LOCUS       NM_006804               2770 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens StAR related lipid transfer domain containing 3
            (STARD3), transcript variant 1, mRNA.
ACCESSION   NM_006804
VERSION     NM_006804.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2770)
  AUTHORS   Li,A.X., Zeng,J.J., Khan,E., Dou,Q.P., Zhuang,X., Ji,E.K., Ruge,F.,
            Martin,T.A., Jia,S. and Jiang,W.G.
  TITLE     Metastatic Lymph Node 64 (MLN64) Expression in Gastric Cancer: The
            Clinical and Molecular Implications in Drug Resistance
  JOURNAL   Cancer Genomics Proteomics 21 (1), 30-40 (2024)
   PUBMED   38151289
  REMARK    GeneRIF: Metastatic Lymph Node 64 (MLN64) Expression in Gastric
            Cancer: The Clinical and Molecular Implications in Drug Resistance.
REFERENCE   2  (bases 1 to 2770)
  AUTHORS   Lim,J.M., Sabbasani,V.R., Swenson,R.E. and Levine,R.L.
  TITLE     Methionine sulfoxide reductases and cholesterol transporter STARD3
            constitute an efficient system for detoxification of cholesterol
            hydroperoxides
  JOURNAL   J Biol Chem 299 (9), 105099 (2023)
   PUBMED   37507014
  REMARK    GeneRIF: Methionine sulfoxide reductases and cholesterol
            transporter STARD3 constitute an efficient system for
            detoxification of cholesterol hydroperoxides.
REFERENCE   3  (bases 1 to 2770)
  AUTHORS   Nara,A., Inoue,A., Aoyama,Y. and Yazawa,T.
  TITLE     The ultrastructural function of MLN64 in the late
            endosome-mitochondria membrane contact sites in placental cells
  JOURNAL   Exp Cell Res 429 (2), 113668 (2023)
   PUBMED   37245582
  REMARK    GeneRIF: The ultrastructural function of MLN64 in the late
            endosome-mitochondria membrane contact sites in placental cells.
REFERENCE   4  (bases 1 to 2770)
  AUTHORS   Jose,J., Hoque,M., Engel,J., Beevi,S.S., Wahba,M., Georgieva,M.I.,
            Murphy,K.J., Hughes,W.E., Cochran,B.J., Lu,A., Tebar,F., Hoy,A.J.,
            Timpson,P., Rye,K.A., Enrich,C., Rentero,C. and Grewal,T.
  TITLE     Annexin A6 and NPC1 regulate LDL-inducible cell migration and
            distribution of focal adhesions
  JOURNAL   Sci Rep 12 (1), 596 (2022)
   PUBMED   35022465
  REMARK    GeneRIF: Annexin A6 and NPC1 regulate LDL-inducible cell migration
            and distribution of focal adhesions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2770)
  AUTHORS   Alpy,F., Stoeckel,M.E., Dierich,A., Escola,J.M., Wendling,C.,
            Chenard,M.P., Vanier,M.T., Gruenberg,J., Tomasetto,C. and Rio,M.C.
  TITLE     The steroidogenic acute regulatory protein homolog MLN64, a late
            endosomal cholesterol-binding protein
  JOURNAL   J Biol Chem 276 (6), 4261-4269 (2001)
   PUBMED   11053434
REFERENCE   6  (bases 1 to 2770)
  AUTHORS   Bose,H.S., Whittal,R.M., Huang,M.C., Baldwin,M.A. and Miller,W.L.
  TITLE     N-218 MLN64, a protein with StAR-like steroidogenic activity, is
            folded and cleaved similarly to StAR
  JOURNAL   Biochemistry 39 (38), 11722-11731 (2000)
   PUBMED   10995240
REFERENCE   7  (bases 1 to 2770)
  AUTHORS   Tsujishita,Y. and Hurley,J.H.
  TITLE     Structure and lipid transport mechanism of a StAR-related domain
  JOURNAL   Nat Struct Biol 7 (5), 408-414 (2000)
   PUBMED   10802740
REFERENCE   8  (bases 1 to 2770)
  AUTHORS   Akiyama,N., Sasaki,H., Ishizuka,T., Kishi,T., Sakamoto,H., Onda,M.,
            Hirai,H., Yazaki,Y., Sugimura,T. and Terada,M.
