LOCUS       NM_001384882            4110 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens signal transducer and activator of transcription 1
            (STAT1), transcript variant 3, mRNA.
ACCESSION   NM_001384882
VERSION     NM_001384882.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4110)
  AUTHORS   Olbrich,P. and Freeman,A.F.
  TITLE     STAT1 and STAT3 gain of function: clinically heterogenous immune
            regulatory disorders
  JOURNAL   Curr Opin Allergy Clin Immunol 24 (6), 440-447 (2024)
   PUBMED   39475850
  REMARK    GeneRIF: STAT1 and STAT3 gain of function: clinically heterogenous
            immune regulatory disorders.
            Review article
REFERENCE   2  (bases 1 to 4110)
  AUTHORS   Wang,Y., Song,Q., Huang,W., Lin,Y., Wang,X., Wang,C., Willard,B.,
            Zhao,C., Nan,J., Holvey-Bates,E., Wang,Z., Taylor,D., Yang,J. and
            Stark,G.R.
  TITLE     A virus-induced conformational switch of STAT1-STAT2 dimers boosts
            antiviral defenses
  JOURNAL   Cell Res 31 (2), 206-218 (2021)
   PUBMED   32759968
REFERENCE   3  (bases 1 to 4110)
  AUTHORS   Decker,T. and Kovarik,P.
  TITLE     Serine phosphorylation of STATs
  JOURNAL   Oncogene 19 (21), 2628-2637 (2000)
   PUBMED   10851062
  REMARK    Review article
REFERENCE   4  (bases 1 to 4110)
  AUTHORS   Bowman,T., Garcia,R., Turkson,J. and Jove,R.
  TITLE     STATs in oncogenesis
  JOURNAL   Oncogene 19 (21), 2474-2488 (2000)
   PUBMED   10851046
  REMARK    Review article
REFERENCE   5  (bases 1 to 4110)
  AUTHORS   Haddad,B., Pabon-Pena,C.R., Young,H. and Sun,W.H.
  TITLE     Assignment1 of STAT1 to human chromosome 2q32 by FISH and radiation
            hybrids
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 58-59 (1998)
   PUBMED   9925928
REFERENCE   6  (bases 1 to 4110)
  AUTHORS   Yan,R., Qureshi,S., Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     The genomic structure of the STAT genes: multiple exons in
            coincident sites in Stat1 and Stat2
  JOURNAL   Nucleic Acids Res 23 (3), 459-463 (1995)
   PUBMED   7885841
REFERENCE   7  (bases 1 to 4110)
  AUTHORS   Igarashi,K., Garotta,G., Ozmen,L., Ziemiecki,A., Wilks,A.F.,
            Harpur,A.G., Larner,A.C. and Finbloom,D.S.
  TITLE     Interferon-gamma induces tyrosine phosphorylation of
            interferon-gamma receptor and regulated association of protein
            tyrosine kinases, Jak1 and Jak2, with its receptor
  JOURNAL   J Biol Chem 269 (20), 14333-14336 (1994)
   PUBMED   7514165
REFERENCE   8  (bases 1 to 4110)
  AUTHORS   Shuai,K., Horvath,C.M., Huang,L.H., Qureshi,S.A., Cowburn,D. and
            Darnell,J.E. Jr.
  TITLE     Interferon activation of the transcription factor Stat91 involves
            dimerization through SH2-phosphotyrosyl peptide interactions
  JOURNAL   Cell 76 (5), 821-828 (1994)
   PUBMED   7510216
REFERENCE   9  (bases 1 to 4110)
  AUTHORS   Schindler,C., Fu,X.Y., Improta,T., Aebersold,R. and Darnell,J.E.
            Jr.
  TITLE     Proteins of transcription factor ISGF-3: one gene encodes the
            91-and 84-kDa ISGF-3 proteins that are activated by interferon
            alpha
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7836-7839 (1992)
   PUBMED   1502203
REFERENCE   10 (bases 1 to 4110)
  AUTHORS   Schindler,C., Shuai,K., Prezioso,V.R. and Darnell,J.E. Jr.
