LOCUS       NM_015879              10087 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 3 (ST8SIA3), mRNA.
ACCESSION   NM_015879 NM_017529
VERSION     NM_015879.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10087)
  AUTHORS   Volkers,G., Worrall,L.J., Kwan,D.H., Yu,C.C., Baumann,L.,
            Lameignere,E., Wasney,G.A., Scott,N.E., Wakarchuk,W., Foster,L.J.,
            Withers,S.G. and Strynadka,N.C.
  TITLE     Structure of human ST8SiaIII sialyltransferase provides insight
            into cell-surface polysialylation
  JOURNAL   Nat Struct Mol Biol 22 (8), 627-635 (2015)
   PUBMED   26192331
  REMARK    GeneRIF: Data indicate that the crystal structure of ST8SiaIII
            sialyltransferase show a cluster of polysialyltransferase-specific
            structural motifs that provide an extended electropositive surface
            groove for binding of oligo-polysialic acid chain products.
REFERENCE   2  (bases 1 to 10087)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 10087)
  AUTHORS   Kim,S.J., Chung,T.W., Jin,U.H., Suh,S.J., Lee,Y.C. and Kim,C.H.
  TITLE     Molecular mechanisms involved in transcriptional activation of the
            human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase
            (hST8Sia III) gene induced by KCl in human glioblastoma cells
  JOURNAL   Biochem Biophys Res Commun 344 (4), 1057-1064 (2006)
   PUBMED   16643848
  REMARK    GeneRIF: These results suggest that the expression of hST8Sia III
            gene via the PI-3K signaling pathway is enhanced during KCl-induced
            differentiation of U-87 cells by increasing expression of
            beta-tubulin III.
REFERENCE   4  (bases 1 to 10087)
  AUTHORS   Angata,K., Suzuki,M., McAuliffe,J., Ding,Y., Hindsgaul,O. and
            Fukuda,M.
  TITLE     Differential biosynthesis of polysialic acid on neural cell
            adhesion molecule (NCAM) and oligosaccharide acceptors by three
            distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II
            (STX), and ST8Sia III
  JOURNAL   J Biol Chem 275 (24), 18594-18601 (2000)
   PUBMED   10766765
REFERENCE   5  (bases 1 to 10087)
  AUTHORS   Lee,Y.C., Kim,Y.J., Lee,K.Y., Kim,K.S., Kim,B.U., Kim,H.N.,
            Kim,C.H. and Do,S.I.
  TITLE     Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1,
            4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III)
  JOURNAL   Arch Biochem Biophys 360 (1), 41-46 (1998)
   PUBMED   9826427
REFERENCE   6  (bases 1 to 10087)
  AUTHORS   Zeng,G., Gao,L. and Yu,R.K.
  TITLE     Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8
            sialyltransferase
  JOURNAL   Gene 187 (1), 131-134 (1997)
   PUBMED   9073076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090208.4 and AB208996.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015879.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.8248.1,
                                           SRR1803615.56132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324000.4/ ENSP00000320431.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC090208.4         169476-169689
            215-1930            AB208996.1         286-2001
