LOCUS       NM_005843               5472 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA.
ACCESSION   NM_005843
VERSION     NM_005843.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5472)
  AUTHORS   Ma,A., Shi,W., Chen,L., Huang,Z., Zhang,Y., Tang,Z., Jiang,W.,
            Xu,M., Zhou,J., Zhang,W. and Tang,S.
  TITLE     GRASLND regulates melanoma cell progression by targeting the
            miR-218-5p/STAM2 axis
  JOURNAL   J Transl Med 22 (1), 684 (2024)
   PUBMED   39060946
  REMARK    GeneRIF: GRASLND regulates melanoma cell progression by targeting
            the miR-218-5p/STAM2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5472)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5472)
  AUTHORS   Yang,Y., Zhang,Q., Liang,J., Yang,M., Wang,Z., Tang,D. and Wang,D.
  TITLE     STAM2 knockdown inhibits proliferation, migration, and invasion by
            affecting the JAK2/STAT3 signaling pathway in gastric cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (6), 697-706 (2021)
   PUBMED   33778841
  REMARK    GeneRIF: STAM2 knockdown inhibits proliferation, migration, and
            invasion by affecting the JAK2/STAT3 signaling pathway in gastric
            cancer.
REFERENCE   4  (bases 1 to 5472)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5472)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5472)
  AUTHORS   Pandey,A., Fernandez,M.M., Steen,H., Blagoev,B., Nielsen,M.M.,
            Roche,S., Mann,M. and Lodish,H.F.
  TITLE     Identification of a novel immunoreceptor tyrosine-based activation
            motif-containing molecule, STAM2, by mass spectrometry and its
            involvement in growth factor and cytokine receptor signaling
            pathways
  JOURNAL   J Biol Chem 275 (49), 38633-38639 (2000)
   PUBMED   10993906
REFERENCE   7  (bases 1 to 5472)
  AUTHORS   Kato,M., Miyazawa,K. and Kitamura,N.
  TITLE     A deubiquitinating enzyme UBPY interacts with the Src homology 3
            domain of Hrs-binding protein via a novel binding motif
            PX(V/I)(D/N)RXXKP
  JOURNAL   J Biol Chem 275 (48), 37481-37487 (2000)
   PUBMED   10982817
REFERENCE   8  (bases 1 to 5472)
  AUTHORS   Endo,K., Takeshita,T., Kasai,H., Sasaki,Y., Tanaka,N., Asao,H.,
            Kikuchi,K., Yamada,M., Chenb,M., O'Shea,J.J. and Sugamura,K.
  TITLE     STAM2, a new member of the STAM family, binding to the Janus
            kinases
  JOURNAL   FEBS Lett 477 (1-2), 55-61 (2000)
   PUBMED   10899310
REFERENCE   9  (bases 1 to 5472)
  AUTHORS   Rosenthal,J.A., Chen,H., Slepnev,V.I., Pellegrini,L., Salcini,A.E.,
            Di Fiore,P.P. and De Camilli,P.
  TITLE     The epsins define a family of proteins that interact with
            components of the clathrin coat and contain a new protein module
  JOURNAL   J Biol Chem 274 (48), 33959-33965 (1999)
   PUBMED   10567358
REFERENCE   10 (bases 1 to 5472)
  AUTHORS   Sulman,E.P., Tang,X.X., Allen,C., Biegel,J.A., Pleasure,D.E.,
            Brodeur,G.M. and Ikegaki,N.
  TITLE     ECK, a human EPH-related gene, maps to 1p36.1, a common region of
            alteration in human cancers
  JOURNAL   Genomics 40 (2), 371-374 (1997)
   PUBMED   9119409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC028740.2, AC079790.6 and
            BU619301.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005843.5.