  TITLE     Interferon-dependent tyrosine phosphorylation of a latent
            cytoplasmic transcription factor
  JOURNAL   Science 257 (5071), 809-813 (1992)
   PUBMED   1496401
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067945.4.
            
            Summary: The protein encoded by this gene is a member of the STAT
            protein family. In response to cytokines and growth factors, STAT
            family members are phosphorylated by the receptor associated
            kinases, and then form homo- or heterodimers that translocate to
            the cell nucleus where they act as transcription activators. The
            protein encoded by this gene can be activated by various ligands
            including interferon-alpha, interferon-gamma, EGF, PDGF and IL6.
            This protein mediates the expression of a variety of genes, which
            is thought to be important for cell viability in response to
            different cell stimuli and pathogens. The protein plays an
            important role in immune responses to viral, fungal and
            mycobacterial pathogens. Mutations in this gene are associated with
            Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2885966.1,
                                           SRR18074967.777735.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: involved in immune response or antiviral
                                   activity
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC067945.4         90160-90313         c
            155-308             AC067945.4         89667-89820         c
            309-437             AC067945.4         86018-86146         c
            438-582             AC067945.4         85105-85249         c
            583-681             AC067945.4         83705-83803         c
            682-771             AC067945.4         77216-77305         c
            772-850             AC067945.4         75768-75846         c
            851-942             AC067945.4         74359-74450         c
            943-1094            AC067945.4         73998-74149         c
            1095-1253           AC067945.4         71203-71361         c
            1254-1346           AC067945.4         67370-67462         c
            1347-1406           AC067945.4         65757-65816         c
            1407-1436           AC067945.4         63181-63210         c
            1437-1524           AC067945.4         62996-63083         c
            1525-1566           AC067945.4         61761-61802         c
            1567-1650           AC067945.4         60452-60535         c
            1651-1749           AC067945.4         59784-59882         c
            1750-1885           AC067945.4         58525-58660         c
            1886-1935           AC067945.4         56762-56811         c
            1936-2030           AC067945.4         55914-56008         c
            2031-2176           AC067945.4         54998-55143         c
            2177-2362           AC067945.4         52982-53167         c
            2363-2438           AC067945.4         51954-52029         c
            2439-2541           AC067945.4         50972-51074         c
            2542-4110           AC067945.4         45291-46859         c
FEATURES             Location/Qualifiers
     source          1..4110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..4110
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="signal transducer and activator of transcription 1"
                     /db_xref="GeneID:6772"
                     /db_xref="HGNC:HGNC:11362"
                     /db_xref="MIM:600555"
     exon            1..154
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            155..308
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            309..437
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..2556
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transcription factor ISGF-3 components p91/p84; signal
                     transducer and activator of transcription 1-alpha/beta;
                     signal transducer and activator of transcription 1, 91kD;
