LOCUS       NM_139164               4631 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens StAR related lipid transfer domain containing 4
            (STARD4), transcript variant 1, mRNA.
ACCESSION   NM_139164
VERSION     NM_139164.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4631)
  AUTHORS   Yahya,N.A., King,S.R., Shi,B., Shaaban,A., Whitfield,N.E., Yan,C.,
            Kordus,R.J., Whitman-Elia,G.F. and LaVoie,H.A.
  TITLE     Differential regulation of STARD1, STARD4 and STARD6 in the human
            ovary
  JOURNAL   J Endocrinol 262 (2), e230385 (2024)
   PUBMED   38829257
  REMARK    GeneRIF: Differential regulation of STARD1, STARD4 and STARD6 in
            the human ovary.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4631)
  AUTHORS   Talandashti,R., van Ek,L., Gehin,C., Xue,D., Moqadam,M., Gavin,A.C.
            and Reuter,N.
  TITLE     Membrane specificity of the human cholesterol transfer protein
            STARD4
  JOURNAL   J Mol Biol 436 (11), 168572 (2024)
   PUBMED   38615744
  REMARK    GeneRIF: Membrane specificity of the human cholesterol transfer
            protein STARD4.
REFERENCE   3  (bases 1 to 4631)
  AUTHORS   Yue,X., Kong,Y., Zhang,Y., Sun,M., Liu,S., Wu,Z., Gao,L., Liang,X.
            and Ma,C.
  TITLE     SREBF2-STARD4 axis confers sorafenib resistance in hepatocellular
            carcinoma by regulating mitochondrial cholesterol homeostasis
  JOURNAL   Cancer Sci 114 (2), 477-489 (2023)
   PUBMED   35642354
  REMARK    GeneRIF: SREBF2-STARD4 axis confers sorafenib resistance in
            hepatocellular carcinoma by regulating mitochondrial cholesterol
            homeostasis.
REFERENCE   4  (bases 1 to 4631)
  AUTHORS   Huang,T., Shan,R., Zhang,M., Li,L., Huang,J., Liu,B. and Zhou,W.
  TITLE     [Steroidogenic acute regulatory protein-related lipid transfer 4
            (StarD4) promotes breast cancer cell proliferation and its
            mechanism]
  JOURNAL   Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 38 (6), 1118-1125 (2021)
   PUBMED   34970895
  REMARK    GeneRIF: [Steroidogenic acute regulatory protein-related lipid
            transfer 4 (StarD4) promotes breast cancer cell proliferation and
            its mechanism].
REFERENCE   5  (bases 1 to 4631)
  AUTHORS   Zhang,M., Xiang,Z., Wang,F., Shan,R., Li,L., Chen,J., Liu,B.A.,
            Huang,J., Sun,L.Q. and Zhou,W.B.
  TITLE     STARD4 promotes breast cancer cell malignancy
  JOURNAL   Oncol Rep 44 (6), 2487-2502 (2020)
   PUBMED   33125124
  REMARK    GeneRIF: STARD4 promotes breast cancer cell malignancy.
REFERENCE   6  (bases 1 to 4631)
  AUTHORS   Rodriguez-Agudo,D., Ren,S., Wong,E., Marques,D., Redford,K.,
            Gil,G., Hylemon,P. and Pandak,W.M.
  TITLE     Intracellular cholesterol transporter StarD4 binds free cholesterol
            and increases cholesteryl ester formation
  JOURNAL   J Lipid Res 49 (7), 1409-1419 (2008)
   PUBMED   18403318
  REMARK    GeneRIF: StarD4 plays an important role as a directional
            cholesterol transporter in the maintenance of cellular cholesterol
            homeostasis
REFERENCE   7  (bases 1 to 4631)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   8  (bases 1 to 4631)
  AUTHORS   Yamada,S., Yamaguchi,T., Hosoda,A., Iwawaki,T. and Kohno,K.
  TITLE     Regulation of human STARD4 gene expression under endoplasmic
            reticulum stress
  JOURNAL   Biochem Biophys Res Commun 343 (4), 1079-1085 (2006)
   PUBMED   16579971
  REMARK    GeneRIF: Induction of STARD4 depended on both transcription factor
            ATF6 and an ERSE-like element in its promoter.
