LOCUS       NM_001004470            6994 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 6 (ST8SIA6), transcript variant 1,
            mRNA.
ACCESSION   NM_001004470 XM_291725
VERSION     NM_001004470.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6994)
  AUTHORS   Feng,T., Yao,Y., Luo,L., Zou,H., Xiang,G., Wei,L., Yang,Q., Shi,Y.,
            Huang,X. and Lai,C.
  TITLE     ST8SIA6-AS1 contributes to hepatocellular carcinoma progression by
            targeting miR-142-3p/HMGA1 axis
  JOURNAL   Sci Rep 13 (1), 650 (2023)
   PUBMED   36635290
  REMARK    GeneRIF: ST8SIA6-AS1 contributes to hepatocellular carcinoma
            progression by targeting miR-142-3p/HMGA1 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6994)
  AUTHORS   Hatanaka,R., Araki,E., Hane,M., Go,S., Wu,D., Kitajima,K. and
            Sato,C.
  TITLE     The alpha2,8-sialyltransferase 6 (St8sia6) localizes in the ER and
            enhances the anchorage-independent cell growth in cancer
  JOURNAL   Biochem Biophys Res Commun 608, 52-58 (2022)
   PUBMED   35390672
  REMARK    GeneRIF: The alpha2,8-sialyltransferase 6 (St8sia6) localizes in
            the ER and enhances the anchorage-independent cell growth in
            cancer.
REFERENCE   3  (bases 1 to 6994)
  AUTHORS   Kuai,J., Zheng,L., Yi,X., Liu,Z., Qiu,B., Lu,Z. and Jiang,Y.
  TITLE     ST8SIA6-AS1 promotes the development of hepatocellular carcinoma
            cells through miR-338-3p/NONO Axis
  JOURNAL   Dig Liver Dis 53 (9), 1192-1200 (2021)
   PUBMED   33722502
  REMARK    GeneRIF: ST8SIA6-AS1 promotes the development of hepatocellular
            carcinoma cells through miR-338-3p/NONO Axis.
REFERENCE   4  (bases 1 to 6994)
  AUTHORS   Chen,Z., Huang,J., Feng,Y., Li,Z. and Jiang,Y.
  TITLE     Profiling of specific long non-coding RNA signatures identifies
            ST8SIA6-AS1 AS a novel target for breast cancer
  JOURNAL   J Gene Med 23 (2), e3286 (2021)
   PUBMED   33037712
  REMARK    GeneRIF: Profiling of specific long non-coding RNA signatures
            identifies ST8SIA6-AS1 AS a novel target for breast cancer.
REFERENCE   5  (bases 1 to 6994)
  AUTHORS   Qin,S.J., Zhou,H.Z., Xu,N.S., Yang,H.C. and Chen,P.X.
  TITLE     The Diagnostic Value of Serum ST8SIA6-AS1 as Biomarker in
            Hepatocellular Carcinoma
  JOURNAL   Clin Lab 66 (12) (2020)
   PUBMED   33337846
  REMARK    GeneRIF: The Diagnostic Value of Serum ST8SIA6-AS1 as Biomarker in
            Hepatocellular Carcinoma.
REFERENCE   6  (bases 1 to 6994)
  AUTHORS   Zhang,X., Dong,W., Zhou,H., Li,H., Wang,N., Miao,X. and Jia,L.
  TITLE     alpha-2,8-Sialyltransferase Is Involved in the Development of
            Multidrug Resistance via PI3K/Akt Pathway in Human Chronic Myeloid
            Leukemia
  JOURNAL   IUBMB Life 67 (2), 77-87 (2015)
   PUBMED   25855199
  REMARK    GeneRIF: ST8SIA6 gene is involved in the development of multidrug
            resistance via PI3K/Akt pathway in chronic myeloid leukemia.
REFERENCE   7  (bases 1 to 6994)
  AUTHORS   Yang,J.J., Cheng,C., Yang,W., Pei,D., Cao,X., Fan,Y., Pounds,S.B.,
            Neale,G., Trevino,L.R., French,D., Campana,D., Downing,J.R.,
            Evans,W.E., Pui,C.H., Devidas,M., Bowman,W.P., Camitta,B.M.,
            Willman,C.L., Davies,S.M., Borowitz,M.J., Carroll,W.L., Hunger,S.P.
            and Relling,M.V.
