LOCUS       NM_001353971            6380 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens STAM binding protein (STAMBP), transcript variant 8,
            mRNA.
ACCESSION   NM_001353971 XM_017003180
VERSION     NM_001353971.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6380)
  AUTHORS   Zhang,W., Xu,Z., Du,Y., Liu,T., Xiong,Z., Hu,J., Chen,L., Peng,X.
            and Zhou,F.
  TITLE     Identification of STAM-binding protein as a target for the
            treatment of gemcitabine resistance pancreatic cancer in a
            nutrient-poor microenvironment
  JOURNAL   Cell Death Dis 15 (9), 657 (2024)
   PUBMED   39242557
  REMARK    GeneRIF: Identification of STAM-binding protein as a target for the
            treatment of gemcitabine resistance pancreatic cancer in a
            nutrient-poor microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6380)
  AUTHORS   Li,L., Yang,X., He,M., Xu,X., Xuan,X., Zhang,J., Zhang,L., Xu,H.
            and Li,D.
  TITLE     The expression and clinical significance of STAMBP in breast cancer
  JOURNAL   Mol Biol Rep 50 (1), 899-906 (2023)
   PUBMED   36309616
  REMARK    GeneRIF: The expression and clinical significance of STAMBP in
            breast cancer.
REFERENCE   3  (bases 1 to 6380)
  AUTHORS   Yang,Q., Yan,D., Zou,C., Xue,Q., Lin,S., Huang,Q., Li,X., Tang,D.,
            Chen,X. and Liu,J.
  TITLE     The deubiquitinating enzyme STAMBP is a newly discovered driver of
            triple-negative breast cancer progression that maintains RAI14
            protein stability
  JOURNAL   Exp Mol Med 54 (11), 2047-2059 (2022)
   PUBMED   36434041
  REMARK    GeneRIF: The deubiquitinating enzyme STAMBP is a newly discovered
            driver of triple-negative breast cancer progression that maintains
            RAI14 protein stability.
REFERENCE   4  (bases 1 to 6380)
  AUTHORS   Yu,S., E,C. and Yang,J.
  TITLE     STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic
            potential in pancreatic cancer
  JOURNAL   Pancreatology 22 (7), 1003-1012 (2022)
   PUBMED   36089485
  REMARK    GeneRIF: STAM binding protein regulated by hsa_circ_0007334 exerts
            oncogenic potential in pancreatic cancer.
REFERENCE   5  (bases 1 to 6380)
  AUTHORS   Schor,S., Pu,S., Nicolaescu,V., Azari,S., Koivomagi,M., Karim,M.,
            Cassonnet,P., Saul,S., Neveu,G., Yueh,A., Demeret,C.,
            Skotheim,J.M., Jacob,Y., Randall,G. and Einav,S.
  TITLE     The cargo adapter protein CLINT1 is phosphorylated by the
            Numb-associated kinase BIKE and mediates dengue virus infection
  JOURNAL   J Biol Chem 298 (6), 101956 (2022)
   PUBMED   35452674
REFERENCE   6  (bases 1 to 6380)
  AUTHORS   Itoh,F., Asao,H., Sugamura,K., Heldin,C.H., ten Dijke,P. and
            Itoh,S.
  TITLE     Promoting bone morphogenetic protein signaling through negative
            regulation of inhibitory Smads
  JOURNAL   EMBO J 20 (15), 4132-4142 (2001)
   PUBMED   11483516
REFERENCE   7  (bases 1 to 6380)
  AUTHORS   Endo,K., Takeshita,T., Kasai,H., Sasaki,Y., Tanaka,N., Asao,H.,
            Kikuchi,K., Yamada,M., Chenb,M., O'Shea,J.J. and Sugamura,K.