                     signal transducer and activator of transcription 1, 91kDa"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     1-alpha/beta isoform 3"
                     /protein_id="NP_001371811.1"
                     /db_xref="CCDS:CCDS92918.1"
                     /db_xref="GeneID:6772"
                     /db_xref="HGNC:HGNC:11362"
                     /db_xref="MIM:600555"
                     /translation="MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWE
                     HAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMS
                     MIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEI
                     KSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKII
                     ELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQ
                     LKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLV
                     LKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGKFNILGTHTKVMNMEE
                     STNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTS
                     LPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVT
                     KRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKH
                     LLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEP
                     DFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRP
                     KEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVE
                     FDSMMNTV"
     exon            438..582
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            583..681
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            682..771
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            772..850
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            851..942
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1094
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1253
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1346
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1406
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1436
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1524
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1566
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1650
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1749
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1885
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1935
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2030
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2176
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2362
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2438
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2541
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..4110
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3952..3957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="hexamer: AATATA"
     polyA_site      3993
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="major polyA site"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="hexamer: ATTAAA"
     polyA_site      4110
                     /gene="STAT1"
                     /gene_synonym="CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3;
                     STAT91"
                     /note="major polyA site"
ORIGIN      
        1 gtttcgcttt cctgcgcaga gtctgcggag gggctcggct gcaccggggg gatcgcgcct
       61 ggcagacccc agaccgagca gaggcgaccc agcgcgctcg ggagaggctg caccgccgcg
      121 cccccgccta gcccttccgg atcctgcgcg cagaaaagtt tcatttgctg tatgccatcc
      181 tcgagagctg tctaggttaa cgttcgcact ctgtgtatat aacctcgaca gtcttggcac
      241 ctaacgtgct gtgcgtagct gctcctttgg ttgaatcccc aggcccttgt tggggcacaa
      301 ggtggcagga tgtctcagtg gtacgaactt cagcagcttg actcaaaatt cctggagcag
      361 gttcaccagc tttatgatga cagttttccc atggaaatca gacagtacct ggcacagtgg
      421 ttagaaaagc aagactggga gcacgctgcc aatgatgttt catttgccac catccgtttt
      481 catgacctcc tgtcacagct ggatgatcaa tatagtcgct tttctttgga gaataacttc
      541 ttgctacagc ataacataag gaaaagcaag cgtaatcttc aggataattt tcaggaagac
      601 ccaatccaga tgtctatgat catttacagc tgtctgaagg aagaaaggaa aattctggaa
      661 aacgcccaga gatttaatca ggctcagtcg gggaatattc agagcacagt gatgttagac
      721 aaacagaaag agcttgacag taaagtcaga aatgtgaagg acaaggttat gtgtatagag