  TITLE     Genome-wide interrogation of germline genetic variation associated
            with treatment response in childhood acute lymphoblastic leukemia
  JOURNAL   JAMA 301 (4), 393-403 (2009)
   PUBMED   19176441
REFERENCE   8  (bases 1 to 6994)
  AUTHORS   Avril,T., North,S.J., Haslam,S.M., Willison,H.J. and Crocker,P.R.
  TITLE     Probing the cis interactions of the inhibitory receptor Siglec-7
            with alpha2,8-disialylated ligands on natural killer cells and
            other leukocytes using glycan-specific antibodies and by analysis
            of alpha2,8-sialyltransferase gene expression
  JOURNAL   J Leukoc Biol 80 (4), 787-796 (2006)
   PUBMED   16857734
  REMARK    GeneRIF: NK cells consistently expressed mRNA encoding ST8Sia VI,
            which creates alpha2,8-linked disialic acids on O-linked glycans of
            glycoproteins and NK cells variably expressed high levels of ST8Sia
            V mRNA required for GT3 expression.
REFERENCE   9  (bases 1 to 6994)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   10 (bases 1 to 6994)
  AUTHORS   Takashima,S., Ishida,H.K., Inazu,T., Ando,T., Ishida,H., Kiso,M.,
            Tsuji,S. and Tsujimoto,M.
  TITLE     Molecular cloning and expression of a sixth type of alpha
            2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans
  JOURNAL   J Biol Chem 277 (27), 24030-24038 (2002)
   PUBMED   11980897
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL160289.14, BC137103.1 and
            AL158164.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001004470.2.
            
            Summary: This gene encodes a member of the glycosyltransferase 29
            protein family. Members of this protein family synthesize
            sialylglycoconjugates. Sialylation may contribute to multidrug
            resistance in cancer cells. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137102.1, AJ621583.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377602.5/ ENSP00000366827.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL160289.14        41528-41735         c
            209-1574            BC137103.1         1-1366
            1575-6994           AL158164.15        51850-57269         c
FEATURES             Location/Qualifiers
     source          1..6994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.33"
     gene            1..6994
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 6"
                     /db_xref="GeneID:338596"
                     /db_xref="HGNC:HGNC:23317"
                     /db_xref="MIM:610139"
     exon            1..441
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..1537
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /EC_number="2.4.99.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sialyltransferase 8F (alpha-2, 8-sialyltransferase);
                     sialyltransferase St8Sia VI; ST8 alpha-N-acetylneuraminate
                     alpha-2,8-sialyltransferase 6; alpha-2,8-sialyltransferase
                     8F"
                     /codon_start=1
                     /product="alpha-2,8-sialyltransferase 8F isoform 1"
                     /protein_id="NP_001004470.1"
                     /db_xref="CCDS:CCDS31158.1"
                     /db_xref="GeneID:338596"
                     /db_xref="HGNC:HGNC:23317"
                     /db_xref="MIM:610139"
