LOCUS       NM_001042750            6179 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens STAG2 cohesin complex component (STAG2), transcript
            variant 2, mRNA.
ACCESSION   NM_001042750
VERSION     NM_001042750.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6179)
  AUTHORS   Fischer,A., Hernandez-Rodriguez,B., Mulet-Lazaro,R., Nuetzel,M.,
            Holzl,F., van Herk,S., Kavelaars,F.G., Stanewsky,H., Ackermann,U.,
            Niang,A.H., Diaz,N., Reuschel,E., Strieder,N., Hernandez-Lopez,I.,
            Valk,P.J.M., Vaquerizas,J.M., Rehli,M., Delwel,R. and Gebhard,C.
  TITLE     STAG2 mutations reshape the cohesin-structured spatial chromatin
            architecture to drive gene regulation in acute myeloid leukemia
  JOURNAL   Cell Rep 43 (8), 114498 (2024)
   PUBMED   39084219
  REMARK    GeneRIF: STAG2 mutations reshape the cohesin-structured spatial
            chromatin architecture to drive gene regulation in acute myeloid
            leukemia.
REFERENCE   2  (bases 1 to 6179)
  AUTHORS   Huber,J., Tanasie,N.L., Zernia,S. and Stigler,J.
  TITLE     Single-molecule imaging reveals a direct role of CTCF's zinc
            fingers in SA interaction and cluster-dependent RNA recruitment
  JOURNAL   Nucleic Acids Res 52 (11), 6490-6506 (2024)
   PUBMED   38742641
  REMARK    GeneRIF: Single-molecule imaging reveals a direct role of CTCF's
            zinc fingers in SA interaction and cluster-dependent RNA
            recruitment.
REFERENCE   3  (bases 1 to 6179)
  AUTHORS   Xu,W., Kim,J.S., Yang,T., Ya,A., Sadzewicz,L., Tallon,L.,
            Harris,B.T., Sarkaria,J., Jin,F. and Waldman,T.
  TITLE     STAG2 mutations regulate 3D genome organization, chromatin loops,
            and Polycomb signaling in glioblastoma multiforme
  JOURNAL   J Biol Chem 300 (6), 107341 (2024)
   PUBMED   38705393
  REMARK    GeneRIF: STAG2 mutations regulate 3D genome organization, chromatin
            loops, and Polycomb signaling in glioblastoma multiforme.
REFERENCE   4  (bases 1 to 6179)
  AUTHORS   Ros-Pardo,D., Gomez-Puertas,P. and Marcos-Alcalde,I.
  TITLE     STAG2: Computational Analysis of Missense Variants Involved in
            Disease
  JOURNAL   Int J Mol Sci 25 (2), 1280 (2024)
   PUBMED   38279279
  REMARK    GeneRIF: STAG2: Computational Analysis of Missense Variants
            Involved in Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6179)
  AUTHORS   Zhou,J., Nie,R.C., He,Z.P., Cai,X.X., Chen,J.W., Lin,W.P.,
            Yin,Y.X., Xiang,Z.C., Zhu,T.C., Xie,J.J., Zhang,Y.C., Wang,X.,
            Lin,P., Xie,D., D'Andrea,A.D. and Cai,M.Y.
  TITLE     STAG2 Regulates Homologous Recombination Repair and Sensitivity to
            ATM Inhibition
  JOURNAL   Adv Sci (Weinh) 10 (36), e2302494 (2023)
   PUBMED   37985839
  REMARK    GeneRIF: STAG2 Regulates Homologous Recombination Repair and
            Sensitivity to ATM Inhibition.
REFERENCE   6  (bases 1 to 6179)
  AUTHORS   Gregson,H.C., Schmiesing,J.A., Kim,J.S., Kobayashi,T., Zhou,S. and
            Yokomori,K.
  TITLE     A potential role for human cohesin in mitotic spindle aster
            assembly
  JOURNAL   J Biol Chem 276 (50), 47575-47582 (2001)
   PUBMED   11590136
REFERENCE   7  (bases 1 to 6179)
  AUTHORS   Sumara,I., Vorlaufer,E., Gieffers,C., Peters,B.H. and Peters,J.M.
