LOCUS       NM_178006               5915 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens StAR related lipid transfer domain containing 13
            (STARD13), transcript variant 1, mRNA.
ACCESSION   NM_178006
VERSION     NM_178006.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5915)
  AUTHORS   Lu,Y., Zheng,W., Rao,X., Du,Y. and Xue,J.
  TITLE     MicroRNA-9-5p Facilitates Lung Adenocarcinoma Cell Malignant
            Progression via Targeting STARD13
  JOURNAL   Biochem Genet 60 (6), 1865-1880 (2022)
   PUBMED   35119587
  REMARK    GeneRIF: MicroRNA-9-5p Facilitates Lung Adenocarcinoma Cell
            Malignant Progression via Targeting STARD13.
REFERENCE   2  (bases 1 to 5915)
  AUTHORS   Abdellatef,S., Fakhoury,I., Haddad,M.A., Jaafar,L., Maalouf,H.,
            Hanna,S., Khalil,B., El Masri,Z., Hodgson,L. and El-Sibai,M.
  TITLE     StarD13 negatively regulates invadopodia formation and invasion in
            high-grade serous (HGS) ovarian adenocarcinoma cells by inhibiting
            Cdc42
  JOURNAL   Eur J Cell Biol 101 (1), 151197 (2022)
   PUBMED   34958986
  REMARK    GeneRIF: StarD13 negatively regulates invadopodia formation and
            invasion in high-grade serous (HGS) ovarian adenocarcinoma cells by
            inhibiting Cdc42.
REFERENCE   3  (bases 1 to 5915)
  AUTHORS   Qian,Y., Zhang,Y., Ji,H., Shen,Y., Zheng,L., Cheng,S. and Lu,X.
  TITLE     LINC01089 suppresses lung adenocarcinoma cell proliferation and
            migration via miR-301b-3p/STARD13 axis
  JOURNAL   BMC Pulm Med 21 (1), 242 (2021)
   PUBMED   34281560
  REMARK    GeneRIF: LINC01089 suppresses lung adenocarcinoma cell
            proliferation and migration via miR-301b-3p/STARD13 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5915)
  AUTHORS   El-Sitt,S. and El-Sibai,M.
  TITLE     The STAR of the DLC family
  JOURNAL   J Recept Signal Transduct Res 33 (1), 10-13 (2013)
   PUBMED   23316797
  REMARK    GeneRIF: In the present review, we discuss the family of
            RhoGTPases, their regulation and their RhoGAPs, focusing mainly on
            STARD13. [review]
            Review article
REFERENCE   5  (bases 1 to 5915)
  AUTHORS   Ng,D.C., Chan,S.F., Kok,K.H., Yam,J.W., Ching,Y.P., Ng,I.O. and
            Jin,D.Y.
  TITLE     Mitochondrial targeting of growth suppressor protein DLC2 through
            the START domain
  JOURNAL   FEBS Lett 580 (1), 191-198 (2006)
   PUBMED   16364308
REFERENCE   6  (bases 1 to 5915)
  AUTHORS   Leung,T.H., Ching,Y.P., Yam,J.W., Wong,C.M., Yau,T.O., Jin,D.Y. and
            Ng,I.O.
  TITLE     Deleted in liver cancer 2 (DLC2) suppresses cell transformation by
            means of inhibition of RhoA activity
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15207-15212 (2005)
   PUBMED   16217026
REFERENCE   7  (bases 1 to 5915)
  AUTHORS   Popescu,N.C. and Durkin,M.E.
  TITLE     Rho GTPase activating protein cDNA on chromosome 13q12 is the
            deleted in liver cancer (DLC2) gene
  JOURNAL   Biochem Biophys Res Commun 315 (4), 781 (2004)
   PUBMED   14985079
REFERENCE   8  (bases 1 to 5915)
  AUTHORS   Nagaraja,G.M. and Kandpal,R.P.
  TITLE     Chromosome 13q12 encoded Rho GTPase activating protein suppresses
            growth of breast carcinoma cells, and yeast two-hybrid screen shows
            its interaction with several proteins
  JOURNAL   Biochem Biophys Res Commun 313 (3), 654-665 (2004)
   PUBMED   14697242
REFERENCE   9  (bases 1 to 5915)
  AUTHORS   Ching,Y.P., Wong,C.M., Chan,S.F., Leung,T.H., Ng,D.C., Jin,D.Y. and
            Ng,I.O.