                     /translation="MRPGGALLALLASLLLLLLLRLLWCPADAPGRARILVEESREAT
                     HGTPAALRTLRSPATAVPRATNSTYLNEKSLQLTEKCKNLQYGIESFSNKTKGYSEND
                     YLQIITDIQSCPWKRQAEEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKK
                     EIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPT
                     TGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRAN
                     TGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVEL
                     CKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQF
                     SKCEVA"
     exon            442..540
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            541..630
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            631..717
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            718..862
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            863..975
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1068
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..6994
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6972..6977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /note="hexamer: AATAAA"
     polyA_site      6994
                     /gene="ST8SIA6"
                     /gene_synonym="SIA8F; SIAT8-F; SIAT8F; ST8SIA-VI;
                     ST8SiaVI"
                     /note="major polyA site"
ORIGIN      
        1 agcagcagtg gcagcggcga ccggagcccg cagcagctcc gagcgcctcc gggaggacag
       61 gcggcgagct cggcgaatcg tcatctgcca gccgatcgcg gcgctccgcg ggccggggcc
      121 gggagcccgg ggcgagcccg aacgcggctt cttctccgcc cgccgcggag actctgccgg
      181 gtgggctgcg ggcgcccctc gctgccgcct gtgaacgctg tgggtgcgcg gggctgcggc
      241 cacggcggcg gtggcggcgg cggcgggagc cgcgagtcgg ggccgcccgg gctgtgcttc
      301 gccccggcag cagcggtggc ggcggcgcct gtggctcagg atgcggccgg ggggcgcact
      361 gctcgccctg ctcgccagcc tgctgctgct gctgctgctg cgcctgctct ggtgcccggc
      421 agacgcgccc ggccgcgcca ggattctggt ggaggaaagc agggaggcca cccacggcac
      481 ccccgcagcg ctgaggacgc tccggagccc ggcgaccgcg gtaccgcgcg ccactaacag
      541 cacatatctg aatgagaagt cgctccaact gacggagaaa tgcaaaaatc tgcaatatgg
      601 cattgagtct ttctctaaca aaacgaaagg gtattcagag aacgactacc ttcagattat
      661 cacagatata cagagttgtc catggaaacg gcaagcagaa gaatatgcaa attttagagc
      721 caaacttgct tcctgctgtg atgctgttca aaactttgtt gtttctcaga ataacactcc
      781 agttgggact aatatgagtt acgaggtgga aagcaaaaaa gaaatcccaa ttaagaagaa
      841 catttttcat atgtttccag tgtcccagcc ttttgtggac tacccttata atcagtgtgc
      901 agtggtcgga aatgggggaa ttctgaataa gtctctctgt ggaactgaaa tagataaatc
      961 cgacttcgtt tttaggtgta acctaccccc aaccacagga gatgttagta aagatgttgg
     1021 cagtaaaaca aatcttgtga ctataaatcc aagcatcata actctgaaat atgggaactt
     1081 aaaggaaaaa aaagccctat ttctggagga cattgcaacc tatggagatg cattttttct
     1141 tctgccagca ttttccttca gggccaacac gggtacctct ttcaaagtat actacacgct
     1201 cgaagagtct aaagcaagac aaaaggttct atttttccat cccaagtacc tgaaagatct
     1261 ggcccttttc tggagaacta aaggtgtgac tgcataccgc ttgtccaccg gcttgatgat
     1321 cacaagtgtt gcagtggaac tgtgtaaaaa tgtgaagctg tatggattct ggcccttctc
     1381 taaaactgta gaagacatac ctgtcagcca tcactattat gacaacaagc tacctaaaca
     1441 tggtttccat cagatgccca aagaatacag ccagatcctc caacttcaca tgaaaggaat
     1501 cctcaaactg caatttagca aatgtgaagt cgcctaaaca aagtatctta aaatgggaat
     1561 aattttaata taatgcagta ggtgattaac aatgtctcca aacaccaaag gaggtggcta
