LOCUS       NM_001353974            6894 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens STAM binding protein (STAMBP), transcript variant 11,
            mRNA.
ACCESSION   NM_001353974 XM_017003178
VERSION     NM_001353974.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6894)
  AUTHORS   Zhang,W., Xu,Z., Du,Y., Liu,T., Xiong,Z., Hu,J., Chen,L., Peng,X.
            and Zhou,F.
  TITLE     Identification of STAM-binding protein as a target for the
            treatment of gemcitabine resistance pancreatic cancer in a
            nutrient-poor microenvironment
  JOURNAL   Cell Death Dis 15 (9), 657 (2024)
   PUBMED   39242557
  REMARK    GeneRIF: Identification of STAM-binding protein as a target for the
            treatment of gemcitabine resistance pancreatic cancer in a
            nutrient-poor microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6894)
  AUTHORS   Li,L., Yang,X., He,M., Xu,X., Xuan,X., Zhang,J., Zhang,L., Xu,H.
            and Li,D.
  TITLE     The expression and clinical significance of STAMBP in breast cancer
  JOURNAL   Mol Biol Rep 50 (1), 899-906 (2023)
   PUBMED   36309616
  REMARK    GeneRIF: The expression and clinical significance of STAMBP in
            breast cancer.
REFERENCE   3  (bases 1 to 6894)
  AUTHORS   Yang,Q., Yan,D., Zou,C., Xue,Q., Lin,S., Huang,Q., Li,X., Tang,D.,
            Chen,X. and Liu,J.
  TITLE     The deubiquitinating enzyme STAMBP is a newly discovered driver of
            triple-negative breast cancer progression that maintains RAI14
            protein stability
  JOURNAL   Exp Mol Med 54 (11), 2047-2059 (2022)
   PUBMED   36434041
  REMARK    GeneRIF: The deubiquitinating enzyme STAMBP is a newly discovered
            driver of triple-negative breast cancer progression that maintains
            RAI14 protein stability.
REFERENCE   4  (bases 1 to 6894)
  AUTHORS   Yu,S., E,C. and Yang,J.
  TITLE     STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic
            potential in pancreatic cancer
  JOURNAL   Pancreatology 22 (7), 1003-1012 (2022)
   PUBMED   36089485
  REMARK    GeneRIF: STAM binding protein regulated by hsa_circ_0007334 exerts
            oncogenic potential in pancreatic cancer.
REFERENCE   5  (bases 1 to 6894)
  AUTHORS   Schor,S., Pu,S., Nicolaescu,V., Azari,S., Koivomagi,M., Karim,M.,
            Cassonnet,P., Saul,S., Neveu,G., Yueh,A., Demeret,C.,
            Skotheim,J.M., Jacob,Y., Randall,G. and Einav,S.
  TITLE     The cargo adapter protein CLINT1 is phosphorylated by the
            Numb-associated kinase BIKE and mediates dengue virus infection
  JOURNAL   J Biol Chem 298 (6), 101956 (2022)
   PUBMED   35452674
REFERENCE   6  (bases 1 to 6894)
  AUTHORS   Itoh,F., Asao,H., Sugamura,K., Heldin,C.H., ten Dijke,P. and
            Itoh,S.
  TITLE     Promoting bone morphogenetic protein signaling through negative
            regulation of inhibitory Smads
  JOURNAL   EMBO J 20 (15), 4132-4142 (2001)
   PUBMED   11483516
REFERENCE   7  (bases 1 to 6894)
  AUTHORS   Endo,K., Takeshita,T., Kasai,H., Sasaki,Y., Tanaka,N., Asao,H.,
            Kikuchi,K., Yamada,M., Chenb,M., O'Shea,J.J. and Sugamura,K.
  TITLE     STAM2, a new member of the STAM family, binding to the Janus
            kinases
  JOURNAL   FEBS Lett 477 (1-2), 55-61 (2000)
   PUBMED   10899310
REFERENCE   8  (bases 1 to 6894)
  AUTHORS   Tanaka,N., Kaneko,K., Asao,H., Kasai,H., Endo,Y., Fujita,T.,
            Takeshita,T. and Sugamura,K.
