LOCUS       NM_003473               3856 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens signal transducing adaptor molecule (STAM), transcript
            variant 1, mRNA.
ACCESSION   NM_003473
VERSION     NM_003473.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3856)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3856)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3856)
  AUTHORS   Zhuo,Y., Gurevich,V.V., Vishnivetskiy,S.A., Klug,C.S. and
            Marchese,A.
  TITLE     A non-GPCR-binding partner interacts with a novel surface on
            beta-arrestin1 to mediate GPCR signaling
  JOURNAL   J Biol Chem 295 (41), 14111-14124 (2020)
   PUBMED   32753481
  REMARK    GeneRIF: A non-GPCR-binding partner interacts with a novel surface
            on beta-arrestin1 to mediate GPCR signaling.
REFERENCE   4  (bases 1 to 3856)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3856)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3856)
  AUTHORS   Endo,K., Takeshita,T., Kasai,H., Sasaki,Y., Tanaka,N., Asao,H.,
            Kikuchi,K., Yamada,M., Chenb,M., O'Shea,J.J. and Sugamura,K.
  TITLE     STAM2, a new member of the STAM family, binding to the Janus
            kinases
  JOURNAL   FEBS Lett 477 (1-2), 55-61 (2000)
   PUBMED   10899310
REFERENCE   7  (bases 1 to 3856)
  AUTHORS   Tanaka,N., Kaneko,K., Asao,H., Kasai,H., Endo,Y., Fujita,T.,
            Takeshita,T. and Sugamura,K.
  TITLE     Possible involvement of a novel STAM-associated molecule 'AMSH' in
            intracellular signal transduction mediated by cytokines
  JOURNAL   J Biol Chem 274 (27), 19129-19135 (1999)
   PUBMED   10383417
REFERENCE   8  (bases 1 to 3856)
  AUTHORS   Asao,H., Sasaki,Y., Arita,T., Tanaka,N., Endo,K., Kasai,H.,
            Takeshita,T., Endo,Y., Fujita,T. and Sugamura,K.
  TITLE     Hrs is associated with STAM, a signal-transducing adaptor molecule.
            Its suppressive effect on cytokine-induced cell growth
  JOURNAL   J Biol Chem 272 (52), 32785-32791 (1997)
   PUBMED   9407053
REFERENCE   9  (bases 1 to 3856)
  AUTHORS   Takeshita,T., Arita,T., Higuchi,M., Asao,H., Endo,K., Kuroda,H.,
            Tanaka,N., Murata,K., Ishii,N. and Sugamura,K.
  TITLE     STAM, signal transducing adaptor molecule, is associated with Janus
            kinases and involved in signaling for cell growth and c-myc
            induction
  JOURNAL   Immunity 6 (4), 449-457 (1997)
   PUBMED   9133424
REFERENCE   10 (bases 1 to 3856)
  AUTHORS   Takeshita,T., Arita,T., Asao,H., Tanaka,N., Higuchi,M., Kuroda,H.,
            Kaneko,K., Munakata,H., Endo,Y., Fujita,T. and Sugamura,K.
  TITLE     Cloning of a novel signal-transducing adaptor molecule containing
            an SH3 domain and ITAM
  JOURNAL   Biochem Biophys Res Commun 225 (3), 1035-1039 (1996)
   PUBMED   8780729
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU118708.1, U43899.1 and
            AC069542.7.
            
            On Nov 22, 2018 this sequence version replaced NM_003473.3.
            
            Summary: This gene encodes a member of the signal-transducing
            adaptor molecule family. These proteins mediate downstream
            signaling of cytokine receptors and also play a role in ER to Golgi
            trafficking by interacting with the coat protein II complex. The
            encoded protein also associates with hepatocyte growth
            factor-regulated substrate to form the endosomal sorting complex
            required for transport-0 (ESCRT-0), which sorts ubiquitinated
            membrane proteins to the ESCRT-1 complex for lysosomal degradation.
