LOCUS       NM_005668               6321 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 4 (ST8SIA4), transcript variant 1,
            mRNA.
ACCESSION   NM_005668
VERSION     NM_005668.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6321)
  AUTHORS   Hatanaka,R., Hane,M., Hayakawa,K., Morishita,S., Ohno,S.,
            Yamaguchi,Y., Wu,D., Kitajima,K. and Sato,C.
  TITLE     Identification of a buried beta-strand as a novel disease-related
            motif in the human polysialyltransferases
  JOURNAL   J Biol Chem 300 (1), 105564 (2024)
   PUBMED   38103644
  REMARK    GeneRIF: Identification of a buried beta-strand as a novel
            disease-related motif in the human polysialyltransferases.
REFERENCE   2  (bases 1 to 6321)
  AUTHORS   Mori,A., Hane,M., Niimi,Y., Kitajima,K. and Sato,C.
  TITLE     Different properties of polysialic acids synthesized by the
            polysialyltransferases ST8SIA2 and ST8SIA4
  JOURNAL   Glycobiology 27 (9), 834-846 (2017)
   PUBMED   28810663
  REMARK    GeneRIF: Different properties of polysialic acids synthesized by
            the polysialyltransferases ST8SIA2 and ST8SIA4 have been described.
REFERENCE   3  (bases 1 to 6321)
  AUTHORS   Ma,W., Zhao,X., Liang,L., Wang,G., Li,Y., Miao,X. and Zhao,Y.
  TITLE     miR-146a and miR-146b promote proliferation, migration and invasion
            of follicular thyroid carcinoma via inhibition of ST8SIA4
  JOURNAL   Oncotarget 8 (17), 28028-28041 (2017)
   PUBMED   28427206
  REMARK    GeneRIF: our results demonstrate that miR-146a and miR-146b promote
            proliferation, migration and invasion of FTC via inhibition of
            ST8SIA4.
REFERENCE   4  (bases 1 to 6321)
  AUTHORS   Bhide,G.P., Prehna,G., Ramirez,B.E. and Colley,K.J.
  TITLE     The Polybasic Region of the Polysialyltransferase ST8Sia-IV Binds
            Directly to the Neural Cell Adhesion Molecule, NCAM
  JOURNAL   Biochemistry 56 (10), 1504-1517 (2017)
   PUBMED   28233978
  REMARK    GeneRIF: The polybasic region of the polysialyltransferase
            ST8Sia-IV binds directly to NCAM.
REFERENCE   5  (bases 1 to 6321)
  AUTHORS   Ma,X., Dong,W., Su,Z., Zhao,L., Miao,Y., Li,N., Zhou,H. and Jia,L.
  TITLE     Functional roles of sialylation in breast cancer progression
            through miR-26a/26b targeting ST8SIA4
  JOURNAL   Cell Death Dis 7 (12), e2561 (2016)
   PUBMED   28032858
  REMARK    GeneRIF: changes in the glycosylation patterns and sialylation
            levels may be useful markers of the progression of breast cancer,
            as well as miR-26a/26b may be widely involved in the regulation of
            sialylation machinery by targeting ST8SIA4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6321)
  AUTHORS   Close,B.E. and Colley,K.J.
  TITLE     In vivo autopolysialylation and localization of the
            polysialyltransferases PST and STX
  JOURNAL   J Biol Chem 273 (51), 34586-34593 (1998)
   PUBMED   9852130
REFERENCE   7  (bases 1 to 6321)
  AUTHORS   Angata,K., Suzuki,M. and Fukuda,M.
  TITLE     Differential and cooperative polysialylation of the neural cell
            adhesion molecule by two polysialyltransferases, PST and STX
  JOURNAL   J Biol Chem 273 (43), 28524-28532 (1998)
   PUBMED   9774483
REFERENCE   8  (bases 1 to 6321)
  AUTHORS   Angata,K., Nakayama,J., Fredette,B., Chong,K., Ranscht,B. and
            Fukuda,M.