            
            Summary: The protein encoded by this gene is closely related to
            STAM, an adaptor protein involved in the downstream signaling of
            cytokine receptors, both of which contain a SH3 domain and the
            immunoreceptor tyrosine-based activation motif (ITAM). Similar to
            STAM, this protein acts downstream of JAK kinases, and is
            phosphorylated in response to cytokine stimulation. This protein
            and STAM thus are thought to exhibit compensatory effects on the
            signaling pathway downstream of JAK kinases upon cytokine
            stimulation. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.33883.1,
                                           SRR1660807.86413.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263904.5/ ENSP00000263904.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1790              BC028740.2         230-2019
            1791-4853           AC079790.6         70370-73432         c
            4854-5472           BU619301.1         18-636              c
FEATURES             Location/Qualifiers
     source          1..5472
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..5472
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /note="signal transducing adaptor molecule 2"
                     /db_xref="GeneID:10254"
                     /db_xref="HGNC:HGNC:11358"
                     /db_xref="MIM:606244"
     exon            1..161
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1699
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /note="STAM-like protein containing SH3 and ITAM domains
                     2; HSE1 homolog; Hrs-binding protein; STAM-2; signal
                     transducing adaptor molecule (SH3 domain and ITAM motif)
                     2"
                     /codon_start=1
                     /product="signal transducing adapter molecule 2"
                     /protein_id="NP_005834.4"
                     /db_xref="CCDS:CCDS2196.1"
                     /db_xref="GeneID:10254"
                     /db_xref="HGNC:HGNC:11358"
                     /db_xref="MIM:606244"
                     /translation="MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAK
                     DCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAH
                     PKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTS
                     SNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVED
                     NELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVID
                     DDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMID
                     EKLEEIDRKHSELSELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPM
                     QTYPVQSHGGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLS
                     TGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVP
                     AHPVAQQHTNYHQQPLL"
     exon            162..246
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            247..322
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            323..421
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            422..568
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            569..638
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            639..825
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            826..920
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1003
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1091
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1146
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1300
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1470
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..5472