REFERENCE   9  (bases 1 to 4631)
  AUTHORS   Soccio,R.E., Adams,R.M., Maxwell,K.N. and Breslow,J.L.
  TITLE     Differential gene regulation of StarD4 and StarD5 cholesterol
            transfer proteins. Activation of StarD4 by sterol regulatory
            element-binding protein-2 and StarD5 by endoplasmic reticulum
            stress
  JOURNAL   J Biol Chem 280 (19), 19410-19418 (2005)
   PUBMED   15760897
  REMARK    GeneRIF: StarD4 is regulated by sterols via SREBP-2, and StarD5 is
            activated by ER stress cholesterol metabolism; they serve different
            functions
REFERENCE   10 (bases 1 to 4631)
  AUTHORS   Soccio,R.E., Adams,R.M., Romanowski,M.J., Sehayek,E., Burley,S.K.
            and Breslow,J.L.
  TITLE     The cholesterol-regulated StarD4 gene encodes a StAR-related lipid
            transfer protein with two closely related homologues, StarD5 and
            StarD6
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6943-6948 (2002)
   PUBMED   12011452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB475661.1, AK054566.1, AK125317.1, BI091150.1, AK026207.1 and
            BU607573.1.
            
            On Nov 22, 2018 this sequence version replaced NM_139164.2.
            
            Summary: Cholesterol homeostasis is regulated, at least in part, by
            sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM
            184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon
            sterol depletion, LXRs are inactive and SREBPs are cleaved, after
            which they bind promoter SREs and activate genes involved in
            cholesterol biosynthesis and uptake. Sterol transport is mediated
            by vesicles or by soluble protein carriers, such as steroidogenic
            acute regulatory protein (STAR; MIM 600617). STAR is homologous to
            a family of proteins containing a 200- to 210-amino acid
            STAR-related lipid transfer (START) domain, including STARD4
            (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Both variants 1 and 2 encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP281046.1, SRR1660803.157181.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296632.8/ ENSP00000296632.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DB475661.1         67-142
            77-1704             AK054566.1         1-1628
            1705-2747           AK125317.1         1488-2530
            2748-3295           BI091150.1         164-711
            3296-4130           AK026207.1         143-977
            4131-4631           BU607573.1         15-515              c
FEATURES             Location/Qualifiers
     source          1..4631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..4631
                     /gene="STARD4"
                     /note="StAR related lipid transfer domain containing 4"
                     /db_xref="GeneID:134429"
                     /db_xref="HGNC:HGNC:18058"
                     /db_xref="MIM:607049"
     exon            1..151
                     /gene="STARD4"
                     /inference="alignment:Splign:2.1.0"
     exon            152..265
                     /gene="STARD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..778
                     /gene="STARD4"
                     /note="isoform a is encoded by transcript variant 1; START
                     domain containing 4, sterol regulated; stAR-related lipid
                     transfer protein 4; START domain-containing protein 4;
                     StAR-related lipid transfer (START) domain containing 4"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 4 isoform a"
