LOCUS       NM_005419               4405 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens signal transducer and activator of transcription 2
            (STAT2), transcript variant 1, mRNA.
ACCESSION   NM_005419
VERSION     NM_005419.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4405)
  AUTHORS   Huang,Z., Mai,Z., Kong,C., You,J., Lin,S., Gao,C., Zhang,W.,
            Chen,X., Xie,Q., Wang,H., Tang,S., Zhou,P., Gong,L. and Zhang,G.
  TITLE     African swine fever virus pB475L evades host antiviral innate
            immunity via targeting STAT2 to inhibit IFN-I signaling
  JOURNAL   J Biol Chem 300 (7), 107472 (2024)
   PUBMED   38879005
  REMARK    GeneRIF: African swine fever virus pB475L evades host antiviral
            innate immunity via targeting STAT2 to inhibit IFN-I signaling.
REFERENCE   2  (bases 1 to 4405)
  AUTHORS   Calvo-Apalategi,A., Nevado,M.L., Bravo-Gallego,L.Y.,
            Gonzalez-Granado,L.I., Allende,L.M., Pena,R.R., Lopez-Granados,E.
            and Reyburn,H.T.
  TITLE     The lack of either IRF9, or STAT2, has surprisingly little effect
            on human natural killer cell development and function
  JOURNAL   Immunology 172 (3), 440-450 (2024)
   PUBMED   38514903
  REMARK    GeneRIF: The lack of either IRF9, or STAT2, has surprisingly little
            effect on human natural killer cell development and function.
REFERENCE   3  (bases 1 to 4405)
  AUTHORS   Nowicka,H., Sekrecka,A., Blaszczyk,K., Kluzek,K., Chang,C.Y.,
            Wesoly,J., Lee,C.K. and Bluyssen,H.A.R.
  TITLE     ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription
            through Genome-Wide Binding of Phosphorylated and Unphosphorylated
            Complexes to Common ISRE-Containing ISGs
  JOURNAL   Int J Mol Sci 24 (24), 17635 (2023)
   PUBMED   38139463
  REMARK    GeneRIF: ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced
            Transcription through Genome-Wide Binding of Phosphorylated and
            Unphosphorylated Complexes to Common ISRE-Containing ISGs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4405)
  AUTHORS   Gomes,J.A., Sgarioni,E., Boquett,J.A., Kowalski,T.W., Fraga,L.R.,
            Tercas-Trettel,A.C.P., da Silva,J.H., Ribeiro,B.F.R., Galera,M.F.,
            de Oliveira,T.M., Carvalho de Andrade,M.D.F., Carvalho,I.F.,
            Schuler-Faccini,L. and Vianna,F.S.L.
  TITLE     Investigation of the impact of AXL, TLR3, and STAT2 in congenital
            Zika syndrome through genetic polymorphisms and protein-protein
            interaction network analyses
  JOURNAL   Birth Defects Res 115 (16), 1500-1512 (2023)
   PUBMED   37526179
  REMARK    GeneRIF: Investigation of the impact of AXL, TLR3, and STAT2 in
            congenital Zika syndrome through genetic polymorphisms and
            protein-protein interaction network analyses.
REFERENCE   5  (bases 1 to 4405)
  AUTHORS   Zeng,T., Ye,J., Wang,H. and Tian,W.
  TITLE     STAT2 act a prognostic biomarker and associated with immune
            infiltration in kidney renal clear cell carcinoma
  JOURNAL   Medicine (Baltimore) 102 (17), e33662 (2023)
   PUBMED   37115061
  REMARK    GeneRIF: STAT2 act a prognostic biomarker and associated with
            immune infiltration in kidney renal clear cell carcinoma.
REFERENCE   6  (bases 1 to 4405)
  AUTHORS   Wang,Y., Song,Q., Huang,W., Lin,Y., Wang,X., Wang,C., Willard,B.,
            Zhao,C., Nan,J., Holvey-Bates,E., Wang,Z., Taylor,D., Yang,J. and
            Stark,G.R.
  TITLE     A virus-induced conformational switch of STAT1-STAT2 dimers boosts
            antiviral defenses
  JOURNAL   Cell Res 31 (2), 206-218 (2021)
   PUBMED   32759968
REFERENCE   7  (bases 1 to 4405)
  AUTHORS   Uddin,S., Chamdin,A. and Platanias,L.C.
