LOCUS       NM_001282717            4199 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens STAG3 cohesin complex component (STAG3), transcript
            variant 3, mRNA.
ACCESSION   NM_001282717 XM_005250114
VERSION     NM_001282717.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4199)
  AUTHORS   Yi,J., Peng,F., Zhao,J. and Gong,X.
  TITLE     METTL3/IGF2BP2 axis affects the progression of colorectal cancer by
            regulating m6A modification of STAG3
  JOURNAL   Sci Rep 13 (1), 17292 (2023)
   PUBMED   37828232
  REMARK    GeneRIF: METTL3/IGF2BP2 axis affects the progression of colorectal
            cancer by regulating m6A modification of STAG3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4199)
  AUTHORS   Zhao,M., Wang,Y., Zhang,Y., Li,X., Mi,J., Wang,Q., Geng,Z., Zuo,L.,
            Song,X., Ge,S., Zhang,Z., Tang,M., Li,H., Wang,Z., Jiang,C. and
            Su,F.
  TITLE     The upregulation of stromal antigen 3 expression suppresses the
            phenotypic hallmarks of hepatocellular carcinoma through the
            Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways
  JOURNAL   BMC Gastroenterol 22 (1), 378 (2022)
   PUBMED   35941537
  REMARK    GeneRIF: The upregulation of stromal antigen 3 expression
            suppresses the phenotypic hallmarks of hepatocellular carcinoma
            through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4199)
  AUTHORS   Gomez-Rojas,S., Aristizabal-Duque,J.E., Munoz-Fernandez,L.F.,
            Sarmiento-Ramon,M.P. and Pereira-Gomez,M.D.P.
  TITLE     New STAG3 gene variant as a cause of premature ovarian
            insufficiency
  JOURNAL   Rev Colomb Obstet Ginecol 73 (1), 142-148 (2022)
   PUBMED   35503298
  REMARK    GeneRIF: New STAG3 gene variant as a cause of premature ovarian
            insufficiency', trans 'Nueva variante del gen STAG3 causante de
            insuficiencia ovarica prematura
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4199)
  AUTHORS   Demain,L.A.M., Boetje,E., Edgerley,J.J., Miles,E., Fitzgerald,C.T.,
            Busby,G., Beaman,G.M., O'Sullivan,J., O'Keefe,R.T. and Newman,W.G.
  TITLE     Biallelic loss of function variants in STAG3 result in primary
            ovarian insufficiency
  JOURNAL   Reprod Biomed Online 43 (5), 899-902 (2021)
   PUBMED   34497033
  REMARK    GeneRIF: Biallelic loss of function variants in STAG3 result in
            primary ovarian insufficiency.
REFERENCE   5  (bases 1 to 4199)
  AUTHORS   Mellone,S., Zavattaro,M., Vurchio,D., Ronzani,S., Caputo,M.,
            Leone,I., Prodam,F. and Giordano,M.
  TITLE     A Long Contiguous Stretch of Homozygosity Disclosed a Novel STAG3
            Biallelic Pathogenic Variant Causing Primary Ovarian Insufficiency:
            A Case Report and Review of the Literature
  JOURNAL   Genes (Basel) 12 (11), 1709 (2021)
   PUBMED   34828315
  REMARK    GeneRIF: A Long Contiguous Stretch of Homozygosity Disclosed a
            Novel STAG3 Biallelic Pathogenic Variant Causing Primary Ovarian
            Insufficiency: A Case Report and Review of the Literature.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4199)
  AUTHORS   Quaye,L., Dafou,D., Ramus,S.J., Song,H., Gentry-Maharaj,A.,
            Notaridou,M., Hogdall,E., Kjaer,S.K., Christensen,L., Hogdall,C.,
            Easton,D.F., Jacobs,I., Menon,U., Pharoah,P.D. and Gayther,S.A.
  TITLE     Functional complementation studies identify candidate genes and
            common genetic variants associated with ovarian cancer survival
  JOURNAL   Hum Mol Genet 18 (10), 1869-1878 (2009)
   PUBMED   19270026
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2009 Aug 1;18(15):2928. Maharaj, Aleksandra
            Gentry [corrected to Gentry-Maharaj, Aleksandra]]
REFERENCE   7  (bases 1 to 4199)
  AUTHORS   Maeshima,K., Yoshida,K. and Shirahige,K.
