LOCUS       NM_020799               2021 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens STAM binding protein like 1 (STAMBPL1), mRNA.
ACCESSION   NM_020799
VERSION     NM_020799.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2021)
  AUTHORS   Jin,J., Wang,Y. and Hu,Y.
  TITLE     STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant
            behaviors of hepatocellular carcinoma cells via Wnt/beta-catenin
            signaling pathway
  JOURNAL   Mol Carcinog 63 (11), 2158-2173 (2024)
   PUBMED   39150093
  REMARK    GeneRIF: STAMBPL1, transcriptionally regulated by SREBP1, promotes
            malignant behaviors of hepatocellular carcinoma cells via
            Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 2021)
  AUTHORS   Wang,Z., Zhang,Y., Shen,Y., Zhou,H., Gao,Y., Zhu,C. and Qin,X.
  TITLE     Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated
            TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway
  JOURNAL   Biol Direct 19 (1), 18 (2024)
   PUBMED   38419066
  REMARK    GeneRIF: Unlocking hepatocellular carcinoma aggression:
            STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2021)
  AUTHORS   Liu,R., Yang,G., Bao,M., Zhou,Z., Mao,X., Liu,W., Jiang,X., Zhu,D.,
            Ren,X., Huang,J. and Chen,C.
  TITLE     STAMBPL1 promotes breast cancer cell resistance to cisplatin
            partially by stabilizing MKP-1 expression
  JOURNAL   Oncogene 41 (16), 2265-2274 (2022)
   PUBMED   35236965
  REMARK    GeneRIF: STAMBPL1 promotes breast cancer cell resistance to
            cisplatin partially by stabilizing MKP-1 expression.
REFERENCE   4  (bases 1 to 2021)
  AUTHORS   Wang,D., Xu,C., Yang,W., Chen,J., Ou,Y., Guan,Y., Guan,J. and
            Liu,Y.
  TITLE     E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and
            cancer progression
  JOURNAL   Mol Cell 82 (4), 770-784 (2022)
   PUBMED   35114100
  REMARK    GeneRIF: E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR
            and cancer progression.
REFERENCE   5  (bases 1 to 2021)
  AUTHORS   Chaithongyot,S. and Naumann,M.
  TITLE     Helicobacter pylori-induced reactive oxygen species direct turnover
            of CSN-associated STAMBPL1 and augment apoptotic cell death
  JOURNAL   Cell Mol Life Sci 79 (2), 86 (2022)
   PUBMED   35066747
  REMARK    GeneRIF: Helicobacter pylori-induced reactive oxygen species direct
            turnover of CSN-associated STAMBPL1 and augment apoptotic cell
            death.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2021)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2021)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   8  (bases 1 to 2021)
  AUTHORS   Ibarrola,N., Kratchmarova,I., Nakajima,D., Schiemann,W.P.,
            Moustakas,A., Pandey,A. and Mann,M.
  TITLE     Cloning of a novel signaling molecule, AMSH-2, that potentiates
            transforming growth factor beta signaling
  JOURNAL   BMC Cell Biol 5, 2 (2004)
   PUBMED   14728725
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2021)
  AUTHORS   Kitajima,K., Matsumoto,K., Tahara,M., Takahashi,H., Nakamura,T. and
            Nakamura,T.
  TITLE     A newly identified AMSH-family protein is specifically expressed in
            haploid stages of testicular germ cells
  JOURNAL   Biochem Biophys Res Commun 309 (1), 135-142 (2003)
   PUBMED   12943674
REFERENCE   10 (bases 1 to 2021)
  AUTHORS   Kikuchi,K., Ishii,N., Asao,H. and Sugamura,K.