            Alternatively spliced transcript variants have been observed for
            this gene. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.53942.1,
                                           SRR1660805.15866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377524.8/ ENSP00000366746.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AU118708.1         28-174
            148-2328            U43899.1           1-2181
            2329-3856           AC069542.7         18895-20422         c
FEATURES             Location/Qualifiers
     source          1..3856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.33"
     gene            1..3856
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="signal transducing adaptor molecule"
                     /db_xref="GeneID:8027"
                     /db_xref="HGNC:HGNC:11357"
                     /db_xref="MIM:601899"
     exon            1..229
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1812
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="isoform a is encoded by transcript variant 1; HSE1
                     homolog; signal transducing adapter molecule 1; signal
                     transducing adaptor molecule (SH3 domain and ITAM motif)
                     1"
                     /codon_start=1
                     /product="signal transducing adapter molecule 1 isoform a"
                     /protein_id="NP_003464.1"
                     /db_xref="CCDS:CCDS7122.1"
                     /db_xref="GeneID:8027"
                     /db_xref="HGNC:HGNC:11357"
                     /db_xref="MIM:601899"
                     /translation="MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPK
                     DCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHP
                     KVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALV
                     AKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAI
                     YDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIK
                     TEKKTVQFSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEA
                     MCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPY
                     YMQSSGVSGSQVYAGPPPSGAYLVAGNAQMSHLQSYSLPPEQLSSLSQAVVPPSANPA
                     LPSQQTQAAYPNTMVSSVQGNTYPSQAPVYSPPPAATAAAATADVTLYQNAGPNMPQV
                     PNYNLTSSTLPQPGGSQQPPQPQQPYSQKALL"
     exon            230..314
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..390
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..486
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..633
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..724
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..917
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1012
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1101
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1189
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1244
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1398
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1574
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..3856
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2909..2914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="hexamer: ATTAAA"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="hexamer: AATAAG"
     polyA_site      2929
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="major polyA site"
     polyA_site      2942
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="major polyA site"
     regulatory      3559..3564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="hexamer: ATTATA"
     polyA_site      3580
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
     regulatory      3635..3640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="hexamer: GATAAA"
     polyA_site      3661
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
                     /note="hexamer: TATAAA"
     polyA_site      3856
                     /gene="STAM"
                     /gene_synonym="STAM-1; STAM1"
ORIGIN      
        1 ccttgctgtt gccgccgccg cagctgctgc cgcggttggt ggggttgggt gagaggagga
       61 gctgtcgcgg accctgtaga gtcggtctct gttgctcttt ttgcctgagg agtcttccat
      121 cctacgtcga gctctgactc ccgtgctgtc gagagggagt ccccggggac acctcggcac
      181 gcagcggaga tgcctctttt tgccaccaat cccttcgatc aggatgttga gaaagcaacc
      241 agcgagatga atactgctga ggactggggc ctcattttgg atatctgtga taaagttggt