  TITLE     [Function of cohesin in transcription]
  JOURNAL   Tanpakushitsu Kakusan Koso 53 (11), 1337-1344 (2008)
   PUBMED   18788457
  REMARK    GeneRIF: plays a role in regulation of transcription due to genetic
            imprinting, sister chromatid exchange, chromosome segregation and
            as an insulator element. (review)
            Review article
REFERENCE   8  (bases 1 to 4199)
  AUTHORS   Barber,T.D., McManus,K., Yuen,K.W., Reis,M., Parmigiani,G.,
            Shen,D., Barrett,I., Nouhi,Y., Spencer,F., Markowitz,S.,
            Velculescu,V.E., Kinzler,K.W., Vogelstein,B., Lengauer,C. and
            Hieter,P.
  TITLE     Chromatid cohesion defects may underlie chromosome instability in
            human colorectal cancers
  JOURNAL   Proc Natl Acad Sci U S A 105 (9), 3443-3448 (2008)
   PUBMED   18299561
  REMARK    GeneRIF: identified as one of five genes containing 11 somatic
            mutations in a panel that included 132 colorectal cancers, then
            demonstrated that down-regulation of such homologs resulted in
            chromosomal instability and chromatid cohesion defects in human
            cells
REFERENCE   9  (bases 1 to 4199)
  AUTHORS   Prieto,I., Pezzi,N., Buesa,J.M., Kremer,L., Barthelemy,I.,
            Carreiro,C., Roncal,F., Martinez,A., Gomez,L., Fernandez,R.,
            Martinez-A,C. and Barbero,J.L.
  TITLE     STAG2 and Rad21 mammalian mitotic cohesins are implicated in
            meiosis
  JOURNAL   EMBO Rep 3 (6), 543-550 (2002)
   PUBMED   12034751
REFERENCE   10 (bases 1 to 4199)
  AUTHORS   Pezzi,N., Prieto,I., Kremer,L., Perez Jurado,L.A., Valero,C., Del
            Mazo,J., Martinez-A,C. and Barbero,J.L.
  TITLE     STAG3, a novel gene encoding a protein involved in meiotic
            chromosome pairing and location of STAG3-related genes flanking the
            Williams-Beuren syndrome deletion
  JOURNAL   FASEB J 14 (3), 581-592 (2000)
   PUBMED   10698974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073842.5 and AC005071.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 25, 2019 this sequence version replaced NM_001282717.1.
            
            Summary: The protein encoded by this gene is expressed in the
            nucleus and is a subunit of the cohesin complex which regulates the
            cohesion of sister chromatids during cell division. A mutation in
            this gene is associated with premature ovarian failure. Alternate
            splicing results in multiple transcript variants encoding distinct
            isoforms. This gene has multiple pseudogenes. [provided by RefSeq,
            Apr 2014].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            acceptor splice site in the 3' coding region compared to variant 1.
            The resulting isoform (2) is 1 aa longer than isoform 1. Variants 3
            and 5 both encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.614696.1,
                                           SRR14038195.1604618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615138.5/ ENSP00000477973.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC073842.5         26689-26776         c
            89-268              AC073842.5         24022-24201         c
            269-371             AC073842.5         22502-22604         c
            372-488             AC073842.5         21855-21971         c
            489-585             AC073842.5         18398-18494         c
            586-662             AC073842.5         16165-16241         c
            663-867             AC073842.5         15678-15882         c
            868-1019            AC073842.5         15098-15249         c
            1020-1093           AC073842.5         9312-9385           c
            1094-1217           AC073842.5         7415-7538           c
            1218-1316           AC073842.5         6818-6916           c
            1317-1396           AC073842.5         6528-6607           c
