LOCUS       NM_013305              13897 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 5 (ST8SIA5), transcript variant 2,
            mRNA.
ACCESSION   NM_013305
VERSION     NM_013305.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13897)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 13897)
  AUTHORS   Liang,D., Hong,D., Tang,F., Wang,Y., Li,J., Li,L. and Chen,H.
  TITLE     Upregulated lnc-HRK-2:1 prompts nucleus pulposus cell senescence in
            intervertebral disc degeneration
  JOURNAL   Mol Med Rep 22 (6), 5251-5261 (2020)
   PUBMED   33174041
  REMARK    GeneRIF: Upregulated lncHRK2:1 prompts nucleus pulposus cell
            senescence in intervertebral disc degeneration.
REFERENCE   3  (bases 1 to 13897)
  AUTHORS   Ariga,T., Yanagisawa,M., Wakade,C., Ando,S., Buccafusco,J.J.,
            McDonald,M.P. and Yu,R.K.
  TITLE     Ganglioside metabolism in a transgenic mouse model of Alzheimer's
            disease: expression of Chol-1alpha antigens in the brain
  JOURNAL   ASN Neuro 2 (4), e00044 (2010)
   PUBMED   20930939
  REMARK    GeneRIF: Chol-1alpha antigens (cholinergic neuron-specific
            gangliosides), such as GT1aalpha and GQ1balpha, which are minor
            species in the brain, are increased in the double-transgenic mouse
            brain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13897)
  AUTHORS   Kim,Y.J., Kim,K.S., Do,S., Kim,C.H., Kim,S.K. and Lee,Y.C.
  TITLE     Molecular cloning and expression of human
            alpha2,8-sialyltransferase (hST8Sia V)
  JOURNAL   Biochem Biophys Res Commun 235 (2), 327-330 (1997)
   PUBMED   9199191
REFERENCE   5  (bases 1 to 13897)
  AUTHORS   Yoshikawa,T., Sanders,A.R., Esterling,L.E., Overhauser,J.,
            Garnes,J.A., Lennon,G., Grewal,R. and Detera-Wadleigh,S.D.
  TITLE     Isolation of chromosome 18-specific brain transcripts as positional
            candidates for bipolar disorder
  JOURNAL   Am J Med Genet 74 (2), 140-149 (1997)
   PUBMED   9129712
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090311.12, AK056270.1,
            AC064800.8 and U55966.1.
            
            On Jun 2, 2019 this sequence version replaced NM_013305.5.
            
            Summary: The protein encoded by this gene is a type II membrane
            protein that may be present in the Golgi apparatus. The encoded
            protein, which is a member of glycosyltransferase family 29, may be
            involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3
            from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.156866.1, AK056270.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315087.12/ ENSP00000321343.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC090311.12        1417-1575
            160-1507            AK056270.1         276-1623
            1508-1508           AC064800.8         22050-22050