  TITLE     Characterization of vertebrate cohesin complexes and their
            regulation in prophase
  JOURNAL   J Cell Biol 151 (4), 749-762 (2000)
   PUBMED   11076961
REFERENCE   8  (bases 1 to 6179)
  AUTHORS   Carramolino,L., Lee,B.C., Zaballos,A., Peled,A., Barthelemy,I.,
            Shav-Tal,Y., Prieto,I., Carmi,P., Gothelf,Y., Gonzalez de
            Buitrago,G., Aracil,M., Marquez,G., Barbero,J.L. and Zipori,D.
  TITLE     SA-1, a nuclear protein encoded by one member of a novel gene
            family: molecular cloning and detection in hemopoietic organs
  JOURNAL   Gene 195 (2), 151-159 (1997)
   PUBMED   9305759
  REMARK    Erratum:[Gene 1998 Jan 12;206(2):283]
REFERENCE   9  (bases 1 to 6179)
  AUTHORS   Wu,C., Friedlander,P., Lamoureux,C., Zannis-Hadjopoulos,M. and
            Price,G.B.
  TITLE     cDNA clones contain autonomous replication activity
  JOURNAL   Biochim Biophys Acta 1174 (3), 241-257 (1993)
   PUBMED   7690594
REFERENCE   10 (bases 1 to 6179)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA214149.1, CR749433.1,
            BC001765.1, CB250478.1, BC017095.1 and AA428995.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001042750.1.
            
            Summary: The protein encoded by this gene is a subunit of the
            cohesin complex, which regulates the separation of sister
            chromatids during cell division. Targeted inactivation of this gene
            results in chromatid cohesion defects and aneuploidy, suggesting
            that genetic disruption of cohesin is a cause of aneuploidy in
            human cancer. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749433.1, SRR14038194.1284828.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371145.8/ ENSP00000360187.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA214149.1         1-32
            33-3223             CR749433.1         2-3192
            3224-3780           BC001765.1         3108-3664
            3781-4145           CR749433.1         3750-4114
            4146-4421           BC001765.1         3919-4194
            4422-5038           CB250478.1         34-650
            5039-6022           BC017095.1         139-1122
            6023-6179           AA428995.1         8-164               c
FEATURES             Location/Qualifiers
     source          1..6179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq25"
     gene            1..6179
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /note="STAG2 cohesin complex component"
                     /db_xref="GeneID:10735"
                     /db_xref="HGNC:HGNC:11355"
                     /db_xref="MIM:300826"
     exon            1..151
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            152..216
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            217..357
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..4120
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /note="isoform a is encoded by transcript variant 2; SCC3
                     homolog 2; cohesin subunit SA-2; SA2 stromalin; sister
                     chromatid cohesion 3 homolog B; stromal antigen 2"
                     /codon_start=1
                     /product="cohesin subunit SA-2 isoform a"
                     /protein_id="NP_001036215.1"
                     /db_xref="CCDS:CCDS43990.1"
                     /db_xref="GeneID:10735"
                     /db_xref="HGNC:HGNC:11355"
                     /db_xref="MIM:300826"
                     /translation="MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCK
                     KGKKGPAEKGKGGNGGGKPPSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDW
                     IESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYP
                     LTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHT
                     STLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANERLELLLQKRKELQE
                     NQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGW
                     TMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMTLDKEYDVAVQAIK
                     LLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSRRDPEEDGMMKR
                     RGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMNSLLLEEPLS
                     GEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTKITEL
                     FAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIVEKHT
                     DTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEPDED
                     DAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCTHYV
                     ILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIF
                     SHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDNNSADGQQEDEASKIE
                     ALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQ
                     CAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAM
                     LHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQM
                     SLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGSTVRSKKSKPSTGKRKVVEGM
                     QLSLTEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMSVYPMQT
                     EHHQTPLDYNTQVTWMLAQRQQEEARQQQERAAMSYVKLRTNLQHAIRRGTSLMEDDE
                     EPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPPSKNRRERTELKPDFFDPASIMDESV
                     LGVSMF"
     exon            358..436
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            437..601
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            602..698
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            699..775
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            776..980
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1132
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1206
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1330
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1429
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1509
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1617
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1729
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1847
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1951
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2044
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2134
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2338
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2409
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2497
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2578
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2671
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2846
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2986
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3088
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3237
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3366
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3590
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3780
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3891
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..4018
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4096
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            4097..6179
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6002..6007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /note="hexamer: AATAAA"
     polyA_site      6022
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /note="major polyA site"
     regulatory      6153..6158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
                     /note="hexamer: AATAAA"
     polyA_site      6179
                     /gene="STAG2"
                     /gene_synonym="bA517O1.1; HPE13; MKMS; NEDXCF; SA-2; SA2;