            1931-10087          AC090208.4         177694-185850
FEATURES             Location/Qualifiers
     source          1..10087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.31"
     gene            1..10087
                     /gene="ST8SIA3"
                     /gene_synonym="SIAT8C; ST8SiaIII"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 3"
                     /db_xref="GeneID:51046"
                     /db_xref="HGNC:HGNC:14269"
                     /db_xref="MIM:609478"
     exon            1..469
                     /gene="ST8SIA3"
                     /gene_synonym="SIAT8C; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1433
                     /gene="ST8SIA3"
                     /gene_synonym="SIAT8C; ST8SiaIII"
                     /EC_number="2.4.3.8"
                     /note="sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha
                     2,8-sialyltransferase); alpha-2,8-sialyltransferase III;
                     sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha
                     2,8-sialyltransferase; SIAT8-C; sialytransferase St8Sia
                     III; alpha-2,8-sialyltransferase 8C; sialyltransferase
                     St8Sia III; ST8 alpha-N-acetylneuraminate
                     alpha-2,8-sialyltransferase 3; hST8Sia III; ganglioside
                     GD3 synthase ST8SIA3;
                     sia-a2,3-Gal-b1,4-Glc-NAc-R:a2,8-sialyltransferase"
                     /codon_start=1
                     /product="alpha-N-acetylneuraminate
                     alpha-2,8-sialyltransferase ST8SIA3"
                     /protein_id="NP_056963.2"
                     /db_xref="CCDS:CCDS32834.1"
                     /db_xref="GeneID:51046"
                     /db_xref="HGNC:HGNC:14269"
                     /db_xref="MIM:609478"
                     /translation="MRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKY
                     ASPGAPRMYMFHAGFRSQFALKFLDPSFVPITNSLTQELQEKPSKWKFNRTAFLHQRQ
                     EILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYN
                     ICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKY
                     YNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLA
                     WPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDL
                     PYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA"
     exon            470..592
                     /gene="ST8SIA3"
                     /gene_synonym="SIAT8C; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     exon            593..1150
                     /gene="ST8SIA3"
                     /gene_synonym="SIAT8C; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..10087
                     /gene="ST8SIA3"
                     /gene_synonym="SIAT8C; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10059..10064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST8SIA3"
                     /gene_synonym="SIAT8C; ST8SiaIII"
                     /note="hexamer: AATAAA"
     polyA_site      10087
                     /gene="ST8SIA3"
                     /gene_synonym="SIAT8C; ST8SiaIII"
