LOCUS       NM_001142503            4943 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens StAR related lipid transfer domain containing 8
            (STARD8), transcript variant 1, mRNA.
ACCESSION   NM_001142503
VERSION     NM_001142503.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4943)
  AUTHORS   Harb,O.A., Elfeky,M.A., Alabiad,M.A., Hemeda,R., Allam,A.S., El
            Hawary,A.T., Elbaz,M., Sharaf,A.L., Gertallah,L.M., Abdelaziz,A.M.,
            Shalaby,A.M., Alorini,M., Yahia,A.I.O. and Negm,M.
  TITLE     PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma: A
            Clinicopathologic, Prognostic, and Immunohistochemical Study
  JOURNAL   Appl Immunohistochem Mol Morphol 32 (2), 102-110 (2024)
   PUBMED   37982568
  REMARK    GeneRIF: PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma:
            A Clinicopathologic, Prognostic, and Immunohistochemical Study.
REFERENCE   2  (bases 1 to 4943)
  AUTHORS   Mo,H.Y., Moon,S.W., An,C.H. and Lee,S.H.
  TITLE     Regional bias of tumor suppressor gene mutations of STARD8 and WNK2
            in colon cancers
  JOURNAL   Pathol Res Pract 253, 155000 (2024)
   PUBMED   38091885
  REMARK    GeneRIF: Regional bias of tumor suppressor gene mutations of STARD8
            and WNK2 in colon cancers.
REFERENCE   3  (bases 1 to 4943)
  AUTHORS   Sotillos,S., von der Decken,I., Domenech Mercade,I., Srinivasan,S.,
            Sirokha,D., Livshits,L., Vanni,S., Nef,S., Biason-Lauber,A.,
            Rodriguez Gutierrez,D. and Castelli-Gair Hombria,J.
  TITLE     A conserved function of Human DLC3 and Drosophila Cv-c in testis
            development
  JOURNAL   Elife 11, e82343 (2022)
   PUBMED   36326091
  REMARK    GeneRIF: A conserved function of Human DLC3 and Drosophila Cv-c in
            testis development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4943)
  AUTHORS   Noll,B., Benz,D., Frey,Y., Meyer,F., Lauinger,M., Eisler,S.A.,
            Schmid,S., Hordijk,P.L. and Olayioye,M.A.
  TITLE     DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling
            RhoB and actin remodeling at endosomal membranes
  JOURNAL   J Cell Sci 132 (11) (2019)
   PUBMED   31076513
  REMARK    GeneRIF: The authors propose that DLC3 function is required to
            limit endosomal actin polymerization, Rab4-dependent recycling of
            MT1-MMP and, consequently, matrix degradation mediated by
            invadopodial activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4943)
  AUTHORS   Hendrick,J., Franz-Wachtel,M., Moeller,Y., Schmid,S., Macek,B. and
            Olayioye,M.A.
  TITLE     The polarity protein Scribble positions DLC3 at adherens junctions
            to regulate Rho signaling
  JOURNAL   J Cell Sci 129 (19), 3583-3596 (2016)
   PUBMED   27505894
  REMARK    GeneRIF: a new function for Scribble in Rho regulation that entails
            positioning of DLC3 GAP activity at cell junctions in polarized
            epithelial cells, is reported.
REFERENCE   6  (bases 1 to 4943)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4943)
  AUTHORS   Kawai,K., Kiyota,M., Seike,J., Deki,Y. and Yagisawa,H.
  TITLE     START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in
            focal adhesions regulating cell morphology
  JOURNAL   Biochem Biophys Res Commun 364 (4), 783-789 (2007)
   PUBMED   17976533
REFERENCE   8  (bases 1 to 4943)
  AUTHORS   Durkin,M.E., Ullmannova,V., Guan,M. and Popescu,N.C.
  TITLE     Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating
            protein, is downregulated in cancer and inhibits tumor cell growth
  JOURNAL   Oncogene 26 (31), 4580-4589 (2007)
   PUBMED   17297465
REFERENCE   9  (bases 1 to 4943)
  AUTHORS   Qian,X., Li,G., Asmussen,H.K., Asnaghi,L., Vass,W.C., Braverman,R.,
            Yamada,K.M., Popescu,N.C., Papageorge,A.G. and Lowy,D.R.
