  AUTHORS   Caldenhoven,E., van Dijk,T.B., Solari,R., Armstrong,J.,
            Raaijmakers,J.A., Lammers,J.W., Koenderman,L. and de Groot,R.P.
  TITLE     STAT3beta, a splice variant of transcription factor STAT3, is a
            dominant negative regulator of transcription
  JOURNAL   J Biol Chem 271 (22), 13221-13227 (1996)
   PUBMED   8675499
REFERENCE   6  (bases 1 to 4921)
  AUTHORS   Nielsen,M., Svejgaard,A., Skov,S. and Odum,N.
  TITLE     Interleukin-2 induces tyrosine phosphorylation and nuclear
            translocation of stat3 in human T lymphocytes
  JOURNAL   Eur J Immunol 24 (12), 3082-3086 (1994)
   PUBMED   7528668
REFERENCE   7  (bases 1 to 4921)
  AUTHORS   Akira,S., Nishio,Y., Inoue,M., Wang,X.J., Wei,S., Matsusaka,T.,
            Yoshida,K., Sudo,T., Naruto,M. and Kishimoto,T.
  TITLE     Molecular cloning of APRF, a novel IFN-stimulated gene factor 3
            p91-related transcription factor involved in the gp130-mediated
            signaling pathway
  JOURNAL   Cell 77 (1), 63-71 (1994)
   PUBMED   7512451
REFERENCE   8  (bases 1 to 4921)
  AUTHORS   Shuai,K., Horvath,C.M., Huang,L.H., Qureshi,S.A., Cowburn,D. and
            Darnell,J.E. Jr.
  TITLE     Interferon activation of the transcription factor Stat91 involves
            dimerization through SH2-phosphotyrosyl peptide interactions
  JOURNAL   Cell 76 (5), 821-828 (1994)
   PUBMED   7510216
REFERENCE   9  (bases 1 to 4921)
  AUTHORS   Hsu,A.P., Davis,J., Puck,J.M., Holland,S.M. and Freeman,A.F.
  TITLE     STAT3 Hyper IgE Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301786
REFERENCE   10 (bases 1 to 4921)
  AUTHORS   DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and
            Calos,M.P.
  TITLE     Analysis of mutation in human cells by using an Epstein-Barr virus
            shuttle system
  JOURNAL   Mol Cell Biol 7 (1), 379-387 (1987)
   PUBMED   3031469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI461226.1, BC014482.1,
            AK092965.1, CB216860.1, BC008044.2, CF454565.1, AI631896.1 and
            AC087691.9.
            
            On Feb 27, 2020 this sequence version replaced NM_139276.2.
            
            Summary: The protein encoded by this gene is a member of the STAT
            protein family. In response to cytokines and growth factors, STAT
            family members are phosphorylated by the receptor associated
            kinases, and then form homo- or heterodimers that translocate to
            the cell nucleus where they act as transcription activators. This
            protein is activated through phosphorylation in response to various
            cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF,
            LIF and BMP2. This protein mediates the expression of a variety of
            genes in response to cell stimuli, and thus plays a key role in
            many cellular processes such as cell growth and apoptosis. The
            small GTPase Rac1 has been shown to bind and regulate the activity
            of this protein. PIAS3 protein is a specific inhibitor of this
            protein. This gene also plays a role in regulating host response to
            viral and bacterial infections. Mutations in this gene are
            associated with infantile-onset multisystem autoimmune disease and
            hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.12860.1,
                                           SRR11853564.12189.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000264657.10/ ENSP00000264657.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BI461226.1         59-113
            56-3102             BC014482.1         1-3047
            3103-3373           AK092965.1         1711-1981
            3374-3789           CB216860.1         86-501
            3790-4170           BC008044.2         315-695
            4171-4352           CF454565.1         342-523
            4353-4853           BC008044.2         878-1378
            4854-4920           AI631896.1         6-72                c
            4921-4921           AC087691.9         50988-50988
FEATURES             Location/Qualifiers
     source          1..4921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..4921
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /note="signal transducer and activator of transcription 3"
                     /db_xref="GeneID:6774"
                     /db_xref="HGNC:HGNC:11364"
                     /db_xref="MIM:102582"
     exon            1..164
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            165..315
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2500