                     /note="major polyA site"
ORIGIN      
        1 ccttcgccac gccgccgcgc agcccctcca tcttcctgct cggcaccggg ccccgcgcgc
       61 ccctgcctac ggggtcccgc tgctctccgg ggctcctgcc agccccaacc cccggccccg
      121 gtggcctccc cccacccccg cccgggtccc cctcctccgc cacacgcgcg cgcgctcaca
      181 cacacacaca cacacacaca cacacacaca cacatatata cacgccagcg agctgctggc
      241 cgctcaatgg accgatttcc ccggtttccc tgaacccagc ccagcccggg atgagaaact
      301 gcaaaatggc ccgggtcgcc agtgtgctgg ggctggtcat gctcagcgtc gccctgctga
      361 ttttatcgct catcagctac gtgtccctga aaaaggagaa catcttcacc actcccaagt
      421 acgccagccc gggggcgccc cgaatgtaca tgttccacgc gggattccgg tcacaatttg
      481 cgctgaagtt tctagacccg tcattcgtgc ccattacgaa ttctctcacc caggaactcc
      541 aagagaaacc ttctaagtgg aaatttaatc ggacagcgtt tttacatcaa aggcaagaaa
      601 ttcttcagca tgtcgatgta ataaaaaatt tttctttgac caagaatagt gttcggattg
      661 gacaactgat gcactatgat tattccagcc ataaatatgt tttctctatt agcaataact
      721 tccggtcact tcttccagat gtgtcaccca ttatgaacaa gcattataat atttgtgctg
      781 tggttggaaa tagtgggatc ctgacaggga gccagtgtgg acaagaaata gataaatcag
      841 attttgtttt ccgttgcaat ttcgccccta cggaggcttt ccaaagagat gttggaagaa
      901 aaaccaatct taccaccttc aaccccagca tcctggaaaa atattacaac aatctcttga
      961 ctattcagga ccgtaacaac tttttcctca gtttaaaaaa gcttgacggg gccattcttt
     1021 ggatccctgc atttttcttc cacacttcag caactgtgac caggacatta gttgactttt
     1081 ttgttgaaca cagaggtcag ttaaaagtcc aactggcttg gccgggaaat ataatgcaac
     1141 atgtcaacag gtactggaaa aacaaacatt tgtcacctaa acggctgagc acaggtattc
     1201 ttatgtacac ccttgcatca gcaatatgtg aagagatcca cttgtatgga ttttggccgt
     1261 ttggatttga ccccaacaca agggaagatc ttccatacca ttactatgac aaaaaaggaa
     1321 ccaaatttac caccaagtgg caggagtccc accagctgcc tgctgagttt cagctgctgt
     1381 accgaatgca tggggaaggg ctcaccaagc tgactctgtc acactgtgcc taagaactcc
     1441 aaacggaaag cgccaaatgg ctgtttaaaa agtgccccaa atcaaattga atagccttca
     1501 gaatagaacc ctagagaatg tcttataagg attgtctgcc atttaaaagg aaagatgtct
     1561 tttctctttt gcactgctct tttaagagtt ttagcagatt tagcaggaca gatgcattga
     1621 agccacatgg tttagacttg attgataaag ggaatgttgc atttgggact atgctgctaa
     1681 cgaaatggtt tgaagtattt tcatgtttgg attttaataa taaactgcct ctcattttta
     1741 tgaggactag agctatagtt tctgcagctc tgctcagata gtcctcataa tcagaggcct
     1801 ctggccaact ggggcaggac ctgttttgct ggtgggatca gactctgaaa aatggaaacg
     1861 taaaaaactg gtttgcatat ctcatcttct atctatctcc ctatctccat ctctatcacc
     1921 atctcactcc ttccctctgc aactactccc tgccctacca ccgtggagtt taataatttg
     1981 ctaggaatcc tattgaattc gctttgcttg tatatgttgc atttgtactt gatgtgttta
     2041 aggttctggg taactttgat gcttcatgac aaaataggca aatcacgatg gactcccttg
     2101 tgattccttt tttaaagaaa tgcctctgat gcagtcctca ccagtccatt cagtcattct
     2161 acagcaagat ggtccctctg tggtgagtgg gatataaggc agtgcatctt tcatgatcac
     2221 aaagaaagcc tatgttgtgg atagcattgc gtctcttgat gtaggcattg ttatggcaaa
     2281 taatagcact gtggccacat ctgtaaggcc attccagcct aaatttagtg tctcccataa
     2341 tcccaaccca tgcactaggc tgggtgttct ctcagaatat agaggcaatg aatcagctta
     2401 agaccctggg acacacaaag gaaaaggaag aagaatattt agaagttgtt atggaatcct