  TITLE     Isolation of a candidate gene, CAB1, for cholesterol transport to
            mitochondria from the c-ERBB-2 amplicon by a modified cDNA
            selection method
  JOURNAL   Cancer Res 57 (16), 3548-3553 (1997)
   PUBMED   9270027
REFERENCE   9  (bases 1 to 2770)
  AUTHORS   Watari,H., Arakane,F., Moog-Lutz,C., Kallen,C.B., Tomasetto,C.,
            Gerton,G.L., Rio,M.C., Baker,M.E. and Strauss,J.F. 3rd.
  TITLE     MLN64 contains a domain with homology to the steroidogenic acute
            regulatory protein (StAR) that stimulates steroidogenesis
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8462-8467 (1997)
   PUBMED   9237999
REFERENCE   10 (bases 1 to 2770)
  AUTHORS   Moog-Lutz,C., Tomasetto,C., Regnier,C.H., Wendling,C., Lutz,Y.,
            Muller,D., Chenard,M.P., Basset,P. and Rio,M.C.
  TITLE     MLN64 exhibits homology with the steroidogenic acute regulatory
            protein (STAR) and is over-expressed in human breast carcinomas
  JOURNAL   Int J Cancer 71 (2), 183-191 (1997)
   PUBMED   9139840
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008356.1 and AC087491.5.
            
            On Nov 23, 2018 this sequence version replaced NM_006804.3.
            
            Summary: This gene encodes a member of a subfamily of lipid
            trafficking proteins that are characterized by a C-terminal
            steroidogenic acute regulatory domain and an N-terminal metastatic
            lymph node 64 domain. The encoded protein localizes to the
            membranes of late endosomes and may be involved in exporting
            cholesterol. Alternative splicing results in multiple transcript
            variants.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008356.1, AK225069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336308.10/ ENSP00000337446.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2053              BC008356.1         16-2068
            2054-2770           AC087491.5         94084-94800
FEATURES             Location/Qualifiers
     source          1..2770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2770
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /note="StAR related lipid transfer domain containing 3"
                     /db_xref="GeneID:10948"
                     /db_xref="HGNC:HGNC:17579"
                     /db_xref="MIM:607048"
     exon            1..88
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            89..358
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1477
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /note="isoform 1 is encoded by transcript variant 1;
                     steroidogenic acute regulatory protein related;
                     stAR-related lipid transfer protein 3; metastatic lymph
                     node protein 64; MLN 64; START domain-containing protein
                     3; metastatic lymph node gene 64 protein; StAR-related
                     lipid transfer (START) domain containing 3"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 3 isoform 1"
                     /protein_id="NP_006795.3"
                     /db_xref="CCDS:CCDS11341.1"
                     /db_xref="GeneID:10948"
                     /db_xref="HGNC:HGNC:17579"
                     /db_xref="MIM:607048"
                     /translation="MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRR
                     AISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLA
                     FFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFV
                     LAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSD
                     NESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEV
                     PFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVS
                     AGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLK
                     SASNPRVCTFVWILNTDLKGRLPRYLIHQSLAATMFEFAFHLRQRISELGARA"
     exon            359..436
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            437..514
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            515..568
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            569..686
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            687..785