            1509-2477           AK056270.1         1625-2593
            2478-2564           AC064800.8         23020-23106
            2565-2600           U55966.1           9-44                c
            2601-13897          AC064800.8         23143-34439
FEATURES             Location/Qualifiers
     source          1..13897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..13897
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 5"
                     /db_xref="GeneID:29906"
                     /db_xref="HGNC:HGNC:17827"
                     /db_xref="MIM:607162"
     exon            1..676
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     CDS             546..1676
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /EC_number="2.4.99.-"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sialyltransferase 8E (alpha-2, 8-polysialytransferase);
                     alpha-2,8-sialyltransferase 8E; sialyltransferase St8Sia
                     V; ST8 alpha-N-acetylneuraminate
                     alpha-2,8-sialyltransferase 5"
                     /codon_start=1
                     /product="alpha-2,8-sialyltransferase 8E isoform 2"
                     /protein_id="NP_037437.2"
                     /db_xref="CCDS:CCDS11930.1"
                     /db_xref="GeneID:29906"
                     /db_xref="HGNC:HGNC:17827"
                     /db_xref="MIM:607162"
                     /translation="MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKR
                     YFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQ
                     FKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQ
                     FKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSII
                     TERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYY
                     FHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYIT
                     HHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC"
     exon            677..769
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            770..856
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1001
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1114
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1207
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..13897
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13871..13876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /note="hexamer: AATAAA"
     polyA_site      13897
                     /gene="ST8SIA5"
                     /gene_synonym="SIAT8-E; SIAT8E; ST8SiaV"
                     /note="major polyA site"
ORIGIN      
        1 atcggcagaa ccggaggcca accttcgcga tcccttgctg cgggcccgga gatcaaacgt
       61 ggcccgcccc cggcagggca cagcgcgctg ggcaaccgcg atccggcgcc ggactggagg
      121 ggtcgatgcg cggcgcgctg gggcgcacag gggacggagc ccgggtcttg ctccccattg