  TITLE     Oncogenic inhibition by a deleted in liver cancer gene requires
            cooperation between tensin binding and Rho-specific
            GTPase-activating protein activities
  JOURNAL   Proc Natl Acad Sci U S A 104 (21), 9012-9017 (2007)
   PUBMED   17517630
REFERENCE   10 (bases 1 to 4943)
  AUTHORS   Twigg,S.R., Matsumoto,K., Kidd,A.M., Goriely,A., Taylor,I.B.,
            Fisher,R.B., Hoogeboom,A.J., Mathijssen,I.M., Lourenco,M.T.,
            Morton,J.E., Sweeney,E., Wilson,L.C., Brunner,H.G., Mulliken,J.B.,
            Wall,S.A. and Wilkie,A.O.
  TITLE     The origin of EFNB1 mutations in craniofrontonasal syndrome:
            frequent somatic mosaicism and explanation of the paucity of
            carrier males
  JOURNAL   Am J Hum Genet 78 (6), 999-1010 (2006)
   PUBMED   16685650
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732324.6, BC035587.1 and
            AL360076.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001142503.2.
            
            Summary: This gene encodes a member of a subfamily of Rho GTPase
            activating proteins that contain a steroidogenic acute regulatory
            protein related lipid transfer domain. The encoded protein
            localizes to focal adhesions and may be involved in regulating cell
            morphology. This protein may also function as a tumor suppressor.
            [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749411.1, SRR14038196.2246014.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374599.8/ ENSP00000363727.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL732324.6         85287-85289
            4-102               BC035587.1         12-110
            103-262             AL732324.6         85389-85548
            263-296             AL732324.6         103120-103153
            297-368             AL360076.9         36474-36545
            369-450             AL360076.9         38854-38935
            451-514             AL360076.9         39928-39991
            515-1932            AL360076.9         40772-42189
            1933-2106           AL360076.9         42785-42958
            2107-2266           AL360076.9         43824-43983
            2267-2465           AL360076.9         44484-44682
            2466-2676           AL360076.9         45096-45306
            2677-2791           AL360076.9         45607-45721
            2792-3016           AL360076.9         45982-46206
            3017-3234           AL360076.9         47186-47403
            3235-3411           AL360076.9         47505-47681
            3412-4943           AL360076.9         47865-49396
FEATURES             Location/Qualifiers
     source          1..4943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..4943
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /note="StAR related lipid transfer domain containing 8"
                     /db_xref="GeneID:9754"
                     /db_xref="HGNC:HGNC:19161"
                     /db_xref="MIM:300689"
     exon            1..262
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..3529
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /note="isoform a is encoded by transcript variant 1; START
                     domain containing 8; deleted in liver cancer 3 protein;
                     StAR-related lipid transfer (START) domain containing 8"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 8 isoform a"
                     /protein_id="NP_001135975.1"
                     /db_xref="CCDS:CCDS48134.1"
                     /db_xref="GeneID:9754"
                     /db_xref="HGNC:HGNC:19161"
                     /db_xref="MIM:300689"
                     /translation="MPLLDVFWSCFRKVKCFPLLQVKKNAEAEAKRACEWLQATGFPQ
                     YVQLFEEGSFPLDIGSVKKNHGFLDEDSLGALCRRLMTLNNCASMKLEVHFQSKQNED
                     SEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGLPATSSCESVLTELSATSLPV
                     ITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKAKKRHRNRSFLKHLESLRR
                     KEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSGANTRK
                     AWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLCPEDGHRLADWQPGR
                     RWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDDIL
                     QHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHG
                     ESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPT
                     FASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPRERRDSGVGAS
                     LTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKYTVPH
                     KQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLD
                     QVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKL
                     TTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNL
                     AVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKL
                     FQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAER
                     FKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLL
                     RAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPV
                     PESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIR
                     DSFPTLQAAGPETKL"
     exon            263..296
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..368
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..450
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..514
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            515..1932
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2106
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2266
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2465
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2676
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2791
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..3016
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3234
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3411
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..4943
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4921..4926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /note="hexamer: AATAAA"
     polyA_site      4943
                     /gene="STARD8"
                     /gene_synonym="ARHGAP38; DLC3; STARTGAP3"
                     /note="major polyA site"
ORIGIN      
        1 ggtggccttc caggaggcgg gaggcgcccg ctgtcgaggc agctgagccc cggcaaccgc
       61 tgctctccgc ctctcccctc gcggggccgg ctcatggagc gcagggaccg ggctggctct
      121 cgccgagccc cgggcctctt ttagcctcgt ccccagagag ggaggagccg gtgcccggca
      181 cagccccgcc ggccctagaa gctccccacg cgccaccatg cctctgctgg acgttttctg
      241 gtcttgcttc aggaaggtga agtgcttccc attgctgcag gtgaagaaga acgctgaagc
      301 cgaggccaaa agagcatgtg agtggcttca agcaacagga ttccctcagt atgtgcagct
      361 ttttgaagaa ggttcgtttc ccctggatat tggctctgtg aagaaaaacc acggttttct
      421 ggacgaggac tctttggggg ccctgtgtag gaggctgatg accttgaata attgtgcctc
      481 gatgaaactg gaggttcatt ttcaaagcaa gcagaatgaa gactcagaag aggaagagca
      541 gtgtaccatc agtagccact gggccttcca gcaggaaagt aagtgctggt ctcctatggg
      601 gtcctctgat ctgttggccc caccgagccc tggcctgcca gcgacctcaa gctgtgagag
      661 cgtcctcacc gagcttagtg ccacctctct gccagtcatc accgtgagcc taccacccga
      721 gccagcagac ttgcccttgc caggccgtgc ccccagctcg agtgaccggc ccctcctcag
      781 ccccacccag ggccaggagg gtccccagga caaagccaag aagcgccatc gtaaccgtag
      841 cttcctcaag caccttgaat ctctgaggcg gaaggaaaag agtggcagcc agcaagcaga
      901 gcccaagcat agtccagcca cctcagagaa ggtctccaaa gcctcatctt tccgcagttg
      961 tcgtggcttc ctctcagctg gattttacag ggccaagaac tgggccgcca cctcagccgg
     1021 tggcagtggt gccaatactc ggaaggcctg ggaggcctgg cctgtggcct cgttccggca
     1081 tcctcagtgg acacaccggg gtgattgcct ggtgcacgtt cctggggacc acaaaccagg
     1141 cacattccct cgctccctgt ccattgagag cctgtgtcct gaggatggac accgcctggc
     1201 agactggcag ccaggtaggc ggtggggctg tgaggggcgc cggggctcct gtggctcaac
     1261 gggcagccat gccagcacgt atgacaactt gcctgagctg tacccagctg agcctgtaat
     1321 ggttggggct gaggctgaag atgaagatga tgaggagagt gggggcagct atgctcacct
     1381 agacgacatc ctccagcacg tgtgggggct acagcaacga gtagagctgt ggtctcgggc
     1441 catgtaccca gacctggggc ctggagatga ggaagaggag gaggccactt catcagtaga
     1501 aatagccaca gttgaggtca aatgccaagc tgaggctctc agccagatgg aggttccggc
     1561 ccatggagag tccccagcct gggcccaggc tgaagtccag ccagcagtcc tggctccggc