  TITLE     Human STX polysialyltransferase forms the embryonic form of the
            neural cell adhesion molecule. Tissue-specific expression, neurite
            outgrowth, and chromosomal localization in comparison with another
            polysialyltransferase, PST
  JOURNAL   J Biol Chem 272 (11), 7182-7190 (1997)
   PUBMED   9054414
REFERENCE   9  (bases 1 to 6321)
  AUTHORS   Nakayama,J., Fukuda,M.N., Fredette,B., Ranscht,B. and Fukuda,M.
  TITLE     Expression cloning of a human polysialyltransferase that forms the
            polysialylated neural cell adhesion molecule present in embryonic
            brain
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 7031-7035 (1995)
   PUBMED   7624364
REFERENCE   10 (bases 1 to 6321)
  AUTHORS   Eckhardt,M., Muhlenhoff,M., Bethe,A., Koopman,J., Frosch,M. and
            Gerardy-Schahn,R.
  TITLE     Molecular characterization of eukaryotic polysialyltransferase-1
  JOURNAL   Nature 373 (6516), 715-718 (1995)
   PUBMED   7854457
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA862968.1, AK292872.1,
            AC117530.2 and AA836260.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005668.5.
            
            Summary: The protein encoded by this gene catalyzes the
            polycondensation of alpha-2,8-linked sialic acid required for the
            synthesis of polysialic acid, a modulator of the adhesive
            properties of neural cell adhesion molecule (NCAM1). The encoded
            protein, which is a member of glycosyltransferase family 29, is a
            type II membrane protein that may be present in the Golgi
            apparatus. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.144379.1,
                                           SRR1660803.80785.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231461.10/ ENSP00000231461.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                DA862968.1         4-48
            46-1620             AK292872.1         1-1575
            1621-5874           AC117530.2         44188-48441
            5875-6319           AA836260.1         11-455              c
            6320-6321           AC117530.2         48887-48888
FEATURES             Location/Qualifiers
     source          1..6321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21.1"
     gene            1..6321
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 4"
                     /db_xref="GeneID:7903"
                     /db_xref="HGNC:HGNC:10871"
                     /db_xref="MIM:602547"
     exon            1..440
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1407
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /EC_number="2.4.99.-"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; sialyltransferase 8 (alpha-2,
                     8-polysialytransferase) D;
                     CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase;
                     polysialyltransferase-1; alpha-2,8-sialyltransferase 8D;
                     CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase;
                     sialytransferase St8Sia IV; sialyltransferase St8Sia IV;
                     ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
                     4"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-poly-alpha-2,