  TITLE     STAM2, a new member of the STAM family, binding to the Janus
            kinases
  JOURNAL   FEBS Lett 477 (1-2), 55-61 (2000)
   PUBMED   10899310
REFERENCE   8  (bases 1 to 6380)
  AUTHORS   Tanaka,N., Kaneko,K., Asao,H., Kasai,H., Endo,Y., Fujita,T.,
            Takeshita,T. and Sugamura,K.
  TITLE     Possible involvement of a novel STAM-associated molecule 'AMSH' in
            intracellular signal transduction mediated by cytokines
  JOURNAL   J Biol Chem 274 (27), 19129-19135 (1999)
   PUBMED   10383417
REFERENCE   9  (bases 1 to 6380)
  AUTHORS   Asada,H., Ishii,N., Sasaki,Y., Endo,K., Kasai,H., Tanaka,N.,
            Takeshita,T., Tsuchiya,S., Konno,T. and Sugamura,K.
  TITLE     Grf40, A novel Grb2 family member, is involved in T cell signaling
            through interaction with SLP-76 and LAT
  JOURNAL   J Exp Med 189 (9), 1383-1390 (1999)
   PUBMED   10224278
REFERENCE   10 (bases 1 to 6380)
  AUTHORS   Carter,M.T., Mirzaa,G., McDonell,L.M. and Boycott,K.M.
  TITLE     Microcephaly-Capillary Malformation Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24354023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073046.7.
            
            On Aug 14, 2020 this sequence version replaced NM_001353971.1.
            
            Summary: Cytokine-mediated signal transduction in the JAK-STAT
            cascade requires the involvement of adaptor molecules. One such
            signal-transducing adaptor molecule contains an SH3 domain that is
            required for induction of MYC and cell growth. The protein encoded
            by this gene binds to the SH3 domain of the signal-transducing
            adaptor molecule, and plays a critical role in cytokine-mediated
            signaling for MYC induction and cell cycle progression. Multiple
            alternatively spliced transcript variants encoding the same protein
            isoform have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2957599.1,
                                           SRR14038192.3979626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC073046.7         9055-9090
            37-251              AC073046.7         10939-11153
            252-475             AC073046.7         24907-25130
            476-571             AC073046.7         25261-25356
            572-938             AC073046.7         27481-27847
            939-1063            AC073046.7         29457-29581
            1064-1201           AC073046.7         30470-30607
            1202-1314           AC073046.7         39348-39460
            1315-1414           AC073046.7         40146-40245
            1415-6380           AC073046.7         42297-47262
FEATURES             Location/Qualifiers
     source          1..6380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..6380
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="STAM binding protein"
                     /db_xref="GeneID:10617"
                     /db_xref="HGNC:HGNC:16950"
                     /db_xref="MIM:606247"
     exon            1..36
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            37..251
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            252..475
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            476..571
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            572..938