     1621 tcaggctcca gctgaggctg aaccagtggc acaggaagag gctgaggccc cggccccagc
     1681 cccggccccg gccccagccc aggacagtga gcaggaggca cattcaggcg gggaacccac
     1741 ctttgcctct agcctgtctg tggaagaagg acactccatt tctgacactg tggcctcctc
     1801 cagcgaactt gacagtagtg ggaactccat gaatgaggct gaggctgcgg ggcccctggc
     1861 tggactccag gcatcaatgc cccgtgaacg gcgcgattca ggtgttgggg cctcacttac
     1921 cagaccctgc aggaagctcc gttggcatag cttccagaac tcccatcgtc ccagcctcaa
     1981 ctcagagtcg ctggagatca accggcagtt tgcaggccag atcaacctcc tgcacaaggg
     2041 ctcactgctg cggcttaccg cgttcatgga gaagtacact gtgccccaca agcagggctg
     2101 ggtctggtca atgcccaagt tcatgaggag gaacaagacc ccagattacc ggggacagca
     2161 cgtatttggg gtgccacccc tcatccacgt gcagcgcacg ggccagccac tgccacagag
     2221 cattcagcaa gccatgcgct acttgcgcag ccagtgcctg gaccaagtag gcatcttccg
     2281 caagtctggg gtcaagtcca ggatccagaa cctgcgtcaa atgaatgaga cctcgcctga
     2341 caatgtctgc tacgagggcc agtcagccta cgacgtggct gacctgctaa agcagtattt
     2401 ccgggacctg cctgagccca tcttcaccag caagctcacc accactttcc tccagatcta
     2461 ccagctcctc cccaaggatc agtggttggc agcagcacaa gccgccacct tgctgctccc
     2521 cgatgagaac cgagaggtgc tacagaccct gctctacttc ttaagtgaca ttgcctctgc
     2581 cgaggaaaac cagatgacag caggcaacct ggcagtgtgc ctggcgccct ccatcttcca
     2641 cctcaatgtc tctaagaagg atagcccctc tcccaggatc aagagcaaac gcagcctcat
     2701 tggcaggcca ggccctaggg acctgagtga caacatggca gccacccagg gcctgtcgca
     2761 catgatcagt gactgcaaga aacttttcca ggtgccccag gacatggtgc tgcagctgtg
     2821 cagctcctac agcgcagctg agctcagccc tcccggccca gccctggctg agctgcgtca
     2881 ggcccaagct gcaggggtaa gcctgagcct ctacatggaa gagaatatcc aggacctgct
     2941 gcgtgatgct gctgagcgct tcaagggctg gatgagcgtg ccagggcccc agcacacgga
     3001 gctggcttgc aggaaggcac cggatgggca ccccctgcgg ctatggaagg catccacaga
     3061 ggtggcagcc cccccagctg tggtgctgca tcgtgttctc cgggagcggg ccctctggga
     3121 tgaggatctg ctgcgggccc aggtgctgga agccctgatg ccgggtgtgg agctgtacca
     3181 ctatgtcacc gacagcatgg caccccatcc ctgccgcgac tttgtggtgc ttcggatgtg
     3241 gcgctctgac ctgcctcgtg ggggttgcct gcttgtctcc cagtccctgg atccggaaca
     3301 acctgtgcca gagtcgggtg tgcgagccct catgctcaca tcccagtacc tcatggagcc
     3361 ttgcggcttg ggccgctctc ggctcacaca catctgccgg gctgacctca ggggccgttc
     3421 tcctgactgg tacaacaaag tctttggaca cctgtgtgcc atggaagtgg caaagatccg
     3481 ggactccttc cccaccctgc aggcagcggg ccctgagaca aagctgtgag ccttgggctg
     3541 gtcccagggt ggcaccaccc aggccccctg ggcaccaagg gagcgagggg gaataagagc
     3601 agggcagccc cctgggtgcc gctgtcagga gcagagccag gcccaggtgg ctccagctgc
     3661 ctgtcctgtc ccctttccta aagctcctct gcacatagag gggagaaaaa gagaatttag
     3721 gcaactccac tcccccttca cccccaaccc tgtattctac tctcccgaaa agagaagaga
     3781 atcgcatgag tagcaagact gctgccacca gccacctgct tgtgaggccg ccacttggca
     3841 tgaagcctcc acagctcccc gcctgcaggg gcaaagaggt cgacagcaat gtgtgatccc
     3901 agctctctgc cagactgaga gggcaagccg tcttgtttgc tgcaaggatg cttttgaggt
     3961 tggacaggag gttctggtcc tgcctttggg gccaacgctg gctctgaagt gtctttttca
     4021 gaggaattgg actggagtga atgggcacag gggtggagcg cagggcagcc ccagtcacca
     4081 cgagctgttt catttgtgta aatacgatgc tgaattttat gaggctgagt taagagtggg
     4141 cactgacggg cccctaatat gtgacatgac gatttggcat agatagggat gtgagagtgg
     4201 agtaccttcc tttctcaagt ctcgagatgc cagtgaaacc agtattccct gacttgggtt
     4261 tcacacttta tcgaccaccc catggggtcc tgtgtagcct ttggccacgc actgacactg
     4321 cccaggccaa gcaaaagcag agtgtggtta agagacaagg gtctatgtca tcatcccttt
     4381 tgcttatggt agtgggctaa cataacagcc cctttctcaa gcagagacct ggcccctggg
     4441 ccagccagat ggaagggcct atcttagcca gctggagctt aagccaaacc tgttctgtcc
     4501 cactggccag ccatctttgc tcacatggaa attcaaatgc cattcaaagg ccactggtgc
     4561 tttatttttc tatctgctga gtaaactgaa atgagatggg tcccaaccac cactgtaatt
     4621 ttcaagccta ttttatttgt acctgtaaat actgtacagc taatatatat atatatatat
     4681 atatatgtgt gtgtgtgtgt gtgtgtatat gtgtttatag agatacacac acatatatat
     4741 gtgtgtatat atatacacat acatatatat acacacacgc atttgcacag acacacacat
     4801 atatcaattc tcatgagtgt attataatct ctggtggggg caagtgtctg gaaggcctga
     4861 ggggcacttc agatgagaat ggagaggtag ggagccaggt gcagcaggat ccctcaaatc
     4921 aataaagcat taccagagat gca
//