  TITLE     Possible involvement of a novel STAM-associated molecule 'AMSH' in
            intracellular signal transduction mediated by cytokines
  JOURNAL   J Biol Chem 274 (27), 19129-19135 (1999)
   PUBMED   10383417
REFERENCE   9  (bases 1 to 6894)
  AUTHORS   Asada,H., Ishii,N., Sasaki,Y., Endo,K., Kasai,H., Tanaka,N.,
            Takeshita,T., Tsuchiya,S., Konno,T. and Sugamura,K.
  TITLE     Grf40, A novel Grb2 family member, is involved in T cell signaling
            through interaction with SLP-76 and LAT
  JOURNAL   J Exp Med 189 (9), 1383-1390 (1999)
   PUBMED   10224278
REFERENCE   10 (bases 1 to 6894)
  AUTHORS   Carter,M.T., Mirzaa,G., McDonell,L.M. and Boycott,K.M.
  TITLE     Microcephaly-Capillary Malformation Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24354023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073046.7.
            
            On Aug 13, 2020 this sequence version replaced NM_001353974.1.
            
            Summary: Cytokine-mediated signal transduction in the JAK-STAT
            cascade requires the involvement of adaptor molecules. One such
            signal-transducing adaptor molecule contains an SH3 domain that is
            required for induction of MYC and cell growth. The protein encoded
            by this gene binds to the SH3 domain of the signal-transducing
            adaptor molecule, and plays a critical role in cytokine-mediated
            signaling for MYC induction and cell cycle progression. Multiple
            alternatively spliced transcript variants encoding the same protein
            isoform have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2639656.1,
                                           SRR1660803.149044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               AC073046.7         9055-9604
            551-765             AC073046.7         10939-11153
            766-989             AC073046.7         24907-25130
            990-1085            AC073046.7         25261-25356
            1086-1452           AC073046.7         27481-27847
            1453-1577           AC073046.7         29457-29581
            1578-1715           AC073046.7         30470-30607
            1716-1828           AC073046.7         39348-39460
            1829-1928           AC073046.7         40146-40245
            1929-6894           AC073046.7         42297-47262
FEATURES             Location/Qualifiers
     source          1..6894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..6894
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="STAM binding protein"
                     /db_xref="GeneID:10617"
                     /db_xref="HGNC:HGNC:16950"
                     /db_xref="MIM:606247"
     exon            1..550
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            551..765
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            766..989
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1085
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1452
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             1116..1985
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /EC_number="3.1.2.15"
                     /note="isoform 3 is encoded by transcript variant 11;
                     associated molecule with the SH3 domain of STAM;
                     endosome-associated ubiquitin isopeptidase; testicular