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             602..1471
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /EC_number="3.1.2.15"
                     /note="isoform 3 is encoded by transcript variant 8;
                     associated molecule with the SH3 domain of STAM;
                     endosome-associated ubiquitin isopeptidase; testicular
                     secretory protein Li 54"
                     /codon_start=1
                     /product="STAM-binding protein isoform 3"
                     /protein_id="NP_001340900.1"
                     /db_xref="CCDS:CCDS92779.1"
                     /db_xref="GeneID:10617"
                     /db_xref="HGNC:HGNC:16950"
                     /db_xref="MIM:606247"
                     /translation="MAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERL
                     KIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSL
                     KPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFT
                     ITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHC
                     SYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHV
                     TVVDRAVTITDLR"
     exon            939..1063
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1201
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1314
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1414
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..6380
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="hexamer: AATAAA"
     polyA_site      2096
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="major polyA site"
     regulatory      6344..6349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
                     /note="hexamer: AATAAA"
     polyA_site      6380
                     /gene="STAMBP"
                     /gene_synonym="AMSH; MICCAP"
ORIGIN      
        1 gtttccggaa cctccgggtg tcatccgcgg ggaaagaact tggtcctgat gtctgaccat
       61 ggagatgtga gcctcccgcc cgaagaccgg gtgagggctc tctcccagct gggtagtgcg
      121 gtagaggtga atgaagacat tccaccccgt cggtacttcc gctctggagt tgagattatc
      181 cgaatggcat ccatttactc tgaggaaggc aacattgaac atgccttcat cctctataac
      241 aagtatatca cgctctttat tgagaaacta ccaaaacatc gagattacaa atctgctgtc
      301 attcctgaaa agaaagacac agtaaaggtg ggtcttcact ttcattgttg cccatctaaa
      361 agcttcagag cagcacagac tgacttcaag ataaaagtag tagtctctgc atctgagtac
      421 cagatcctgc aataggagat aaggccattt caccacaaca gttctgaagt agcagaaatt
      481 aaaggagatt gcatttccca aagcagaaga gctgaaggca gagctgttaa aacgatatac
      541 caaagaatat acagaatata atgaagaaaa gaagaaggaa gcagaggaat tggcccggaa
      601 catggccatc cagcaagagc tggaaaagga aaaacagagg gtagcacaac agaagcagca
      661 gcaattggaa caggaacagt tccatgcctt cgaggagatg atccggaacc aggagctaga
      721 aaaagagcga ctgaaaattg tacaggagtt tgggaaggta gaccctggcc taggtggccc
      781 gctagtgcct gacttggaga agccctcctt agatgtgttc cccaccttaa cagtctcatc
      841 catacagcct tcagactgtc acacaactgt aaggccagct aagccacctg tggtggacag
      901 gtccttgaaa cctggagcac tgagcaactc agaaagtatt cccacaatcg atggattgcg
      961 ccatgtggtg gtgcctgggc ggctgtgccc acagtttctc cagttagcca gtgccaacac
     1021 tgcccgggga gtggagacat gtggaattct ctgtggaaaa ctgatgagga atgaatttac
     1081 cattacccat gttctcatcc ccaagcaaag tgctgggtct gattactgca acacagagaa