                     8-sialyltransferase isoform a precursor"
                     /protein_id="NP_005659.1"
                     /db_xref="CCDS:CCDS4091.1"
                     /db_xref="GeneID:7903"
                     /db_xref="HGNC:HGNC:10871"
                     /db_xref="MIM:602547"
                     /translation="MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSL
                     SRSLVNSSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSF
                     KPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEI
                     DSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSML
                     NDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIK
                     RPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMP
                     LEFKTLNVLHNRGALKLTTGKCVKQ"
     exon            441..572
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     exon            573..830
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1124
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..6321
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3259..3264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /note="hexamer: AATAAA"
     polyA_site      3276
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /note="major polyA site"
     regulatory      3571..3576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /note="hexamer: AATAAA"
     polyA_site      3601
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /note="major polyA site"
     regulatory      6029..6034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /note="hexamer: AATAAA"
     polyA_site      6051
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /note="major polyA site"
     regulatory      6299..6304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
                     /note="hexamer: AATAAA"
     polyA_site      6321
                     /gene="ST8SIA4"
                     /gene_synonym="PST; PST1; SIAT8-D; SIAT8D; ST8SIA-IV;
                     ST8SiaIV"
ORIGIN      
        1 gacgcccccg aacccagctg cagaagctgc cgccacctcc aatgcacaag gtgtctcatc
       61 tgaaaagaaa cctgagcccc agggaggcgg cgcggagcga ccctggcaga gctggcgcaa
      121 acagggcgag aggtcgctgg gcagcgttcg aggaccagag ggagctcggc cacagaagac
      181 cccagtgatc tgatcccggg atcccggctc caagctctcc tcgcatttta cagatttcac
      241 ccccgcgact atctccccaa aacggagcct ttatatcaag agaaggtgcg ggagctgggg
      301 caaccaggac tttctcgggc acccaagatg cgctccatta ggaagaggtg gacgatctgc
      361 acaataagtc tgctcctgat cttttataag acaaaagaaa tagcaagaac tgaggagcac
      421 caggagacgc aactcatcgg agatggtgaa ttgtctttga gtcggtcact tgtcaatagc
      481 tctgataaaa tcattcgaaa ggctggctct tcaatcttcc agcacaatgt agaaggttgg
      541 aaaatcaatt cctctttggt cctagagata aggaagaaca tacttcgttt cttagatgca
      601 gaacgagatg tgtcagtggt caagagcagt tttaagcctg gtgatgtcat acactatgtg
      661 cttgacaggc gccggacact aaacatttct catgatctac atagcctcct acctgaagtt
      721 tcaccaatga agaatcgcag gtttaagacc tgtgcagttg ttggaaattc tggcattctg
      781 ttagacagtg aatgtggaaa ggagattgac agtcacaatt ttgtaataag gtgtaatcta
      841 gctcctgtgg tggagtttgc tgcagatgtg ggaactaaat cagattttat taccatgaat
      901 ccatcagttg tacaaagagc atttggaggc tttcgaaatg agagtgacag agaaaaattt
      961 gtgcatagac tttccatgct gaatgacagt gtcctttgga ttcctgcttt catggtcaaa