      181 gccgccacct cggcgggagg ggccgcctcc ggctcgtggc acctggcgtc tcccctccgc
      241 ggggaaatcg gcggctaccc ggcaccggcg cctggaggta aaggtacccg ggggtgggga
      301 aggcccctgg ccgcggcaga gctccctgcc accggccctg tcctgcttgc cgccccagcg
      361 cctgcgacgc ttggatgccc ccagctccgg ccgcgccaac cagaaacttt gcccctcgaa
      421 gtcccccgcc tgcctgaccg caccgtgagg cgccaagtcg gccgcgcgcc ccccggggcc
      481 ccggaacccc gcgagtcatt gcctggccgc cccgtacccc gcgcccgcgg cgcccggtag
      541 ccaggatgcg ctacgcggac ccctcggcca accgggattt gttggggagc cgaactttgc
      601 tcttcatctt catctgcgcc tttgccttgg tgaccttgct gcaacagatc ctgtatggca
      661 ggaactacat taagaggtac tttgaatttt atgaggggcc ttttgaatat aactccacaa
      721 gatgcctgga gctgaggcac gaaatattgg aagtgaaggt gctgtccatg gtgaagcagt
      781 cagagctgtt cgacaggtgg aagagcctcc agatgtgcaa atgggcgatg aacatctctg
      841 aggccaacca gttcaagtct actctgtcca ggtgctgcaa cgcccctgcc tttctcttca
      901 ccacccagaa gaacactccc ctggggacaa agctcaagta tgaggtggac accagtggca
      961 tctaccacat caaccaggag atcttccgca tgtttcccaa ggacatgccc tactaccggt
     1021 cccagtttaa gaagtgtgct gtagtgggca acggaggcat cttgaagaac agccgctgcg
     1081 ggagggagat caacagcgcc gacttcgtct tccggtgcaa cctgcccccc atctcagaga
     1141 agtacaccat ggatgtgggg gtgaagacgg atgtggtcac tgtgaacccc agcatcatca
     1201 cagagaggtt ccacaagctg gagaagtggc ggcggccgtt ctatcgcgtg ctgcaggtgt
     1261 acgagaacgc gtcggtgctg ctgcctgcct tctacaacac gcgcaacacc gacgtgtcca
     1321 tccgcgtcaa gtacgtgctg gacgacttcg aatcgccgca agctgtctac tacttccatc
     1381 cgcagtacct ggtcaacgtg tcgcgctact ggctcagcct gggggtgcgc gccaagcgca
     1441 tcagcaccgg cctcattctg gtcactgcgg cgctggagct ctgtgaggag gtgcacctct
     1501 ttggcttctg ggccttcccc atgaacccct cgggcctcta catcactcac cactactatg
     1561 acaacgtcaa gccgcgtccc ggcttccacg ccatgccctc tgagatcttc aacttcctgc
     1621 acttgcacag ccgaggcatc ctccgcgtgc acacgggcac ctgcagctgc tgctgatggc
     1681 tgccagccag gctgcccggc aagcggcgcc ccctctcctg ctgtccctcc tggtggaact
     1741 gggagccccg aaccgggcag cgtggggtcc tggcgttcag gctgtctctc cctccattgt
     1801 tcagctctgt acttggatcc tggggtaggg aggcagggtt aggaaccggg gcagagtcag
     1861 ctctgtgctg agcctcctgg cctggccccc accggtgcat ccgcccagtg cgtccacctg
     1921 ccctggctag catgctgctg ggccacaccc caagatcagg ggccctgggg acggcaagtg
     1981 aataaagcac atttccaccc aattttgtca tccgagagag agcacaaact gcaggccctt
     2041 gttgcagctg aaggaagacc ctacagagaa tggaattgag agtggagaca ggacacttca
     2101 caggacactt gagcacagtc aagattttat tcacactttt ggttcctgtg ttttatatcg
     2161 aagacttagc tatgaattgc tatctaaatc tcagagctta gaagccaacc cagtgactag
     2221 accttccagt gaagaaagtg atctcaagag gtccagggac ttaacagcca agccacacca
     2281 cccgacaggt tcttctgtga caccgagaga tctaacccaa ggcctgggtt atgtcttagt
     2341 cgagacatca tcatctgaga agcaccacat cctttcagac acatcctcgg acacacatgc
     2401 ggtcttggtg cccccaggtt caatcctgcg ttagctcttt tgatgagaag gaaataaacc