      781 catgaaatca agagcctgga agatttacaa gatgaatatg acttcaaatg caaaaccttg
      841 cagaacagag aacacgagac caatggtgtg gcaaagagtg atcagaaaca agaacagctg
      901 ttactcaaga agatgtattt aatgcttgac aataagagaa aggaagtagt tcacaaaata
      961 atagagttgc tgaatgtcac tgaacttacc cagaatgccc tgattaatga tgaactagtg
     1021 gagtggaagc ggagacagca gagcgcctgt attggggggc cgcccaatgc ttgcttggat
     1081 cagctgcaga actggttcac tatagttgcg gagagtctgc agcaagttcg gcagcagctt
     1141 aaaaagttgg aggaattgga acagaaatac acctacgaac atgaccctat cacaaaaaac
     1201 aaacaagtgt tatgggaccg caccttcagt cttttccagc agctcattca gagctcgttt
     1261 gtggtggaaa gacagccctg catgccaacg caccctcaga ggccgctggt cttgaagaca
     1321 ggggtccagt tcactgtgaa gttgagactg ttggtgaaat tgcaagagct gaattataat
     1381 ttgaaagtca aagtcttatt tgataaagat gtgaatgaga gaaatacagt aaaagggaag
     1441 ttcaacattt tgggcacgca cacaaaagtg atgaacatgg aggagtccac caatggcagt
     1501 ctggcggctg aatttcggca cctgcaattg aaagaacaga aaaatgctgg caccagaacg
     1561 aatgagggtc ctctcatcgt tactgaagag cttcactccc ttagttttga aacccaattg
     1621 tgccagcctg gtttggtaat tgacctcgag acgacctctc tgcccgttgt ggtgatctcc
     1681 aacgtcagcc agctcccgag cggttgggcc tccatccttt ggtacaacat gctggtggcg
     1741 gaacccagga atctgtcctt cttcctgact ccaccatgtg cacgatgggc tcagctttca
     1801 gaagtgctga gttggcagtt ttcttctgtc accaaaagag gtctcaatgt ggaccagctg
     1861 aacatgttgg gagagaagct tcttggtcct aacgccagcc ccgatggtct cattccgtgg
     1921 acgaggtttt gtaaggaaaa tataaatgat aaaaattttc ccttctggct ttggattgaa
     1981 agcatcctag aactcattaa aaaacacctg ctccctctct ggaatgatgg gtgcatcatg
     2041 ggcttcatca gcaaggagcg agagcgtgcc ctgttgaagg accagcagcc ggggaccttc
     2101 ctgctgcggt tcagtgagag ctcccgggaa ggggccatca cattcacatg ggtggagcgg
     2161 tcccagaacg gaggcgaacc tgacttccat gcggttgaac cctacacgaa gaaagaactt
     2221 tctgctgtta ctttccctga catcattcgc aattacaaag tcatggctgc tgagaatatt
     2281 cctgagaatc ccctgaagta tctgtatcca aatattgaca aagaccatgc ctttggaaag
     2341 tattactcca ggccaaagga agcaccagag ccaatggaac ttgatggccc taaaggaact
     2401 ggatatatca agactgagtt gatttctgtg tctgaagttc acccttctag acttcagacc
     2461 acagacaacc tgctccccat gtctcctgag gagtttgacg aggtgtctcg gatagtgggc
     2521 tctgtagaat tcgacagtat gatgaacaca gtatagagca tgaatttttt tcatcttctc
     2581 tggcgacagt tttccttctc atctgtgatt ccctcctgct actctgttcc ttcacatcct
     2641 gtgtttctag ggaaatgaaa gaaaggccag caaattcgct gcaacctgtt gatagcaagt
     2701 gaatttttct ctaactcaga aacatcagtt actctgaagg gcatcatgca tcttactgaa
     2761 ggtaaaattg aaaggcattc tctgaagagt gggtttcaca agtgaaaaac atccagatac
     2821 acccaaagta tcaggacgag aatgagggtc ctttgggaaa ggagaagtta agcaacatct
     2881 agcaaatgtt atgcataaag tcagtgccca actgttatag gttgttggat aaatcagtgg
     2941 ttatttaggg aactgcttga cgtaggaacg gtaaatttct gtgggagaat tcttacatgt
     3001 tttctttgct ttaagtgtaa ctggcagttt tccattggtt tacctgtgaa atagttcaaa
     3061 gccaagttta tatacaatta tatcagtcct ctttcaaagg tagccatcat ggatctggta
     3121 gggggaaaat gtgtatttta ttacatcttt cacattggct atttaaagac aaagacaaat
     3181 tctgtttctt gagaagagaa tattagcttt actgtttgtt atggcttaat gacactagct
     3241 aatatcaata gaaggatgta catttccaaa ttcacaagtt gtgtttgata tccaaagctg
     3301 aatacattct gctttcatct tggtcacata caattatttt tacagttctc ccaagggagt
     3361 taggctattc acaaccactc attcaaaagt tgaaattaac catagatgta gataaactca
     3421 gaaatttaat tcatgtttct taaatgggct actttgtcct ttttgttatt agggtggtat
     3481 ttagtctatt agccacaaaa ttgggaaagg agtagaaaaa gcagtaactg acaacttgaa
     3541 taatacacca gagataatat gagaatcaga tcatttcaaa actcatttcc tatgtaactg
     3601 cattgagaac tgcatatgtt tcgctgatat atgtgttttt cacatttgcg aatggttcca
     3661 ttctctctcc tgtacttttt ccagacactt ttttgagtgg atgatgtttc gtgaagtata
     3721 ctgtattttt acctttttcc ttccttatca ctgacacaaa aagtagatta agagatgggt
     3781 ttgacaaggt tcttcccttt tacatactgc tgtctatgtg gctgtatctt gtttttccac
     3841 tactgctacc acaactatat tatcatgcaa atgctgtatt cttctttggt ggagataaag
     3901 atttcttgag ttttgtttta aaattaaagc taaagtatct gtattgcatt aaatataata
     3961 tgcacacagt gctttccgtg gcactgcata caatctgagg cctcctctct cagtttttat
     4021 atagatggcg agaacctaag tttcagttga ttttacaatt gaaatgacta aaaaacaaag
     4081 aagacaacat taaaacaata ttgtttctaa
//