            1397-1504           AC073842.5         6112-6219           c
            1505-1619           AC073842.5         5737-5851           c
            1620-1725           AC073842.5         5327-5432           c
            1726-1829           AC073842.5         5050-5153           c
            1830-1922           AC073842.5         4366-4458           c
            1923-2012           AC073842.5         4152-4241           c
            2013-2213           AC073842.5         3725-3925           c
            2214-2284           AC073842.5         3534-3604           c
            2285-2372           AC073842.5         3343-3430           c
            2373-2453           AC073842.5         2828-2908           c
            2454-2546           AC073842.5         2653-2745           c
            2547-2715           AC073842.5         2354-2522           c
            2716-2852           AC073842.5         2104-2240           c
            2853-2954           AC073842.5         572-673             c
            2955-3021           AC073842.5         1-67                c
            3022-3103           AC005071.2         2000-2081
            3104-3232           AC005071.2         2311-2439
            3233-3390           AC005071.2         2533-2690
            3391-3565           AC005071.2         8317-8491
            3566-3670           AC005071.2         8741-8845
            3671-3752           AC005071.2         9101-9182
            3753-3824           AC005071.2         11041-11112
            3825-4199           AC005071.2         11313-11687
FEATURES             Location/Qualifiers
     source          1..4199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..4199
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /note="STAG3 cohesin complex component"
                     /db_xref="GeneID:10734"
                     /db_xref="HGNC:HGNC:11356"
                     /db_xref="MIM:608489"
     exon            1..88
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            89..268
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..3833
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /note="isoform 2 is encoded by transcript variant 3;
                     cohesin subunit SA-3; SCC3 homolog 3; stromal antigen 3;
                     stromalin-3"
                     /codon_start=1
                     /product="cohesin subunit SA-3 isoform 2"
                     /protein_id="NP_001269646.1"
                     /db_xref="CCDS:CCDS75642.1"
                     /db_xref="GeneID:10734"
                     /db_xref="HGNC:HGNC:11356"
                     /db_xref="MIM:608489"
                     /translation="MSSPLQRAVGDTKRALSASSSSSASLPFDDRDSNHTSEGNGDSL
                     LADEDTDFEDSLNRNVKKRAAKRPPKTTPVAKHPKKGSRVVHRHSRKQSEPPANDLFN
                     AVKAAKSDMQSLVDEWLDSYKQDQDAGFLELVNFFIQSCGCKGIVTPEMFKKMSNSEI
                     IQHLTEQFNEDSGDYPLIAPGPSWKKFQGSFCEFVRTLVCQCQYSLLYDGFPMDDLIS
                     LLTGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSVHQDNNQRQYEAERNKGPGQRA
                     PERLESLLEKRKELQEHQEEIEGMMNALFRGVFVHRYRDVLPEIRAICIEEIGCWMQS
                     YSTSFLTDSYLKYIGWTLHDKHREVRLKCVKALKGLYGNRDLTTRLELFTSRFKDRMV
                     SMVMDREYDVAVEAVRLLILILKNMEGVLTDADCESVYPVVYASHRGLASAAGEFLYW
                     KLFYPECEIRMMGGREQRQSPGAQRTFFQLLLSFFVESELHDHAAYLVDSLWDCAGAR
                     LKDWEGLTSLLLEKDQNLGDVQESTLIEILVSSARQASEGHPPVGRVTGRKGLTSKER
                     KTQADDRVKLTEHLIPLLPQLLAKFSADAEKVTPLLQLLSCFDLHIYCTGRLEKHLEL
                     FLQQLQEVVVKHAEPAVLEAGAHALYLLCNPEFTFFSRADFARSQLVDLLTDRFQQEL
                     EELLQSSFLDEDEVYNLAATLKRLSAFYNTHDLTRWELYEPCCQLLQKAVDTGEVPHQ
                     VILPALTLVYFSILWTLTHISKSDASQKQLSSLRDRMVAFCELCQSCLSDVDTEIQEQ
                     AFVLLSDLLLIFSPQMIVGGRDFLRPLVFFPEATLQSELASFLMDHVFIQPGDLGSGD
                     SQEDHLQIERLHQRRRLLAGFCKLLLYGVLEMDAASDVFKHYNKFYNDYGDIIKETLT
