LOCUS       NM_006645               2330 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens StAR related lipid transfer domain containing 10
            (STARD10), mRNA.
ACCESSION   NM_006645
VERSION     NM_006645.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2330)
  AUTHORS   Floris,A., Luo,J., Frank,J., Zhou,J., Orru,S., Biancolella,M.,
            Pucci,S., Orlandi,A., Campagna,P., Balzano,A., Ramani,K. and
            Tomasi,M.L.
  TITLE     Star-related lipid transfer protein 10 (STARD10): a novel key
            player in alcohol-induced breast cancer progression
  JOURNAL   J Exp Clin Cancer Res 38 (1), 4 (2019)
   PUBMED   30611309
  REMARK    GeneRIF: Finding proved that STARD10 and ERBB2 positively regulate
            each other's expression and function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2330)
  AUTHORS   Zhao,G., Li,Y. and Wang,T.
  TITLE     Potentiation of docetaxel sensitivity by miR-638 via regulation of
            STARD10 pathway in human breast cancer cells
  JOURNAL   Biochem Biophys Res Commun 487 (2), 255-261 (2017)
   PUBMED   28412359
  REMARK    GeneRIF: Hence, we provide a molecular explanation for acquired
            resistance to DTX that is caused by the miR-638 deficiency and
            subsequent STARD10 upregulation. In consequence, alteration of
            miR-638/STARD10 cascade may represent an attractive strategy in
            future adjuvant therapy along with DTX chemotherapy.
REFERENCE   3  (bases 1 to 2330)
  AUTHORS   Carrat,G.R., Hu,M., Nguyen-Tu,M.S., Chabosseau,P., Gaulton,K.J.,
            van de Bunt,M., Siddiq,A., Falchi,M., Thurner,M., Canouil,M.,
            Pattou,F., Leclerc,I., Pullen,T.J., Cane,M.C., Prabhala,P.,
            Greenwald,W., Schulte,A., Marchetti,P., Ibberson,M.,
            MacDonald,P.E., Manning Fox,J.E., Gloyn,A.L., Froguel,P.,
            Solimena,M., McCarthy,M.I. and Rutter,G.A.
  TITLE     Decreased STARD10 Expression Is Associated with Defective Insulin
            Secretion in Humans and Mice
  JOURNAL   Am J Hum Genet 100 (2), 238-256 (2017)
   PUBMED   28132686
  REMARK    GeneRIF: StarD10 is required for normal insulin secretion, though
            its deletion enhances proinsulin processing.
REFERENCE   4  (bases 1 to 2330)
  AUTHORS   Yang,S.K., Hong,M., Zhao,W., Jung,Y., Baek,J., Tayebi,N., Kim,K.M.,
            Ye,B.D., Kim,K.J., Park,S.H., Lee,I., Lee,E.J., Kim,W.H.,
            Cheon,J.H., Kim,Y.H., Jang,B.I., Kim,H.S., Choi,J.H., Koo,J.S.,
            Lee,J.H., Jung,S.A., Lee,Y.J., Jang,J.Y., Shin,H.D., Kang,D.,
            Youn,H.S., Liu,J. and Song,K.
  TITLE     Genome-wide association study of Crohn's disease in Koreans
            revealed three new susceptibility loci and common attributes of
            genetic susceptibility across ethnic populations
  JOURNAL   Gut 63 (1), 80-87 (2014)
   PUBMED   23850713
REFERENCE   5  (bases 1 to 2330)
  AUTHORS   Toro,C., Olive,M., Dalakas,M.C., Sivakumar,K., Bilbao,J.M.,
            Tyndel,F., Vidal,N., Farrero,E., Sambuughin,N. and Goldfarb,L.G.
  TITLE     Exome sequencing identifies titin mutations causing hereditary
            myopathy with early respiratory failure (HMERF) in families of
            diverse ethnic origins
  JOURNAL   BMC Neurol 13, 29 (2013)
   PUBMED   23514108
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2330)
  AUTHORS   Murphy,N.C., Biankin,A.V., Millar,E.K., McNeil,C.M., O'Toole,S.A.,
            Segara,D., Crea,P., Olayioye,M.A., Lee,C.S., Fox,S.B., Morey,A.L.,
            Christie,M., Musgrove,E.A., Daly,R.J., Lindeman,G.J.,
            Henshall,S.M., Visvader,J.E. and Sutherland,R.L.
  TITLE     Loss of STARD10 expression identifies a group of poor prognosis
            breast cancers independent of HER2/Neu and triple negative status
  JOURNAL   Int J Cancer 126 (6), 1445-1453 (2010)
   PUBMED   19676041
  REMARK    GeneRIF: Data show that in multivariate analyses incorporating
            tumor size, tumor grade, lymph node status, ER, PR and HER2 status,
            low STARD10 expression was an independent predictor of death from
            breast cancer.