     1141 cgaagaagaa cttttcctca tacaggatca gcagggcctc atcacactgg gctggattca
     1201 tactcacccc acacagaccg cgtttctctc cagtgtcgac ctacacactc actgctctta
     1261 ccagatgatg ttgccagagt cagtagccat tgtttgctcc cccaagttcc aggaaactgg
     1321 attctttaaa ctaactgacc atggactaga ggagatttct tcctgtcgcc agaaaggatt
     1381 tcatccacac agcaaggatc cacctctgtt ctgtagctgc agccacgtga ctgttgtgga
     1441 cagagcagtg accatcacag accttcgatg agcgtttgag tccaacacct tccaagaaca
     1501 acaaaaccat atcagtgtac tgtagcccct taatttaagc tttctagaaa gctttggaag
     1561 tttttgtaga tagtagaaag gggggcatca cctgagaaag agctgatttt gtatttcagg
     1621 tttgaaaaga aataactgaa catatttttt aggcaagtca gaaagagaac atggtcaccc
     1681 aaaagcaact gtaactcaga aattaagtta ctcagaaatt aagtagctca gaaattaaga
     1741 aagaatggta taatgaaccc ccatataccc ttccttctgg attcaccaat tgttaacatt
     1801 tttttcctct cagctatcct tctaatttct ctctaatttc aatttgttta tatttacctc
     1861 tgggctcaat aagggcatct gtgcagaaat ttggaagcca tttagaaaat cttttggatt
     1921 ttcctgtggt ttatggcaat atgaatggag cttattactg gggtgaggga cagcttactc
     1981 catttgacca gattgtttgg ctaacacatc ccgaagaatg attttgtcag gaattattgt
     2041 tatttaataa atatttcagg atatttttcc tctacaataa agtaacaatt aacttatgtt
     2101 tttgtgcttc agagtgatcc atttgatcaa gcattgtata aacaggttaa aaaaaaggta
     2161 tggttgtttt ggaaaggtga aggaaaaatg gaatttgaga tatactgaca ctgatggtgt
     2221 gtcccagttc acttttaatt actccttgtt ttttatctgc ctgttgccat cttccagagg
     2281 tgttgtgaag tcatctctgt tcttttggtg ctgtctcaaa tgggtcaacc attcacttcc
     2341 tccttatgcc ctccatgctt ttggctgagg ataatgaagc ctttgtttgg agtaccaggt
     2401 tacactccaa taaatgatta catttcccag ccaccccacc ctaccaattt cattgtgttg
     2461 gctgttcttt tctgactaag gcaataccta ggaaaacgct tgaagcagca attgttactg
     2521 caattttctg tgagctgagc ctggtgttct aggtggccta gaaataatgg tgtcatttgt
     2581 gacacctcga gtgagggcag gagagtaaat actttggcta ggagaagagt gatttattct
     2641 ttatcagaat tctaggtggg ggagggagaa tctgtgaatg cataaagttt tcttcatttt
     2701 taaattttgt ctcagtcttt attgcttagg ttagtggtcc ttgaacttgt cccctgaaag
     2761 agcccagttc tctatattct ttttcttctc ttgggttctt aattccccat atagtggaaa
     2821 ttccttcttt gctgttttgg tatgggtggg tctgggggcc agctgggctt ggacaagcca
     2881 tttcctgctg cagcccagag cagcctggct gttccacctt gctctaaaca gtcctgaaat
     2941 tgcccagtcc tctgcttttg ggaaatccat ccccttcttc ccattctttg tctaccactt
     3001 agcttagggc tttcttacct tttatttcga ctgtagccgt tggcttttac caagtctctt
     3061 tgtttttagc atttcttcat tccagtctgt tctgcacact ttgatcagga gaagcttctc
     3121 acattccagc catgttcatg ttttctctct tgctcaaaaa cctgcaatag cttcccattg
     3181 ctgaaaatct aaatttagct tttagtcaga actttccact taaagttctt acccctggct
     3241 atatattcaa atatctaggg agcaatttaa aaaatactga tgcctgtgtt ctacccccca
     3301 ccaattaaag ctgaatctct agggtggagc ctcagatgtt gtttctgcat ttgtctttca
     3361 agctgctaga attctcaagt acaaccaggg ttgacaacca ctgcattggt ctttgatacc
     3421 taagaattgt gagctctctt atccgtctct gcccaccaaa gacattcagc caggtcaaca
     3481 acatatcata cgttgcaacc acattgatca cagactgatc accaaactgc tatattttct
     3541 tttctcttcc tctaggcaca agatatctta gtggctagat gggtgcagga aatcagtctg
     3601 tagatccctc ttcatatctg ctgcagccta gccactgcag aggcactctg cataggatgg
     3661 tctaagtgtc tctgtcttca tcttacctct gtggaggaga cgtggaatca agccagccca
     3721 caagccctga gactggatag gccggagaga aagaggagta gccagagcgg tcgggaaaag