                     secretory protein Li 54"
                     /codon_start=1
                     /product="STAM-binding protein isoform 3"
                     /protein_id="NP_001340903.1"
                     /db_xref="CCDS:CCDS92779.1"
                     /db_xref="GeneID:10617"
                     /db_xref="HGNC:HGNC:16950"
                     /db_xref="MIM:606247"
                     /translation="MAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERL
                     KIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSL
                     KPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFT
                     ITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHC
                     SYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHV
                     TVVDRAVTITDLR"
     exon            1453..1577
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1715
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1828
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1928
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..6894
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2590..2595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="hexamer: AATAAA"
     polyA_site      2610
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="major polyA site"
     regulatory      6858..6863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="hexamer: AATAAA"
     polyA_site      6894
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
ORIGIN      
        1 gtttccggaa cctccgggtg tcatccgcgg ggaaaggtgg ggaagggtcc cgggaacgtg
       61 gtggggcagg gcctccgagc gtggttggac tttgaagggg atcggccgcc gtgagtgtgg
      121 ggcctgcagc ctactctccc cgagtcccct gcccggcctg cctcgctcga ggcacccgac
      181 ggcttctgtc tccgcgggct ggcgcctgac cagccaggcc cagcggttcc ccgcctactg
      241 catttgaaag atcccgaaaa ccctggatga ttgtgcctgg ggttggcaag ttcgtcttga
      301 gtgccttcaa gaagggttcc tcaagcagtt gtcgatagag ccctccctac tgtatacgcc
      361 ccctccgctc attcctgcta cttcctttct cctcctcgta tttccccctc ggtcctttac
      421 gccgcctttc cccctcattt gcagatgctg catccccttt ttggaattgc tcaaccaggt
      481 ggtaaccggc gccgcttcct ggccttggga ggtggttcct ttcttaaccc acaagaacct
      541 ctcccaagag aacttggtcc tgatgtctga ccatggagat gtgagcctcc cgcccgaaga
      601 ccgggtgagg gctctctccc agctgggtag tgcggtagag gtgaatgaag acattccacc
      661 ccgtcggtac ttccgctctg gagttgagat tatccgaatg gcatccattt actctgagga
      721 aggcaacatt gaacatgcct tcatcctcta taacaagtat atcacgctct ttattgagaa
      781 actaccaaaa catcgagatt acaaatctgc tgtcattcct gaaaagaaag acacagtaaa
      841 ggtgggtctt cactttcatt gttgcccatc taaaagcttc agagcagcac agactgactt
      901 caagataaaa gtagtagtct ctgcatctga gtaccagatc ctgcaatagg agataaggcc
      961 atttcaccac aacagttctg aagtagcaga aattaaagga gattgcattt cccaaagcag
     1021 aagagctgaa ggcagagctg ttaaaacgat ataccaaaga atatacagaa tataatgaag
     1081 aaaagaagaa ggaagcagag gaattggccc ggaacatggc catccagcaa gagctggaaa
     1141 aggaaaaaca gagggtagca caacagaagc agcagcaatt ggaacaggaa cagttccatg
     1201 ccttcgagga gatgatccgg aaccaggagc tagaaaaaga gcgactgaaa attgtacagg
     1261 agtttgggaa ggtagaccct ggcctaggtg gcccgctagt gcctgacttg gagaagccct
     1321 ccttagatgt gttccccacc ttaacagtct catccataca gccttcagac tgtcacacaa
     1381 ctgtaaggcc agctaagcca cctgtggtgg acaggtcctt gaaacctgga gcactgagca
     1441 actcagaaag tattcccaca atcgatggat tgcgccatgt ggtggtgcct gggcggctgt
