LOCUS       NM_213622               6746 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens STAM binding protein (STAMBP), transcript variant 3,
            mRNA.
ACCESSION   NM_213622
VERSION     NM_213622.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6746)
  AUTHORS   Zhang,W., Xu,Z., Du,Y., Liu,T., Xiong,Z., Hu,J., Chen,L., Peng,X.
            and Zhou,F.
  TITLE     Identification of STAM-binding protein as a target for the
            treatment of gemcitabine resistance pancreatic cancer in a
            nutrient-poor microenvironment
  JOURNAL   Cell Death Dis 15 (9), 657 (2024)
   PUBMED   39242557
  REMARK    GeneRIF: Identification of STAM-binding protein as a target for the
            treatment of gemcitabine resistance pancreatic cancer in a
            nutrient-poor microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6746)
  AUTHORS   Li,L., Yang,X., He,M., Xu,X., Xuan,X., Zhang,J., Zhang,L., Xu,H.
            and Li,D.
  TITLE     The expression and clinical significance of STAMBP in breast cancer
  JOURNAL   Mol Biol Rep 50 (1), 899-906 (2023)
   PUBMED   36309616
  REMARK    GeneRIF: The expression and clinical significance of STAMBP in
            breast cancer.
REFERENCE   3  (bases 1 to 6746)
  AUTHORS   Yang,Q., Yan,D., Zou,C., Xue,Q., Lin,S., Huang,Q., Li,X., Tang,D.,
            Chen,X. and Liu,J.
  TITLE     The deubiquitinating enzyme STAMBP is a newly discovered driver of
            triple-negative breast cancer progression that maintains RAI14
            protein stability
  JOURNAL   Exp Mol Med 54 (11), 2047-2059 (2022)
   PUBMED   36434041
  REMARK    GeneRIF: The deubiquitinating enzyme STAMBP is a newly discovered
            driver of triple-negative breast cancer progression that maintains
            RAI14 protein stability.
REFERENCE   4  (bases 1 to 6746)
  AUTHORS   Yu,S., E,C. and Yang,J.
  TITLE     STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic
            potential in pancreatic cancer
  JOURNAL   Pancreatology 22 (7), 1003-1012 (2022)
   PUBMED   36089485
  REMARK    GeneRIF: STAM binding protein regulated by hsa_circ_0007334 exerts
            oncogenic potential in pancreatic cancer.
REFERENCE   5  (bases 1 to 6746)
  AUTHORS   Schor,S., Pu,S., Nicolaescu,V., Azari,S., Koivomagi,M., Karim,M.,
            Cassonnet,P., Saul,S., Neveu,G., Yueh,A., Demeret,C.,
            Skotheim,J.M., Jacob,Y., Randall,G. and Einav,S.
  TITLE     The cargo adapter protein CLINT1 is phosphorylated by the
            Numb-associated kinase BIKE and mediates dengue virus infection
  JOURNAL   J Biol Chem 298 (6), 101956 (2022)
   PUBMED   35452674
REFERENCE   6  (bases 1 to 6746)
  AUTHORS   Itoh,F., Asao,H., Sugamura,K., Heldin,C.H., ten Dijke,P. and
            Itoh,S.
  TITLE     Promoting bone morphogenetic protein signaling through negative
            regulation of inhibitory Smads
  JOURNAL   EMBO J 20 (15), 4132-4142 (2001)
   PUBMED   11483516
REFERENCE   7  (bases 1 to 6746)
  AUTHORS   Endo,K., Takeshita,T., Kasai,H., Sasaki,Y., Tanaka,N., Asao,H.,
            Kikuchi,K., Yamada,M., Chenb,M., O'Shea,J.J. and Sugamura,K.
  TITLE     STAM2, a new member of the STAM family, binding to the Janus
            kinases
  JOURNAL   FEBS Lett 477 (1-2), 55-61 (2000)
   PUBMED   10899310
REFERENCE   8  (bases 1 to 6746)
  AUTHORS   Tanaka,N., Kaneko,K., Asao,H., Kasai,H., Endo,Y., Fujita,T.,
            Takeshita,T. and Sugamura,K.