                     /protein_id="NP_631903.1"
                     /db_xref="CCDS:CCDS4104.1"
                     /db_xref="GeneID:134429"
                     /db_xref="HGNC:HGNC:18058"
                     /db_xref="MIM:607049"
                     /translation="MEGLSDVASFATKLKNTLIQYHSIEEDKWRVAKKTKDVTVWRKP
                     SEEFNGYLYKAQGVIDDLVYSIIDHIRPGPCRLDWDSLMTSLDILENFEENCCVMRYT
                     TAGQLWNIISPREFVDFSYTVGYKEGLLSCGISLDWDEKRPEFVRGYNHPCGWFCVPL
                     KDNPNQSLLTGYIQTDLRGMIPQSAVDTAMASTLTNFYGDLRKAL"
     exon            266..315
                     /gene="STARD4"
                     /inference="alignment:Splign:2.1.0"
     exon            316..442
                     /gene="STARD4"
                     /inference="alignment:Splign:2.1.0"
     exon            443..557
                     /gene="STARD4"
                     /inference="alignment:Splign:2.1.0"
     exon            558..4631
                     /gene="STARD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4605..4610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD4"
                     /note="hexamer: AATAAA"
     polyA_site      4631
                     /gene="STARD4"
                     /note="major polyA site"
ORIGIN      
        1 agttggctgc gaccagcggt gacttacaag ttggctgctg tcgcctgcgc atcggcgggc
       61 cgggaggctg agcagtactg ttgagagcgg tgtgaggtgc ttggtagcgc gccgtagctg
      121 cttccacgtc cttgcttcac ctcaggtaaa gagagaagta atggaaggcc tgtctgatgt
      181 tgcttctttt gcaactaaac ttaaaaacac tctcatccag taccatagca ttgaagaaga
      241 taagtggcga gttgctaaga aaacgaaaga tgtaactgtt tggagaaaac cctcagaaga
      301 atttaatgga tatctctaca aagcccaagg tgttatagat gaccttgtct atagtataat
      361 agaccatata cgcccagggc cttgtcgttt ggattgggac agcttgatga cttctttgga
      421 tattctggag aactttgaag agaattgctg tgtgatgcgt tacactactg ctggtcagct
      481 ttggaatata atttccccaa gagaatttgt tgatttctcc tatactgtgg gctataaaga
      541 agggctttta tcttgtggaa taagtcttga ctgggatgaa aagagaccag aatttgttcg
      601 aggatataac catccctgtg gttggttttg tgttccactt aaagacaacc caaaccagag
      661 tcttttgaca ggatatattc agacagatct gcgtgggatg attcctcagt ctgcggtaga
      721 tacagccatg gcaagcactt taaccaactt ctatggtgat ttacgaaaag ctttatgaga
      781 ggcaaaatac attcaaactt gtagtactac agatcaactc tctcagctac atggcctgta
      841 aaaatcattg attccacttt tctgcatagc cggtagaaaa atttgaaatg tttttggttc
      901 actagtacaa tgtttggttt tattcctaaa gtaaatagct atctaagaga gggcattttc
      961 actttttttt ttttaaattt tgagacaggc tctcactctg ttgcccatgc tggagggcag
     1021 tggtatgatc acagctcact gcagctttga tctgaccgct caaggggtta ttctacctca
     1081 gcctcctgaa tagctgggaa tacaggtgca cgccactatg catggctaat ttttgtttaa
     1141 ttttttgtag agatgtggtc acactgtgtt gcccaggctg gtcttgaact cctggcctca
     1201 agtcattccc caccttagcc tcccaaagtg ttgggattat aagcgtgagc caccatgcct
     1261 ggccccaatt taaaatgtgg aattcagttg gtgtccaaga cttatcttga gactcttaaa
     1321 agcatcagtc tgtaactaga acaaatacag tcttagattt acccaagtgc ctagatatca
     1381 ttttataatg attagaattg agtattgtgg gtcccctaat tctgtgggtg ccttaagtga
     1441 gaatttctaa atgattttca cattctaaat gactttgggt tttgaactct ccatctagtt
     1501 tacttctaaa atgggaactt gaggcaattc aggtatccag gcaaatcttt gtatatattt
     1561 ttttgtgtac atgcacacat ctcgaaatcc atttccgtgt ttaatgttag ttgtttatgt
     1621 gttagtattc ctgtgtctac tgttttgttg ttgttaatat gggtaaagtg agccctgaaa
     1681 tacatgctaa acaagacatg aaatgcagaa aggtacatag tgtttcaagt gcatggtagt
     1741 ttgatctgtg ttttacttta ttgtgttttc ttgagtgtaa agaaagaata aatcaaagtt