     2461 aaaccagcca cttgcactat ggcttccaag ccaatgttat tgactcaata agtgcttagc
     2521 aattggcttc ctcttttgtc ttcctatttt cagctccatt taaaccagga gttatttata
     2581 aagacctctt cctctcatgt ctctgaatcc tgcagaatcc tgctgtatcg tgttcctcag
     2641 tcggaaccat aggctctggg ctggaaagca ctgacatgtc aggtggtgag cttagcagag
     2701 agaaacgagt tgtggcctcc gacaccagca tcactgaggc ttccgctgtg aaggcgggac
     2761 ttctcacagc agaccccagg gcctgggctt ggggcagtca gctgggctta ggcagagagg
     2821 ggttcacata tcatttcaca tctgaaatta attccctttg cttctccctg tggtgtttcc
     2881 accataaatg ggatggtgtc taagagacac tgttggtgaa ctaactgcct tagaacttag
     2941 ctttgtggaa tcataggatg ttagtgctgg gaggaggact tcagcctacc tgcctggcaa
     3001 cctgtctccc tccctccttc ctttctccct gcctcctccc ctttctcctt ccctcccttc
     3061 ctcttttctt cctcccctta aacatttctg gaaagcctat tctgctttgg tctgtggttg
     3121 gacttaggaa gacataagga taaacaaagg cattatctgt gtcttctggg ggtgcagggc
     3181 ccagagatta tagacccagt cccacgtgct gggtgctctg ggagggttag gagctgtaag
     3241 agtctatcag ggagtgggat ctgctatcca atcacctcat ttgacaggcc ccccggctga
     3301 gccagtcagg gacgtggaga gtgcaggctt tatcccaggc ctccaggctc ctgatccagg
     3361 gctccgttct tggccaaact tttgtgtctt ggcttgggct tcctgtgggg gggttgttgt
     3421 ggaacctgtg ccctgtgcac aacactgttc tcagtgctga ctctcacctg cattctgagc
     3481 tctggtcctg gttgggaaaa cctcaggtgg ctctgagtct cagtctgctg gtcaggaatg
     3541 taggggagta gccaagggga tgaaatgatc ccaaacacct gctaaaccag gaagaactgc
     3601 aaaggacagt ggatggttat tacttgcttg agctctgcct atttctccca gggagggaat
     3661 ttctgggaaa gattccagtt acctgagatt tctagccact gcatggttaa ttgaacccag
     3721 ttcttgaaac catggaatat aaaaactaga aggttcttaa agaccatttt gttccacttt
     3781 aggaaacagg cccagagcaa agatgtgact gggtcaagtc atgcctgggg ctctactgag
     3841 tgcctgctgt ggacagagcc ctctactgga agccctctgg gtactagtta tgttccagat
     3901 gggcagtgtt tgggggaggc tccctggtga cacagacatc aggattccca cagctgaggg
     3961 tgttgcaggt tggaatctgc cccagccagg gccctcgtag gagctgagga ttggagcatc
     4021 gggatccagc ccacagagga gttgggacac ctggctgctg gccatattcc tgcctgtggg
     4081 tcttagggcc agtccttcct ctccctcaat gtctcagttt cctcatctct acaactagaa
     4141 gctttgtaaa aatcttcagc gtctgtacaa tgtccttatt ttggggggac attcatgatg
     4201 aatggatcta aaccataatt aatatttctc attatactag ctagcattta tcaagctacg
     4261 ttaagcactt tccctatatt atctcctgta atcatcatga gacccctttg ggtaaggagg
     4321 ctcccattgt acagatgagg agacagaggc ttaaagcaat tccaggactt gcccttggtc
     4381 aggcacccaa tggagggaac ggcacccaat ggagggaact gcacccagat ctgtagagcc
     4441 ccaaagtctg tgctccaaac ctctgtctta gcttcccaga cagtgacacc agaacatgag
     4501 ggatcctgac caagatgccc ctgcaggata gtacggggcc ctcctccagg gacaaatgct
     4561 ctaggaggct gtcatcgtcc gggaagcagc ctgtgcttat aggtgcctct ccctaaccct
     4621 gccgcctaca gcagtagcga cttacccaca gtggcactgg aggggaactg aggccatcgt
     4681 cacattttta aggtgaggaa agatgcccag agatagcaca tgttaagtga caacacgaat
     4741 gacttgccca gggctacatg gccagcttgt ggctcaactg ggactcacca gtctcctgac