  TITLE     Possible involvement of a novel STAM-associated molecule 'AMSH' in
            intracellular signal transduction mediated by cytokines
  JOURNAL   J Biol Chem 274 (27), 19129-19135 (1999)
   PUBMED   10383417
REFERENCE   9  (bases 1 to 6746)
  AUTHORS   Asada,H., Ishii,N., Sasaki,Y., Endo,K., Kasai,H., Tanaka,N.,
            Takeshita,T., Tsuchiya,S., Konno,T. and Sugamura,K.
  TITLE     Grf40, A novel Grb2 family member, is involved in T cell signaling
            through interaction with SLP-76 and LAT
  JOURNAL   J Exp Med 189 (9), 1383-1390 (1999)
   PUBMED   10224278
REFERENCE   10 (bases 1 to 6746)
  AUTHORS   Carter,M.T., Mirzaa,G., McDonell,L.M. and Boycott,K.M.
  TITLE     Microcephaly-Capillary Malformation Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24354023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073046.7, CX758449.1 and
            BC065574.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_213622.3.
            
            Summary: Cytokine-mediated signal transduction in the JAK-STAT
            cascade requires the involvement of adaptor molecules. One such
            signal-transducing adaptor molecule contains an SH3 domain that is
            required for induction of MYC and cell growth. The protein encoded
            by this gene binds to the SH3 domain of the signal-transducing
            adaptor molecule, and plays a critical role in cytokine-mediated
            signaling for MYC induction and cell cycle progression. Multiple
            alternatively spliced transcript variants encoding the same protein
            isoform have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.71487.1,
                                           SRR1803613.39904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394070.7/ ENSP00000377633.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC073046.7         9055-9091
            38-721              CX758449.1         1-684
            722-2462            BC065574.1         663-2403
            2463-6746           AC073046.7         42979-47262
FEATURES             Location/Qualifiers
     source          1..6746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..6746
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="STAM binding protein"
                     /db_xref="GeneID:10617"
                     /db_xref="HGNC:HGNC:16950"
                     /db_xref="MIM:606247"
     exon            1..550
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            551..765
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             563..1837
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /EC_number="3.1.2.15"
                     /note="isoform 1 is encoded by transcript variant 3;
                     associated molecule with the SH3 domain of STAM;
                     endosome-associated ubiquitin isopeptidase; testicular
                     secretory protein Li 54"
                     /codon_start=1
                     /product="STAM-binding protein isoform 1"
                     /protein_id="NP_998787.1"
                     /db_xref="CCDS:CCDS1929.1"
                     /db_xref="GeneID:10617"
                     /db_xref="HGNC:HGNC:16950"
                     /db_xref="MIM:606247"
                     /translation="MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEII
                     RMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPK
                     AEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQE
                     QFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQP
                     SDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTA
                     RGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWI
                     HTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQ
                     KGFHPHSKDPPLFCSCSHVTVVDRAVTITDLR"
     exon            766..841
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            842..937
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1304
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1429
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1567
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1680
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1780
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..6746
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2442..2447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="hexamer: AATAAA"
     polyA_site      2462
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="major polyA site"
     regulatory      6710..6715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="hexamer: AATAAA"
     polyA_site      6746
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
ORIGIN      
        1 gtttccggaa cctccgggtg tcatccgcgg ggaaaggtgg ggaagggtcc cgggaacgtg
       61 gtggggcagg gcctccgagc gtggttggac tttgaagggg atcggccgcc gtgagtgtgg
      121 ggcctgcagc ctactctccc cgagtcccct gcccggcctg cctcgctcga ggcacccgac
      181 ggcttctgtc tccgcgggct ggcgcctgac cagccaggcc cagcggttcc ccgcctactg
      241 catttgaaag atcccgaaaa ccctggatga ttgtgcctgg ggttggcaag ttcgtcttga
      301 gtgccttcaa gaagggttcc tcaagcagtt gtcgatagag ccctccctac tgtatacgcc
      361 ccctccgctc attcctgcta cttcctttct cctcctcgta tttccccctc ggtcctttac
      421 gccgcctttc cccctcattt gcagatgctg catccccttt ttggaattgc tcaaccaggt
      481 ggtaaccggc gccgcttcct ggccttggga ggtggttcct ttcttaaccc acaagaacct
      541 ctcccaagag aacttggtcc tgatgtctga ccatggagat gtgagcctcc cgcccgaaga
      601 ccgggtgagg gctctctccc agctgggtag tgcggtagag gtgaatgaag acattccacc
      661 ccgtcggtac ttccgctctg gagttgagat tatccgaatg gcatccattt actctgagga
      721 aggcaacatt gaacatgcct tcatcctcta taacaagtat atcacgctct ttattgagaa
      781 actaccaaaa catcgagatt acaaatctgc tgtcattcct gaaaagaaag acacagtaaa
      841 gaaattaaag gagattgcat ttcccaaagc agaagagctg aaggcagagc tgttaaaacg
      901 atataccaaa gaatatacag aatataatga agaaaagaag aaggaagcag aggaattggc
      961 ccggaacatg gccatccagc aagagctgga aaaggaaaaa cagagggtag cacaacagaa
     1021 gcagcagcaa ttggaacagg aacagttcca tgccttcgag gagatgatcc ggaaccagga
     1081 gctagaaaaa gagcgactga aaattgtaca ggagtttggg aaggtagacc ctggcctagg
     1141 tggcccgcta gtgcctgact tggagaagcc ctccttagat gtgttcccca ccttaacagt
     1201 ctcatccata cagccttcag actgtcacac aactgtaagg ccagctaagc cacctgtggt
     1261 ggacaggtcc ttgaaacctg gagcactgag caactcagaa agtattccca caatcgatgg
     1321 attgcgccat gtggtggtgc ctgggcggct gtgcccacag tttctccagt tagccagtgc
     1381 caacactgcc cggggagtgg agacatgtgg aattctctgt ggaaaactga tgaggaatga
     1441 atttaccatt acccatgttc tcatccccaa gcaaagtgct gggtctgatt actgcaacac
