LOCUS       NM_007315               4116 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens signal transducer and activator of transcription 1
            (STAT1), transcript variant alpha, mRNA.
ACCESSION   NM_007315
VERSION     NM_007315.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Olbrich,P. and Freeman,A.F.
  TITLE     STAT1 and STAT3 gain of function: clinically heterogenous immune
            regulatory disorders
  JOURNAL   Curr Opin Allergy Clin Immunol 24 (6), 440-447 (2024)
   PUBMED   39475850
  REMARK    GeneRIF: STAT1 and STAT3 gain of function: clinically heterogenous
            immune regulatory disorders.
            Review article
REFERENCE   2  (bases 1 to 4116)
  AUTHORS   Wang,Y., Song,Q., Huang,W., Lin,Y., Wang,X., Wang,C., Willard,B.,
            Zhao,C., Nan,J., Holvey-Bates,E., Wang,Z., Taylor,D., Yang,J. and
            Stark,G.R.
  TITLE     A virus-induced conformational switch of STAT1-STAT2 dimers boosts
            antiviral defenses
  JOURNAL   Cell Res 31 (2), 206-218 (2021)
   PUBMED   32759968
REFERENCE   3  (bases 1 to 4116)
  AUTHORS   Decker,T. and Kovarik,P.
  TITLE     Serine phosphorylation of STATs
  JOURNAL   Oncogene 19 (21), 2628-2637 (2000)
   PUBMED   10851062
  REMARK    Review article
REFERENCE   4  (bases 1 to 4116)
  AUTHORS   Bowman,T., Garcia,R., Turkson,J. and Jove,R.
  TITLE     STATs in oncogenesis
  JOURNAL   Oncogene 19 (21), 2474-2488 (2000)
   PUBMED   10851046
  REMARK    Review article
REFERENCE   5  (bases 1 to 4116)
  AUTHORS   Haddad,B., Pabon-Pena,C.R., Young,H. and Sun,W.H.
  TITLE     Assignment1 of STAT1 to human chromosome 2q32 by FISH and radiation
            hybrids
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 58-59 (1998)
   PUBMED   9925928
REFERENCE   6  (bases 1 to 4116)
  AUTHORS   Yan,R., Qureshi,S., Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     The genomic structure of the STAT genes: multiple exons in
            coincident sites in Stat1 and Stat2
  JOURNAL   Nucleic Acids Res 23 (3), 459-463 (1995)
   PUBMED   7885841
REFERENCE   7  (bases 1 to 4116)
  AUTHORS   Igarashi,K., Garotta,G., Ozmen,L., Ziemiecki,A., Wilks,A.F.,
            Harpur,A.G., Larner,A.C. and Finbloom,D.S.
  TITLE     Interferon-gamma induces tyrosine phosphorylation of
            interferon-gamma receptor and regulated association of protein
            tyrosine kinases, Jak1 and Jak2, with its receptor
  JOURNAL   J Biol Chem 269 (20), 14333-14336 (1994)
   PUBMED   7514165
REFERENCE   8  (bases 1 to 4116)
  AUTHORS   Shuai,K., Horvath,C.M., Huang,L.H., Qureshi,S.A., Cowburn,D. and
            Darnell,J.E. Jr.
  TITLE     Interferon activation of the transcription factor Stat91 involves
            dimerization through SH2-phosphotyrosyl peptide interactions
  JOURNAL   Cell 76 (5), 821-828 (1994)
   PUBMED   7510216
REFERENCE   9  (bases 1 to 4116)
  AUTHORS   Schindler,C., Fu,X.Y., Improta,T., Aebersold,R. and Darnell,J.E.
            Jr.
  TITLE     Proteins of transcription factor ISGF-3: one gene encodes the
            91-and 84-kDa ISGF-3 proteins that are activated by interferon
            alpha
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7836-7839 (1992)
   PUBMED   1502203
REFERENCE   10 (bases 1 to 4116)
  AUTHORS   Schindler,C., Shuai,K., Prezioso,V.R. and Darnell,J.E. Jr.
  TITLE     Interferon-dependent tyrosine phosphorylation of a latent
            cytoplasmic transcription factor
  JOURNAL   Science 257 (5071), 809-813 (1992)
   PUBMED   1496401
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR998778.1, CR749636.1,
            AK315002.1, AK292604.1, CN410740.1, EB385742.1, AI992149.1 and
            BU738296.1.
            
            On Nov 22, 2019 this sequence version replaced NM_007315.3.
            
            Summary: The protein encoded by this gene is a member of the STAT
            protein family. In response to cytokines and growth factors, STAT
            family members are phosphorylated by the receptor associated
            kinases, and then form homo- or heterodimers that translocate to
            the cell nucleus where they act as transcription activators. The
            protein encoded by this gene can be activated by various ligands
            including interferon-alpha, interferon-gamma, EGF, PDGF and IL6.