     4801 tttcaggata tagtttttct gctgcagcca gtgtttataa gaaaaacatt ttttcaaagg
     4861 ctcagagaga cctggtgttg actctggaag ccttctgcca tgttcctcca cagccctgtc
     4921 accacgccac catgcagtgc agactaccca ttgaattatt attcaaggga aatcgattcc
     4981 cgtaaacaaa acaaccatca tgtcttcctt tgtgctaaac ccactgctcc aggcttgaaa
     5041 ggcagcaaaa acaagtaaat gactcagtgc ttagccaagc acaaagaaag gtggctcaag
     5101 gtcagaggca gcgtctgaga ccatttcagc aatgctgctg cggcagctct gcccactaat
     5161 cacctggtgc ccagagacag catgtgctca tcgcccttga ctttgctgag agcagggagg
     5221 aagcagagca gtgcttagaa acaactgagg cagagtagag tgctggccaa tttagtgagt
     5281 gaattggtga ataaattata tttattgagt gctcatgttg tgccaggcat ggtgccaggt
     5341 gccggggagc tagtgatgaa caaaacgtcg tccctgccct ccgggagttt gtggtctggt
     5401 gtgtgtgtat acagacgtta aatgacgaat cccacaaacg tacgtgggag ctggttgtgc
     5461 tgaacactat caaatccagt ctcagggaca gttatctggg agaggtggag gaggggatga
     5521 ccaaagtcaa ttccgaattc tgaaggttgg cagcataaaa agtgtaatga gcaaagcagc
     5581 agatacttct cagatatcat ccttgacatc cgtgtaacat ttgacaaggt tggcctctct
     5641 ggtctttttt gtttgtttgt ttgagacaga gtctccctct gtcacccagg ctagagggtg
     5701 gtgatataaa tatggctcac tgcagcctcg acacctgggt tcaagtgatc ctcccacctc
     5761 agcttcccaa gtagctagga ccacaggcac gtgccattgc tcccagctaa tttgaaaatt
     5821 tttttttttt tgtagaaacg gggttttgct atgttgacga ggctagtctc gaactcctga
     5881 gctcaagcaa tcctcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccact
     5941 atgcacagtc tctctggtct ttctaaagtc ctctcctctt ctgttttcta actattcttc
     6001 cctgactttc ctcctgtctc tctgaatgct ccttctcagg ttcctttgtg gattcatctt
     6061 ccgtgaagct tcctcagggt tctcttctct tcctaggagc attcctgcag aaatctcatc
     6121 tattcaaagc cttaagtatc ttctgccctg gcatcttaac ccctctacct gcaggccagt
     6181 cctccctagg agcattggaa gcatgctcac tgtggcctcc tgcatgtctg tgtctgcaca
     6241 gcatctcaga cctcaacatg tcctcaactg gtatagttaa aagaacaatc tgaactcaga
     6301 gtctcctcct actacttcgt agctgtgtga aattgaggga gctccagaag cccctggagg
     6361 ctctggactc atcatctgaa atgaggacag gataccaacc acaacagctg ttgcaaagct
     6421 aagtgaaata gtgttgcaca atgcctagca cagtgcccag cacaaactag acactagcaa
     6481 gcacaggttg ccttggccca aaacttggat cacctttgcc tcttccttct ccttcactct
     6541 ttatgtctat ttgttcactg tatcttgtca attccaactc ataaacatcc ctttaagtca
     6601 ttccctccct gcaacccctc tgctactgcc ctaacccaga ccatctgatg gatctttttg
     6661 ctttcagaga ataaccttcc aaaaatacct tttgtggggc ccattgccta cctgtatcat
     6721 aaacttcagg ttctttacca agtcatgcag ggaatgtccc aagctggctt actcaccttc
     6781 ccagagatcc tcctgccacc tccctgccct atcccatact attccaggca cctttgcaca
     6841 ctctgttcaa acacctggaa tggccctcac actcctaagt tcctctctcc ttccttttat
     6901 ctggccactt ttgcagaagt caggtaatgg ccccctgcat cctcccctct agagacctgg
     6961 gctgggcact ctctcctctg tgcttctgct gcaaccatca ccgactccat taggacatcc
     7021 tcacagcaca cagcataagg gcccgtgtgt ccttgataga aggtttgcct tctccccaag