     1501 agagaacgaa gaagaacttt tcctcataca ggatcagcag ggcctcatca cactgggctg
     1561 gattcatact caccccacac agaccgcgtt tctctccagt gtcgacctac acactcactg
     1621 ctcttaccag atgatgttgc cagagtcagt agccattgtt tgctccccca agttccagga
     1681 aactggattc tttaaactaa ctgaccatgg actagaggag atttcttcct gtcgccagaa
     1741 aggatttcat ccacacagca aggatccacc tctgttctgt agctgcagcc acgtgactgt
     1801 tgtggacaga gcagtgacca tcacagacct tcgatgagcg tttgagtcca acaccttcca
     1861 agaacaacaa aaccatatca gtgtactgta gccccttaat ttaagctttc tagaaagctt
     1921 tggaagtttt tgtagatagt agaaaggggg gcatcacctg agaaagagct gattttgtat
     1981 ttcaggtttg aaaagaaata actgaacata ttttttaggc aagtcagaaa gagaacatgg
     2041 tcacccaaaa gcaactgtaa ctcagaaatt aagttactca gaaattaagt agctcagaaa
     2101 ttaagaaaga atggtataat gaacccccat atacccttcc ttctggattc accaattgtt
     2161 aacatttttt tcctctcagc tatccttcta atttctctct aatttcaatt tgtttatatt
     2221 tacctctggg ctcaataagg gcatctgtgc agaaatttgg aagccattta gaaaatcttt
     2281 tggattttcc tgtggtttat ggcaatatga atggagctta ttactggggt gagggacagc
     2341 ttactccatt tgaccagatt gtttggctaa cacatcccga agaatgattt tgtcaggaat
     2401 tattgttatt taataaatat ttcaggatat ttttcctcta caataaagta acaattaact
     2461 tatgtttttg tgcttcagag tgatccattt gatcaagcat tgtataaaca ggttaaaaaa
     2521 aaggtatggt tgttttggaa aggtgaagga aaaatggaat ttgagatata ctgacactga
     2581 tggtgtgtcc cagttcactt ttaattactc cttgtttttt atctgcctgt tgccatcttc
     2641 cagaggtgtt gtgaagtcat ctctgttctt ttggtgctgt ctcaaatggg tcaaccattc
     2701 acttcctcct tatgccctcc atgcttttgg ctgaggataa tgaagccttt gtttggagta
     2761 ccaggttaca ctccaataaa tgattacatt tcccagccac cccaccctac caatttcatt
     2821 gtgttggctg ttcttttctg actaaggcaa tacctaggaa aacgcttgaa gcagcaattg
     2881 ttactgcaat tttctgtgag ctgagcctgg tgttctaggt ggcctagaaa taatggtgtc
     2941 atttgtgaca cctcgagtga gggcaggaga gtaaatactt tggctaggag aagagtgatt
     3001 tattctttat cagaattcta ggtgggggag ggagaatctg tgaatgcata aagttttctt
     3061 catttttaaa ttttgtctca gtctttattg cttaggttag tggtccttga acttgtcccc
     3121 tgaaagagcc cagttctcta tattcttttt cttctcttgg gttcttaatt ccccatatag
     3181 tggaaattcc ttctttgctg ttttggtatg ggtgggtctg ggggccagct gggcttggac
     3241 aagccatttc ctgctgcagc ccagagcagc ctggctgttc caccttgctc taaacagtcc
     3301 tgaaattgcc cagtcctctg cttttgggaa atccatcccc ttcttcccat tctttgtcta
     3361 ccacttagct tagggctttc ttacctttta tttcgactgt agccgttggc ttttaccaag
     3421 tctctttgtt tttagcattt cttcattcca gtctgttctg cacactttga tcaggagaag
     3481 cttctcacat tccagccatg ttcatgtttt ctctcttgct caaaaacctg caatagcttc
     3541 ccattgctga aaatctaaat ttagctttta gtcagaactt tccacttaaa gttcttaccc
     3601 ctggctatat attcaaatat ctagggagca atttaaaaaa tactgatgcc tgtgttctac
     3661 cccccaccaa ttaaagctga atctctaggg tggagcctca gatgttgttt ctgcatttgt
     3721 ctttcaagct gctagaattc tcaagtacaa ccagggttga caaccactgc attggtcttt
     3781 gatacctaag aattgtgagc tctcttatcc gtctctgccc accaaagaca ttcagccagg
     3841 tcaacaacat atcatacgtt gcaaccacat tgatcacaga ctgatcacca aactgctata
     3901 ttttcttttc tcttcctcta ggcacaagat atcttagtgg ctagatgggt gcaggaaatc
     3961 agtctgtaga tccctcttca tatctgctgc agcctagcca ctgcagaggc actctgcata
     4021 ggatggtcta agtgtctctg tcttcatctt acctctgtgg aggagacgtg gaatcaagcc
     4081 agcccacaag ccctgagact ggataggccg gagagaaaga ggagtagcca gagcggtcgg