            This protein mediates the expression of a variety of genes, which
            is thought to be important for cell viability in response to
            different cell stimuli and pathogens. The protein plays an
            important role in immune responses to viral, fungal and
            mycobacterial pathogens. Mutations in this gene are associated with
            Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020].
            
            Transcript Variant: This variant (alpha) encodes isoform alpha.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749636.1, AK315002.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000361099.8/ ENSP00000354394.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               CR998778.1         40-621
            583-2461            CR749636.1         569-2447
            2462-2562           AK315002.1         2456-2556
            2563-2971           AK292604.1         2686-3094
            2972-3389           CN410740.1         237-654
            3390-3997           EB385742.1         141-748
            3998-4044           AI992149.1         76-122              c
            4045-4116           BU738296.1         132-203             c
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..4116
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="signal transducer and activator of transcription 1"
                     /db_xref="GeneID:6772"
                     /db_xref="HGNC:HGNC:11362"
                     /db_xref="MIM:600555"
     exon            1..154
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            155..308
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            309..437
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..2562
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; transcription factor ISGF-3 components p91/p84;
                     signal transducer and activator of transcription
                     1-alpha/beta; signal transducer and activator of
                     transcription 1, 91kD; signal transducer and activator of
                     transcription 1, 91kDa"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     1-alpha/beta isoform alpha"
                     /protein_id="NP_009330.1"
                     /db_xref="CCDS:CCDS2309.1"
                     /db_xref="GeneID:6772"
                     /db_xref="HGNC:HGNC:11362"
                     /db_xref="MIM:600555"
                     /translation="MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWE
                     HAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMS
                     MIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEI
                     KSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKII
                     ELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQ
                     LKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLV
                     LKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNM
                     EESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLET
                     TSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSS
                     VTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIK
                     KHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGG
                     EPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYS
                     RPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGS
                     VEFDSMMNTV"
     exon            438..582
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            583..681
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            682..771
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            772..850
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            851..942
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1094
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1253
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1346
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1406
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1436
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1530
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1572
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1656
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1755
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1891
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1941
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2036
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2182
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2368
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2444
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2547
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..4116
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3958..3963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="hexamer: AATATA"
     polyA_site      3999
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="major polyA site"
     regulatory      4095..4100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="hexamer: ATTAAA"
     polyA_site      4116
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="major polyA site"