                     RARQIDRSHCSRILLLSLKQLYTELLQEHGPQGLNELPAFIEMRDLARRFALSFGPQQ
                     LQNRDLVVMLHKEGIQFSLSELPPAGSSNQPPNLAFLELLSEFSPRLFHQDKQLLLSY
                     LEKCLQHVSQAPGHPWGPVTTYCHSLSPVENTAETSPQVLPSSKRRRVEGPAKPNRED
                     VSSSQEESLQLNSIPPTPTLTSTAVKSRQPLWGLKEMEEEDGSELDFAQGSQPVAGTE
                     RSRFLGPQYFQTPHNPSGPGLGNQLMRLSLMEEDEEEELEIQDESNEERQDTDMQASS
                     YSSTSERGLDLLDSTELDIEDF"
     exon            269..371
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            372..488
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            489..585
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            586..662
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            663..867
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1019
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1093
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1217
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1316
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1396
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1504
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1619
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1725
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1829
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1922
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2012
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2213
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2284
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2372
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2453
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2546
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2715
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2852
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2954
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3103
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3232
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3390
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3565
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3670
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3752
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..3824
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..4199
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4180..4185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /note="hexamer: AATAAA"
     polyA_site      4199
                     /gene="STAG3"
                     /gene_synonym="SA3; SPGF61"
                     /note="major polyA site"
ORIGIN      
        1 gcttttctgg aatctttcgc ccccggaagg gcagcggcgg gcgcctgtgt ggaaggtggg
       61 gtggccagag acacccgagg gacctgagct ggatcgccat acctaccctg tggtcctcat
      121 cttcctggcc tcatagctcc tcctctccaa gcatgtcttc cccgttgcaa agagctgtgg
      181 gagataccaa gagggccttg tctgcatctt ctagttcctc tgccagtcta ccctttgatg
      241 acagggactc aaaccatacc tcagagggga atggcgactc tttgttagct gatgaagaca
      301 ctgactttga agacagcttg aatcgcaatg tgaagaagag agcagcaaaa cgaccaccga
      361 aaacaacacc ggtggcaaaa catccaaaga aagggtcccg agtggtacat cgtcatagcc
      421 ggaaacagtc agagccacca gccaatgatc ttttcaatgc tgtgaaagcc gccaaaagtg
      481 acatgcagtc tttggtagat gagtggctgg atagctacaa gcaagaccag gatgcaggat
      541 ttctggagct tgttaacttt ttcatccaat cttgcggatg taaaggcatt gtgacccctg
      601 agatgttcaa gaagatgtcc aactcagaga tcatccagca cctaacagag cagtttaatg
      661 aggactcggg ggactaccct ctcatagctc caggtccatc ctggaagaag ttccagggca
      721 gcttctgtga atttgtgagg acattggtct gtcagtgcca gtacagcctc ctctatgatg
      781 gcttccctat ggacgacctc atctccctgc tcactggcct ctcagactca caagtccgcg
      841 ccttccgtca cactagcacc ctggctgcta tgaaactgat gacctccctg gtaaaagttg
      901 ccctccaact gagtgtgcac caagataaca atcagcgtca gtatgaggct gaaagaaaca
      961 aggggccagg gcagagggca cctgagcggc tggagagcct gttggagaaa cgcaaagagc
     1021 tccaagagca tcaagaggag attgagggga tgatgaatgc cctcttcagg ggtgtctttg