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acute-phase response factor; DNA-binding protein APRF"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     3 isoform 1"
                     /protein_id="NP_644805.1"
                     /db_xref="CCDS:CCDS32656.1"
                     /db_xref="GeneID:6774"
                     /db_xref="HGNC:HGNC:11364"
                     /db_xref="MIM:102582"
                     /translation="MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWA
                     YAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIA
                     RIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQ
                     KMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIV
                     SELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQ
                     TRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPD
                     RPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTK
                     VMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
                     KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVL
                     SWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLD
                     NIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWV
                     EKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEA
                     FGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNN
                     GEGAEPSAGGQFESLTFDMELTSECATSPM"
     exon            316..460
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            461..559
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            560..655
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            656..737
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            738..832
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            833..984
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1143
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1236
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1296
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1326
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1420
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1468
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1552
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1651
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1787
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1840
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1935
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2075
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2288
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2331
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2444
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..4921
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4898..4903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /note="hexamer: AATAAA"
     polyA_site      4921
                     /gene="STAT3"
                     /gene_synonym="ADMIO; ADMIO1; APRF; HIES"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcagccg agggaacaag ccccaaccgg atcctggaca ggcaccccgg cttggcgctg
       61 tctctccccc tcggctcgga gaggcccttc ggcctgaggg agcctcgccg cccgtccccg
      121 gcacacgcgc agccccggcc tctcggcctc tgccggagaa acagttggga cccctgattt
      181 tagcaggatg gcccaatgga atcagctaca gcagcttgac acacggtacc tggagcagct
      241 ccatcagctc tacagtgaca gcttcccaat ggagctgcgg cagtttctgg ccccttggat
      301 tgagagtcaa gattgggcat atgcggccag caaagaatca catgccactt tggtgtttca
      361 taatctcctg ggagagattg accagcagta tagccgcttc ctgcaagagt cgaatgttct
      421 ctatcagcac aatctacgaa gaatcaagca gtttcttcag agcaggtatc ttgagaagcc
      481 aatggagatt gcccggattg tggcccggtg cctgtgggaa gaatcacgcc ttctacagac
      541 tgcagccact gcggcccagc aagggggcca ggccaaccac cccacagcag ccgtggtgac
      601 ggagaagcag cagatgctgg agcagcacct tcaggatgtc cggaagagag tgcaggatct
      661 agaacagaaa atgaaagtgg tagagaatct ccaggatgac tttgatttca actataaaac
      721 cctcaagagt caaggagaca tgcaagatct gaatggaaac aaccagtcag tgaccaggca
      781 gaagatgcag cagctggaac agatgctcac tgcgctggac cagatgcgga gaagcatcgt
      841 gagtgagctg gcggggcttt tgtcagcgat ggagtacgtg cagaaaactc tcacggacga
      901 ggagctggct gactggaaga ggcggcaaca gattgcctgc attggaggcc cgcccaacat
      961 ctgcctagat cggctagaaa actggataac gtcattagca gaatctcaac ttcagacccg
     1021 tcaacaaatt aagaaactgg aggagttgca gcaaaaagtt tcctacaaag gggaccccat
     1081 tgtacagcac cggccgatgc tggaggagag aatcgtggag ctgtttagaa acttaatgaa
     1141 aagtgccttt gtggtggagc ggcagccctg catgcccatg catcctgacc ggcccctcgt
     1201 catcaagacc ggcgtccagt tcactactaa agtcaggttg ctggtcaaat tccctgagtt