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3651..3656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /note="hexamer: AATAAA"
     polyA_site      3676
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /note="major polyA site"
     regulatory      4134..4139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /note="hexamer: AATAAA"
     polyA_site      4167
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
     regulatory      5451..5456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
                     /note="hexamer: AATAAA"
     polyA_site      5472
                     /gene="STAM2"
                     /gene_synonym="Hbp; STAM2A; STAM2B"
ORIGIN      
        1 aagtgcaggg acggaggccg aagcggagcg gtctagggag ccgcggccgc gggtcacccg
       61 gcgggtagca gttgctgagt gtcagctaga cagcagcgac tagggctcgg gcgccggcga
      121 gatgcctttg ttcaccgcca accccttcga gcaagacgtg gaaaaagcca cgaatgagta
      181 caacactaca gaagattgga gtcttattat ggacatatgt gacaaagttg gaagtactcc
      241 taatggagcg aaagattgcc taaaagccat aatgaaaagg gtaaatcata aggttccaca
      301 tgttgctctg caagcactaa ctcttcttgg ggcttgtgtg gcaaactgtg gaaagatatt
      361 tcatttagaa gtatgttccc gtgattttgc aacagaagta cgtgctgtga ttaaaaataa
      421 ggcacatcct aaagtatgtg aaaaactgaa atctttaatg gtggagtggt cagaagaatt
      481 tcagaaggac cctcagttta gtctgatatc tgcaactatt aaatctatga aagaagaagg
      541 aattactttt cctccagcag gttctcagac tgtctcagct gctgccaaga atggtacgtc
      601 atcgaacaaa aacaaagagg atgaagacat agctaaagct attgaattat cgctgcaaga
      661 acagaaacag caacacacag aaacaaaatc cttatatcca tcttcagaaa ttcagttaaa
      721 taataaggtt gcacggaaag tgagagcttt atatgatttt gaagctgttg aggacaatga
      781 actcaccttt aaacatggtg aaataattat tgttttggat gacagtgatg ccaattggtg
      841 gaaaggagaa aatcacagag gaataggact tttcccatcc aattttgtaa caactaattt
      901 aaacatagag actgaggcag cggctgtgga caaattgaat gtaattgatg atgatgtgga
      961 ggaaattaag aaatcagagc ctgagcctgt ttatatagat gaggataaga tggatagagc
     1021 cctgcaggta cttcagagta tagatccaac agattcaaaa ccagactccc aagacctttt
     1081 ggatttagaa gatatctgcc aacagatggg tccaatgata gatgaaaaac ttgaagaaat
     1141 tgataggaag cattcagaat tgtctgaatt gaatgttaaa gtcctggaag ctctggaact
     1201 atataacaaa ttggtgaatg aagcaccagt gtactcagtc tattcaaagc tccaccctcc
     1261 agcacattac ccacctgcat catctggggt tccaatgcag acatatccag ttcaatcaca
     1321 tggtggaaac tatatgggtc agagcattca ccaagtaact gttgcccaaa gctatagcct
     1381 aggacccgat caaattggtc cactgagatc tctgcctcca aatgtgaatt cctcagtgac
     1441 agcacagcct gctcaaactt catatttaag cactggacaa gacactgttt ccaatcctac
     1501 ttatatgaac cagaactcta acctacagtc agctactggt acaactgctt acacacagca
     1561 aatggggatg tctgtggata tgtcatctta tcagaacact acttccaatt tgcctcaact
     1621 ggcaggcttt ccggtgacag ttccagctca tccagttgca cagcagcaca caaattacca
     1681 tcagcagcct ctcctttaga aacaaatcaa gcattttctt gaaagccttc ataagtgtat
     1741 tattcagtcc ttgtgatacc aacctgaaaa tattaaaact tttttccctc tcaactcaaa
     1801 aggaccatga ataaataaag cacaaaaacc tctcttattc tacaaggcca taaaaggttt
     1861 tttttttttt tttttttcag tccagtttgt ttgaagtcaa tcttttcatc agaggcagct
     1921 taaagatgct ttcagttagt tttgtcttac tttcagattt ctctacataa atctagatac
     1981 tcattaagta gccttatgac aaacagtatg agatacttat gacaaactcg ctctgtcacc
     2041 caggctggag tgcagtagca tgatcgacag agtgagtttg tcaaaagtat ctcatactta
     2101 taaacagtat gagataggag gattaaaata ttattttaaa gaaaccactg tttcccccta
     2161 aaatgtcata agagcactga agaacttgaa atattttttt cagagtttct cacacacttt
     2221 aaaagtctaa cttttttgtg tgtaagcatt tagcttgcca gcatatttct ttttggctcc
     2281 ttaaattgcg gttgtgtttg cagtattgtc acttttgctc tcactgttat gttgaataat
     2341 aattagcata taattgtcta cagaagcaag agcaatctgg aaggaacaaa aatgttttct
     2401 gtgattaaca gtgaagacct tgtaaatgca gatgtgtgat aaagcattta gtcagtcccc