      301 cagtctcgca ctggacctaa ggattgtctt cggtctatta tgagaagagt gaaccacaaa
      361 gatcctcacg ttgctatgca ggctttgact cttctaggag catgtgtatc aaactgtggc
      421 aaaatttttc atttagaagt atgttcaaga gattttgcta gtgaagtaag caacgtatta
      481 aataagggtc atcctaaagt atgtgaaaaa ttaaaggctc ttatggttga atggacagat
      541 gaatttaaga atgatccaca gcttagtcta atatcagcaa tgattaagaa ccttaaggaa
      601 caaggagtta cgttcccagc tattggctct caggctgcag aacaagcaaa agcaagccca
      661 gctcttgtag ccaaggatcc tggtactgtg gctaacaaaa aagaagaaga agatttagca
      721 aaagccattg agttgtctct caaggaacaa aggcagcagt caaccaccct ttccactttg
      781 tatccaagca catccagtct cttaactaac caccaacatg aaggccgaaa agttcgtgct
      841 atatatgact ttgaagctgc tgaagacaat gaacttactt ttaaagctgg agaaattatt
      901 acagttcttg atgacagtga tcctaactgg tggaaaggtg aaacccatca aggcataggg
      961 ttatttcctt ctaattttgt gactgcagat ctcactgctg aaccagaaat gattaaaaca
     1021 gagaagaaga cggtacaatt tagtgatgat gttcaggtag agacaataga accagagccg
     1081 gaaccagcct ttattgatga agataaaatg gaccagttgc tacagatgct gcaaagtaca
     1141 gaccccagtg atgatcagcc agacctacca gagctgcttc atcttgaagc aatgtgtcac
     1201 cagatgggac ctctcattga tgaaaagctg gaagatattg atagaaaaca ttcagaactc
     1261 tcagaactta atgtgaaagt gatggaggcc ctttccttat ataccaagtt aatgaacgaa
     1321 gatccgatgt attccatgta tgcaaagtta cagaatcagc catattatat gcagtcatct
     1381 ggtgtttctg gttctcaggt gtatgcaggg cctcctccaa gtggtgccta cctggttgca
     1441 gggaacgcgc agatgagcca cctccagagc tacagtcttc ccccggagca gctgtcttct
     1501 ctcagccagg cagtggtccc accatccgca aacccagccc ttcctagtca gcagactcag
     1561 gccgcttacc caaatacaat ggtcagttcc gttcaaggaa acacatatcc cagccaggcg
     1621 ccagtatata gtcctcctcc tgccgctact gctgctgctg caactgccga tgtcactctg
     1681 taccagaatg caggacctaa tatgccccag gtgccaaact ataacttaac atcatcaact
     1741 ctgcctcagc ccggaggcag ccaacagcca cctcagccac agcaaccata ttctcagaag
     1801 gctctgctat aggacccggt gttcctcttg gtggcagata cctgctaaat gccactgaca
     1861 atgttatgag attcattact atcttaagat gtgtttatcc tcagcttata ggaatctctc
     1921 caggtcaaca ggttcaaata ttcaagaagg tagaactctc ctcaatttac actgactttt
     1981 tagaggttct tccccccccg cccctgcaga ggaatgaaac tacttacaac atttaattcc
     2041 tttcataata tgaaagaatt gatacaaggc tatttgtctc gtaaacctgg tctgcagaaa
     2101 gtcaaactta caaaaactgt tgtgacaaat gttatgtaca tatattgata tgtaactgca
     2161 ttagtggcca ttttgaatca cagtggtgat cgtgtgaata tatttaacac tgtgttaaat
     2221 taatttacgt tgctatttta ttttaatcat aaacaactac catgtttctt aatgttttgt
     2281 gtaaatttaa ggtaattata ctatcctttt aaacttcaag aaaacaaagt tgttagcgta
     2341 tttacatgaa ggcgcattat gttgtcgtgt gtttcagttt cacattaaac tgaacctttt
     2401 actaattgtg agctaaagag atatatatat atatgtgtgt gtatatatat atatctacat
     2461 gtctttctgt agcctctgca tactactggc tgtcatcaca ccagcgtaca gtagctaaat
     2521 ttttggtgca attatagcaa atgataatgt tcccttttga acttttacat tttggcatga
     2581 catttcagag tattgtggga ccatgagaca aaattaagta cgatcacatt ctttatttct
     2641 cattttaaag aaatgatgtt ggtttacctt ttcctagttg aagatagtaa ttaggtttct
     2701 aagctgtata ctgtgtttat tggtggcagt gacaccaaag atagaggcaa tggatagaaa
     2761 tttttaaact ggaaagaaaa cctgaattac actacatttt cgaagtctct tgtaattatt
     2821 tgggatatca acaaaatttg attcgtctgt ctaatccctt gctagtattt taaatatgtc
     2881 tttaacacat tgtatccttt aattcttcat taaaatggaa ataagtagat gtttcaaagt
     2941 aatctacatt cctggctttg cttaacgttt atataggtat tgttttcttt cacactggat
     3001 ttttgggttg ctctttctgg ccttttaaaa ttctaatgga attattttgg cttcttactt
     3061 gggaatattt tcaaatgaat gcttttcttt taattcatgc gaaaaatgtt ttccactgac
     3121 attgtaatct taaatattta cgatttccct ggttgggcta tactattatt ttagcactat
     3181 ttaaacaacg gaaaagttga gtcgaacatc atatttaatg aattgatgta acaggtttca
     3241 tactataaat gaaaatttca tttttatttt ctaagactgt tgtaatcagg tagcttgttt
     3301 attttctttt tgagagaaga ttaaatcttt agccagtaat cttaagggtg actaatttca
     3361 cagactcaga tttaaagcac cgtagtttta aatctgagcc tgtgaaatta gtcacctgta
     3421 agattactta agggtaactt aagtgtttcg ctcaagtgtt gtgttctgat ttcctgtgtt
     3481 taaaatatgt tgccctgccc tgaagtcaaa tttcacattt taaatactat aagttagttt
     3541 ttgataaata tctgtcggat tataatcttt tccactccaa tttgagtatt atggtttaac
     3601 tgatatactt ttctgcaatt tttctttgtc ttttgataaa ttcctgttta ccaatgttaa
     3661 atgtatcatt ttcccatttt aattttgata tctttcatgc tgaaaatcaa tgacatagtc
     3721 tctactatga tttttgccct ataaaagtca agtaacagtg aatagaaaaa actaccctta
     3781 ttacaaccca tatacatttt tctttacctt ttacattact agccttataa aggtttaaat
     3841 gatgagtact ttaaaa
//