     2461 gtgtacccta aagtgtggta accatgttac ccattccagc tgggttaaag tggaggagga
     2521 tcttggccag gccaggtgcc caggtgacta gtgctgaggt gcgatcgttt tccgtatcat
     2581 tgtgtgcacc accaccaatc cagaaccatt tgctctcttt gagaacattg tagcactgga
     2641 tattccctct ttccactgaa gtcagatcta tacaactaca aattaagcat ttcaaaagaa
     2701 aaagccattg tgcagtggca agagttggaa tccaagatta tgtagacctg cgatgaagga
     2761 agtagctggc cattctcatt ttctttattt cagccatatg agtagaaatc aaatcattcc
     2821 catccctggc tttttactga gcagcacttt gttcttccaa ttcagcccaa cgtctggcca
     2881 agttgatgtt aaattttaat aagagtttct ttcttctttc caaatgccag tcaagcatat
     2941 ttgttatgca tttgagtggg gtagctcatt cttttcctga aatctcatct agattgcttg
     3001 caatgcgaca aataactgtt taaaaaatgt gctgtagttc agtgatgagc tcattgcccc
     3061 tctttaggaa ggtaagatca tgcctaaaat taaaccgaat atggtaagga aagacactat
     3121 cgttatgctc acgttctgcc tggtcctaaa cctgccttat tattattttc agaaagcaat
     3181 ctaattagag caacttgcat agatctagat attaactaat gaaagaaaca ccaagttcaa
     3241 atgtgttacc aattatgaca cacattacaa tataattata aggggagaca ttaaaaacat
     3301 tttgtaattc agtggtataa tttgatgggt atcacaacca caccgtgttt gttccctgtc
     3361 cctttgaaga ggactgtact accatcctca cactgtgctc tgttgggatc actgagagat
     3421 tgacaactga cagaagtgtt tagttggctg ttcctgagca cttagttcat ttggttatag
     3481 ctaagtgata ttaatgccaa tattacttgg gccagattct gactctggag ttttaatccc
     3541 aatgtgccca ttcattttca ctaaatataa atgcatagac actttaaacc aagaagatta
     3601 aaagaggaaa agaccagaat ctctaaaaaa cagtttactg ttctgtagtg gacaatttaa
     3661 attttatctc atcataatgc caaggatttt tgtttgtttt ttaagttcag ggagattttt
     3721 taaatctcct tgcagtcttg gctccatctt aaccttagag tgggaggact ttcccatccc
     3781 ccaccaccgt gttatctatc actttaatga aaactcaaaa tagtgaggaa atggactttt
     3841 cttcagaact tgaggggttt agagatcagg ctcatctctg cttataagga ggacttcctg
     3901 gagatgatcc caatagatca cccttcactt ttgaagaata gcagcttcta gctgaccatg
     3961 caaaatctct gtttgttttt aaagactgtt tcaaagatta aatctataca accactttta
     4021 tgaccaaaaa agttgttgtg tcccaagtgt cctaattaga aaggcagctg gctctcctgc
     4081 agctcccagg cttgtgtagt caagtgcagt gaactgggca gtaatcagct caggaccatt
     4141 ggctctttcc tcctctttca gctacagaca catgccctgg cttttgcatt gaccttgctt
     4201 tgttagttct agactaattt atccttttgt cagacacttt ccctttttta ggatactcac
     4261 aacagagtcc actttcagct attggaatac attttaccat aaagccccca aggctttcta
     4321 cccataacac caacacaaaa aaccaattaa gttgcagagg ggggaaataa tcacaaactt
     4381 ttggcaacct gcttaatgct agacgctctg ttttcactgg ttattctgag tgtcatatgc
     4441 agatgcagat ccaagggaga cagggctaaa tggtggtgtc aagaattcct cccacacccc
     4501 aaaaattctt tccaatattt gattattaaa atatctatca tttctccacc ttgtgtctgt
     4561 gtcttaagtg tctgtgaata ttgtaaaagt gctgtatgtt tagtagtgtt gtgtgcctgg
     4621 cagtgctgac tatgactact gtgccatctg tctgtgacct tgatgtcagg tacctggcca
     4681 tggggctacc agcaaggatg tgcaaaggaa gaaccgctgc ccctgccctc agcttcctta
     4741 tgcccgagcc actacttatc cgtgaatgtg agtgccaaga gaaacctaat ttggtgggga
     4801 agccaaggaa tgggagaacg ttttttctga tttgagtcaa ggcactaatt attagacact
     4861 ctcagacaac aaagcggtat tgacctgaga tcaaaggaag cagggacaat attgtagaat
     4921 gctaggacac tggaaatgaa gaggccttca gcttcgccag tcttgattct tgactttaca