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            786..841
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            842..934
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            935..997
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1093
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1173
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1278
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1372
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..2770
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /note="hexamer: ATTAAA"
     polyA_site      2770
                     /gene="STARD3"
                     /gene_synonym="CAB1; es64; MLN64"
                     /note="major polyA site"
ORIGIN      
        1 cttcttccgc tctgaggcgc tactgaggcc gcggagccgg actgcggttg gggcgggaag
       61 agccggggcc gtggctgaca tggagcagcc ctgctgctga ggccgcgccc tccccgccct
      121 gaggtggggg cccaccagga tgagcaagct gcccagggag ctgacccgag acttggagcg
      181 cagcctgcct gccgtggcct ccctgggctc ctcactgtcc cacagccaga gcctctcctc
      241 gcacctcctt ccgccgcctg agaagcgaag ggccatctct gatgtccgcc gcaccttctg
      301 tctcttcgtc accttcgacc tgctcttcat ctccctgctc tggatcatcg aactgaatac
      361 caacacaggc atccgtaaga acttggagca ggagatcatc cagtacaact ttaaaacttc
      421 cttcttcgac atctttgtcc tggccttctt ccgcttctct ggactgctcc taggctatgc
      481 cgtgctgcgg ctccggcact ggtgggtgat tgcggtcacg acgctggtgt ccagtgcatt
      541 cctcattgtc aaggtcatcc tctctgagct gctcagcaaa ggggcatttg gctacctgct
      601 ccccatcgtc tcttttgtcc tcgcctggtt ggagacctgg ttccttgact tcaaagtcct
      661 accccaggaa gctgaagagg agcgatggta tcttgccgcc caggttgctg ttgcccgtgg
      721 acccctgctg ttctccggtg ctctgtccga gggacagttc tattcacccc cagaatcctt
      781 tgcagggtct gacaatgaat cagatgaaga agttgctggg aagaaaagtt tctctgctca
      841 ggagcgggag tacatccgcc aggggaagga ggccacggca gtggtggacc agatcttggc
      901 ccaggaagag aactggaagt ttgagaagaa taatgaatat ggggacaccg tgtacaccat
      961 tgaagttccc tttcacggca agacgtttat cctgaagacc ttcctgccct gtcctgcgga
     1021 gctcgtgtac caggaggtga tcctgcagcc cgagaggatg gtgctgtgga acaagacagt
     1081 gactgcctgc cagatcctgc agcgagtgga agacaacacc ctcatctcct atgacgtgtc
     1141 tgcaggggct gcgggcggcg tggtctcccc aagggacttc gtgaatgtcc ggcgcattga
     1201 gcggcgcagg gaccgatact tgtcatcagg gatcgccacc tcacacagtg ccaagccccc
     1261 gacgcacaaa tatgtccggg gagagaatgg ccctgggggc ttcatcgtgc tcaagtcggc
     1321 cagtaacccc cgtgtttgca cctttgtctg gattcttaat acagatctca agggccgcct
     1381 gccccggtac ctcatccacc agagcctcgc ggccaccatg tttgaatttg cctttcacct
     1441 gcgacagcgc atcagcgagc tgggggcccg ggcgtgactg tgccccctcc caccctgcgg
     1501 gccagggtcc tgtcgccacc acttccagag ccagaaaggg tgccagttgg gctcgcactg
     1561 cccacatggg acctggcccc aggctgtcac cctccaccga gccacgcagt gcctggagtt
     1621 gactgactga gcaggctgtg gggtggagca ctggactccg gggccccact ggctggagga
     1681 agtggggtct ggcctgttga tgtttacatg gcgccctgcc tcctggagga ccagattgct
     1741 ctgccccacc ttgccagggc agggtctggg ctgggcacct gacttggctg gggaggacca
     1801 gggccctggg cagggcaggg cagcctgtca cccgtgtgaa gatgaagggg ctcttcatct
     1861 gcctgcgctc tcgtcggttt ttttaggatt attgaaagag tctgggaccc ttgttgggga
     1921 gtgggtggca ggtgggggtg ggctgctggc catgaatctc tgcctctccc aggctgtccc
     1981 cctcctccca gggcctcctg ggggaccttt gtattaagcc aattaaaaac atgaatttaa
     2041 aaaaaaaaaa aaattccagc ccctcccact gccttgcctc ttgagggaag agaaaggcag
     2101 gcagcagctt ggatgaagag ggaagacccc tcacacagcc tctcctgggc tcacaggagg
     2161 gcggagcccg gggagccagt tcctgaaaca tgccccccat tccccccccg cccacccccc
     2221 actccccgct ttcctgacca gttcaactga gcagatgact ggtcagaaaa aaatgccccg
     2281 ccccctgcca ggcttcagcg gggcaagttt aaagtctcta gtccaggaat ggaggtgggg
     2341 gtatgggcac ctggcagtgc ccacagcaag ccttgactgt gtggcctgga gatggggcct
     2401 gagcttcagg gtcactgagg cacctctggg atccaggcca cctggagccc cggacctccc
     2461 agactccact cacccattcc ctctccccgc acggcactca caccaggggc ggcctggagc
     2521 ccggatcgca gggcggggcc aggccactgc ctgccttcct cctccctccc ggctggcctg
     2581 cccccttgcc tgcctgcatg caggcttcca gcagagccag cttcttcaga gccaggtgga
     2641 tcctgtttcg gtcctgccta ggtgtgtgac cctgggcgaa tctacctctc tcagcttctg
     2701 cttcccactt tatgaaaatg ggactgatgt cacagggttg ttatgagatt aaaagatatg
     2761 aagaaccggg
//
