LOCUS       NM_032016               1703 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens STARD3 N-terminal like (STARD3NL), transcript variant
            1, mRNA.
ACCESSION   NM_032016
VERSION     NM_032016.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1703)
  AUTHORS   Xu,Y., Bao,X., Chen,X., Wu,P., Chen,S., Zhang,B., Ma,J., Xu,G. and
            Ma,D.
  TITLE     STARD3NL inhibits the osteogenic differentiation by inactivating
            the Wnt/beta-catenin pathway via binding to Annexin A2 in
            osteoporosis
  JOURNAL   J Cell Mol Med 26 (5), 1643-1655 (2022)
   PUBMED   35098646
  REMARK    GeneRIF: STARD3NL inhibits the osteogenic differentiation by
            inactivating the Wnt/beta-catenin pathway via binding to Annexin A2
            in osteoporosis.
REFERENCE   2  (bases 1 to 1703)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1703)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1703)
  AUTHORS   Di Mattia,T., Wilhelm,L.P., Ikhlef,S., Wendling,C., Spehner,D.,
            Nomine,Y., Giordano,F., Mathelin,C., Drin,G., Tomasetto,C. and
            Alpy,F.
  TITLE     Identification of MOSPD2, a novel scaffold for endoplasmic
            reticulum membrane contact sites
  JOURNAL   EMBO Rep 19 (7) (2018)
   PUBMED   29858488
REFERENCE   5  (bases 1 to 1703)
  AUTHORS   Rivadeneira,F., Styrkarsdottir,U., Estrada,K., Halldorsson,B.V.,
            Hsu,Y.H., Richards,J.B., Zillikens,M.C., Kavvoura,F.K., Amin,N.,
            Aulchenko,Y.S., Cupples,L.A., Deloukas,P., Demissie,S.,
            Grundberg,E., Hofman,A., Kong,A., Karasik,D., van Meurs,J.B.,
            Oostra,B., Pastinen,T., Pols,H.A., Sigurdsson,G., Soranzo,N.,
            Thorleifsson,G., Thorsteinsdottir,U., Williams,F.M., Wilson,S.G.,
            Zhou,Y., Ralston,S.H., van Duijn,C.M., Spector,T., Kiel,D.P.,
            Stefansson,K., Ioannidis,J.P. and Uitterlinden,A.G.
  CONSRTM   Genetic Factors for Osteoporosis (GEFOS) Consortium
  TITLE     Twenty bone-mineral-density loci identified by large-scale
            meta-analysis of genome-wide association studies
  JOURNAL   Nat Genet 41 (11), 1199-1206 (2009)
   PUBMED   19801982
REFERENCE   6  (bases 1 to 1703)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 1703)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   8  (bases 1 to 1703)
  AUTHORS   Alpy,F. and Tomasetto,C.
  TITLE     MLN64 and MENTHO, two mediators of endosomal cholesterol transport
  JOURNAL   Biochem Soc Trans 34 (Pt 3), 343-345 (2006)
   PUBMED   16709157
  REMARK    GeneRIF: In this review, MENTHO defines discrete
            cholesterol-containing subdomains within the membrane of late
            endosomes where they may function in cholesterol transport.
            Review article
REFERENCE   9  (bases 1 to 1703)
  AUTHORS   Alpy,F., Latchumanan,V.K., Kedinger,V., Janoshazi,A., Thiele,C.,
            Wendling,C., Rio,M.C. and Tomasetto,C.
  TITLE     Functional characterization of the MENTAL domain
  JOURNAL   J Biol Chem 280 (18), 17945-17952 (2005)
   PUBMED   15718238
  REMARK    GeneRIF: The MENTAL (MLN64 amino-terminal shared with MENTHO)
            domain might serve to maintain cholesterol at the membrane of late
            endosomes prior to its shuttle to cytoplasmic acceptor(s).
REFERENCE   10 (bases 1 to 1703)
  AUTHORS   Alpy,F., Wendling,C., Rio,M.C. and Tomasetto,C.
  TITLE     MENTHO, a MLN64 homologue devoid of the START domain
  JOURNAL   J Biol Chem 277 (52), 50780-50787 (2002)
   PUBMED   12393907
  REMARK    GeneRIF: overexpression does not rescue the Niemann-Pick type C
            lipid storage phenotype; overexpression alters severely the
            endocytic compartment by leading at steady state to the
            accumulation of enlarged endosomes
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DT218211.1 and AJ492267.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_032016.3.