     4981 aatgagaaaa tggagaaaca gggaggctag gtgatttgcc ccagatgaca ctgtcaatta
     5041 gtggagaaat tatgattcct cctctagtac ttcttggtct taccagcatc aaatgaagct
     5101 gggctcacag ggaaagtggt ttttggtctg ggatctgcag agcacataaa ataagttaga
     5161 aagtctataa aagaggaaaa aaggttctcc tctccctccc aaaaatgact tcccaacaca
     5221 gaacaataaa ggagatgctt gtgtgggtat gcaactgtcc accaattatc acctaccttc
     5281 tccctgagat gaaacaaaac acgcttggta aatcatgatt tgataaataa caattaagtt
     5341 actggtggtt catgcttgac agctgcaatc ttacccaata agctattcat cttagtaaaa
     5401 ccttgtttta gtaatataca tgcataattt agaagttgaa ggctgaaaat tgttgtgttc
     5461 ttctccatat atatacaact ttcatcgggg tcccttgagt taagaaatgc cttctatttt
     5521 ataggtaatc tcaacagcag actttgaaat attgtgtttg gttcaatatg ctaagaagat
     5581 atacaaataa taataacttc gtgagtcttc atgtgcaaaa tgacaaactg agcaattttc
     5641 tgtataattc tagattctta aaaccttttt tcccataatt gtttgaatgc actaggcaca
     5701 agtttctgtt taagcctctg cttctccctg aatgtgtaga actgtcactt tgcttacaaa
     5761 ggggctgtgt gtttgtggct ggcagcccag atagagcact ctgggtgctg gggattgagg
     5821 gcaccttggc cagctgattg acctgtctgg actctgtggc ccaattaatc gaggccacag
     5881 atcagttggt actaagcatc aaaatgattc attatgcctc tctcacactc cgattgcttt
     5941 gccacataga taacagcatt tgaaatggga aacactttag aatgtcatta ttgtattata
     6001 tattgtcatc ttatgcagta tttctgaaaa tttattttta ttgtgatgac tgattgaaga
     6061 catatgtgta tgaatagatg ttcctcagtg aagcctattc tcttgttgtt gatgacagtg
     6121 gcatcagagt gaagagttgt tgcagagtaa ctgacttcag tttaaggtta ccctggggtt
     6181 ctggggttag gacccggatt atgcagctga tctcccagca aacacagctg tatgaaataa
     6241 gcaactcttc aaaatacaat tcttgccact cattctggac ctttgattca taatgtcctg
     6301 ggataagtcc aacttacaaa gattcccagg tgattcgtgt gaccaccatt tggaaaccag
     6361 taatatatac atccggagtc atatatacca ttttgaacaa agtagctaaa tgcttatctc
     6421 tccttgtgcg attagtttca catgttcgtt gaggttatca tgttaaatgg caatatagac
     6481 acagtcttag tgattcaaca attcagctgt ttcagccgaa ttgaccagtt gctaatttat
     6541 aagcaaattg taactgatca atttagtcag aatggatgca agcccaaaga caaggtggag
     6601 agcaagcttt aatatacact ttgtctcaag gccagctctt catatttccc tctttatatt
     6661 tcaaactaag aggcagatct caggtcactc atctttagaa ttggtgagaa tgagaaacag
     6721 ggaactgaag tgattcattc agattcaatt tggaagtcat tcccagagcc taaaatattt
     6781 atctaagggg tctgatttat caacctcagg tagtctccaa aacacaaagg tattcaggct
     6841 aaaataaaac caatcaaaaa aggaaattca ggaggctcca gttctaagac taacccagta
     6901 taacaagggt gatcagttat tacttgtggc cttgtaccac ctctgttgga taatgtgcca
     6961 ccgtcctaat gaagctttgg ccagacttct ttctatagct gtgcacatag aaaggcttta
     7021 gacaacagtg ataccaaagg gttcctttga ttttccttct gtgtgattct cagacagttt
     7081 tagctctttg gtgtgctgcc aaatgtttaa caactggctc tggaaaacag tggaacccag
     7141 atttttagca cctaccaatt tctatggtgt aaatactctc atctcagcca atttcaggct
     7201 actaacttaa tgtcaaccag ctgaaaacac aacaatatgt tttcaagagc cagtataagt
     7261 tggctccaat acagcatgag ccagctccag catagcactg cctgaacaat ttttaagtca
     7321 gtgagtacca aataggagag gctagcagag gctttggagg gacttttaaa tgtcccctcc
     7381 accaagggaa gcatttccat gttggttagt tttactgatt tttagtaaaa gagcatatta
     7441 ttggatccca aggtgttcaa atattccacg tgactcttag gaacctctca acagactccc