  TITLE     Interaction of the transcriptional activator Stat-2 with the type I
            interferon receptor
  JOURNAL   J Biol Chem 270 (42), 24627-24630 (1995)
   PUBMED   7559568
REFERENCE   8  (bases 1 to 4405)
  AUTHORS   Marrero,M.B., Schieffer,B., Paxton,W.G., Heerdt,L., Berk,B.C.,
            Delafontaine,P. and Bernstein,K.E.
  TITLE     Direct stimulation of Jak/STAT pathway by the angiotensin II AT1
            receptor
  JOURNAL   Nature 375 (6528), 247-250 (1995)
   PUBMED   7746328
REFERENCE   9  (bases 1 to 4405)
  AUTHORS   Yan,R., Qureshi,S., Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     The genomic structure of the STAT genes: multiple exons in
            coincident sites in Stat1 and Stat2
  JOURNAL   Nucleic Acids Res 23 (3), 459-463 (1995)
   PUBMED   7885841
REFERENCE   10 (bases 1 to 4405)
  AUTHORS   Fu,X.Y., Schindler,C., Improta,T., Aebersold,R. and Darnell,J.E.
            Jr.
  TITLE     The proteins of ISGF-3, the interferon alpha-induced
            transcriptional activator, define a gene family involved in signal
            transduction
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7840-7843 (1992)
   PUBMED   1502204
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB482283.1 and BC051284.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005419.3.
            
            Summary: The protein encoded by this gene is a member of the STAT
            protein family. In response to cytokines and growth factors, STAT
            family members are phosphorylated by the receptor associated
            kinases, and then form homo- or heterodimers that translocate to
            the cell nucleus where they act as transcription activators. In
            response to interferon (IFN), this protein forms a complex with
            STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in
            which this protein acts as a transactivator, but lacks the ability
            to bind DNA directly. The protein mediates innate antiviral
            activity. Mutations in this gene result in Immunodeficiency 44.
            [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051284.1, SRR18074968.1920962.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000314128.9/ ENSP00000315768.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DB482283.1         147-180
            35-3705             BC051284.1         1-3671
            3706-4405           BC051284.1         3673-4372
FEATURES             Location/Qualifiers
     source          1..4405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..4405
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /note="signal transducer and activator of transcription 2"
                     /db_xref="GeneID:6773"
                     /db_xref="HGNC:HGNC:11363"
                     /db_xref="MIM:600556"
     exon            1..50
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            51..188
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..2613
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interferon alpha induced transcriptional activator; signal
                     transducer and activator of transcription 2, 113kDa"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     2 isoform 1"
                     /protein_id="NP_005410.1"
                     /db_xref="CCDS:CCDS8917.1"
                     /db_xref="GeneID:6773"
                     /db_xref="HGNC:HGNC:11363"
                     /db_xref="MIM:600556"
                     /translation="MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNW
                     QEAALGSDDSKATMLFFHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQPFSQDPT
                     QLAEMIFNLLLEEKRILIQAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLV
                     KSISQLKDQQDVFCFRYKIQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASK
                     ALLGRLTTLIELLLPKLEEWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLL
                     KELKGLSCLVSYQDDPLTKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLIL
                     KTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQ
                     SQGLIWDFGYLTLVEQRSGGSGKGSNKGPLGVTEELHIISFTVKYTYQGLKQELKTDT
                     LPVVIISNMNQLSIAWASVLWFNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYV
                     GRGLNSDQLSMLRNKLFGQNCRTEDPLLSWADFTKRESPPGKLPFWTWLDKILELVHD
                     HLKDLWNDGRIMGFVSRSQERRLLKKTMSGTFLLRFSESSEGGITCSWVEHQDDDKVL
                     IYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPRIPRDEAFGCYYQEKV
                     NLQERRKYLKHRLIVVSNRQVDELQQPLELKPEPELESLELELGLVPEPELSLDLEPL
                     LKAGLDLGPELESVLESTLEPVIEPTLCMVSQTVPEPDQGPVSQPVPEPDLPCDLRHL
                     NTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEVYVSRPSHFYTDGPLMPSDF"
     exon            189..342
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            343..438
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            439..528
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            529..604
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            605..690
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            691..839
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            840..998
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1091
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1151
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1172
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1266
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1314
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1398
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1497
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1633
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1686
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1781
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1918
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2101
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2159
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2470
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..4405
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /note="hexamer: AATAAA"
     polyA_site      4405
                     /gene="STAT2"
                     /gene_synonym="IMD44; ISGF-3; P113; PTORCH3; STAT113"
                     /note="major polyA site"
ORIGIN      
        1 aagtcgcgac cagagccatt ggagggcgcg gggactgcaa ccctaatcag agcccaaatg
       61 gcgcagtggg aaatgctgca gaatcttgac agcccctttc aggatcagct gcaccagctt
      121 tactcgcaca gcctcctgcc tgtggacatt cgacagtact tggctgtctg gattgaagac
      181 cagaactggc aggaagctgc acttgggagt gatgattcca aggctaccat gctattcttc
      241 cacttcttgg atcagctgaa ctatgagtgt ggccgttgca gccaggaccc agagtccttg
      301 ttgctgcagc acaatttgcg gaaattctgc cgggacattc agcccttttc ccaggatcct
      361 acccagttgg ctgagatgat ctttaacctc cttctggaag aaaaaagaat tttgatccag
      421 gctcagaggg cccaattgga acaaggagag ccagttctcg aaacacctgt ggagagccag
      481 caacatgaga ttgaatcccg gatcctggat ttaagggcta tgatggagaa gctggtaaaa
      541 tccatcagcc aactgaaaga ccagcaggat gtcttctgct tccgatataa gatccaggcc
      601 aaagggaaga caccctctct ggacccccat cagaccaaag agcagaagat tctgcaggaa
      661 actctcaatg aactggacaa aaggagaaag gaggtgctgg atgcctccaa agcactgcta
      721 ggccgattaa ctaccctaat cgagctactg ctgccaaagt tggaggagtg gaaggcccag
      781 cagcaaaaag cctgcatcag agctcccatt gaccacgggt tggaacagct ggagacatgg
      841 ttcacagctg gagcaaagct gttgtttcac ctgaggcagc tgctgaagga gctgaaggga
      901 ctgagttgcc tggttagcta tcaggatgac cctctgacca aaggggtgga cctacgcaac
      961 gcccaggtca cagagttgct acagcgtctg ctccacagag cctttgtggt agaaacccag
     1021 ccctgcatgc cccaaactcc ccatcgaccc ctcatcctca agactggcag caagttcacc
     1081 gtccgaacaa ggctgctggt gagactccag gaaggcaatg agtcactgac tgtggaagtc
     1141 tccattgaca ggaatcctcc tcaattacaa ggcttccgga agttcaacat tctgacttca
     1201 aaccagaaaa ctttgacccc cgagaagggg cagagtcagg gtttgatttg ggactttggt