     1261 gaattatcag cttaaaatta aagtgtgcat tgacaaagac tctggggacg ttgcagctct
     1321 cagaggatcc cggaaattta acattctggg cacaaacaca aaagtgatga acatggaaga
     1381 atccaacaac ggcagcctct ctgcagaatt caaacacttg accctgaggg agcagagatg
     1441 tgggaatggg ggccgagcca attgtgatgc ttccctgatt gtgactgagg agctgcacct
     1501 gatcaccttt gagaccgagg tgtatcacca aggcctcaag attgacctag agacccactc
     1561 cttgccagtt gtggtgatct ccaacatctg tcagatgcca aatgcctggg cgtccatcct
     1621 gtggtacaac atgctgacca acaatcccaa gaatgtaaac ttttttacca agcccccaat
     1681 tggaacctgg gatcaagtgg ccgaggtcct gagctggcag ttctcctcca ccaccaagcg
     1741 aggactgagc atcgagcagc tgactacact ggcagagaaa ctcttgggac ctggtgtgaa
     1801 ttattcaggg tgtcagatca catgggctaa attttgcaaa gaaaacatgg ctggcaaggg
     1861 cttctccttc tgggtctggc tggacaatat cattgacctt gtgaaaaagt acatcctggc
     1921 cctttggaac gaagggtaca tcatgggctt tatcagtaag gagcgggagc gggccatctt
     1981 gagcactaag cctccaggca ccttcctgct aagattcagt gaaagcagca aagaaggagg
     2041 cgtcactttc acttgggtgg agaaggacat cagcggtaag acccagatcc agtccgtgga
     2101 accatacaca aagcagcagc tgaacaacat gtcatttgct gaaatcatca tgggctataa
     2161 gatcatggat gctaccaata tcctggtgtc tccactggtc tatctctatc ctgacattcc
     2221 caaggaggag gcattcggaa agtattgtcg gccagagagc caggagcatc ctgaagctga
     2281 cccaggtagc gctgccccat acctgaagac caagtttatc tgtgtgacac caacgacctg
     2341 cagcaatacc attgacctgc cgatgtcccc ccgcacttta gattcattga tgcagtttgg
     2401 aaataatggt gaaggtgctg aaccctcagc aggagggcag tttgagtccc tcacctttga
     2461 catggagttg acctcggagt gcgctacctc ccccatgtga ggagctgaga acggaagctg
     2521 cagaaagata cgactgaggc gcctacctgc attctgccac ccctcacaca gccaaacccc
     2581 agatcatctg aaactactaa ctttgtggtt ccagattttt tttaatctcc tacttctgct
     2641 atctttgagc aatctgggca cttttaaaaa tagagaaatg agtgaatgtg ggtgatctgc
     2701 ttttatctaa atgcaaataa ggatgtgttc tctgagaccc atgatcaggg gatgtggcgg
     2761 ggggtggcta gagggagaaa aaggaaatgt cttgtgttgt tttgttcccc tgccctcctt
     2821 tctcagcagc tttttgttat tgttgttgtt gttcttagac aagtgcctcc tggtgcctgc
     2881 ggcatccttc tgcctgtttc tgtaagcaaa tgccacaggc cacctatagc tacatactcc
     2941 tggcattgca ctttttaacc ttgctgacat ccaaatagaa gataggacta tctaagccct
     3001 aggtttcttt ttaaattaag aaataataac aattaaaggg caaaaaacac tgtatcagca
     3061 tagcctttct gtatttaaga aacttaagca gccgggcatg gtggctcacg cctgtaatcc
     3121 cagcactttg ggaggccgag gcggatcata aggtcaggag atcaagacca tcctggctaa
     3181 cacggtgaaa ccccgtctct actaaaagta caaaaaatta gctgggtgtg gtggtgggcg
     3241 cctgtagtcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc tgagaggcgg
     3301 aggttgcagt gagccaaaat tgcaccactg cacactgcac tccatcctgg gcgacagtct
     3361 gagactctgt ctcaaaaaaa aaaaaaaaaa aaagaaactt cagttaacag cctccttggt
     3421 gctttaagca ttcagcttcc ttcaggctgg taatttatat aatccctgaa acgggcttca
     3481 ggtcaaaccc ttaagacatc tgaagctgca acctggcctt tggtgttgaa ataggaaggt
     3541 ttaaggagaa tctaagcatt ttagactttt ttttataaat agacttattt tcctttgtaa
     3601 tgtattggcc ttttagtgag taaggctggg cagagggtgc ttacaacctt gactcccttt
     3661 ctccctggac ttgatctgct gtttcagagg ctaggttgtt tctgtgggtg ccttatcagg
     3721 gctgggatac ttctgattct ggcttccttc ctgccccacc ctcccgaccc cagtccccct
     3781 gatcctgcta gaggcatgtc tccttgcgtg tctaaaggtc cctcatcctg tttgttttag
     3841 gaatcctggt ctcaggacct catggaagaa gagggggaga gagttacagg ttggacatga
     3901 tgcacactat ggggccccag cgacgtgtct ggttgagctc agggaatatg gttcttagcc
     3961 agtttcttgg tgatatccag tggcacttgt aatggcgtct tcattcagtt catgcagggc
     4021 aaaggcttac tgataaactt gagtctgccc tcgtatgagg gtgtatacct ggcctccctc
     4081 tgaggctggt gactcctccc tgctggggcc ccacaggtga ggcagaacag ctagagggcc
     4141 tccccgcctg cccgccttgg ctggctagct cgcctctcct gtgcgtatgg gaacacctag
     4201 cacgtgctgg atgggctgcc tctgactcag aggcatggcc ggatttggca actcaaaacc
     4261 accttgcctc agctgatcag agtttctgtg gaattctgtt tgttaaatca aattagctgg
     4321 tctctgaatt aagggggaga cgaccttctc taagatgaac agggttcgcc ccagtcctcc
     4381 tgcctggaga cagttgatgt gtcatgcaga gctcttactt ctccagcaac actcttcagt
     4441 acataataag cttaactgat aaacagaata tttagaaagg tgagacttgg gcttaccatt
     4501 gggtttaaat catagggacc tagggcgagg gttcagggct tctctggagc agatattgtc
     4561 aagttcatgg ccttaggtag catgtatctg gtcttaactc tgattgtagc aaaagttctg
     4621 agaggagctg agccctgttg tggcccatta aagaacaggg tcctcaggcc ctgcccgctt
     4681 cctgtccact gccccctccc catccccagc ccagccgagg gaatcccgtg ggttgcttac
     4741 ctacctataa ggtggtttat aagctgctgt cctggccact gcattcaaat tccaatgtgt
     4801 acttcatagt gtaaaaattt atattattgt gaggtttttt gtcttttttt tttttttttt
     4861 tttttggtat attgctgtat ctactttaac ttccagaaat aaacgttata taggaaccgt
     4921 c
//