     1621 aagagtattt tgagatgagc cccaaaattt ggtttgacca aagcttcccc actcattttg
     1681 caatgatggc aagtcattca atccttctca tcttcatttt ttctccttat aacatggaca
     1741 ccatatctga ctcatacaaa tttttataat ttatgaaaat tattggcatg gcctttggtg
     1801 tgaggtaggg actcaaagaa tatttctttc ttactattta taccagccat ctccaccttc
     1861 accagaccga taataaaagc atgctttctt ggagatctct tctaaagaga atagctgcat
     1921 taccagtatc cattggattt ctttctgtgg caggtctcta tcaataatat ccttcccatt
     1981 tttctgtctc aaagactgca tgcaagaaaa ttatatactt aagcaaaaag ttcttgatca
     2041 ttcgggaatg aaattcttct ctgagtatgg cagtatgcct gcttctgatt aaattcactt
     2101 ttaatagtag ctgtgatgat attttggttg aatttaagcc atttattttc ctcttatgtc
     2161 tacatttctt catcacttaa taattttatt ttaacttcct gcctcattct tacacttttt
     2221 tctctctcac ttatacgata tacttcaagg acgtgaacag ttacaatacc cagtctttct
     2281 tacctgttgt cttgcctgtg gggtcactca ctcaatttta ttttaaaatt actgaataac
     2341 tacttcatgc caggccctgc accaggctct gtgagaggac aagaaggatt attgcctctt
     2401 gtaggagaaa acagatgtgc atatcattaa ttatgatggg gtatgataag tattacaatg
     2461 acaaaagcta tgaataaagt gctacaagga acagaagcag ggataattaa atccatttca
     2521 gtggaatcta tttcaatgta caatagtctc ccctaatctg cagatatggg aagaccccct
     2581 gtggatgcct gaaaccattg atgatattag aaatatgtaa ttgattagta aaagtaacaa
     2641 aatatactga aataattaaa tatacaatgt ggggacttta tatgctattt taataaaact
     2701 tacatatagt taggacattt agagcttact tttttttccc atataatatc ctatcttaaa
     2761 aatttttctt tagaacatca aaacagaatc tctagtatca ctgatatgga tttcagaaat
     2821 attccaaatg gtgtgagatc aaacagcata gtgataccca tgttccagta aaagcttagg
     2881 agaaaaagaa tgtttgcggg ttttcttttg tggagaaaat tgtagacatt tccaagttaa
     2941 cacatctgaa gtttctggtt cgacatctgt gttgccatcc taaaagcacg tgtgaaattt
     3001 tacaacaatc ctacctagat tcacgttagc caaaaatctt tggctaaaca gacaccccga
     3061 gatttcataa agtgtgttat agtcagaatt ggtggtaatt aatctacaaa tctgcaaaat
     3121 agtgttcata gtttttcttt ttattttgat cttggtgaaa aacttgcagt aactcaccat
     3181 tacagagcga caagaactgt gacgcatgtt ttatgattta catagctgat gtggtgtatt
     3241 atcgatatcc ataatctgtc atatttagac acattcattg tgacacatat aacatgtgca
     3301 ttctttttat ctttttctca agtgggtcta tagttgtgat ttcacagcag attggggttg
     3361 ttggccattg tttgaagctc tcctactctc tttctagcat agtcagtgtg ttgcagagaa
     3421 ctaaagggag taaaagacac agtgcctcat tgaatcctaa cattttcttc ctggtagggc
     3481 atatatccca ccttccatat atcctgctgt gaggtgccaa taatgttctt ttgttccaaa
     3541 acagaacatt acttagaact ttctaaaata tgatagaaca tgaatgttta caatacagca
     3601 tgtcagctat gtaaactgta aaacgtaagt cacagttctt tttgttctgt attggtgaat
     3661 cattgcaaat ttttcaccaa gtgcaaaaca aaaagaaaaa ctataaactc catcttgtag
     3721 atttgtagat tcgccacaac caagtctgac tgtgacactc ccaagaaatc tgtatgtaat
     3781 cagcattgct taaatattgt tagatctaat gtgatcttct gctcttaaaa ctcaagtaca
     3841 tctaagggca ttgagaatgg aaagtctgag ttctggtact agacaagagc agccctttag
     3901 gccaggcgca atggctcaca cctgtaatcc cagcactttg ggaggccaag gtgggtgggt
     3961 cacttgaggc caggagtttg agactagcct gggcaacata gtgagtaccc ttctctacaa
     4021 aaaacaaaaa aattagctga gcatagtggc gtgcacctgt ggtcccagct acttgggagg
     4081 ctaaggaggg aggttcactg gagcccagga ggtagaggct gcagtgagct gtgatcttac
     4141 cactgcattc tagcctgtgt gacagagtga gaccctgtct caaaaaagaa aaaaaaaaag
     4201 tagcccttta gttaggattc tagctcataa cgctgcatac taccagtttc taagagaaat
     4261 actagcttgc tggattctat tttccacttg ttgttcagcc tcattgagca atgaaacaga