     7081 ggaagacacg atatctaagc tcattttgta ttgccagcac tggcggggaa gcacatgcca
     7141 tggccactca acacatgttt actacagtaa tgaggtctct ggttcctggg ggactccagc
     7201 agttcaggat accccgctaa taaactgagt aacaccttgg ggaaattgtc agctgaggag
     7261 agtcctctat tgattttttt acctagcaca tcccaggaag gcagagactc ctcctgcctg
     7321 tccaggggag ctcggggctc aggaggctga aatgtctgtc tagtgggggc ttatgggctt
     7381 ggctagcctc tttttgtttt ccctcattat aatcctgctc atctgctttt tgctggctag
     7441 ccaatccttt ttcctctagt ttaaatgaaa gaagggagag acattttctg tgtttcttgt
     7501 tgtctacttc ttcccttcct caaagccaca caaacatgtc aggctcttac atcactgtgg
     7561 ctgaggtgca gcctgggaag caatgtaaga gggatttatc aatggtgttt aaaaaactag
     7621 aggaacatgc tgaatgcttt ggctgggaaa caggtgagct gagctttgca ggatgtctgc
     7681 tccagatgcg aaggggaaga ccaggagcat ggggttgttt cctgggggaa aaaaggtgct
     7741 gcttctctga gctcaacaca cgccctgacc tagtctcctc cctgtaacca gagcaccctc
     7801 tgggaagagg ctaactgtgg ctcaggggtc aggtgaggcc aggcgagggg tgcaccagtg
     7861 gccagggtgt gccttgtgct attgtttaga ggtctagtca aacgaggcca gtctgtggag
     7921 gctgattcca tcctacgggg catcctaata aaccagtgtg atcttcaaag ggtagactgg
     7981 atagatctac agtgtgatct tcaaagggta gactggatag acctacagta tagatctaca
     8041 gtatagatct acagtctacc ctttgaagat cacatgggtt tattaggatg ccctgtagga
     8101 tggccttctg atggcctgca tcagaatcac ctgggtgctt gttaaaacta tggactgaga
     8161 acctggggga gaggtggcgc ctgggaatca gcatgtgtga ggccctatct gttccctgag
     8221 catacaactg cttgtggttc agaagttgcc accagttgag tggccatgta tggcttgaaa
     8281 ttcagactgg agccttgagt aggaaaagaa tgaaaagaag aatttggcac acaacccaac
     8341 ttctgccttt tctgtacata caaatataat atataaccca ctatgtacct agcaacaaaa
     8401 gtcaagtgct cgggaatcta acatttacaa aattggtttt gctttaacac aaacaaagat
     8461 ttctttttca tttgtaatta tggtaaaata cacataacat agaatttatc atcttaacca
     8521 tttttaagtg tacagttcag taatggtaag tacattcaca ctgttgtata ttctgtctct
     8581 ggaactcttc tcatcttgca aaatgaaaac tttaaaccca ttaaatgaca agtcttcact
     8641 tcccccttcc ccagcccctg gcaatcgcaa ttctactttc tttctctatg aattttactg
     8701 ctctaggtcc ctcatataag tagaatcata taatatttgt ctttctgatg actggcttat
     8761 ttcacttagt atagtatacc agagactttt tagaatcact taggtgcaag cagctctcaa
     8821 atgacattaa ctgttttggg tgtccctaaa gcagaaatct gatttttgtt tttgtttttg
     8881 ccttgggcag ttgtcctggg ctggtcgttg gcccctggct tcctgagacc ttggcccctt
     8941 gctgagggag agtgcagacc tggccttgct ctgccacctg ggctccactg tcctggccag
     9001 catgtcctga gagacaatag ccttgctgat cttttagaag tctttaggta ttttcccctg
     9061 cacagtctct tctgagaacc tttctttttt ttttttttta tttcaaagga aaaaaaccaa
     9121 aagcaaaaac atacacttcc atgacttagc tgttggccac aaaagccaga aatcagtgac
     9181 tctctcttca gttgaagatg gttcccatgg caacaaatct ctcatttcct tcaactaaat
     9241 gatctgctca gctttggggt aaaagttctg ttttctctag aattgccatt tgcaaccttg
     9301 tgtgtacata ggaatcacct ggaagtcttt ataaaataat ccccaagcca ggtcctttac