     1081 ttcatcggta cagggatgtc cttcctgaga tccgtgctat ctgcattgag gaaattgggt
     1141 gttggatgca aagctacagc acgtctttcc tcaccgacag ctatttaaaa tatattggtt
     1201 ggactctgca tgataagcac cgagaagtcc gcctgaagtg tgtgaaggcc ctgaaagggc
     1261 tgtacggtaa ccgggacctg accacacgcc tggagctctt caccagccgc ttcaaggacc
     1321 ggatggtttc catggtcatg gacagagagt atgatgtggc agtggaggct gtcagattac
     1381 tgatacttat ccttaagaac atggaagggg tgctgacgga cgcggattgt gagagcgtct
     1441 acccagttgt gtatgcctct catcgaggcc tggcctctgc cgcaggcgaa tttctgtact
     1501 ggaaactctt ctaccctgag tgcgagataa gaatgatggg tggaagagag caacgccaga
     1561 gcccaggcgc ccagaggact ttcttccagc ttctgctgtc cttctttgtg gagagcgagc
     1621 tccatgacca cgctgcttac ttagtagaca gtctgtggga ctgtgcaggg gctcggctga
     1681 aggactggga gggtctgaca agcctgctgc tggagaagga ccagaacctg ggtgatgtgc
     1741 aggagagcac actgatagaa atccttgtgt ccagtgcccg gcaagcttca gaggggcacc
     1801 cgcctgtggg ccgggtcact gggaggaagg gcttaacctc taaggagcgc aagacccaag
     1861 ccgatgacag ggtgaagttg actgagcacc tcatccccct gctgccccag ctcctggcca
     1921 agttctcagc tgatgcagag aaggtcactc ccctgctcca gcttctcagc tgctttgacc
     1981 tccacatcta ctgcactggg cgcttggaga agcacctgga gctgttcctg cagcaactcc
     2041 aggaggtggt ggtgaagcat gcagagccag cggtgcttga ggctggggcg catgccctct
     2101 acctgctctg taatcccgaa ttcactttct tcagccgggc ggactttgcc cgcagccagc
     2161 tagtagattt gctgactgac cgcttccagc aggagcttga agagctgtta cagtcgtcct
     2221 tcctagatga ggatgaggta tataatctgg cagccactct gaaacgcctc tctgccttct
     2281 acaacactca tgacctgact cgctgggagc tctatgagcc atgttgccaa ctcctgcaga
     2341 aggctgtgga cacaggagag gttcctcacc aggttatcct gccagccttg actcttgtct
     2401 atttttccat tctctggaca ctaacccaca tttctaaatc agatgcttcc cagaagcagc
     2461 tgtcgagttt gagggacaga atggtggcct tctgtgaact ctgccagagt tgcctctcag
     2521 atgtggatac tgagatccag gagcaggctt ttgtcttatt aagtgatcta cttctcatct
     2581 ttagccctca gatgattgtt gggggccgtg atttccttag gccacttgtc ttttttcctg
     2641 aagctactct ccagtctgag ctagccagct tcctcatgga ccacgtcttc atccagccgg
     2701 gagacctggg cagtggtgat tcccaggagg atcatttaca gatagagcgg ctacaccagc
     2761 ggcgccgcct cctagccggg ttctgcaagc tgttgcttta tggggtgctg gagatggatg
     2821 cagcctcaga tgttttcaaa cactacaaca agttctacaa tgactatggt gacattatca
     2881 aggaaacatt aactagagca aggcagattg accgaagtca ttgttcccga atcctgctgc
     2941 tgagcctcaa gcagctgtac acagaactgc tgcaggagca tgggccccag ggcctgaatg
     3001 agcttcctgc cttcatcgag atgagggacc tggcccggag gtttgccttg agttttggac
     3061 cccagcagct gcagaaccgt gacctcgtgg tcatgctaca caaggaaggc atccagttct
     3121 ccttgtctga gcttcctcca gctggctcct ccaatcagcc tccaaatctg gcattcctgg
     3181 agctcctttc agagttttcc ccccgactct tccatcagga caagcagctt ttactgtcct
     3241 atctagaaaa gtgcctgcag catgtctccc aggcacctgg ccatccctgg ggcccagtca
     3301 ccacctactg ccactccctc agccctgtgg agaacacagc agagaccagc cctcaggtcc
     3361 tccccagctc caagaggagg cgcgttgaag ggcctgccaa gcctaacaga gaggacgtct
     3421 cctcgtccca ggaagaaagt ctgcagctga acagcatccc gcccacgccc accctcacct
     3481 ccacagctgt gaagagcagg cagcccctgt gggggttgaa agagatggag gaagaagatg
     3541 gctcagagtt ggattttgcc cagggcagtc agcccgtcgc aggcaccgag aggtcaaggt
     3601 tcttgggtcc acaatatttc cagactccac acaacccttc aggtcctggc ctgggcaacc
     3661 agctgatgcg actcagcctt atggaagagg acgaggaaga agagttagaa atccaggatg
     3721 agtcaaatga agaacggcag gatacagaca tgcaagcaag tagctactct tccaccagtg
     3781 agcgcgggct ggacctctta gattctacag agctggatat tgaggatttc tgacaggact
     3841 ctgggcccct ccccagctcc actccctacc tcaagaatgt gaccatttgg aaaaggcaaa
     3901 gagaaaagga gcaaaatgaa gcattccccc aggcttcagc cctgggctct gaggggaaag
     3961 agttgggcat tgtttttcta acctaacctt tccctctggg gtagagaagc cgagagaccc
     4021 tgtcctccct aatgcactgt ggcccagtcc ccttgccttt ttcctgttct gtttggagtg
     4081 gagaagggca gcacctctgt gtttaatgga aatagcccat agtctcctgg atttttggaa
     4141 catctttctc agcctatttt gtgtcctaat gattcgctca ataaacatgt ttgaatcca
//