ORIGIN      
        1 gtttcgcttt cctgcgcaga gtctgcggag gggctcggct gcaccggggg gatcgcgcct
       61 ggcagacccc agaccgagca gaggcgaccc agcgcgctcg ggagaggctg caccgccgcg
      121 cccccgccta gcccttccgg atcctgcgcg cagaaaagtt tcatttgctg tatgccatcc
      181 tcgagagctg tctaggttaa cgttcgcact ctgtgtatat aacctcgaca gtcttggcac
      241 ctaacgtgct gtgcgtagct gctcctttgg ttgaatcccc aggcccttgt tggggcacaa
      301 ggtggcagga tgtctcagtg gtacgaactt cagcagcttg actcaaaatt cctggagcag
      361 gttcaccagc tttatgatga cagttttccc atggaaatca gacagtacct ggcacagtgg
      421 ttagaaaagc aagactggga gcacgctgcc aatgatgttt catttgccac catccgtttt
      481 catgacctcc tgtcacagct ggatgatcaa tatagtcgct tttctttgga gaataacttc
      541 ttgctacagc ataacataag gaaaagcaag cgtaatcttc aggataattt tcaggaagac
      601 ccaatccaga tgtctatgat catttacagc tgtctgaagg aagaaaggaa aattctggaa
      661 aacgcccaga gatttaatca ggctcagtcg gggaatattc agagcacagt gatgttagac
      721 aaacagaaag agcttgacag taaagtcaga aatgtgaagg acaaggttat gtgtatagag
      781 catgaaatca agagcctgga agatttacaa gatgaatatg acttcaaatg caaaaccttg
      841 cagaacagag aacacgagac caatggtgtg gcaaagagtg atcagaaaca agaacagctg
      901 ttactcaaga agatgtattt aatgcttgac aataagagaa aggaagtagt tcacaaaata
      961 atagagttgc tgaatgtcac tgaacttacc cagaatgccc tgattaatga tgaactagtg
     1021 gagtggaagc ggagacagca gagcgcctgt attggggggc cgcccaatgc ttgcttggat
     1081 cagctgcaga actggttcac tatagttgcg gagagtctgc agcaagttcg gcagcagctt
     1141 aaaaagttgg aggaattgga acagaaatac acctacgaac atgaccctat cacaaaaaac
     1201 aaacaagtgt tatgggaccg caccttcagt cttttccagc agctcattca gagctcgttt
     1261 gtggtggaaa gacagccctg catgccaacg caccctcaga ggccgctggt cttgaagaca
     1321 ggggtccagt tcactgtgaa gttgagactg ttggtgaaat tgcaagagct gaattataat
     1381 ttgaaagtca aagtcttatt tgataaagat gtgaatgaga gaaatacagt aaaaggattt
     1441 aggaagttca acattttggg cacgcacaca aaagtgatga acatggagga gtccaccaat
     1501 ggcagtctgg cggctgaatt tcggcacctg caattgaaag aacagaaaaa tgctggcacc
     1561 agaacgaatg agggtcctct catcgttact gaagagcttc actcccttag ttttgaaacc
     1621 caattgtgcc agcctggttt ggtaattgac ctcgagacga cctctctgcc cgttgtggtg
     1681 atctccaacg tcagccagct cccgagcggt tgggcctcca tcctttggta caacatgctg
     1741 gtggcggaac ccaggaatct gtccttcttc ctgactccac catgtgcacg atgggctcag
     1801 ctttcagaag tgctgagttg gcagttttct tctgtcacca aaagaggtct caatgtggac
     1861 cagctgaaca tgttgggaga gaagcttctt ggtcctaacg ccagccccga tggtctcatt
     1921 ccgtggacga ggttttgtaa ggaaaatata aatgataaaa attttccctt ctggctttgg
     1981 attgaaagca tcctagaact cattaaaaaa cacctgctcc ctctctggaa tgatgggtgc
     2041 atcatgggct tcatcagcaa ggagcgagag cgtgccctgt tgaaggacca gcagccgggg
     2101 accttcctgc tgcggttcag tgagagctcc cgggaagggg ccatcacatt cacatgggtg
     2161 gagcggtccc agaacggagg cgaacctgac ttccatgcgg ttgaacccta cacgaagaaa
     2221 gaactttctg ctgttacttt ccctgacatc attcgcaatt acaaagtcat ggctgctgag
     2281 aatattcctg agaatcccct gaagtatctg tatccaaata ttgacaaaga ccatgccttt
     2341 ggaaagtatt actccaggcc aaaggaagca ccagagccaa tggaacttga tggccctaaa
     2401 ggaactggat atatcaagac tgagttgatt tctgtgtctg aagttcaccc ttctagactt
     2461 cagaccacag acaacctgct ccccatgtct cctgaggagt ttgacgaggt gtctcggata
     2521 gtgggctctg tagaattcga cagtatgatg aacacagtat agagcatgaa tttttttcat
     2581 cttctctggc gacagttttc cttctcatct gtgattccct cctgctactc tgttccttca
     2641 catcctgtgt ttctagggaa atgaaagaaa ggccagcaaa ttcgctgcaa cctgttgata
     2701 gcaagtgaat ttttctctaa ctcagaaaca tcagttactc tgaagggcat catgcatctt
     2761 actgaaggta aaattgaaag gcattctctg aagagtgggt ttcacaagtg aaaaacatcc
     2821 agatacaccc aaagtatcag gacgagaatg agggtccttt gggaaaggag aagttaagca
     2881 acatctagca aatgttatgc ataaagtcag tgcccaactg ttataggttg ttggataaat
     2941 cagtggttat ttagggaact gcttgacgta ggaacggtaa atttctgtgg gagaattctt
     3001 acatgttttc tttgctttaa gtgtaactgg cagttttcca ttggtttacc tgtgaaatag
     3061 ttcaaagcca agtttatata caattatatc agtcctcttt caaaggtagc catcatggat
     3121 ctggtagggg gaaaatgtgt attttattac atctttcaca ttggctattt aaagacaaag
     3181 acaaattctg tttcttgaga agagaatatt agctttactg tttgttatgg cttaatgaca
     3241 ctagctaata tcaatagaag gatgtacatt tccaaattca caagttgtgt ttgatatcca
     3301 aagctgaata cattctgctt tcatcttggt cacatacaat tatttttaca gttctcccaa
     3361 gggagttagg ctattcacaa ccactcattc aaaagttgaa attaaccata gatgtagata
     3421 aactcagaaa tttaattcat gtttcttaaa tgggctactt tgtccttttt gttattaggg
     3481 tggtatttag tctattagcc acaaaattgg gaaaggagta gaaaaagcag taactgacaa
     3541 cttgaataat acaccagaga taatatgaga atcagatcat ttcaaaactc atttcctatg
     3601 taactgcatt gagaactgca tatgtttcgc tgatatatgt gtttttcaca tttgcgaatg
     3661 gttccattct ctctcctgta ctttttccag acactttttt gagtggatga tgtttcgtga
     3721 agtatactgt atttttacct ttttccttcc ttatcactga cacaaaaagt agattaagag
     3781 atgggtttga caaggttctt cccttttaca tactgctgtc tatgtggctg tatcttgttt
     3841 ttccactact gctaccacaa ctatattatc atgcaaatgc tgtattcttc tttggtggag
     3901 ataaagattt cttgagtttt gttttaaaat taaagctaaa gtatctgtat tgcattaaat
     3961 ataatatgca cacagtgctt tccgtggcac tgcatacaat ctgaggcctc ctctctcagt
     4021 ttttatatag atggcgagaa cctaagtttc agttgatttt acaattgaaa tgactaaaaa
     4081 acaaagaaga caacattaaa acaatattgt ttctaa
//