REFERENCE   7  (bases 1 to 2330)
  AUTHORS   Olayioye,M.A., Buchholz,M., Schmid,S., Schoffler,P., Hoffmann,P.
            and Pomorski,T.
  TITLE     Phosphorylation of StarD10 on serine 284 by casein kinase II
            modulates its lipid transfer activity
  JOURNAL   J Biol Chem 282 (31), 22492-22498 (2007)
   PUBMED   17561512
  REMARK    GeneRIF: C-terminal StarD10 phosphorylation on serine 284 regulates
            its association with cellular membranes
REFERENCE   8  (bases 1 to 2330)
  AUTHORS   Olayioye,M.A., Vehring,S., Muller,P., Herrmann,A., Schiller,J.,
            Thiele,C., Lindeman,G.J., Visvader,J.E. and Pomorski,T.
  TITLE     StarD10, a START domain protein overexpressed in breast cancer,
            functions as a phospholipid transfer protein
  JOURNAL   J Biol Chem 280 (29), 27436-27442 (2005)
   PUBMED   15911624
  REMARK    GeneRIF: StarD10 interacts with phosphatidylcholine and
            phosphatidylethanolamine and preferentially selects lipid species
            containing a palmitoyl or stearoyl chain on the sn-1 and an
            unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position
REFERENCE   9  (bases 1 to 2330)
  AUTHORS   Tabibiazar,R., Wagner,R.A., Liao,A. and Quertermous,T.
  TITLE     Transcriptional profiling of the heart reveals chamber-specific
            gene expression patterns
  JOURNAL   Circ Res 93 (12), 1193-1201 (2003)
   PUBMED   14576202
  REMARK    GeneRIF: Stard10 (Sdccag28) is much more highly transcribed in
            mouse cardiac atria than in cardiac ventricles.
REFERENCE   10 (bases 1 to 2330)
  AUTHORS   Scanlan,M.J., Chen,Y.T., Williamson,B., Gure,A.O., Stockert,E.,
            Gordan,J.D., Tureci,O., Sahin,U., Pfreundschuh,M. and Old,L.J.
  TITLE     Characterization of human colon cancer antigens recognized by
            autologous antibodies
  JOURNAL   Int J Cancer 76 (5), 652-658 (1998)
   PUBMED   9610721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002381.3 and AP003065.2.
            
            On Aug 11, 2020 this sequence version replaced NM_006645.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1849895.1,
                                           SRR18074967.1411120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334805.11/ ENSP00000335247.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AP002381.3         11630-11971         c
            343-1173            AP002381.3         10799-11629         c
            1174-1493           AP003065.2         177015-177334       c
            1494-1641           AP003065.2         155274-155421       c
            1642-1745           AP003065.2         154570-154673       c
            1746-1863           AP003065.2         153807-153924       c
            1864-1916           AP003065.2         151741-151793       c
            1917-2330           AP003065.2         150769-151182       c
FEATURES             Location/Qualifiers
     source          1..2330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..2330
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /note="StAR related lipid transfer domain containing 10"
                     /db_xref="GeneID:10809"
                     /db_xref="HGNC:HGNC:10666"
                     /db_xref="MIM:617382"
     exon            1..1173
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1493
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /inference="alignment:Splign:2.1.0"
     CDS             1287..2162
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /note="START domain containing 10; serologically defined
                     colon cancer antigen 28; StAR-related lipid transfer
                     (START) domain containing 10; PCTP-like protein; PCTP-L;
                     antigen NY-CO-28; stAR-related lipid transfer protein 10"
                     /codon_start=1
                     /product="START domain-containing protein 10"
                     /protein_id="NP_006636.2"
                     /db_xref="CCDS:CCDS41688.1"
                     /db_xref="GeneID:10809"