     3781 aggaaaggaa tactgtgggt aaaagggaca aagaccacgc aacctgagga aagacattgt
     3841 attgaaaggg taatgactat ttggctaaag ggactgactc ctgggttccc gaggctcaaa
     3901 gaccaggaga cttttccact cttgcaagct gcacaagtac catacttagt gttctgggct
     3961 gagaggggag acaaaagcat cgtcaggttg ccaaacaatg tcccagttgc cctgggaggc
     4021 acaaacctac caaagtgcca taggccaggt gcagagagaa tcagaggagc tgatttgctt
     4081 ggggtcagag cagagctggg ttttttcaga tgatcacttt cacatactcc ttgttaaatg
     4141 ggaccaaagg ggaagaagaa gaaaccctta agcttttgta atattgtctt gggtaccaga
     4201 taccataaaa ggcagcatga gagaaacatt cccttgggcc agtgtcatgg tggattttct
     4261 tgcttgagag gcaaggattt cagctttcat ttggtaccac agaatttaaa attgtaagtg
     4321 cctatccctt ttgactgttg atggcttctt tggggtttta gttaccccag ttgaaagaga
     4381 aatttttcat attggggttg agaagaatgg aggctattag gagcaaagct ttaatgagtg
     4441 aaagtctggt gaatcctgca attttgatat gtttccagtg gattttgaga acacagtttt
     4501 aggaccagag tagatgttgt tccctagaaa atagagtcag ctattgatat tgtgcctccc
     4561 atccctcata tctcagtgtt ttaaccccac ctgagtttgg agaccagttt gtccaaggat
     4621 ctttcaaaca tgtgagccca gagtagaact tctgagtcaa ggatcatgtc tttttctgag
     4681 gagctttgct tggggcactg gaaatcctgt ttagatcagg actattggaa tattatcctc
     4741 tccaggggaa gtgccaggtt gaacatttaa ggctttgctt ctaggcccag ctatacattc
     4801 accagcaaat cacttaactt cctaaatttc tttaaaatct gtaaaatggg atcagtctaa
     4861 tatgcctacc tcaaatgatg acagaatgac atctatatgc atatgaggcc tacgttagtt
     4921 gaaagatgct ataaagatat aagggatttg ttacttgtct ttcttgaaat gttacagttg
     4981 gggtgcggtt gcttctatct tctggacctc tgcccattca gcatacagct agaggaatct
     5041 ttgggcagat ccacattctt tagcactagc taggctttga ctccaaagct atctggtcta
     5101 ccttgatgtt ctgagcagga aaactgagga cctcaagaac cattccaaat ttctactcat
     5161 tctccctaag acccagagca gacccaggac ctaaagaaat tacatcatct ctattttccc
     5221 ttggctccag cccactcttg tttgaacctc ccacttttgt tgttccaact acttcttgag
     5281 atgaaggaag ggcagaacat tggccctctt cactgaagtc ttcacccctt aatccagggt
     5341 tcaattttta gttcacctta gcctgtttga gattagaagc tgggccttaa cttacaggtg
     5401 tgtccggcat cattcaatca gcctgttaga tccagaatcc agcactgtga cgctacataa
     5461 ccatgggctc tgtccttcca gttcctttag tgccttccct cactggtagg ttcactctga
     5521 gggcttcctt ccttgaactc cagtggcaac tatagtctgt ttcccacaat ttgttgtgtg
     5581 tgttttttgt tgttttgcag cgttttcata ttgtctttta tgtaagtcat gtttctgaac
     5641 tatcgtataa atttcattag ggtaagaatc atgtttgctt tatgcactgt gtaacatgcc
     5701 ttgcagtcag tataggcact taaccttatt gatcagttgt tccttggtgt tgaataatgt
     5761 gttaggtagc caggtggacc tgtgtcctag cctggagaag ctctatgtca ccttgtagga
     5821 agccatctga atttgactca gcatcatatg ctgggcctgt gctgcacttg agctttcttt
     5881 ccagccgcca ggagggatgg ttgtcctggc caacagcgaa tttaatgggt ggtcaaaaga
     5941 agatgtgcct gcatagaagg ctgaaagagg gagctggaag taggaggaga caaggagata
     6001 gtgacaccag tatcttgtca cagaaatcaa ggaaggcaac agtttaaagg aggggaggga
     6061 gatcagtggt gccaactggc tcagaagagg tttgctgggt taaatctcaa gatgagccca
     6121 tgagatctgg tggttagcag aggcctttcc tgacaacccc attttaagca cctcttcccc
     6181 atcactctat ctcatcactg ttactgtctg tgtagccctg tcatgagcta aaatcatcct
     6241 gtttgtttat tgctagctta tgtgtctaaa gtatactcct tgagaacagc aactttgtct
     6301 ttttcacctt tgtactgagt cccctgacat ggaataagat atgaataaat gcacagactt
     6361 gtccaaaatc atccaattaa
//