                     SCC3B"
ORIGIN      
        1 ctctcttcct cccttcctag agagggaaca acattcatgt gacgggcccc tctgcttctc
       61 ccccgcccca tcatctccag cgcgtggtgg gggaactgct ggggaaggcg attggcatcg
      121 atctctccat cccttccgag gcccgacttc ggtggccacc gagtactaaa ttcacttggg
      181 aataaaagaa aaacataaga aaattataag agaaaggaat tgtcttagaa gaaagaaggc
      241 aagccaccat tttacccacg taaatatatg aatatatttc tgacattgag gtgttccaga
      301 agatgataaa gaaatgatag cagctccaga aataccaact gattttaatc tactacagga
      361 gtcagaaaca catttttctt ctgacacaga ttttgaagat atcgaaggaa aaaaccaaaa
      421 gcaaggcaaa ggcaaaactt gtaaaaaagg caaaaagggc ccagcagaaa agggcaaagg
      481 tggaaatgga ggaggaaaac ctccttctgg tccaaaccga atgaatggtc atcaccaaca
      541 gaatggagtg gaaaacatga tgttgtttga agttgttaaa atgggcaaga gtgctatgca
      601 gtcggtggta gatgattgga tagaatcata caagcatgac cgagatatag cacttcttga
      661 ccttatcaac ttttttattc agtgttcagg ctgtaaagga gttgtcacag cagaaatgtt
      721 tagacatatg cagaactctg agataattcg aaaaatgact gaagaattcg atgaggatag
      781 tggagattat ccacttacca tggctggtcc tcagtggaag aagttcaaat ccagtttttg
      841 tgaattcatt ggcgtgttag tacggcaatg tcaatatagt atcatatatg atgagtatat
      901 gatggataca gtcatttcac ttcttacagg attgtctgac tcacaagtca gagcatttcg
      961 acatacaagc accctggcag ctatgaagtt gatgacagct ttggtgaatg tggcactaaa
     1021 tcttagcatt aatatggata atacacaaag acaatatgaa gcagaacgga ataaaatgat
     1081 tggaaaacga gccaatgaga ggctagaact cctgctacaa aagcggaaag agcttcagga
     1141 aaatcaagat gaaatagaaa atatgatgaa tgcaatattt aaaggagtgt ttgtacatag
     1201 ataccgtgat gcgatagctg aaattcgagc tatttgcatt gaagagattg gcatttggat
     1261 gaagatgtat agtgatgcct ttcttaatga cagttattta aaatatgttg gttggactat
     1321 gcatgataag caaggtgaag taagactcaa atgtcttact gctctacaag ggctttatta
     1381 taacaaagag cttaattcca aactggaact ttttaccagt cggttcaagg atagaattgt
     1441 gtctatgacc cttgacaaag aatatgatgt tgcagtacaa gcaataaaat tactcactct
     1501 tgttttacag agtagtgaag aagttctcac tgcagaagat tgtgaaaatg tctatcatct
     1561 ggtttattca gctcaccggc cagtagcagt agcagctgga gaatttctct acaaaaagct
     1621 cttcagtcgt agagatccag aggaggatgg aatgatgaaa agaagaggaa gacaaggtcc
     1681 aaatgccaac cttgttaaga cattggtttt tttctttcta gaaagtgagt tacatgagca
     1741 tgcagcatac cttgtggata gcatgtggga ctgtgctact gagctgctga aagactggga
     1801 atgtatgaat agcttgttac tggaagagcc acttagtgga gaggaagcac taacagatag
     1861 gcaagagagt gctctgattg aaataatgct ttgtaccatt agacaagcgg ctgaatgtca
     1921 tcctcccgtg ggaagaggga caggaaaaag ggtgcttaca gcaaaggaga agaagacaca
     1981 gttggatgat aggacaaaaa tcactgagct ttttgccgtg gcccttcctc agttattagc
     2041 aaaatactct gtagatgcag aaaaggtgac taacttgttg cagttgcctc agtactttga
     2101 tttggaaata tataccactg gacgattaga aaagcatttg gatgccttat tgcgacagat
     2161 ccggaatatt gtagagaagc acacagatac agatgttttg gaagcatgtt ctaaaactta
     2221 ccatgcactc tgtaatgaag agttcacaat cttcaacaga gtagatattt caagaagtca
     2281 actgatagat gaattggcag ataaatttaa ccggcttctt gaagattttc tgcaagaggg
     2341 tgaagaacct gatgaagatg atgcatatca ggtattgtca acattgaaga ggatcactgc
     2401 ttttcataat gcccatgacc tttcaaagtg ggatttattt gcttgtaatt acaaactctt
     2461 gaaaactgga atcgaaaatg gagacatgcc tgagcagatt gttattcacg cactgcagtg
     2521 tactcactat gtaatccttt ggcaacttgc taagataact gaaagcagct ctacaaagga
     2581 ggacttgctg cgtttaaaga aacaaatgag agtattttgt cagatatgtc aacattacct
     2641 gaccaacgtg aatactactg ttaaggaaca ggccttcact attctgtgtg atattttgat
     2701 gatcttcagc catcagatta tgtcaggagg gcgtgacatg ttagagccat tagtgtatac
     2761 ccctgattct tcattgcagt ctgagttgct cagctttatt ttggatcatg tcttcattga
     2821 acaggatgat gataataata gtgcagatgg tcagcaagag gatgaagcca gtaaaattga
     2881 agctctgcac aagagaagaa atttacttgc agcattttgt aagctaattg tatatactgt
     2941 ggtggagatg aatacagctg cagatatctt caaacagtat atgaagtatt ataatgacta
     3001 tggagatatc atcaaagaaa caatgagtaa aacaaggcag atagacaaaa ttcagtgtgc