  TITLE     Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with
            growth suppressor function and is underexpressed in hepatocellular
            carcinoma
  JOURNAL   J Biol Chem 278 (12), 10824-10830 (2003)
   PUBMED   12531887
  REMARK    GeneRIF: has GAP activity specific for RhoA and Cdc42; inhibits the
            Rho mediated assembly of actin stress fibers in cultured cells and
            is underexpressed in hepatocellular carcinoma tissues
REFERENCE   10 (bases 1 to 5915)
  AUTHORS   Couch,F.J., Rommens,J.M., Neuhausen,S.L., Belanger,C., Dumont,M.,
            Abel,K., Bell,R., Berry,S., Bogden,R., Cannon-Albright,L.,
            Farid,L., Frye,C., Hattier,T., Janecki,T., Jiang,P., Kehrer,R.,
            Leblanc,J.F., McArthur-Morrison,J., Meney,D., Miki,Y., Peng,Y.,
            Samson,C., Schroeder,M., Snyder,S.C., Simard,J. et al.
  TITLE     Generation of an integrated transcription map of the BRCA2 region
            on chromosome 13q12-q13
  JOURNAL   Genomics 36 (1), 86-99 (1996)
   PUBMED   8812419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC402824.1, AY082589.1,
            AY366448.1, CB163673.1, AY082590.1 and AA256386.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_178006.3.
            
            Summary: This gene encodes a protein which contains an N-terminal
            sterile alpha motif (SAM) for protein-protein interactions,
            followed by an ATP/GTP-binding motif, a GTPase-activating protein
            (GAP) domain, and a C-terminal STAR-related lipid transfer (START)
            domain. It may be involved in regulation of cytoskeletal
            reorganization, cell proliferation, and cell motility, and acts as
            a tumor suppressor in hepatoma cells. The gene is located in a
            region of chromosome 13 that is associated with loss of
            heterozygosity in hepatocellular carcinomas. Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as DLC2alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312888.1, AY082589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16364308
            MANE Ensembl match                 :: ENST00000336934.10/
                                                  ENSP00000338785.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DC402824.1         12-25
            15-1274             AY082589.1         19-1278
            1275-1305           AY366448.1         1219-1249
            1306-5123           AY082589.1         1310-5127
            5124-5256           CB163673.1         389-521
            5257-5882           AY082590.1         5185-5810
            5883-5915           AA256386.1         6-38                c
FEATURES             Location/Qualifiers
     source          1..5915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.1-q13.2"
     gene            1..5915
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /note="StAR related lipid transfer domain containing 13"
                     /db_xref="GeneID:90627"
                     /db_xref="HGNC:HGNC:19164"
                     /db_xref="MIM:609866"
     exon            1..286
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3459
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /note="isoform 1 is encoded by transcript variant 1; Rho
                     GTPase activating protein on chromosome 13q12;
                     stAR-related lipid transfer protein 13; deleted in liver
                     cancer 2 protein; long intergenic non-protein coding RNA
                     464; StAR-related lipid transfer (START) domain containing
                     13"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 13 isoform
                     1"