     4321 ataacaagat tccaatataa ttttcagcca aatccaaagg caaggcagaa atattcattt
     4381 aagtatatag tccatagtac tctgtggtcc ctgcaaaggg cttcatgatc aattgcatag
     4441 tgttaatttt tgcgcagtgt aataatcctc gaacatcctt gaagtctctg gtgcttttcc
     4501 cttggaacaa aaggcaatga caaatagatc atggctttca ctaaaggata tttccttctt
     4561 catgtaagtc ctaacccagt aactgcgtgg gctctcagcc aggtaatcag tcaaaaagtc
     4621 tttttttgag gactctctgt agaatacaga attaagcagc aaatcagacc tgtgtttgcc
     4681 taaatttttc cttgcttata aaaaatttac cagctaagta ttatgtaatg tcaagtaccg
     4741 taaatcactc catgaattag gaagctttgg gaaaagtgga aaattttgtg gaaaacaggt
     4801 ccactaacat cctaaacagc tactgcagaa gtatagttaa gatgtgatat ataatatatt
     4861 gtgatcttca agacatttta tttatctaac atgacatgga aacacattat tatgccatta
     4921 aaaattgaag gcattgtagg aattcatctg atatatctga tgcacttgat ctgataaatc
     4981 cacttgaggc tgctaggagt gttgaagatt tcctatttac atgtggcttc agaaggctga
     5041 tcccatagcg aggaacagtg tcaccagtac cctcctgaga gtggaaaggc aagaatattt
     5101 ctcatggtct ttcttatttt gggtcatcac tcttccagaa gcattcttct ttttataaaa
     5161 aaaatgtggg tgatatatga taaagatgcg ctacttatgt aatggagaca gggcaaactc
     5221 tttagcagat aatattgaaa cattggctca ctctatggag aaaaataaat gcctacattg
     5281 caccatataa aaagttgggc tccagaggga tgaaaacgat ggattaaaaa gaaaacttta
     5341 aagctcatag aagaaaatgt aggagaatta tgtttgagat acaggtgagg aactgtactt
     5401 cttcaacatg acccaaaaat atctttttaa atagttgggt taagaaagga tggctatgac
     5461 tgtattaaaa tgaaagagtt ctagtcagtg aatgacacct taaagttaat aggctgggga
     5521 cagactgaaa tagcttttag taatgcataa aattaatgac attaatagag agacattcca
     5581 aggaattgta aatcaacaag taaaagacag gaaactcaat ataaaaatga acaaaagata
     5641 agaatgtgat ttacaaaggg gaaagctgag tagctaataa gaataggaag tgatactcaa
     5701 atttaccagt aacctgagaa atgcaaatga aagtgagata ctacatccat tgcattggta
     5761 aaaatgagta aggtcattaa cttcaagtgt ggaagtataa gctgattgaa tcattttgga
     5821 aagcaaccta ggagtactga gttagtaaaa ttcatcatat gtctgtccta tagtccagta
     5881 attgcacttt tgcatataca gccaagagga cctgttctga tccacacaaa aaaacaagta
     5941 ttaaggtatt tattccatta tggtttgcgg tagtaagtag acaaattgga ctcacagata
     6001 tctgtctctt cggaagtcag tgaactaact tgactggatc catagtgtgg aatatgatac
     6061 agcagttaga agcaacttac tggacatata tacagaaata agggtatgtc ctttaaattt
     6121 agcataaagg gaaaacaaaa gctttagcac aatgccattt aattacttta aagcgtatgc
     6181 atgcatacat acaaacatat tcaaggctac gtgtcaaata caagaagggt acccattaag
     6241 aagagggtaa tcggagtggg tttagggata aagaagaaaa atatacatgt tattatattt
     6301 aatacagcaa gcctttgaca tatatattct tatactcaca tatgatattc ttactactac
     6361 ataaataaat atagaagctg actcaaaatt gtaagtaact tatataaggt tgcattatat
     6421 ataagagcag agctagtatt caactcatat gtctgactct aaagccaata ttatttccat
     6481 tatgcaatta taaaatgaaa agaaaaatca gtattatccc atgtcattga catgtaataa
     6541 atggcacata tttatgtaca tgcatatacc catgaaaccg tctctccaat taagacaatg
     6601 tatatattca ttaccccaaa atgttttctt gtgctacttt gtaatccctc cctcttcttc
     6661 ctccctgtcc atcccaccct cgtccccaga aaattcctaa tctgtttttc tatagacatt
     6721 tacattttta cactatagac tgtttacatt ttttagaatt ttatataaat ggaatcttac
     6781 tgtctgtact catttcttgt cttgcacttt tgctcgacat aataatatta aaactcattc
     6841 atgttgattg tgtatctgta gtttatgcct ttatttactg agtagaatta tgttatatgg
     6901 atggaccaca gttggcttat ctgctcattt gttgatgaac attttactat ctcctggttt
     6961 tggctattac aaataaaggt atcatgaaca ttaa
//