            
            Summary: This gene encodes a late-endosomal protein that contains a
            conserved MENTAL (MLN64 N-terminal) domain. The encoded protein
            binds cholesterol molecules and may play a role in endosomal
            cholesterol transport through interactions with metastatic lymph
            node protein 64 (MLN64). [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.259540.1,
                                           SRR1803613.194392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000009041.12/ ENSP00000009041.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                DT218211.1         40-125
            87-1703             AJ492267.1         1-1617
FEATURES             Location/Qualifiers
     source          1..1703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..1703
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /note="STARD3 N-terminal like"
                     /db_xref="GeneID:83930"
                     /db_xref="HGNC:HGNC:19169"
                     /db_xref="MIM:611759"
     exon            1..176
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     exon            177..459
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..939
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /note="isoform 1 is encoded by transcript variant 1; MLN64
                     N-terminal domain homolog; STARD3 N-terminal-like protein"
                     /codon_start=1
                     /product="STARD3 N-terminal-like protein isoform 1"
                     /protein_id="NP_114405.1"
                     /db_xref="CCDS:CCDS5455.1"
                     /db_xref="GeneID:83930"
                     /db_xref="HGNC:HGNC:19169"
                     /db_xref="MIM:611759"
                     /translation="MNHLPEDMENALTGSQSSHASLRNIHSINPTQLMARIESYEGRE
                     KKGISDVRRTFCLFVTFDLLFVTLLWIIELNVNGGIENTLEKEVMQYDYYSSYFDIFL
                     LAVFRFKVLILAYAVCRLRHWWAIALTTAVTSAFLLAKVILSKLFSQGAFGYVLPIIS
                     FILAWIETWFLDFKVLPQEAEEENRLLIVQDASERAALIPGGLSDGQFYSPPESEAGS
                     EEAEEKQDSEKPLLEL"
     exon            460..537
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     exon            538..615
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     exon            616..669
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     exon            670..787
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     exon            788..883
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     exon            884..956
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1703
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /note="hexamer: AATAAA"
     polyA_site      1444
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /note="hexamer: ATTAAA"
     polyA_site      1703
                     /gene="STARD3NL"
                     /gene_synonym="MENTHO"
                     /note="major polyA site"
ORIGIN      
        1 gacgtcacgg gccggaggtc ccggggctgc tgggtgcggg cggtgggctg cgcgttgtcc
       61 gctggactgg gtcccggtca cgccccgcca agccccgccc ctcaggccgg ggcgcgaccg
      121 cggatccgca gttcccgggc cagcctgggg cggccggcca ggaaccaccc gttaaggtgt
      181 cttctcttta gggatggtga ggttggaaaa aggctcctgt aaccctcctc caggatgaac
      241 cacctgccag aagacatgga gaacgctctc accgggagcc agagctccca tgcttctctg
      301 cgcaatatcc attccatcaa ccccacacaa ctcatggcca ggattgagtc ctatgaagga
      361 agggaaaaga aaggcatatc tgatgtcagg aggactttct gtttgtttgt cacctttgac
      421 ctcttattcg taacattact gtggataata gagttaaatg tgaatggagg cattgagaac
      481 acattagaga aggaggtgat gcagtatgac tactattctt catattttga tatatttctt
      541 ctggcagttt ttcgatttaa agtgttaata cttgcatatg ctgtgtgcag actgcgccat
      601 tggtgggcaa tagcgttgac aacggcagtg accagtgcct ttttactagc aaaagtgatc
      661 ctttcgaagc ttttctctca aggggctttt ggctatgtgc tgcccatcat ttcattcatc
      721 cttgcctgga ttgagacgtg gttcctggat ttcaaagtgt tacctcaaga agcagaagaa
      781 gaaaacagac tcctgatagt tcaggatgct tcagagaggg cagcacttat acctggtggt
      841 ctttctgatg gtcagtttta ttcccctcct gaatccgaag caggatctga agaagctgaa
      901 gaaaaacagg acagtgagaa accactttta gaactatgag tactactttt gttaaatgtg
      961 aaaaaccctc acagaaagtc atcgaggcaa aaagaggcag gcagtggagt ctccctgtcg
     1021 acagtaaagt tgaaatggtg acgtccactg ctggctttat tgaacagcta ataaagattt
     1081 atttattgta atacctcaca gacgttgtac catatccatg cacatttagt tgcctgcctg
     1141 tggctggtaa ggtaatgtca tgattcatcc tctcttcagt gagactgagc ctgatgtgtt
     1201 aacaaatagg tgaagaaagt cttgtgctgt attcctaatc aaaagactta atatattgaa
     1261 gtaacacttt tttagtaagc aagatacctt tttatttcaa ttcacagaat ggaatttttt
     1321 tgtttcatgt ctcagattta ttttgtattt cttttttaac actctacatt tcccttgttt
     1381 tttaactcat gcacatgtgc tctttgtaca gttttaaaaa gtgtaataaa atctgacatg
     1441 tcaatgtggc tagttttatt tttcttgttt tgcattatgt gtatggcctg aagtgttgga
     1501 cttgcaaaag gggaagaaag gaattgcgaa tacatgtaaa atgtcaccag acatttgtat
     1561 tatttttatc atgaaatcat gtttttctct gattgttctg aaatgttcta aatactctta
     1621 ttttgaatgc acaaaatgac ttaaaccatt catatcatgt ttcctttgcg ttcagccaat
     1681 ttcaattaaa atgaactaaa tta
//