     1501 gcccacagtt tctccagtta gccagtgcca acactgcccg gggagtggag acatgtggaa
     1561 ttctctgtgg aaaactgatg aggaatgaat ttaccattac ccatgttctc atccccaagc
     1621 aaagtgctgg gtctgattac tgcaacacag agaacgaaga agaacttttc ctcatacagg
     1681 atcagcaggg cctcatcaca ctgggctgga ttcatactca ccccacacag accgcgtttc
     1741 tctccagtgt cgacctacac actcactgct cttaccagat gatgttgcca gagtcagtag
     1801 ccattgtttg ctcccccaag ttccaggaaa ctggattctt taaactaact gaccatggac
     1861 tagaggagat ttcttcctgt cgccagaaag gatttcatcc acacagcaag gatccacctc
     1921 tgttctgtag ctgcagccac gtgactgttg tggacagagc agtgaccatc acagaccttc
     1981 gatgagcgtt tgagtccaac accttccaag aacaacaaaa ccatatcagt gtactgtagc
     2041 cccttaattt aagctttcta gaaagctttg gaagtttttg tagatagtag aaaggggggc
     2101 atcacctgag aaagagctga ttttgtattt caggtttgaa aagaaataac tgaacatatt
     2161 ttttaggcaa gtcagaaaga gaacatggtc acccaaaagc aactgtaact cagaaattaa
     2221 gttactcaga aattaagtag ctcagaaatt aagaaagaat ggtataatga acccccatat
     2281 acccttcctt ctggattcac caattgttaa catttttttc ctctcagcta tccttctaat
     2341 ttctctctaa tttcaatttg tttatattta cctctgggct caataagggc atctgtgcag
     2401 aaatttggaa gccatttaga aaatcttttg gattttcctg tggtttatgg caatatgaat
     2461 ggagcttatt actggggtga gggacagctt actccatttg accagattgt ttggctaaca
     2521 catcccgaag aatgattttg tcaggaatta ttgttattta ataaatattt caggatattt
     2581 ttcctctaca ataaagtaac aattaactta tgtttttgtg cttcagagtg atccatttga
     2641 tcaagcattg tataaacagg ttaaaaaaaa ggtatggttg ttttggaaag gtgaaggaaa
     2701 aatggaattt gagatatact gacactgatg gtgtgtccca gttcactttt aattactcct
     2761 tgttttttat ctgcctgttg ccatcttcca gaggtgttgt gaagtcatct ctgttctttt
     2821 ggtgctgtct caaatgggtc aaccattcac ttcctcctta tgccctccat gcttttggct
     2881 gaggataatg aagcctttgt ttggagtacc aggttacact ccaataaatg attacatttc
     2941 ccagccaccc caccctacca atttcattgt gttggctgtt cttttctgac taaggcaata
     3001 cctaggaaaa cgcttgaagc agcaattgtt actgcaattt tctgtgagct gagcctggtg
     3061 ttctaggtgg cctagaaata atggtgtcat ttgtgacacc tcgagtgagg gcaggagagt
     3121 aaatactttg gctaggagaa gagtgattta ttctttatca gaattctagg tgggggaggg
     3181 agaatctgtg aatgcataaa gttttcttca tttttaaatt ttgtctcagt ctttattgct
     3241 taggttagtg gtccttgaac ttgtcccctg aaagagccca gttctctata ttctttttct
     3301 tctcttgggt tcttaattcc ccatatagtg gaaattcctt ctttgctgtt ttggtatggg
     3361 tgggtctggg ggccagctgg gcttggacaa gccatttcct gctgcagccc agagcagcct
     3421 ggctgttcca ccttgctcta aacagtcctg aaattgccca gtcctctgct tttgggaaat
     3481 ccatcccctt cttcccattc tttgtctacc acttagctta gggctttctt accttttatt
     3541 tcgactgtag ccgttggctt ttaccaagtc tctttgtttt tagcatttct tcattccagt
     3601 ctgttctgca cactttgatc aggagaagct tctcacattc cagccatgtt catgttttct
     3661 ctcttgctca aaaacctgca atagcttccc attgctgaaa atctaaattt agcttttagt
     3721 cagaactttc cacttaaagt tcttacccct ggctatatat tcaaatatct agggagcaat
     3781 ttaaaaaata ctgatgcctg tgttctaccc cccaccaatt aaagctgaat ctctagggtg
     3841 gagcctcaga tgttgtttct gcatttgtct ttcaagctgc tagaattctc aagtacaacc
     3901 agggttgaca accactgcat tggtctttga tacctaagaa ttgtgagctc tcttatccgt
     3961 ctctgcccac caaagacatt cagccaggtc aacaacatat catacgttgc aaccacattg
     4021 atcacagact gatcaccaaa ctgctatatt ttcttttctc ttcctctagg cacaagatat
     4081 cttagtggct agatgggtgc aggaaatcag tctgtagatc cctcttcata tctgctgcag
     4141 cctagccact gcagaggcac tctgcatagg atggtctaag tgtctctgtc ttcatcttac