                     /protein_id="NP_821074.1"
                     /db_xref="CCDS:CCDS9348.1"
                     /db_xref="GeneID:90627"
                     /db_xref="HGNC:HGNC:19164"
                     /db_xref="MIM:609866"
                     /translation="MFSQVPRTPASGCYYLNSMTPEGQEMYLRFDQTTRRSPYRMSRI
                     LARHQLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDL
                     VEPLCRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLY
                     TLLPRGDRNGSPGGTGMRNTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTD
                     NPVMLDAPLVSSSLPQPPRDVLNHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHK
                     GSGRTGGLVISGPMLQQEPESFKAMQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESS
                     PSEHSSSGVSTPCLKERKCHEANKRGGMYLEDLDVLAGTALPDAGDQSRMHEFHSQEN
                     LVVHIPKDHKPGTFPKALSIESLSPTDSSNGVNWRTGSISLGREQVPGAREPRLMASC
                     HRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILQHVNGLQEVVDDWSKDVL
                     PELQTHDTLVGEPGLSTFPSPNQITLDFEGNSVSEGRTTPSDVERDVTSLNESEPPGV
                     RDRRDSGVGASLTRPNRRLRWNSFQLSHQPRPAPASPHISSQTASQLSLLQRFSLLRL
                     TAIMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQ
                     ALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVNYEDQSAYDVADMVKQFFR
                     DLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVN
                     LVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQG
                     LAHMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLEESGATFHTYLNHLI
                     QGLQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLR
                     ERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLV
                     SLSVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGH
                     LCAAEVARIRNSFQPLIAEGPETKI"
     exon            287..358
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            359..440
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            441..504
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1865
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2039
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2199
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2398
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2609
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2724
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2946
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3164
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3341
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..5915
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3783..3788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /note="hexamer: AATAAA"
     polyA_site      3807
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /note="major polyA site"
     regulatory      5040..5045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /note="hexamer: AATAAA"
     polyA_site      5059
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
     regulatory      5768..5773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /note="hexamer: AATAAA"
     polyA_site      5797
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
     regulatory      5874..5879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /note="hexamer: AATAAA"
     regulatory      5889..5894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /note="hexamer: ATTAAA"
     polyA_site      5896
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
     polyA_site      5915
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
ORIGIN      
        1 aaaaatcgct gggtctgttg agctgtcctg ggctgggtgc cttgctcttt gactgagact
