LOCUS       NM_003149               3067 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SH3 and cysteine rich domain (STAC), transcript
            variant 1, mRNA.
ACCESSION   NM_003149
VERSION     NM_003149.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3067)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3067)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3067)
  AUTHORS   Maciukiewicz,M., Marshe,V.S., Tiwari,A.K., Fonseka,T.M.,
            Freeman,N., Kennedy,J.L., Rotzinger,S., Foster,J.A., Kennedy,S.H.
            and Muller,D.J.
  TITLE     Genome-wide association studies of placebo and duloxetine response
            in major depressive disorder
  JOURNAL   Pharmacogenomics J 18 (3), 406-412 (2018)
   PUBMED   28696415
  REMARK    GeneRIF: Our findings suggest that a variant upstream of STAC1 is
            associated with placebo response, which might have implications for
            treatment optimization, clinical trial design and drug development.
REFERENCE   5  (bases 1 to 3067)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3067)
  AUTHORS   Hotaling,J.M., Waggott,D.R., Goldberg,J., Jarvik,G., Paterson,A.D.,
            Cleary,P.A., Lachin,J., Sarma,A. and Wessells,H.
  CONSRTM   DCCT/EDIC Research Group
  TITLE     Pilot genome-wide association search identifies potential loci for
            risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC
            study cohort
  JOURNAL   J Urol 188 (2), 514-520 (2012)
   PUBMED   22704111
REFERENCE   7  (bases 1 to 3067)
  AUTHORS   Troiani,S., Lupi,R., Perego,R., Depaolini,S.R., Thieffine,S.,
            Bosotti,R. and Rusconi,L.
  TITLE     Identification of candidate substrates for poly(ADP-ribose)
            polymerase-2 (PARP2) in the absence of DNA damage using
            high-density protein microarrays
  JOURNAL   FEBS J 278 (19), 3676-3687 (2011)
   PUBMED   21812934
REFERENCE   8  (bases 1 to 3067)
  AUTHORS   Satoh,J., Nanri,Y. and Yamamura,T.
  TITLE     Rapid identification of 14-3-3-binding proteins by protein
            microarray analysis
  JOURNAL   J Neurosci Methods 152 (1-2), 278-288 (2006)
   PUBMED   16260042
REFERENCE   9  (bases 1 to 3067)
  AUTHORS   Petek,E., Emberger,W., Kroisel,P.M. and Wagner,K.
  TITLE     Assignment of STAC to human chromosome band 3p22.3 between D3S3718
            and D3S1611
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 184-185 (1999)
   PUBMED   10393425
REFERENCE   10 (bases 1 to 3067)
  AUTHORS   Suzuki,H., Kawai,J., Taga,C., Yaoi,T., Hara,A., Hirose,K.,
            Hayashizaki,Y. and Watanabe,S.
  TITLE     Stac, a novel neuron-specific protein with cysteine-rich and SH3
            domains
  JOURNAL   Biochem Biophys Res Commun 229 (3), 902-909 (1996)
   PUBMED   8954993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC351652.1, BC020221.1 and AW137199.1.
            
            On Aug 11, 2020 this sequence version replaced NM_003149.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86640.1, SRR14038197.1531143.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273183.8/ ENSP00000273183.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               DC351652.1         18-545
            529-2694            BC020221.1         538-2703
            2695-3067           AW137199.1         15-387              c
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3-p22.2"
     gene            1..3067
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /note="SH3 and cysteine rich domain"
                     /db_xref="GeneID:6769"
                     /db_xref="HGNC:HGNC:11353"
                     /db_xref="MIM:602317"
     exon            1..251
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1349
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     and cysteine-rich domain-containing protein; SRC homology
                     3 and cysteine-rich domain-containing protein"
                     /codon_start=1
                     /product="SH3 and cysteine-rich domain-containing protein
                     isoform 1"
                     /protein_id="NP_003140.1"
                     /db_xref="CCDS:CCDS2662.1"
                     /db_xref="GeneID:6769"
                     /db_xref="HGNC:HGNC:11353"
                     /db_xref="MIM:602317"
                     /translation="MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRS
                     LSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLH
                     PGGKAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCM
                     GKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSS
                     GSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINH
                     QGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFF
                     PANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKG
                     LIPLDVLENI"
     exon            252..528
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..629
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..711
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..827
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..906
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..971
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1060
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1112
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1250
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..3067
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3038..3043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /note="hexamer: AATACA"
     polyA_site      3067
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /note="major polyA site"
ORIGIN      
        1 ggagggcacg tcggcgcctc ggcgaggatg ggagtcccca ggacccggag ctgagcagcc
       61 tggcgcgcgg cgggcagggc gcgcaggaca gaagcctcgc tgttcctccg ggagcccaac
      121 accgttcccg cgcggccacg atgatccctc cgagcagccc ccgcgaggac ggcgtggacg
      181 ggctgcccaa ggaggcggtg ggcgccgagc aaccgccctc tcctgcatcc accagcagcc
      241 aggaatccaa gctccagaaa ctaaaacgat cactttcttt caagaccaag agtttacgga
      301 gcaaaagtgc tgacaacttc ttccagcgaa ccaacagcga agacatgaaa ctgcaagcac
      361 acatggtggc tgagatcagc cccagctcca gcccactccc tgctccagga agcctgacgt
      421 ccacacccgc cagggctggt ctgcatccag gtggcaaggc tcatgccttt caggaataca
      481 tcttcaagaa gcccactttc tgtgatgtct gcaaccacat gatagtggga acaaatgcta
      541 agcatggact gcgctgcaaa gcctgtaaga tgagcatcca ccacaagtgc acagatggcc
      601 tggcacccca gcggtgcatg ggcaagctgc caaaggggtt tcggcgttac tacagctccc
      661 ccttgctcat tcatgaacag tttggctgca ttaaagaagt tatgcccatt gcctgtggca
      721 ataaggtgga ccctgtctac gagaccctcc gcttcggcac ctccctggcc cagaggacaa
      781 agaagggcag ctccggcagt ggctctgact cacctcacag aacctctact tcagatcttg
      841 tggaggttcc tgaggaagcc aatgggccag gaggcgggta tgacctaagg aaacgcagca
      901 acagcgtgtt tacatatcca gaaaatggca ctgatgattt cagagatcca gcgaagaaca
      961 taaaccacca gggatctctt tccaaagacc cattacagat gaacacctat gttgccttgt
     1021 acaaatttgt accacaggag aatgaagatt tggaaatgag gccaggagac ataattactc
     1081 ttttagagga ttccaatgaa gactggtgga aagggaaaat tcaagacaga attggcttct
     1141 ttccagccaa ctttgttcag agactacaac aaaatgagaa gatttttaga tgtgttagaa
     1201 ccttcattgg gtgtaaggaa caggggcaga taacactgaa agagaatcag atctgcgtga
     1261 gttctgaaga agaacaagat ggttttatca gagtcctcag tggaaaaaag aaaggcctca
     1321 tcccccttga tgtactagaa aacatctgat tgctggctcc tcctccgttt gcagtaggca
     1381 agctctgctg cgatgcctct gcctcatctc acactgcgtc aacccaaagg agctgccgca
     1441 ctgacccagc cccccaggaa acagtgagac aagaatcaag tatctgagac tgtggagtaa
     1501 tagccacaaa acagagggcc cactgcacag catatccagg ctgccacagg tggggacgag
     1561 gctgagagag tcagcaggca gagccagatg ccatgcttgg cagcagcagt aggactataa
     1621 accacagctg tcccccagga tcccactcct ttcctgtctg tgtggtgtaa gttaacacac
     1681 tggagtgtgc tccagtttgc agggtagccc agtgcaaggt tcagatccat gtagctaagt
     1741 attatcctgc ttccagacct atgtcaccag taccaatcag tcagtgtcat cacatttcag
     1801 gccccaagca atctctgtgc aaagcatcag aaagacctgc ttcccagccc ccagcattcc
     1861 agtgctctcc aggcttcctc tctttgtgat tgtgctgtcc agagtgtcca gcttgttctt
     1921 tctttctctt cagtcctctg agtacatctg gtggtgtgca ttagatgtga gggctatgtt
     1981 gacatggcat cacctccaaa gacctgacct gcctaaagac tgatgacagg ccatccttcc
     2041 tgctgttcta ggtactggcc tgggtgacag agcaggacat gagacataga tacagtgggg
     2101 aggagaagtg gggaaaggtg gagcagagag ttcttactta ttgaagatta tacagccctt
     2161 tcggttatga agtccctgct tgaaggcaat ggacctgggg aagagactat cacaaaaagt
     2221 ctccattttc attttacatc ctctctattg gaggcagcac ttttccctca tgctgtccta
     2281 taggactcca ctttgaaggt tgtgcctacg ttgcagggaa ctaggaacat ggaggggaac
     2341 caacaacagc atcttagaag aaatgtagcc aaattggagt ccattcttct ttagggcagt
     2401 atatgaaatc ctagcagatg taaaatggaa aagaatccta atgcttcttc cttcagaaag
     2461 tagaggaact aggggcccaa ttagcatcat ctaggggaat ctctattact ctgtacttat
     2521 actaatgttt acaagaatgc aatatactgt gatgccttcc tactcaagcc tcctagcatt
     2581 caaacttcca tcctattagt cattaacatg gttaaacttc aattcacaat caccttggaa
     2641 tcaatgtcag tttgatttat tttgttacag agcaataaaa tcattagaac aatggttttt
     2701 aaaagactta agtggatgca tcctatgcat gtaagcatta tttcccaaac caaagcatca
     2761 ttcatctcca tttatttctt ttgttcccgc tcagtgtgaa gttgggaact gagaggggat
     2821 ggctgctggt ttcacagaag tttggatgcc ttactcttat cttaaagcca gcatccagaa
     2881 tttcctccct ctctgatgcc acatgcaaaa ccaggtgtac gatgtcaaga tggattcttt
     2941 gagagccagg gtagatcata tgactgcctt tctgtaaaat tggatgccta gtacaaatgc
     3001 tctttgcctc taattcagta ttccatttaa taaaaacaat acagtggctg gaaaggagca
     3061 tcagaaa
//