     9361 ttcccggagg atctgattca gcaggcctgg ggatagggcc tggtatccct attttgaaag
     9421 atctcattaa gtggttctgt ctcacatggt tgggagtcat taccctaagg caggcagtct
     9481 atgccttggt gcacgctaga gtcgtctgaa gagctttaag aaatactcgt gcgaccccac
     9541 cccttgacat tctgagtcag gtggtctgag atgtgacctg aatattagga tttcacaaat
     9601 tctccagatg tttctaatgt gcagccagcc ttgagaacca ctattctagg tcagcagttc
     9661 tcaaactgga ggctgcctca gaatctcttg gagagctcct tgattatggg ccccgcccca
     9721 gagttatttg gtgaggccag ggtggagcat ctctaacaag ttcccaggtg atgccaatgc
     9781 tggtccaggg actgcacttg gaggctcatg gctctagatg atcctttaat gagattggcc
     9841 ctgttctgct gccctgttct ttttcctggt tgggggttgg tggacccttc cttccctcag
     9901 tctgactcag gcgtgagact tcttaaaggt accagctttt ctttttctga acattttagc
     9961 attcagataa atattatgac atatttttaa agcaaagtaa catagatttc ttctcccggg
    10021 gctaggagcc tcagagtctg cctgaattaa gaatttatct gtgcctaaga ttaggatgca
    10081 tttagtgatc tgagctaagg ggttggtgga tctgcagcaa taggttcagc ctgtgcctgg
    10141 gtgagggtca ccttgtgacc ggcgctgggt aggatctgag taccacacac ttggccctct
    10201 agcatgggga ggacctgtct ggtccacctg ggggaaagcc tggttttctg atgcagaccc
    10261 agccctctgc ccacctccac atctgtgcac aaacatggaa ggtagcaatg aggaaacaca
    10321 gcaccaggac tgccgtgagc ccaggagcta gggttagagc ctcacttctt tatgcatttc
    10381 cttttctatc atactttgga acaggcttga gctgaaacca gagagttagt acctggtttc
    10441 tgcctcaatc tagtctccct cctccaaaga tgcccccaca acgtgggcaa cttcaacccc
    10501 catgagagct cagaattcca cattcagcga caaagttgac aagagcctct ggagatctca
    10561 aagacttatt aaaagtggaa atggctactg ttttactgag gcagggtgaa aacacaactc
    10621 acttcctagg atcgaaccca gcaaattcac tcagccccca ggtaactgag gactcagttg
    10681 aaggaaaata attttgagcc cctgaaaata gatgctataa agctgtgtat caagggccaa
    10741 ccattttgct aatatcacat atctcacggc atttgctttg attttaaatt cagttctagt
    10801 gaacttggtt ctgatttcta atgacaaagc aaactaagag aatgatgaca tgtgctagat
    10861 aaagcaagaa gtggcagcta atagcctaaa ttgtgatggc attaagaaga ccaaaactag
    10921 tttacttgtt caacgacagc ttgtctttgg aaaaaaaaaa acactacatt aaggataaga
    10981 aaatatgtcc aggcatggtg gctcacatct gtaatcccag cattttggga ggctgaggcg
    11041 ggagatcgct tgagctcaag agttgacgac caacctgggc aacatggcaa aaccctgtct
    11101 caataaagaa tacaaaagca cacctgtagt cagtcccagc tactcaagag gttgaggtgg
    11161 gagactggct tgagcccagg aggcagaggt tgcagtgagc tgagatcata ccactacact
    11221 ccagcctggg tgacagagcc agaccctgtc tcaaaataat aattaaaaaa gaccaaaact
    11281 aaatacatat ctcaggaacc atcaagtagc ctgaggtcgt tggtcgttta gtggggaaga
    11341 gagggagaat atgttataat aaccccggga gcaacacagc atttcagctc agttcaccct
    11401 gtgacatcca ggacatgcag aggtaaaaaa gcgttccaac aatgttcaat acactgtcta
    11461 agaaggcagg gctgcgtttt atccacttta gaattatttc catccccaaa cagttaaaat
    11521 actttcacaa aagtcttggt gcttaaaaga taaatgctca gtgacctgga agttcacata
    11581 aatgaaacgg ttgatgatct gatgatgaag gataggcgag atgggtaaac tcactctttt