     1261 tacctgactc tggtggagca acgttcaggt ggttcaggaa agggcagcaa taaggggcca
     1321 ctaggtgtga cagaggaact gcacatcatc agcttcacgg tcaaatatac ctaccagggt
     1381 ctgaagcagg agctgaaaac ggacaccctc cctgtggtga ttatttccaa catgaaccag
     1441 ctctcaattg cctgggcttc agttctctgg ttcaatttgc tcagcccaaa ccttcagaac
     1501 cagcagttct tctccaaccc ccccaaggcc ccctggagct tgctgggccc tgctctcagt
     1561 tggcagttct cctcctatgt tggccgaggc ctcaactcag accagctgag catgctgaga
     1621 aacaagctgt tcgggcagaa ctgtaggact gaggatccat tattgtcctg ggctgacttc
     1681 actaagcgag agagccctcc tggcaagtta ccattctgga catggctgga caaaattctg
     1741 gagttggtac atgaccacct gaaggatctc tggaatgatg gacgcatcat gggctttgtg
     1801 agtcggagcc aggagcgccg gctgctgaag aagaccatgt ctggcacctt tctactgcgc
     1861 ttcagtgaat cgtcagaagg gggcattacc tgctcctggg tggagcacca ggatgatgac
     1921 aaggtgctca tctactctgt gcaaccgtac acgaaggagg tgctgcagtc actcccgctg
     1981 actgaaatca tccgccatta ccagttgctc actgaggaga atatacctga aaacccactg
     2041 cgcttcctct atccccgaat cccccgggat gaagcttttg ggtgctacta ccaggagaaa
     2101 gttaatctcc aggaacggag gaaatacctg aaacacaggc tcattgtggt ctctaataga
     2161 caggtggatg aactgcaaca accgctggag cttaagccag agccagagct ggagtcatta
     2221 gagctggaac tagggctggt gccagagcca gagctcagcc tggacttaga gccactgctg
     2281 aaggcagggc tggatctggg gccagagcta gagtctgtgc tggagtccac tctggagcct
     2341 gtgatagagc ccacactatg catggtatca caaacagtgc cagagccaga ccaaggacct
     2401 gtatcacagc cagtgccaga gccagatttg ccctgtgatc tgagacattt gaacactgag
     2461 ccaatggaaa tcttcagaaa ctgtgtaaag attgaagaaa tcatgccgaa tggtgaccca
     2521 ctgttggctg gccagaacac cgtggatgag gtttacgtct cccgccccag ccacttctac
     2581 actgatggac ccttgatgcc ttctgacttc taggaaccac atttcctctg ttcttttcat
     2641 atctcttgcc cttcctactc ctcatagcat gatattgttc tccaaggatg ggaatcaggc
     2701 atgtgtccct tccaagctgt gttaactgtt caaactcagg cctgtgtgac tccattgggg
     2761 tgagaggtga aagcataaca tgggtacaga ggggacaaca atgaatcaga acagatgctg
     2821 agccataggt ctaaatagga tcctggaggc tgcctgctgt gctgggaggt ataggggtcc
     2881 tgggggcagg ccagggcagt tgacaggtac ttggagggct cagggcagtg gcttctttcc
     2941 agtatggaag gatttcaaca ttttaatagt tggttaggct aaactggtgc atactggcat
     3001 tggcccttgg tggggagcac agacacagga taggactcca tttctttctt ccattccttc
     3061 atgtctagga taacttgctt tcttctttcc tttactcctg gctcaagccc tgaatttctt
     3121 cttttcctgc aggggttgag agctttctgc cttagcctac catgtgaaac tctaccctga
     3181 agaaagggat ggataggaag tagacctctt tttcttacca gtctcctccc ctactctgcc
     3241 cctaagctgg ctgtacctgt tcctccccca taaaatgatc ctgccaatct aatgtgagtg
     3301 tgaagctttg cacactagtt tatgctacct agtctccact ttctcaatgc ttaggagaca
     3361 gatcactcct ggaggctggg gatggtagga ttgctgggga tttttttttt tttaaacagg
     3421 gtctcactct gttgcccagg ctagagtgca atggtgcaat cacagctcac tgcagcctca
     3481 acctcctggg ttcaagcaat cctcctacct cagcctcctg ggtagctagc accatggcat
     3541 gcgccaccat gccctatttt ttttttttaa agacagggtc ttgctatatt gcccaggctg
     3601 gtcttgaact gggctcaagt gatcctcacg ccttggcctc ccaaagtgct gggattatag
     3661 gcatgagcca ctgtgcttgg ccaggatttt tttttttttt tttttgagat ggagtttctc
     3721 tcttgttgtc caggctggag tgcaatggtg tgatctcggc tcactgcaac ctccgccttc
     3781 cgggttcaag tgactctcct gcctcagcct ccccagtagc tgggattaca gatctgcacc
     3841 accatgccca gctaattttg tatttttagt agagacgggg tttctccatg ttggtcaggc
     3901 tggtctcgaa ctcctgacct caagtgatct gtccacctcg gcctcccaga gtgctgggat
     3961 tacaggcgtg agccactgtt cccagcagga atttcttttt tatagtattg gataaagttt
     4021 ggtgttttta cagaggagaa gcaatgggtc ttagctcttt ctctattatg ttatcatcct
     4081 cccttttttg tacaatatgt tgtttacctg aaaggaaggt ttctattcgt tggttgtgga
     4141 cctggacaaa gtccaagtct gtggaactta aaaccttgaa ggtctgtcat aggactctgg
     4201 acaatctcac accttagcta ttcccaggga accccagggg gcaactgaca ttgctccaag
     4261 atgttctcct gatgtagctt gagatataaa ggaaaggccc tgcacaggtg gctgtttctt
     4321 gtctgttatg tcagaggaac agtcctgttc agaaaggggc tcttctgagc agaaatggct
     4381 aataaacttt gtgctgatct ggaaa
//