     1021 ggaggagaga agcacgtgga gtgggttaat gcattaatcc ttaagaataa actgaaagtg
     1081 cgaactgcct atccgtcatt gagacttatt catgctgtca gaggttactg gctgaccaac
     1141 aaagttccta tcaaaagacc cagcacaggt cttctcatgt atacacttgc cacaagattc
     1201 tgtgatgaaa ttcacctgta tggattctgg cccttcccta aggatttaaa tggaaaagcg
     1261 gtcaaatatc attattatga tgacttaaaa tataggtact tttccaatgc aagccctcac
     1321 agaatgccat tagaattcaa aacattaaat gtgctacata atagaggagc tctaaaactg
     1381 acaacaggaa agtgtgtaaa gcaataaagc acattttgaa acaaacaata tgcacttctt
     1441 ttctgaagat gcttccgaag atttgaaaat aggatccaaa acacggctgg gtttcagcat
     1501 ccaccaatga actgaaaggt gaataaagga cgttcatgag aaatcgacta ccagctgatg
     1561 aaatacctgc aaagtgctct aaaaattaaa tattttgact ttaagggtcc tagtaagtgc
     1621 cacttccact aagaatacag tttgaatgta taatcagtag tgtttacaag atccaacagt
     1681 gcactcatca ttagttaaca aagcaaatat gttcatcact gtcaggctgc ccacagcaac
     1741 accaagcata ttagaagagg aaccccagga acgcaactca gaccttggga aattaaacca
     1801 tccttgtcag cagaagccaa gatggaagca gtttgagcaa tgaaatccgt aagattaaac
     1861 aactcaagta aatgcttcag tcaggactct gagtctgatc atgaatttta tgttttaatt
     1921 tatgtttttt ttttgtcttc tggaatctct tttggtttgg atattgggat gcttagaaat
     1981 cctttctgag atgcatatga gtgaggaaat aaactttaag taattatttt taaagttctt
     2041 atacttttta aaagctatca cacaaagact tttttttttt tttttgtctc gctctgttgc
     2101 ccaggctgga gtacagtggc gcgatctcag ctcactgcaa gctccgcctc ccaagttcac
     2161 tccattctcc tgcctcagcc tccggagtag ctgggactgc aggcgcctgc caccacgcct
     2221 ggctaatttt ttgtattttt agtggagacg gattttcacc gtgttagcca ggatggtctc
     2281 aatctcctga cctcgtgatc cacccgcctt ggcctcccaa agtgctggga ttacaggcgt
     2341 gagccaccgt gcctggccga catttttaaa aaagttttat tttgcacggc tctaaacctc
     2401 catgttattt tccagtggtg tagaaggtac cagctaaagt gaaccactat gtaatattag
     2461 gccattctaa aggaaagatg ttccatgtca tcagagatgg taaaataggc cgggaaaaaa
     2521 aaatctttgg taccaaagat tacacttgtg tttctacaca gcaaaccatt tttctttcat
     2581 gaaaataata tattattaac atgaatatat tattttgcta ttaatgtgaa agttgtctct
     2641 aaatattttt taattttcaa actcatactt tattttcatt tgaaatgttt ttcacacctt
     2701 ttgcattaca taataatttt gtggaagcat tttgcccttt agaataaata ttagattgat
     2761 atagctgaaa tgtgacttcc agttctttga tattcccctt gttattcaaa tagaaatatg
     2821 gaaatgcttt atatattact gttaaatttc ttagtgcaga aataacatta ttaatagagt
     2881 attgttttca aaacagagat gattaatttc aagaggttta acagtgaaat tgtgtcaata
     2941 ttttgcattt aaaatgaatt taattgaccg atattttctg tagttaaatt tagtcacaat
     3001 atcacatatg ttcttcaaga aacacatgaa attattaata aagtaattaa aaaattttta
     3061 atgtataaca gaattgacca ataggccagt tttctggtaa cttatgatag tagattgttt
     3121 ctttagaaac tgggcagaag ctctgcattc tcacttgtac tttgatttct tatttcttgg
     3181 gcaggcaatt tgaggaaaga agaaatggca tggggaatat atatgttttg tttcttaggg
     3241 aaaacagtct gagaaatgaa taaaaagcat gaagtacgtg tgtgtgtgtg tgtgttacca
     3301 tggaaaagga tattcacagt agtacagttc tcaatatttt taattagatg tcatattttt
     3361 ttaatatagt aaaaccttgg gatatagaat attacatctt ttgagaatgt atgtgtctct
     3421 aagtaagtaa aatctaatgc gtataggaga ctgatagcta aaaatgaatg gaacattaat
     3481 gtacttttat aattaaacct cttatctatc agaaattgta agagaataga tacatgtttt
     3541 gaatgtaaag ttgaaaagtc tggtttactt aataaattga aagtgattta taaaatctaa
     3601 atttggacta cttgcaaatg ataagctatt ctagtagcct ttagtttaaa tccaacagaa