       61 ggagacagac ggcaacagcc acaggcagac tgaggtggca ataggaaatc tgccgagatg
      121 ttcagtcagg tgcccaggac cccagcctca ggctgctact acctaaattc catgacacct
      181 gagggccagg agatgtactt gcgatttgat cagactacaa gacgctctcc ttacaggatg
      241 agccggattc tagcacgcca tcagctagtg actaaaattc aacaagaaat tgaggcaaaa
      301 gaagcatgtg actggctccg tgctgccggg ttcccgcaat acgctcagtt atatgaggat
      361 tcacaatttc ccatcaacat tgtggctgtc aagaatgatc atgattttct tgaaaaggac
      421 cttgtagaac ctctttgcag acgactaaat acgttgaaca agtgtgcctc aatgaaactt
      481 gatgtgaact tccaaaggaa aaagggtgac gactccgatg aggaagatct ttgtatcagc
      541 aacaaatgga ctttccaaag aaccagtcgc aggtggtctc gtgtggacga cctctacacg
      601 ctgctccctc gaggagacag aaatgggtca ccgggaggca cggggatgag gaacacgacc
      661 agcagtgaga gcgtcctcac agacctgagc gagcctgagg tctgctccat tcacagcgaa
      721 agcagtggag gcagcgacag tcgcagccag ccgggccagt gctgtacaga caacccggtc
      781 atgctggatg ccccactcgt cagcagcagc ctcccacagc cccccagaga tgtcctcaac
      841 caccccttcc accccaagaa tgagaagccc acgagggcta gggccaaatc atttttgaaa
      901 cgcatggaaa cactccgagg gaagggagcc cacgggaggc ataaggggtc tgggcggaca
      961 ggtggcctgg tgatcagtgg gcccatgttg cagcaggagc cagagtcctt taaggctatg
     1021 cagtgcatcc aaataccaaa tggagatctc cagaattcgc cgccacctgc ctgcagaaaa
     1081 gggctcccat gctctggcaa gtcgagtggc gagagcagcc cgtcggagca cagcagcagc
     1141 ggggtgagca cgccctgcct gaaggaacgc aagtgccacg aggccaacaa gcgcgggggc
     1201 atgtacttgg aggacctaga tgtgctggcg gggacagcac tgccggatgc aggggaccaa
     1261 agccgtatgc atgaatttca ctcccaagag aatttggtgg tgcatattcc caaggatcac
     1321 aaaccaggaa cattccccaa ggcactttct attgaaagcc tctctcccac agatagtagc
     1381 aatggggtta attggaggac cggtagcatc tccctgggca gagagcaggt ccctggtgcc
     1441 agggagcccc ggctcatggc gtcctgccac agagccagcc gagtcagtat ctatgacaat
     1501 gtccctggct cccatctgta tgccagcaca ggagatcttt tggacttgga gaaagatgac
     1561 cttttccctc acttggatga cattctgcag catgtcaatg ggctccaaga ggtagtcgat
     1621 gactggtcca aagatgtctt gcctgaactg caaactcatg atacattggt tggggaacct
     1681 ggcttatcca cctttccatc tcctaatcag atcaccttag attttgaagg taactctgtc
     1741 tcagaaggtc ggacgacacc cagtgatgtg gaaagagatg taacatctct taatgaatct
     1801 gagcctcctg gggtcagaga caggagggat tctggtgtag gggcctctct gaccaggcca
     1861 aacaggcgac tccgatggaa cagtttccag ctgtcgcacc agccccggcc ggccccagca
     1921 tcgccccaca tcagcagcca gacggccagc cagctgagcc tgctccagcg cttctcactg
     1981 ctccgcctca cggccatcat ggagaagcac tccatgtcca acaagcacgg ctggacatgg
     2041 tcagttccaa agttcatgaa gaggatgaaa gttcccgact acaaagacaa ggctgtcttt
     2101 ggcgttcctc tcatagtcca cgtccaaaga acgggacagc ccctgcctca aagtattcag
     2161 caagcactga gatatctacg cagcaactgc ctcgatcagg tgggtctttt tcgcaaatca
     2221 ggagtgaagt ctcgaatcca tgcccttcgc caaatgaatg aaaacttccc tgagaacgtc
     2281 aactatgaag accagtctgc ttatgatgtg gcggatatgg tgaaacagtt cttccgggac
     2341 ctccctgagc ctcttttcac caacaagctc agtgagacct ttctccatat ctatcagtat
     2401 gtctccaaag agcagcggct gcaggccgtg caggctgcca tcctgctact ggccgatgag
     2461 aacagggagg tcctgcagac gctcttgtgt ttcctgaacg acgtcgtcaa cttggtggaa
     2521 gagaatcaga tgacgcccat gaacctggca gtgtgtctgg ccccctccct ctttcatctt
     2581 aatttattga agaaagaaag ctctccacga gtcatacaga agaaatatgc cactgggaag
     2641 ccagatcaaa aggacctcaa cgagaatctg gcagcagctc aggggctagc gcacatgatc
     2701 atggaatgcg acagactttt tgaggttcca cacgagttgg tggcccagtc tcgtaactcg
     2761 tatgtggagg ctgagatcca cgtgccaacc ctggaagaat tggggacaca gctggaggag
     2821 agtggggcaa ctttccacac ttacctgaac catctcatcc agggcctcca gaaagaagcc
     2881 aaggagaagt tcaaaggatg ggtcacgtgc tccagcacgg acaatacaga tcttgctttc
     2941 aaaaaggtgg gcgacgggaa cccgctgaag ctgtggaagg cttctgtgga ggtggaagca