                     /db_xref="HGNC:HGNC:10666"
                     /db_xref="MIM:617382"
                     /translation="MEKLAASTEPQGPRPVLGRESVQVPDDQDFRSFRSECEAEVGWN
                     LTYSRAGVSVWVQAVEMDRTLHKIKCRMECCDVPAETLYDVLHDIEYRKKWDSNVIET
                     FDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKD
                     LVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKA
                     CLKYPEWKQKHLPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVAESREERM
                     GGAGGEGSDDDTSLT"
     exon            1494..1641
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1745
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1863
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1916
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2330
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2309..2314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /note="hexamer: AATAAA"
     polyA_site      2330
                     /gene="STARD10"
                     /gene_synonym="CGI-52; NY-CO-28; PCTP2; SDCCAG28"
                     /note="major polyA site"
ORIGIN      
        1 agtttgccat gatggatgcc agaacctgca cgtggggctt ggtgacgcga tgactgagat
       61 gctggagtcc ccggtcagaa ggacgatgcc gagcgcgccg tattttctcc tgcctctcct
      121 cagatcgccg ccgttgttgg gctgtggaga cgtctcaacc aaagtggagc cgacagaggc
      181 cccgggagcc gtggtgacag agcggccaca accactaggg ggcgggaggc agagcggccc
      241 ctagtccgcc cctagtccgg gacctctggg cggtcccggg cgggaagcgc acgcgcaaac
      301 gcggggcttc gcggccgctg taaacaccaa agagcgcctg cgcaagccga gagtctcggg
      361 atcgacacgt gggggcgcct gagcgaagat aaccgtaata aatagtaacc taacggtcca
      421 gtcatcgttc tgtggtcctt tcttttatga ttcacaagga atgaccctct tcatcgcctc
      481 tcctaattca gtcctcacaa cagtcctttt acaaatggga caacaggtta gaggaagtca
      541 ggcagatttc cagcatcata gagagtaaag gaccagggaa ggatcaggat tcaaggactg
      601 cacccaggct ctgcttccag cttgctgtgt gactttgggt aattttgttc ccttagggaa
      661 ctgagctttc tcatttgtaa atgcaaacag gctgttggga ggatcaaatg agatccaggg
      721 gtgaaaacag cttagtttac tttcaggaat ttacccacgc ggtatataaa ggcaaaatat
      781 tattatagtc aggtgattgt agattgagga acccatttcc tcattctgca aattgcaaac
      841 ctgagggccc aaagagggac aggggcttgc cccaggtctc agcaggctgt gagcaagagc
      901 taaagcctaa tcctcctgcc tttgggcctg gagcccttcc ttgtacccca ggggtcagtg
      961 tctttgttgg atacaggctt agattgactg actgtaccct gagaacctag gggagtccct
     1021 gttcccaatt cttctcctac ccccaccttg gcctgatgga ggaagaccct gctgtgttga
     1081 gatgagcacc agagccaaga agctgaggag gatctggaga attctggagg aagaggagag
     1141 tgttgctgga gctgtacaga ccctgcttct caggtcccag gaaggtggcg tcagcatctg
     1201 cagccgcgtc gacgttgtcg gagcctccgc ggaggaccca ggagagccgg actaggacca
     1261 gggccctggg cctccccaca ctccccatgg agaagctggc ggcctctaca gagccccaag
     1321 ggcctcggcc ggtcctgggc cgtgagagtg tccaggtgcc cgatgaccaa gactttcgca
     1381 gcttccggtc agagtgtgag gctgaggtgg gctggaacct gacctatagc agggctgggg
     1441 tgtctgtctg ggtgcaggct gtggagatgg atcggacgct gcacaagatc aagtgccgga
     1501 tggagtgctg tgatgtgcca gccgagacac tctacgacgt cctacacgac attgagtacc
     1561 gcaagaaatg ggacagcaac gtcattgaga cttttgacat cgcccgcttg acagtcaacg
     1621 ctgacgtggg ctattactcc tggaggtgtc ccaagcccct gaagaaccgt gatgtcatca
     1681 ccctccgctc ctggctcccc atgggcgctg attacatcat tatgaactac tcagtcaaac
     1741 atcccaaata cccacctcgg aaagacttgg tccgagctgt gtccatccag acgggctacc
     1801 tcatccagag cacagggccc aagagctgcg tcatcaccta cctggcccag gtggacccca
     1861 aaggctcctt acccaagtgg gtggtgaata aatcttctca gttcctggct cccaaggcca
     1921 tgaagaagat gtacaaggcg tgcctcaagt accccgagtg gaaacagaag cacctgcctc
     1981 acttcaagcc gtggctgcac ccggagcaga gcccgttgcc gagcctggcg ctgtcggagc
     2041 tgtcggtgca gcatgcggac tcactggaga acatcgacga gagcgcggtg gccgagagca
     2101 gagaggagcg gatgggcggc gcgggcggcg agggcagcga cgacgacacc tcgctcacct
     2161 gagcgccgca ccgcttcagg gacggagaca ggaccgggcg agccctgggg cggcggccgc
     2221 tcctgcactt tctcccctcc cccacccggc acctggtggc accgggccag gcccaggcgg
     2281 gtgctgcagc ctggctggac agagccccaa taaacgatcc cacagcctca
//