     4201 ctctgtggag gagacgtgga atcaagccag cccacaagcc ctgagactgg ataggccgga
     4261 gagaaagagg agtagccaga gcggtcggga aaagaggaaa ggaatactgt gggtaaaagg
     4321 gacaaagacc acgcaacctg aggaaagaca ttgtattgaa agggtaatga ctatttggct
     4381 aaagggactg actcctgggt tcccgaggct caaagaccag gagacttttc cactcttgca
     4441 agctgcacaa gtaccatact tagtgttctg ggctgagagg ggagacaaaa gcatcgtcag
     4501 gttgccaaac aatgtcccag ttgccctggg aggcacaaac ctaccaaagt gccataggcc
     4561 aggtgcagag agaatcagag gagctgattt gcttggggtc agagcagagc tgggtttttt
     4621 cagatgatca ctttcacata ctccttgtta aatgggacca aaggggaaga agaagaaacc
     4681 cttaagcttt tgtaatattg tcttgggtac cagataccat aaaaggcagc atgagagaaa
     4741 cattcccttg ggccagtgtc atggtggatt ttcttgcttg agaggcaagg atttcagctt
     4801 tcatttggta ccacagaatt taaaattgta agtgcctatc ccttttgact gttgatggct
     4861 tctttggggt tttagttacc ccagttgaaa gagaaatttt tcatattggg gttgagaaga
     4921 atggaggcta ttaggagcaa agctttaatg agtgaaagtc tggtgaatcc tgcaattttg
     4981 atatgtttcc agtggatttt gagaacacag ttttaggacc agagtagatg ttgttcccta
     5041 gaaaatagag tcagctattg atattgtgcc tcccatccct catatctcag tgttttaacc
     5101 ccacctgagt ttggagacca gtttgtccaa ggatctttca aacatgtgag cccagagtag
     5161 aacttctgag tcaaggatca tgtctttttc tgaggagctt tgcttggggc actggaaatc
     5221 ctgtttagat caggactatt ggaatattat cctctccagg ggaagtgcca ggttgaacat
     5281 ttaaggcttt gcttctaggc ccagctatac attcaccagc aaatcactta acttcctaaa
     5341 tttctttaaa atctgtaaaa tgggatcagt ctaatatgcc tacctcaaat gatgacagaa
     5401 tgacatctat atgcatatga ggcctacgtt agttgaaaga tgctataaag atataaggga
     5461 tttgttactt gtctttcttg aaatgttaca gttggggtgc ggttgcttct atcttctgga
     5521 cctctgccca ttcagcatac agctagagga atctttgggc agatccacat tctttagcac
     5581 tagctaggct ttgactccaa agctatctgg tctaccttga tgttctgagc aggaaaactg
     5641 aggacctcaa gaaccattcc aaatttctac tcattctccc taagacccag agcagaccca
     5701 ggacctaaag aaattacatc atctctattt tcccttggct ccagcccact cttgtttgaa
     5761 cctcccactt ttgttgttcc aactacttct tgagatgaag gaagggcaga acattggccc
     5821 tcttcactga agtcttcacc ccttaatcca gggttcaatt tttagttcac cttagcctgt
     5881 ttgagattag aagctgggcc ttaacttaca ggtgtgtccg gcatcattca atcagcctgt
     5941 tagatccaga atccagcact gtgacgctac ataaccatgg gctctgtcct tccagttcct
     6001 ttagtgcctt ccctcactgg taggttcact ctgagggctt ccttccttga actccagtgg
     6061 caactatagt ctgtttccca caatttgttg tgtgtgtttt ttgttgtttt gcagcgtttt
     6121 catattgtct tttatgtaag tcatgtttct gaactatcgt ataaatttca ttagggtaag
     6181 aatcatgttt gctttatgca ctgtgtaaca tgccttgcag tcagtatagg cacttaacct
     6241 tattgatcag ttgttccttg gtgttgaata atgtgttagg tagccaggtg gacctgtgtc
     6301 ctagcctgga gaagctctat gtcaccttgt aggaagccat ctgaatttga ctcagcatca
     6361 tatgctgggc ctgtgctgca cttgagcttt ctttccagcc gccaggaggg atggttgtcc
     6421 tggccaacag cgaatttaat gggtggtcaa aagaagatgt gcctgcatag aaggctgaaa
     6481 gagggagctg gaagtaggag gagacaagga gatagtgaca ccagtatctt gtcacagaaa
     6541 tcaaggaagg caacagttta aaggagggga gggagatcag tggtgccaac tggctcagaa
     6601 gaggtttgct gggttaaatc tcaagatgag cccatgagat ctggtggtta gcagaggcct
     6661 ttcctgacaa ccccatttta agcacctctt ccccatcact ctatctcatc actgttactg
     6721 tctgtgtagc cctgtcatga gctaaaatca tcctgtttgt ttattgctag cttatgtgtc
     6781 taaagtatac tccttgagaa cagcaacttt gtctttttca cctttgtact gagtcccctg
     6841 acatggaata agatatgaat aaatgcacag acttgtccaa aatcatccaa ttaa
//