     3061 taagaccctt attctcagtc tgcaacagct ttttaatgaa atgatacaag aaaatggcta
     3121 taattttgat agatcatcct ctacatttag tggcataaaa gaacttgctc gacgttttgc
     3181 tttaactttt ggacttgatc agttgaaaac aagagaagcc attgccatgc tacacaaaga
     3241 tggcatagaa tttgctttta aagagcctaa tccgcaaggg gagagccatc cacctttaaa
     3301 tttggcattt cttgatattc tgagtgaatt ttcttctaaa ctacttcgac aagacaaaag
     3361 aacagtgtat gtttacttgg aaaagttcat gacctttcag atgtcactcc gaagagagga
     3421 tgtgtggctt ccactgatgt cttaccgaaa ttctttgcta gctggtggtg atgatgacac
     3481 catgtcagtc attagtggaa tcagcagccg ggggtcaaca gtacggagta aaaaatcaaa
     3541 accatctaca ggaaaacgga aagtggttga gggcatgcag ctttcactca ctgaagaaag
     3601 tagtagtagt gacagtatgt ggttaagcag agaacaaaca ctgcacaccc ctgttatgat
     3661 gcagacacca caactcacct ccactattat gagagagccc aaaagattac ggcctgagga
     3721 tagcttcatg agtgtttatc caatgcagac tgaacatcat caaacacctc ttgattataa
     3781 cacgcaggta acatggatgt tagctcaaag acaacaagag gaagcaaggc aacagcagga
     3841 gagagcagca atgagctatg ttaaactgcg aactaatctt cagcatgcca ttcggcgtgg
     3901 cacaagccta atggaagatg atgaagagcc aattgtggaa gatgttatga tgtcctcaga
     3961 agggaggatt gaggatctta atgagggaat ggattttgac accatggata tagatttgcc
     4021 accatcaaag aacagacgag agagaacaga actgaagcct gatttctttg atccagcttc
     4081 aattatggat gaatcagttc ttggagtgtc aatgttttaa taccagtaca caattaaatc
     4141 tgtggtgaag tcattttcta agtggaagag gaaattttaa agtgtggtag atacagtgaa
     4201 attctgtaca gatttttctc taaggagaat atgacatgct tatgcttacc aagatcaagt
     4261 gcattgaggg gcagttttgt ttgcctgaat aaacgtaaag gacaagtaaa caatttgatg
     4321 ataagctaca gtttttctta gaaagtaaat attttattta tgcgctgtta gttggctttt
     4381 gaatcgatta tttcatgctt ttttttaaaa aaaaaaaaaa acaaaataac aatctgaaga
     4441 ggcatttggt acagatatga attctcttac atttatttac tggttgtact aaataatgat
     4501 gacctctgct ggatttctgt ttacatccag aaaacaatgt taaggatgta tttattcccc
     4561 taccctgaag aaagtgtagg atagaattgt ttttagcatt ctaaatttaa atgcttaaaa
     4621 cgtcaatcaa caaaactttg ttttaaatat tgtaattgtg gagaaaagta aacttataag
     4681 cagaactttt acaatttttt catctaaaag tattttaaga tatttttaaa atccaagagc
     4741 ttctctatac ttttcagaaa tatccagatg cagtgaactg ccagaaggta accagtctca
     4801 aacatgctta tcccattatc aaccctgaaa gtttgcttgt cctttaagat aaaaatgtaa
     4861 tgttgtgata ttccttccag taatgccact gtattttgtc tccaaataaa agaagcttat
     4921 tgtagtatgt ttgcagaaaa attctaaaca aaaattatac agcttattag agtgtgggaa
     4981 tagggatcta aattttaaat aaaattatat atatatataa attggtgctg attttataat
     5041 tgcgcagttt gtttagtttt ttcttacttt taaattccaa cttaaaatta tgaggtttca
     5101 gaaatatatt gaaagtttaa caatgtttaa aaatagaaaa gcatgagtgt tcatgcttta
     5161 aaatgatttt taaatttgta ttttatattg ttttatctat ctgtctttgc aagcagtctt
     5221 caggttaaag atacttctaa caggttacag tacatttcct ctgtatgtaa attagatggg
     5281 ataatagaat tcataaccca taatattctt tgaaagctaa gctttaaact tcattttatg
     5341 tcctttcaca aataaattag tttaaaacag aaagtggcta cttgccattt tgacatcaac
     5401 tcattttgcg aggcttaggc agctagacat cgtttaaaac aaaatattaa cttatattac
     5461 atgtgtatct atctattgtc agtcgtctct cagttcttga ggtatattat tttaatcatt
     5521 ccatgcctta atatgcttgc aatacaagaa tatcttcaga tgggtgaata ccaaaaggct
     5581 ttcagttttt agtcagaaat caagcattgg gctgtggtag ccaaaaacca taggttagct
     5641 aaaaagatca tgatacaatt attttattaa gtcatggtta ataacaaatg aatccagact
     5701 tgtctaacag attttccatc aacaaatatt gttatgtgca aaagtattgc ctatgttgtt
     5761 ttacacacca ctgcattaac tagaactgct gagaggactg tatatatgat tttaaaccta
     5821 agttgatttt ttttctcact cttgaaagga gtacttcttt gtgaaagcag ttcttacagc
     5881 tttgttttca accagctaaa aatgttttat atattactct aacctgttgt cctccacatt
     5941 ctattgtcct aattgtactg ttttctgatt tgtatttatg tcttgagaca gtaacttttt
     6001 gaataaaaat aaacctacag tatgttgtat gttttctctt gtactcaaag ggggagggtg
     6061 gctataaatg gtttgcaaat ttatatctat tatcacatct tttaatgtgt ttggggaata
     6121 atttatagag aataccatca gtttatattt ttaataaatc atatgtattt acaatgaaa
//