     3001 cccccctcag tggtcctgaa ccgcgtgctg agagagcgcc acctgtggga cgaggacttt
     3061 gtgcagtgga aggttgtgga aactctagac aggcaaacag agatctacca gtatgtgctg
     3121 aacagcatgg ctccccatcc ttccagagac tttgtggttc tcaggacctg gaaaactgat
     3181 ttgcccaaag gaatgtgtac cctggtgtcc ctctccgtgg agcatgagga agcccagctc
     3241 ctgggtggtg tgcgagcagt ggtgatggac tcgcagtact tgatagaacc gtgtggctct
     3301 ggcaagtcaa gactgactca catctgcagg atagacctga aaggtcactc cccagaatgg
     3361 tacagcaaag gctttggaca tctgtgtgca gcagaagttg ccaggattag aaactctttc
     3421 cagcccctca ttgctgaggg cccagaaact aaaatctgag ttttgcccag tgtgacatca
     3481 aactcaggga agaggaagct aaagtgacga gtgtggcaga gagtgtgcat gtgagaaagc
     3541 gagagaaaga ggaactgaag gacgcggtta atgcctaaaa atggaaacgt taagaagttg
     3601 gaatgttgga gatgcaagaa tttccaagaa ctttcttagc cttcctggag atggctacat
     3661 ccctactaat ataattttaa aatgagaact ttatatatat tacttaaaat taaatggact
     3721 attccttgtg cattgcctaa tttgctattt aaaggcttct aagaagcgta tacctaactg
     3781 taaataaatg tatgtatagc atatgtacat atgtgtgtat atctccatct ttactgtata
     3841 tatgtaaaat accaatttta tatagaattg tgtgttttga aaatgacggt gtctgactca
     3901 gtgagtccct tcctcacaca gttctttcca agtggctctg ggccccatct ctccactgtc
     3961 ctgtaagctg tgcagaacct gctgctaaca ccaaggtgtg aacatgccct gatgcctaac
     4021 caaagatgag ttaaccaaag gaaaataaca ttaaaggaga cttatgtgtt aacgctttgt
     4081 ttctgctatt caaaaactga gagtggagat ctgggataaa gcaaggaaat aataattact
     4141 cctccttaaa gcaaatgggg gggtgagaag tcattaccaa atttaaagct agatgaggag
     4201 ttgccactgg gcccagtaag atggaatttc agtgagatat ggaccaccgg agtcagcgag
     4261 agtgactgaa acagaagcga tacctctcgc tcccatgccc atcactacag accccaagtc
     4321 aagatgaata tcatagcctt tacttcttca cagccaaagg gagcccctgt gttgtctcaa
     4381 gtttttataa atacatttca taatgttatt aaatgtcatt ctatttgacc agtggcctat
     4441 ttggtcacag ttaattggtg ttttcttatt gcactgaatt caactccaga caccatacaa
     4501 agggagatga tggccattcc gttcaaatcc tagatcgtta cagcttcagg gaattcatat
     4561 tttgttatgt gtaggatact cttaaaatgt aattcattaa acttttacaa tctgaaagac
     4621 agggttttta actaacatga gaccaaaact atgttctttg attagtttta gatagtataa
     4681 tcgggtttat taattcttct gtgtttcttc actagccagt ccaagctacc tatgcatttg
     4741 acccaacctt atttattatt gtacagatga agcgaattga ctccctttag ccaactgcta
     4801 atggatcgaa tgtgcttttt attgtaattc aacagctata gagagaaaga taacttattg
     4861 tgtgtttgat ttcagggaga gagattttct ttggtcatcc ataatagaga ttgataagat
     4921 ttagcaactg gtgttggaga aaaaaagaaa agcaaatgag tgttttcagg tttttttgca
     4981 ttatatgcat ttatgtaatg tttctgttat cagcaatgtg caattatttt attgagagga
     5041 ataaaaaagc tttctatgag tttggtatgg tgcgaggaaa atcttacagt ttgaattatg
     5101 acctagaaat ttttcattcc catatctacc taagaaggaa gcagtaaatc cataatttac
     5161 cttttgggca atgctttgtg agcaaaacaa agtcacttct gccataacat cttgaattta
     5221 accatatatg ccagattact ttatatgcat caacaagatc accagtgaag tttaatctag
     5281 ctaaacactg gtcctgctcc tgagatggga tcctatgtgt ttggaaaacg tgataggcac
     5341 acgaggatga gtggctttgt atcgcccaga gaggtgcttg tccagatttc acatgcacat
     5401 gaattgcctg gggatcttgt gaaactgcag actctgctcc aagtaatctg ggctgggcct
     5461 gagattctgc atttctaagg agtctcaggg atgcctatgc tgctggccta aaaccacact
     5521 cagaaacgag gacctagaag atccctaaaa cagaataaga acaaatgtga ttgtatttct
     5581 gattctccct ctcttcgaat tatctgactt ttttgttttt gtgcacatag taatcatatc
     5641 accgctgcat aacaacacag tgcatctttt taaaacaagg aaaagggaaa aaaaggagaa
     5701 aaaacgatgc atcaagcttg tttgtcaaat accacagtat tttattcatt gttatcttgc
     5761 caatggaaat aaagtatgat attgcattta aatattatat ttatacctca tgtatatttt
     5821 tacctcaatt gttgatatca atcatcaatt gtaaataaat aattgccaag gcaaataaat
     5881 ttatatatat taaatatttc ctattttcta taaaa
//