    11641 tttttttttg agatggagtc tcactctgtc acccaggctg gagtgcagtg gcatgatctc
    11701 ggctcacggc aacctccgcc tcccaggttc aagtgattct cctgcctcag cctcccaagt
    11761 agctgggatt acaggcgccc accactttgc ccagctaatt tttggtattt ttagtagaga
    11821 cggggccacc attttggcca ggctggttgt gaactcctga cctcgtgatt cgcccacctc
    11881 ctcctcccaa agtgctggga ttataggtgt gggccaccgt gcccggccaa actcactctt
    11941 ttgaacttaa cattttcccc ctgacattgg agactctcct gctacctctc tcctaagaaa
    12001 aaagggcagg tggtgggggg acaagcccct tccaccttcc catctccaag ggactttgca
    12061 gtgtgggtga tggtgtggct gatcatcctc tttctgcacc tctgattctg cttgtgttgt
    12121 ccttattgtg tggggcagga gggtcaggac ttcagctagg ggtgtgctgg ctctgcagtg
    12181 actcaggcct gggtgttttt tggtgaattt aaaaagatga ccatttctgg gggaaagtga
    12241 cacttttact ttctccacac cttcaccatc cattttctta ctggacttcg ctgcgttcct
    12301 gcaaggagga cagggcagag agtagcaacc ctccttgccg aggcccagaa agatagcgtg
    12361 gtgtgcccag ggcacccatg gtgggtgatg gacatctcct tttgggtgcc aaggcttcct
    12421 caaggtggga ggaactggag ggcaggggac ggtggccagt gtcccgctct agccctctag
    12481 ggcacctttt tctcccctct gaagttgtta ggctgatctg gagtctgctc caggcctggg
    12541 cttcaccctg gcctcatgcc ctgcccagca cctgtgtgga gggacctgtt cgtattcatt
    12601 cctctttggg ggccaagctc agggcacccg aaccagcagc cttgggtggc tgaacctagt
    12661 gggacagaag ggaggcagtt gtatctggca gagtcaccca aggccacagg cctgagcaaa
    12721 gcaggagagc ggggcaagct ggggtcaggg accatggtgc tggccccctg ctgctctggc
    12781 catgtgggag gcagctggag gggtcccaag tggcagctcc tgccagacta ccccggactc
    12841 ccgagcccat cgtcctgtac tcttctccag tgggacgtct ggccctcact gtggctagct
    12901 tctgggcaag tccctctgct caagatcact ttatggggca gctggtgccc cctggggctc
    12961 ccacactctg cacatacaat ttagggacct ggcagggtct tggtggcctg cagcttccct
    13021 ttctggaacc gactcgcctc ccatcagaga gccataactc ttcttcaata cagtattgtt
    13081 tgaactttga aatatatgca tttgtctatg tattttctta aaaattaaca ctgtatctca
    13141 ataagcatac aatggattgt tcaatggtac agtttggaac caatcccccg ccacttccct
    13201 ccccaagtaa agccaggaca gatgctggag tcagcatggg agctgtggaa accttttgcc
    13261 ctggagccag gtgcctgtgg ctgtgcctgg gagtggcttc agcccaggcg tggtgtcagt
    13321 ttcctggcac ccctgcccag gagcctgcat gaaggcagcc gggtctctct ctgagtggct
    13381 ggtgcaccgg ctcatttctg agtggcctcc tgcgtatgaa gaaaaagcgg ccacgtggca
    13441 tgcctccctt ccctcccttg ctttcctctc aaagagccaa gtcacgctgc actgcgctcc
    13501 gtggagcctt tcccgatgga gaagagaagg gaggcctgag atgtcctttg ctgggatgtg
    13561 gagaaacacc atctatatga aaagcccctt gcttgctctg ctgattttct ccctcccctg
    13621 gccctggaga gaaaggctgt gccattcaaa gacagtttgg ggacatgggg gctgcaggcc
    13681 tgatcttatt tttatgcaaa ttttgttctg ggagcagtgg tttatacaaa ctcctgtagc
    13741 ataattccag cttgtgtgtg gctgtccttg agtagtgatt ctgaagtgat gactgtgatg
    13801 ctatgcctaa aaacatcatc agggtacttt gtatctgtca ctgtgtttga acggccctca
    13861 atttctatct aataaaacca gtcaaatggt tcaccta
//