  TITLE     Identification of AMSH-LP containing a Jab1/MPN domain
            metalloenzyme motif
  JOURNAL   Biochem Biophys Res Commun 306 (3), 637-643 (2003)
   PUBMED   12810066
  REMARK    GeneRIF: Data show that associated molecule with the SH3 domain of
            STAM-like protein (AMSH-LP), unlike AMSH, fails to bind to the SH3
            domains of STAM1 (signal transducing adaptor molecule 1) and Grb2.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD244526.1, AK056086.1 and AW006657.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020799.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.102487.1,
                                           SRR3476690.653410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371926.8/ ENSP00000360994.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CD244526.1         84-96
            14-2019             AK056086.1         1-2006
            2020-2021           AW006657.1         19-20               c
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..2021
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /note="STAM binding protein like 1"
                     /db_xref="GeneID:57559"
                     /db_xref="HGNC:HGNC:24105"
                     /db_xref="MIM:612352"
     exon            1..394
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..477
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..1758
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /EC_number="3.1.2.15"
                     /note="associated molecule with the SH3 domain of STAM
                     (AMSH) like protein; associated molecule with the SH3
                     domain of STAM (AMSH) - Family Protein"
                     /codon_start=1
                     /product="AMSH-like protease"
                     /protein_id="NP_065850.1"
                     /db_xref="CCDS:CCDS7391.1"
                     /db_xref="GeneID:57559"
                     /db_xref="HGNC:HGNC:24105"
                     /db_xref="MIM:612352"
                     /translation="MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISE
                     DITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPE
                     KQDIMKKLKEIAFPRTDELKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAE
                     RKRIAQMRQQQLESEQFLFFEDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQ
                     NNSLLNVFADQPNKSDATNYASHSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLC
                     HKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDMENVEELFNV
                     QDQHDLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLT
                     NAGMLEVSACKKKGFHPHTKEPRLFSICKHVLVKDIKIIVLDLR"
     exon            478..695
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..771
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..867
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1225
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1350
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1488
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1601
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1701
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2021
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2001..2006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /note="hexamer: AATAAA"
     polyA_site      2021
                     /gene="STAMBPL1"
                     /gene_synonym="ALMalpha; AMSH-FP; AMSH-LP; bA399O19.2"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgacaa tttattttcc tgcagcagcg gcagcaggga cggttgctgc aggttcgggg
       61 tcggccggcc tgcgcgtggg cttgcgagga cgctgttcgt cccctgcgct ggggtgtccg
      121 acagcgagga ggagaacgac gcacggagcc cgcgcgactg gaaccagcaa agctccatct
      181 gtcggcagag gagaaggggg aggaggcacg gccgaggcaa acgagcggac gcctcgtcgc
      241 cgggtgccgg tatcaccccg ctgcaacgcc ttccagcaaa agccaccgcg gcccgggttg
      301 cagcagccgg acggatgcca aggccacacg gcagccacgg gggcagccgt cgcagtcgcc
      361 gtcccacacg ggctgcggac accaagggtt gctaatgaag tgattgagaa gaaacagtga
      421 acatcctcat ttcacagata agacaacatg gatcagcctt ttactgtgaa ttctctgaaa
      481 aagttagctg ctatgcctga ccatacagat gtttccctaa gcccagaaga gcgagtccgt
      541 gccctaagca agcttggttg taatatcacc atcagtgaag acatcactcc acgacgttac
      601 tttaggtctg gagtagagat ggagaggatg gcgtctgtgt atttggaaga aggaaatttg
      661 gaaaatgcct ttgttcttta taataaattt ataaccttat ttgtagaaaa gcttcctaac
      721 catcgagatt accagcaatg tgcagtacct gaaaagcagg atattatgaa gaaactgaag
      781 gagattgcat tcccaaggac agatgaattg aaaaacgacc ttttaaagaa atataacgta
      841 gaataccaag aatatttgca aagcaaaaac aaatataaag ctgaaattct caaaaaattg
      901 gagcatcaga gattgataga ggcagaaagg aagcggattg ctcagatgcg ccagcagcag
      961 ctagaatcgg agcagtttct gtttttcgaa gatcaactca agaagcaaga gttagcccga
     1021 ggtcaaatgc gaagtcagca aacctcaggg ctgtcagagc agattgatgg gagcgctttg
     1081 tcctgctttt ccacacacca gaacaattcc ttgctgaatg tatttgcaga tcaacctaat
     1141 aaaagtgatg caaccaatta tgctagccac tctcctcctg taaacagggc cttaacgcca
     1201 gctgctactc taagtgctgt tcagaattta gtggttgaag gactgcgatg tgtagttttg
     1261 ccagaagatc tttgccacaa atttctgcaa ctggcagaat ctaatacagt gagaggaata
     1321 gaaacctgtg gaatactctg tggaaaactg acacataatg aatttactat tacccatgta
     1381 attgtgccaa agcagtctgc gggaccagac tattgtgaca tggagaatgt agaggaatta
     1441 ttcaatgttc aggatcaaca tgatctcctc actctaggat ggatccatac acatcccact
     1501 caaactgcat ttttatccag cgttgatctt cacactcact gttcctatca actcatgttg
     1561 ccagaggcca ttgccattgt ttgctcacca aagcataaag acactggcat cttcaggctc
     1621 accaatgctg gcatgcttga ggtttctgct tgtaaaaaaa agggctttca tccacacacc
     1681 aaggagccca ggctgttcag tatatgcaaa catgtgttgg taaaagacat aaaaataatt
     1741 gtgttggatc tgaggtgata tgttctgaat gtaagcaccg tcaacatcag acacctactc
     1801 atggacatgt ggttgccgga ttttcttaag atgtttccag aaatgactga tattttatat
     1861 ttatacattt tagatgacaa agcttgatat ttattgctgt tgcacatttt aaagttttct
     1921 ttttgggttg ctctgtgtca agagaggtta catggtgtta aatcggtacc tgataatgta
     1981 cccaaatact atggccagat aataaattgt gctgcaaaca a
//
