LOCUS       NM_198993               3430 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SH3 and cysteine rich domain 2 (STAC2), transcript
            variant 1, mRNA.
ACCESSION   NM_198993 XM_292673
VERSION     NM_198993.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3430)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3430)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3430)
  AUTHORS   Campiglio,M., Coste de Bagneaux,P., Ortner,N.J., Tuluc,P., Van
            Petegem,F. and Flucher,B.E.
  TITLE     STAC proteins associate to the IQ domain of CaV1.2 and inhibit
            calcium-dependent inactivation
  JOURNAL   Proc Natl Acad Sci U S A 115 (6), 1376-1381 (2018)
   PUBMED   29363593
REFERENCE   4  (bases 1 to 3430)
  AUTHORS   Polster,A., Perni,S., Bichraoui,H. and Beam,K.G.
  TITLE     Stac adaptor proteins regulate trafficking and function of muscle
            and neuronal L-type Ca2+ channels
  JOURNAL   Proc Natl Acad Sci U S A 112 (2), 602-606 (2015)
   PUBMED   25548159
REFERENCE   5  (bases 1 to 3430)
  AUTHORS   Legha,W., Gaillard,S., Gascon,E., Malapert,P., Hocine,M., Alonso,S.
            and Moqrich,A.
  TITLE     stac1 and stac2 genes define discrete and distinct subsets of
            dorsal root ganglia neurons
  JOURNAL   Gene Expr Patterns 10 (7-8), 368-375 (2010)
   PUBMED   20736085
REFERENCE   6  (bases 1 to 3430)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015910.10, DA311257.1,
            AK131500.1 and AJ608762.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_198993.4.
            
            Summary: This gene encodes a protein containing an SH3 domain and a
            zinc finger domain. The encoded protein has been shown to regulate
            calcium channel inactivation in a human cell line. Reduced
            expression of this gene has been observed in human heart failure.
            [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ608762.1, AK131500.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333461.6/ ENSP00000327509.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC015910.10        55229-55301
            74-348              DA311257.1         1-275
            349-2668            AK131500.1         191-2510
            2669-3430           AJ608762.1         2444-3205
FEATURES             Location/Qualifiers
     source          1..3430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..3430
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /note="SH3 and cysteine rich domain 2"
                     /db_xref="GeneID:342667"
                     /db_xref="HGNC:HGNC:23990"
     exon            1..533
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..1679
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     and cysteine-rich domain-containing protein 2; SRC
                     homology 3 and cysteine-rich domain-containing protein 2"
                     /codon_start=1
                     /product="SH3 and cysteine-rich domain-containing protein
                     2 isoform 1"
                     /protein_id="NP_945344.1"
                     /db_xref="CCDS:CCDS11335.1"
                     /db_xref="GeneID:342667"
                     /db_xref="HGNC:HGNC:23990"
                     /translation="MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTIL
                     RSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPL
                     AALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQ
                     CPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMN
                     RSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEK
                     SPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKI
                     GDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFI
                     RVSSGKKRGLVPVDALTEI"
     exon            534..840
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..938
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1029
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1142
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1215
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1286
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1384
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1436
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1574
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..3430
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3411..3416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /note="hexamer: ATTAAA"