     2461 caaacagtca tgccaactgt gaaggaatgt cccacaaaac atttccattc cctgaggaaa
     2521 aacattttct ttcctacatg tatctctggt atttagaatt gtcactaata accttttcaa
     2581 gtgattttgg ctattctcta atgaagatat ggtccatttg tttttcttcc tgcaatgtgg
     2641 tgtgcagaga tgctgcatat cctttttatg ggattgcgtg tgaatttgaa ccatgagaca
     2701 ttcctaataa tttgttgtga gatataccaa gcatggatga taagtgtgtt tttagtggtg
     2761 tgttgttttt ttaaagaggt gattcaagta ccgttgctaa gctgtcaaca taccaagctg
     2821 ttgaaaaaat tgaccatttc tttcagaagt aattctcagc ctgtggaata atagcaggtg
     2881 aagacttcat agaaggcgac agattgatag ggaggctatt gaagcagttt ttctgaagcc
     2941 tgcattttga gttagtttat agtgctaata gattctatat aactgtgaga gtttggtagt
     3001 aaaccagtag ggattgtttt ctctcctaaa aatttgcaca ctacttcatt gtctaccaac
     3061 tttttacata ttggaaaata gaaattgcaa atacatacat gtatggaaac atattcagat
     3121 tgggaaaaac aatggacatt agtttttaaa aagttacgtg gaagcaagat ttctatattt
     3181 gtttttttaa aggaagcagt cattctttct actaaatcca tttcaagcta gttctctgaa
     3241 aattttgcca tttatctaca gaaatttgat tataaatatg ttcctttttc aaagaaactt
     3301 tattctagaa caaaatagtc tatatggtac ttgatctaca tttaagtgga aaaattagca
     3361 gtatttgaaa gctcagttta tgtcattgtc ttaacttcag atacaaataa ctgaacagaa
     3421 agttttaacc tttaatatct catgttctgt tttttattca gtattttcct ttatgttaat
     3481 tcaattatat acttctgaat ggcaccttac tttttggaaa caaatcttct gttatttaca
     3541 aaataataat ttttaaaaaa catttaaaaa aaatccaaag ctgctctcga taatagtcaa
     3601 catttgcata tatatggaat ttcttacttt ttttctccca aactctattt aataaactta
     3661 ttttaatgtt tgtgtatttc atgtataatt gtgatctcaa ttataaaagt ttaattcagc
     3721 atgtctttga gccaatataa ttactgcaca cccactaaat tgggatcagc cattataaat
     3781 aatgtagttt tagaataata aaacatgaca catatatata tatataaata tatagtatat
     3841 attggcacat cggtgaaagt ttatatgtgc agaagttttt ttctttctca agttaaaaat
     3901 tattttttgc catatgtaat tttgtgttgc aggctgtcga gagataaaaa tgattttaaa
     3961 tctgtgtact gatgattctt tcggtgttaa gaaacacagg gttgtgtact tcccttttta
     4021 tgggcttatg gattctattt atattaagac ctgtttataa ttgttttctg ccaaagggaa
     4081 ttgtctaact tcagatttct acattgggtt catacttact gttttatatc agaaataaaa
     4141 aaatagcttc tgctttttca tatgaaatct tggtacatca gaaagaattc ctgaaaattt
     4201 ataatagaat gaattttatt aatgcagaaa aataccccag ggtgttaaaa tatatgaagt
     4261 gtgggatata ttcttatagt ttgtaaaatg tagtcaacca atactgtctt ctaatttggt
     4321 aatttattta taaaattact taaacattag gtaattatat ttgttaggat ttgaaattat
     4381 ttgtagttaa attgtcatgc tgtttgaaat aattgatact tgtctacgta atacatttta
     4441 ctgtatgttt tgaagatggt tataatttca ctttcaaaat ttaaaaaatc aattttaaat
     4501 gttttaaaaa catatagctt agggattttt tttaaaaagg ttttcttagt aaaaacataa
     4561 atttaaaagc ccctgagttc taggagaggg cttattgaat tgctataaga aagctggagt
     4621 tactttgata agtaataaat tataaatagc actgatctat aatgctttat ttctatcgga
     4681 aggtactttt tcttctttca tcatcagttt tagccagtta gtaaatggga atactcagtt
     4741 ttagggattt gatttttgtt tggtttaatt ttctttcaaa aattaaaagt atatttctaa
     4801 aagttttccc cagaggccag atacagtggc tcatgcctat aatcccagca ctttgggagc
     4861 ctgagatagg agtattgctt gaggctagga gtttgagacc aacctggcaa catggcaaga
     4921 ccctatctct acaaaaattt taaaacttag ccaggtgtgg tagtgcacct gtagtcccag
     4981 ctagtcagta ggctgaggtg ggagtattgc ttgaggctgc agtgaggtgt gatcacgcca
     5041 ctgcactccg gcctgacaga atgagatcct gtctcaaaaa gaaaattccc cagaagaaga
     5101 attctaattt tatcaagctg aattaaagtt tgagagtctt ttttttaaaa tcttactgtg
     5161 tcaaaagagg cattatgttg cttgtgtgat atagtgaata gtgtccctcc aaatttcatg
     5221 tacacctgga atgtcacaat gtgacttaac agtagccacc cctcaccccc gcccttatct
     5281 gtggtggata catttgcaag atccccagtg gatgcctgaa accgcagata gtactgaacc
     5341 ttatatatac tgtttgtttt cctatgcata catatcccta tgataaagtt tatgaatttg
     5401 gcacttaaca gcagaactaa taagatgaaa gagttgtaac aatatactct aataaaagtt
     5461 atttaaaatg ta
//