     1801 cttcataccc attttgacaa agtggaacag tggagctgtt ttttgctttt gtttttattt
     1861 attttttgcc actggtgatg atagatttca aaaaacaaaa ggtggcagca gcacaatgtt
     1921 catggtgaat tatctcatag tatctagatt gatcaagatc tgacagaagg aatgcacaaa
     1981 ggattctata ttcttaatga tttattaatt accaggatcc ttttctaaat tgaatgtact
     2041 tttgaattac taggtttctt cttttttttt gttctgcaat agtgaaagaa aactcagtag
     2101 tttagtttca gtttctcatg gaaattggta aatgttagtt ttgacttcat ctatttttta
     2161 tttgttttta ttagcgtaga gtaggaagtc tcatattcta ctgttctatc taggatggtg
     2221 aaattccaaa ggtgcctaac ttgagtaagg gatttgtgac aagatagtac acattactat
     2281 aagggctatt atttcctgaa ctggatgtcc ctaaaagcaa ataaactgcc cactatctct
     2341 actctagtgc tctctttgtc cttatcaaca tatacctcca ataagtaatt acataattca
     2401 ccgttaaaca tggacccact ctaggtaaaa ttaccctcat ggaaacattt tcactgtgag
     2461 aatgatgaat ttaaaaatta tgtttgaatc acctaaaatg tatgtgcagc ttctagatgg
     2521 ccccttagat ctgctgggct ctagctgtgt actttaaaaa aacaaaaaca gctttattga
     2581 tatataattt acatattatg taatttaccc acttttaagt atctaattca gtgatgtttt
     2641 aatacatatg tagaactatg cagccatcag cacaatctgg atttagaacg tttccatcat
     2701 tccaaaagat tccttttgtc ttttttgcag actcatacct aacacaaatc taaagtttat
     2761 cactgttgcc aggataatta cagcaggtta tgtttggttt catttttaag agtggaggtg
     2821 ttcatgattc taagctcagg aatcttgtga tcatgtatta aatatgttat ctcatactat
     2881 aatgataaaa aagcttaatg atgtgggttg ggatggatat taacataaat aattgagtcc
     2941 gctgcttcta tagcaatgct gtaggataga acaataatgt aagtgatata tgtaattaaa
     3001 aaattctaga agccacatta aaaaataaaa ataaacagct gaagttaatt ttaatatttt
     3061 atttaactca atacatccaa aatgttatca ttttaacatg taattgatgt aaagatttat
     3121 tctgatagtt tgtactattt cttgtactaa ttttttgaaa tctggtatgc attttacaaa
     3181 tttgggcaag ccacatttta agtgctcatt agccacatga ggccagtgga tactgtattg
     3241 aatagcacag tcctatagca tatttattaa tttgtcttgt agtaagatga aatagacaat
     3301 aatacggaat aatatcttaa atggaaatct ttgttagtct ctagagcctt cattgcttga
     3361 taaataggac atctaaactt tagatataaa tcagttgtca atgagataaa attattgcca
     3421 gcaaatattt tccttcaaag ataagtaact tttgatatgg cagttggtga aatgaaagaa
     3481 tataatctgc cttcttgtta aatggttgac tattctgtag cttgtaggta gtacgtatta
     3541 gaaacttgtg tatgtgggaa atatttggca taatactgtt ttcagtatat agtagctatt
     3601 ttttaaggaa attagtttca tacaagaaaa agattattat aaaagtgata cttttgcatg
     3661 aaatattagt ttgtgttgat aactcttagt taacccttaa agtttaaaac agtactcaaa
     3721 aaaaaataat gagaatctag tattctgtag ttaactaatc tataagataa attgctaaag
     3781 tactagggag cttgtaaatc ttaaaaatct ttttatttca gtgttcattc aggttggata
     3841 tatttgaaat tgtagatttc tatctgtaca acatctccta gttaatagaa tttttttcct
     3901 tcccctccct tctctctcct cctccttttc taaccaaagg gcattttatc aacaatcatg
     3961 ctgaattcaa ttaatatctc aagctaaaaa actatgtaat tgaggttgta tctggagaag
     4021 atgggaaaac attgtataat ttaagccctt aattgtctgt tgagctttta gggctgagta
     4081 attgcctttc atacaaataa aagctttaac tcttttctca agagtgtacc accgtcctta
     4141 gaatcaggtg ttttaaatcc agtttctttt aattaaatgg gactgtagtg atccctaccc
     4201 tgtagagaaa tcaacagaac tagagaagct aagggcttga tcaggtttcc cctagaacct
     4261 gtgttgcctg cctgctgtat cttccatgtc tttcttattc aacttctaga agtagagaag
     4321 gttgggactt gagtgtagaa gaaacatcag aataatttca aaaaacagga agttggaact
     4381 ataattttta aattattgta ttgtttttac ggattttaca tgtatagtta aatattaaaa
     4441 ttcatctctt gcagttcaat aaaagctata gtatagattt tatttttaag aagtttatat
     4501 aattcttttg tgaaccaata tgtaaaacta gaatatttat taaactaata atatgtatta
     4561 gtatcaataa aatatgtatt tatttttaaa ttggtatgaa acaaaataaa aatttgtaga
     4621 cactcttaaa a
//