     polyA_site      3430
                     /gene="STAC2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /note="major polyA site"
ORIGIN      
        1 caaagttggg cggcgaggac tgggcggagg ggccgccggg tgccgggctg gggccggcgg
       61 gggaggggag gggatggggg gcgggcgcag cggacggcgg agccggctgg acacggacag
      121 ctccttggct ccctccctcg gctcatcccc gcggccccac ttccctcctc cccgcgctgc
      181 gagcagcatc ctctgcagac cctcggtcct cgcgcccggg gtcgtcccgc tcctgcggct
      241 cagcgtggtg gcctcccctc gcccgccacc ccggcaactt tctctgcccg ctcccgcggg
      301 ttgggggctg ccgtgccggg ggctaactgg gggcagcctc tggagaacgg cttcagagtc
      361 ccggagacgc ccgccacccg cagcctgccc gcggtgggcc tgccgtcgga tctcggcacc
      421 ctctcctccc ctctccccga accatgaccg agatgagcga gaaggagaac gaaccggatg
      481 acgcggccac ccacagcccc ccagggaccg tctccgccct ccaggaaacc aagctccagc
      541 gattcaagcg ctccctctcc ctcaagacca tcctccgaag taagagcttg gagaacttct
      601 tccttcgctc gggctctgag ctcaagtgcc ccaccgaggt gctgctgacg cccccaaccc
      661 cactgccccc tccctcccca ccacccacag cctcggacag gggcctggct accccatccc
      721 cctccccatg cccagtccca cgccccctgg cagcgctcaa accagtgagg ctgcacagct
      781 tccaggaaca tgtcttcaag cgagctagcc cttgtgagct gtgccaccag ctcatcgtag
      841 gaaactccaa acagggcttg cgatgtaaga tgtgcaaagt cagcgtccac ctctggtgct
      901 ctgaggagat ctcccaccag caatgcccag gcaagacgtc cacctccttc cgccgcaact
      961 tcagttcccc tctcctggtg catgagccgc caccagtctg tgccacaagc aaagagtccc
     1021 cacccactgg ggacagtggg aaggtggacc ctgtctacga gaccctgcgc tatggcacct
     1081 ccctggcact gatgaaccgc tccagtttca gcagcacctc tgagtccccg acaaggagcc
     1141 tgagtgagcg ggatgagctg accgaggatg gggaaggcag catccgcagc tctgaggagg
     1201 ggcctggtga cagtgcatct ccagtattca cagccccagc agagagtgaa gggccaggac
     1261 cagaggagaa gagtcctgga cagcagctcc ccaaagccac cctgcggaag gatgtggggc
     1321 ccatgtactc ctacgttgca ctctacaagt ttctgcccca ggagaacaat gatctggctc
     1381 tgcagcctgg agatcggatc atgctggtgg atgactctaa cgaggactgg tggaagggca
     1441 agatcggcga ccgggttggc ttcttcccag ctaattttgt gcaacgggtg aggccaggcg
     1501 agaatgtttg gcgctgctgc caacccttct ccgggaacaa ggaacagggt tacatgagcc
     1561 tcaaggagaa ccagatctgc gtgggcgtgg gcagaagcaa ggatgctgac ggcttcatcc
     1621 gcgtcagcag tggcaagaag cggggcctgg tgccagtcga cgccctgact gagatctgag
     1681 aggagccaag ggaacccaga tgacaccctt gcccatgcct ggaccttgct tctggccagg
     1741 gaggggatca ggcccccttg tccactccat acccttcctc cctctgtccc tctcctaggt
     1801 gccacttacc gtggcttagg agccttttgt actggggaag attttatttc ttgggtgggg
     1861 tgccctgagt gggttgatcc tctgggactt ggcggggatg gggtggggtg ggagggaatg
     1921 aggaagctac aggtaggtcc acccaacgcc caggcacccc agtctacttg ctgggctgag
     1981 tccagccctg gggaagattc ctggggaatt tatttgctgc ttctcccagc cttcccctgc
     2041 ccacaccacc tgcgcatgcc tggcacaccc ctctccccac agagcctctg cttgggtcta
     2101 tgtgtgtgtg accgtgcatc tgctcctttg caagtggggt cttgggagca ggcctttttg
     2161 tgtcctcggc cctccaccct tggtggggag gggacccagg accataggaa ggtcctgagt
     2221 ccacctcctg gtctccacct ctgtcattcc gtcaattctc aggaaagttt tgcaggaatc
     2281 tctcccgtta cttgaaacct gggcggacag atgaggggaa ggctgaggtc cctggaaggt
     2341 gtaacaaatc agagactatc tgttcaagta gaaaacccaa gagctggcca ggtgtggtgg
     2401 ctcatgcctg taatcccagc actttgggag gctgaggtgg gcagatcacc tgaggtcagg
     2461 agttcaagac cagcctggcc aacatggtga aaccccgtct ctactaaaag tacgaaactt
     2521 agccaggcat gatgggggtc tgcctgtaat gccagctact ccagaggctg aggcaagaga
     2581 atcacttgaa cccgggaggc ggaggtttca gtgagccgag attgcaccat tgcaccccag
     2641 cctgggcaac agagcgagac tccgtctcaa aaaaaaaaaa agaaagaaag aaaaggaaac
     2701 ccaagagctg cctggacaca cggaaaccca actgagaaca aaatcctggc ccgtgcttgg
     2761 tcaaagcaaa cccatttcac tgtcaggacc cccggtcaca caggaaccac ccgccagggg
     2821 agcctgtgac tgtcagttcc tgtcccaggc tttgcccggc cgccccagga acccaaccct
     2881 ctgggctgac ctttctcctg cttctctcca ggctctgcag gggacagggc aggtgctgca
     2941 ggagcccctt tgctggcttt atctgctccc ttgttctgga cacagagccc tgggaaaaag
     3001 agggggtgga agacagacaa ggaaggtgga atgttctgtt ttggccacca ggaaatgggg
     3061 tggggtgggc atacacagag aggacccctc tcttaataca gctgcttttc tcggtgccaa
     3121 cctccctccc ccaagctcag atcctcctct tatgcccttg attgtgccag cccatgccac
     3181 ccccatcctg ggcacagtta caccctccca tgcagtggga gaaacacaga ccctcgtacc
     3241 caaaggcccc tgccccactt ctcccccaca aagcggggtc tcaagccaca ctgccctgtt
     3301 tgctgccatg aggccccccc ccccagcaat atcccagggg cgggcccaat gcccactgta
     3361 catgaggctg catgatgggt ctggggcctt gctgattccc cagaccccta attaaatgtt
     3421 tcttgtccca
//