     4141 gaaaagagga aaggaatact gtgggtaaaa gggacaaaga ccacgcaacc tgaggaaaga
     4201 cattgtattg aaagggtaat gactatttgg ctaaagggac tgactcctgg gttcccgagg
     4261 ctcaaagacc aggagacttt tccactcttg caagctgcac aagtaccata cttagtgttc
     4321 tgggctgaga ggggagacaa aagcatcgtc aggttgccaa acaatgtccc agttgccctg
     4381 ggaggcacaa acctaccaaa gtgccatagg ccaggtgcag agagaatcag aggagctgat
     4441 ttgcttgggg tcagagcaga gctgggtttt ttcagatgat cactttcaca tactccttgt
     4501 taaatgggac caaaggggaa gaagaagaaa cccttaagct tttgtaatat tgtcttgggt
     4561 accagatacc ataaaaggca gcatgagaga aacattccct tgggccagtg tcatggtgga
     4621 ttttcttgct tgagaggcaa ggatttcagc tttcatttgg taccacagaa tttaaaattg
     4681 taagtgccta tcccttttga ctgttgatgg cttctttggg gttttagtta ccccagttga
     4741 aagagaaatt tttcatattg gggttgagaa gaatggaggc tattaggagc aaagctttaa
     4801 tgagtgaaag tctggtgaat cctgcaattt tgatatgttt ccagtggatt ttgagaacac
     4861 agttttagga ccagagtaga tgttgttccc tagaaaatag agtcagctat tgatattgtg
     4921 cctcccatcc ctcatatctc agtgttttaa ccccacctga gtttggagac cagtttgtcc
     4981 aaggatcttt caaacatgtg agcccagagt agaacttctg agtcaaggat catgtctttt
     5041 tctgaggagc tttgcttggg gcactggaaa tcctgtttag atcaggacta ttggaatatt
     5101 atcctctcca ggggaagtgc caggttgaac atttaaggct ttgcttctag gcccagctat
     5161 acattcacca gcaaatcact taacttccta aatttcttta aaatctgtaa aatgggatca
     5221 gtctaatatg cctacctcaa atgatgacag aatgacatct atatgcatat gaggcctacg
     5281 ttagttgaaa gatgctataa agatataagg gatttgttac ttgtctttct tgaaatgtta
     5341 cagttggggt gcggttgctt ctatcttctg gacctctgcc cattcagcat acagctagag
     5401 gaatctttgg gcagatccac attctttagc actagctagg ctttgactcc aaagctatct
     5461 ggtctacctt gatgttctga gcaggaaaac tgaggacctc aagaaccatt ccaaatttct
     5521 actcattctc cctaagaccc agagcagacc caggacctaa agaaattaca tcatctctat
     5581 tttcccttgg ctccagccca ctcttgtttg aacctcccac ttttgttgtt ccaactactt
     5641 cttgagatga aggaagggca gaacattggc cctcttcact gaagtcttca ccccttaatc
     5701 cagggttcaa tttttagttc accttagcct gtttgagatt agaagctggg ccttaactta
     5761 caggtgtgtc cggcatcatt caatcagcct gttagatcca gaatccagca ctgtgacgct
     5821 acataaccat gggctctgtc cttccagttc ctttagtgcc ttccctcact ggtaggttca
     5881 ctctgagggc ttccttcctt gaactccagt ggcaactata gtctgtttcc cacaatttgt
     5941 tgtgtgtgtt ttttgttgtt ttgcagcgtt ttcatattgt cttttatgta agtcatgttt
     6001 ctgaactatc gtataaattt cattagggta agaatcatgt ttgctttatg cactgtgtaa
     6061 catgccttgc agtcagtata ggcacttaac cttattgatc agttgttcct tggtgttgaa
     6121 taatgtgtta ggtagccagg tggacctgtg tcctagcctg gagaagctct atgtcacctt
     6181 gtaggaagcc atctgaattt gactcagcat catatgctgg gcctgtgctg cacttgagct
     6241 ttctttccag ccgccaggag ggatggttgt cctggccaac agcgaattta atgggtggtc
     6301 aaaagaagat gtgcctgcat agaaggctga aagagggagc tggaagtagg aggagacaag
     6361 gagatagtga caccagtatc ttgtcacaga aatcaaggaa ggcaacagtt taaaggaggg
     6421 gagggagatc agtggtgcca actggctcag aagaggtttg ctgggttaaa tctcaagatg
     6481 agcccatgag atctggtggt tagcagaggc ctttcctgac aaccccattt taagcacctc
     6541 ttccccatca ctctatctca tcactgttac tgtctgtgta gccctgtcat gagctaaaat
     6601 catcctgttt gtttattgct agcttatgtg tctaaagtat actccttgag aacagcaact
     6661 ttgtcttttt cacctttgta ctgagtcccc tgacatggaa taagatatga ataaatgcac
     6721 agacttgtcc aaaatcatcc aattaa
//
