LOCUS       NP_003140                402 aa            linear   PRI 21-SEP-2024
DEFINITION  SH3 and cysteine-rich domain-containing protein isoform 1 [Homo
            sapiens].
ACCESSION   NP_003140
VERSION     NP_003140.1
DBSOURCE    REFSEQ: accession NM_003149.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 402)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 402)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 402)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 402)
  AUTHORS   Maciukiewicz,M., Marshe,V.S., Tiwari,A.K., Fonseka,T.M.,
            Freeman,N., Kennedy,J.L., Rotzinger,S., Foster,J.A., Kennedy,S.H.
            and Muller,D.J.
  TITLE     Genome-wide association studies of placebo and duloxetine response
            in major depressive disorder
  JOURNAL   Pharmacogenomics J 18 (3), 406-412 (2018)
   PUBMED   28696415
  REMARK    GeneRIF: Our findings suggest that a variant upstream of STAC1 is
            associated with placebo response, which might have implications for
            treatment optimization, clinical trial design and drug development.
REFERENCE   5  (residues 1 to 402)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (residues 1 to 402)
  AUTHORS   Hotaling,J.M., Waggott,D.R., Goldberg,J., Jarvik,G., Paterson,A.D.,
            Cleary,P.A., Lachin,J., Sarma,A. and Wessells,H.
  CONSRTM   DCCT/EDIC Research Group
  TITLE     Pilot genome-wide association search identifies potential loci for
            risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC
            study cohort
  JOURNAL   J Urol 188 (2), 514-520 (2012)
   PUBMED   22704111
REFERENCE   7  (residues 1 to 402)
  AUTHORS   Troiani,S., Lupi,R., Perego,R., Depaolini,S.R., Thieffine,S.,
            Bosotti,R. and Rusconi,L.
  TITLE     Identification of candidate substrates for poly(ADP-ribose)
            polymerase-2 (PARP2) in the absence of DNA damage using
            high-density protein microarrays
  JOURNAL   FEBS J 278 (19), 3676-3687 (2011)
   PUBMED   21812934
REFERENCE   8  (residues 1 to 402)
  AUTHORS   Satoh,J., Nanri,Y. and Yamamura,T.
  TITLE     Rapid identification of 14-3-3-binding proteins by protein
            microarray analysis
  JOURNAL   J Neurosci Methods 152 (1-2), 278-288 (2006)
   PUBMED   16260042
REFERENCE   9  (residues 1 to 402)
  AUTHORS   Petek,E., Emberger,W., Kroisel,P.M. and Wagner,K.
  TITLE     Assignment of STAC to human chromosome band 3p22.3 between D3S3718
            and D3S1611
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 184-185 (1999)
   PUBMED   10393425
REFERENCE   10 (residues 1 to 402)
  AUTHORS   Suzuki,H., Kawai,J., Taga,C., Yaoi,T., Hara,A., Hirose,K.,
            Hayashizaki,Y. and Watanabe,S.
  TITLE     Stac, a novel neuron-specific protein with cysteine-rich and SH3
            domains
  JOURNAL   Biochem Biophys Res Commun 229 (3), 902-909 (1996)
   PUBMED   8954993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC351652.1, BC020221.1 and AW137199.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86640.1, SRR14038197.1531143.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273183.8/ ENSP00000273183.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3-p22.2"
     Protein         1..402
                     /product="SH3 and cysteine-rich domain-containing protein
                     isoform 1"
                     /note="SH3 and cysteine-rich domain-containing protein;
                     SRC homology 3 and cysteine-rich domain-containing
                     protein"
                     /calculated_mol_wt=44423
     Region          1..47
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99469.1)"
     Region          106..162
                     /region_name="C1_Stac1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in SH3 and cysteine-rich domain-containing protein
                     (Stac1) and similar proteins; cd20880"
                     /db_xref="CDD:410430"
     Region          165..>271
                     /region_name="STAC2_u1"
                     /note="Unstructured on SH3 and cysteine-rich
                     domain-containing protein 2; pfam16664"
                     /db_xref="CDD:435497"
     Region          211..247
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99469.1)"
     Region          289..341
                     /region_name="SH3_Stac_1"
                     /note="First C-terminal Src homology 3 domain of SH3 and
                     cysteine-rich domain-containing (Stac) proteins; cd11833"
                     /db_xref="CDD:212767"
     Site            order(294,296,299,303,321..322,335,337..338)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212767"
     Region          348..398
                     /region_name="SH3_Stac_2"
                     /note="Second C-terminal Src homology 3 domain of SH3 and
                     cysteine-rich domain-containing proteins 1 and 3; cd11834"
                     /db_xref="CDD:212768"
     Site            order(353,355,358,360,377..378,395,397..398)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212768"
     CDS             1..402
                     /gene="STAC"
                     /gene_synonym="STAC1"
                     /coded_by="NM_003149.3:141..1349"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS2662.1"
                     /db_xref="GeneID:6769"
                     /db_xref="HGNC:HGNC:11353"
                     /db_xref="MIM:602317"
ORIGIN      
        1 mippsspred gvdglpkeav gaeqppspas tssqesklqk lkrslsfktk slrsksadnf
       61 fqrtnsedmk lqahmvaeis psssplpapg sltstparag lhpggkahaf qeyifkkptf
      121 cdvcnhmivg tnakhglrck ackmsihhkc tdglapqrcm gklpkgfrry yssplliheq
      181 fgcikevmpi acgnkvdpvy etlrfgtsla qrtkkgssgs gsdsphrtst sdlvevpeea
      241 ngpgggydlr krsnsvftyp engtddfrdp akninhqgsl skdplqmnty valykfvpqe
      301 nedlemrpgd iitlledsne dwwkgkiqdr igffpanfvq rlqqnekifr cvrtfigcke
      361 qgqitlkenq icvsseeeqd gfirvlsgkk kglipldvle ni
//