     3661 atctagaagt cacaagcaaa tatcttaaag gtaaaatcca tctgggcact catttaaagt
     3721 atatcttaaa aaagcagcag caaggtacct tgccattttt agcatatttt cttccttttt
     3781 cttttttctt tttttttttt ttttgagatg gagtctcact ctgtcacaca ggctggaatg
     3841 cagtgatgcc atctcagctc actgcaacct ccacctcctg ggttcaagtg attctcgtgc
     3901 ctcagcctcc caagtagctg gggttacagg cgcccaccac cacactcggc taattttgtg
     3961 tttttagtag agacaaagtt tcaccatgtt ggccaggctg gtcttgaact tcctgacctc
     4021 aggttatcca cccacctcag cctcccaaag tgctgggatt acaggtgtga gccaccgcag
     4081 ccggaccatt tttagtatat tttcagtaaa tacatttaaa caatgttaag gccacagcac
     4141 acatatctca gccattcatt gttctgtgca ttgatgttta tctcatagat gcattgagta
     4201 gtgccttttt agctttttca cattactttg tcaccatatc ctttgtgttc tctaaataca
     4261 ttgcccactt ccaaaaatgt tcagcatgaa aaaaagggct tcagtgtcga ttgagattgc
     4321 ttttgttcat ctcagggatt tcaatagtca agaatgaatt cagttaaagg tatttagggt
     4381 tcaaagaaga caaactgtac aagcccattt cattccttgt tgtatacctt tccatctgcc
     4441 ctcccatttt aactatctac tgtggccttt ttatggaaac agagcaagat caatgaaggc
     4501 taatggcaag aataagaaaa agagttgaga tttaaccaat agcggagcat aaaggatcat
     4561 gacaaaatca aattataaaa gcatacttga aataggtgga gctttttctt ttgaaaatat
     4621 atattcacaa ttttaatatt ttaatttatt ttttactatt taaccctgta cttggcaatg
     4681 ctcaggcagc tgattgtgaa atattcttgt cctttacaga acatggttgt tattgtgctg
     4741 ttgacatgaa tagaccatgg aaacattttc atcattatta ttcagcctgt gctgtagtta
     4801 atgttaagtt gctgaaataa aaagtgagca agtaatagat tttcttggca aatctaatga
     4861 ttcagcccac aggactgttg aaactactgc ggaagttttt ctatctgaaa gaaggtgctg
     4921 ggcattcaaa tgtgttcatg tattgtatat catatgaatt gtatatcaat tactaatggg
     4981 aatttctaca tatatgctta caaaagcaat ttatttaagt aatgctaggg gtagtgtaca
     5041 taccaattag ttattcagct actatacaga aaaaggatga acaaattaat ttatttctaa
     5101 ttgagccagt tagacataat gcatataacg tgatatttgg ttcatgaaag agttgttttc
     5161 atgtggttat tgtagggagt atatataatt gtggaagggg tatgggaaga gttgtgtata
     5221 gttagttgtt atctctacaa gtttgaaagt tttcccatca aacattatca atataccaat
     5281 gttttaaaaa ttgagtgagg gttattattt gtatttgatg aaagaaaatc caaataaagc
     5341 ccacctagaa atagatattt tattatatat gtgctataga tatacctata tagtacaaat
     5401 agacatgtgt gatgcatata tacaatgtta tatatgtgta tatgtctgta tacacactga
     5461 gtctgtaata tgtatacact aaatttgtgt tatgctaaca tcttcagggt ctgcactgtg
     5521 aactcccctg gagataagta agtccacttt agaataaaga agttcttttg agacttcagt
     5581 tactaacgtg ctttaagagg tatctacttt ataactgaat tctatgtcgt tcatacgtag
     5641 agttacagta agggtctagt atgtccaaat cttaataata aagaagaaaa gtaaaggctt
     5701 caagctagca atgtattcga attacagttt tcagattgtg gctccaggcc ttgtgtttct
     5761 catttaagta gcacctttta ataaaaaccg tttctttgtg taggcaaaag cacaagtgtt
     5821 tcaaatgtaa atagcaggaa aaaaaaagag tttacagaga tagcattgct gcacagaata
     5881 attgctactg agtatttctt atagaatttg tggaactgaa agatgaggtt tattctgtca
     5941 agttcaagtt cattctgttc aacactgttt tcttattgtt tgtgtatagc aaccgggtat
     6001 tattgtttta tcatttgtaa aattgtaaaa taaattaatc cctttttttc actgtttctc
     6061 ttatctcata tatccaagcc cttggttata ctttgtatgt caatgttagg tgatcatttt
     6121 taacaagctt tggcttgtgc tttgcttttc cactcccctt agccctagtg gttggcaatt
     6181 aggcaaacca tttattttta agtgtataca tgggaatatg aacaatgtca aaaaccccat
     6241 gaatattagg aaatccttaa cgatattttg tgtagcacat tctgtttgcg gttgagggaa
     6301 taaagtattt cacaagtgac a
//