     7501 cagtatcttg ggagattacc aactgtggct tttctaattt ctaagggtga ccctccagga
     7561 aaacattctt taatttaact accagttaaa accatgtttg gctgatcttt tttaaaaaat
     7621 ctatacctat agttcatcac ttgtttcccc aactttgtca ttttccctat ccacttgccc
     7681 ctcatccttc tgacacaata aaaaaaatac aggtacccac aaaacagtgc ctgcaaagga
     7741 gcaggggaag aacaaggcac ccagtaagct cacttggctc tacatatctg gaaaggcact
     7801 gaggttccaa ggtctctacc ccaccagggg acacccagta aacatcacgc tgagagttta
     7861 agttgcactc aactggagtt gatttgccct tagaaaagtt tccaacggtg aagaaatacc
     7921 acttggtagg aatatctctg ggcaacttca ttgctgactg ggcaaacttt gtaggataag
     7981 gtgtcatgtg atgtaaggct ggaccatgaa aaacaaaaat ctactaatac acatttggcc
     8041 cctgcagtcc cctggcattg agcaatagag caactgtcct ttctcaccac tagttgtgag
     8101 tgtacttcca actgagtgtt tagaaatcag gtaatctggt aatccacaga acaagctttg
     8161 tttgcaaatt gcaaattttt ctggtagaag tcattcttag gtgggcttca ttaaatcttt
     8221 ggagaggcaa tgctgggaaa aaatatgcct aattcctagg acacagtgag tggccgtaag
     8281 ttgttatctg catgtactaa atcaaaatta gatcatgaag gaccaaatct acttccgttg
     8341 ctataataaa ataccctaca ggttctgtaa ggcatttcta aactgtaaat gcttgaaacg
     8401 caagttggac attttctata ctatgtgtaa aatgccaggt tatacctcta ttttctttct
     8461 tcctaatggt cattgaaatg agcttgtttc tctacattga gcaagctaca ttttatttta
     8521 aatgagtcag gtgcatgttc agatgtctgt attcccaata cattgcatgc agcctgagca
     8581 caagtatgcc ttcaccctct ggctcttttc ctgacaccaa acagagaagt ccacagctac
     8641 aagcacaagg ggcttgacag gtaggccttg ttttattatg aacaaattca ccagaaaacc
     8701 attcttgagg aaccagccac tcccatagca tttttagtct tagggaagaa aattggcagg
     8761 gaagaaaaat tggcagacaa tgggaaagag gtttggtcaa cctgcataag tggaataaag
     8821 tcattgaagt acttgcaaaa agaagaggga ggtttccctc tgaaggaatc tagaccattt
     8881 tttaatatgg agaataactg taccccatgt tagaagtgct ctttagccat atttcaagat
     8941 ccagatctga acccatactg tgcagaaaag cacaagagcg cttacagcca agagccctgg
     9001 gaggagttga gtaacaggct gagatccggt caccaagcat cattagttag cactgaaatt
     9061 ctcccaggac acaaaacaaa tgtatggaaa catcgcaata cactatcatt tactcacatg
     9121 ggacaaccac ctaagtccat agcaaaactt tacagatcta gatgttatct caagtcagga
     9181 ttccagatca acatcctcca tgtggagatg agacaactga ggttcagaaa gttggagtga
     9241 cttatttgcc cagctagcta actggaatta gagtctgggt ctcccaacca ctgattctgc
     9301 tacaccacac tgtgctgctt ccattagtta gatggacatt gacaattaat tgtgaaagca
     9361 ttaattagaa gtcaagacaa aagaatgttt gtgatatctt ctctcgctta acatactttg
     9421 atttcaccat tgcatttcag cattttaaag aatagtgtat cagtatagaa ggaggagcaa
     9481 agctctttaa gagtaatgat gaaaccaaaa ggtcaaaaag tagaagaata gcgaatgtaa
     9541 gttattaaat aaatgagcaa gaagtatgtg tcagggaaaa taaatgcttc ttatattgtt
     9601 aataccgtga ttccctgccc gctcaccccg tcactcaaca cttgatgcat ttgttttgga
     9661 aagtgccatt ttatgctgag atactggtat tgaaaacttc cctctttccc aactctgtca
     9721 gaagttctct tgctctttgg aagaagccga gggccttaac aaatcagact gacctccctt
     9781 gtgacaggca gcctcgcctg cccttggaaa caagctgcca gaatgtgagg gccacagaga
     9841 cccaagagaa gccagcactg ctagactgag gaacttgtaa atatcttctg ctttcttggt
     9901 gaacaaggac agaggcaatt gcgtgtatat tgtgactgta gtttgtgaag aaaatgcaac
     9961 catttgcttc gacagctcct caaatgtact tgttaagtgt gaatgtgcct gcctcattgc
    10021 cttgtgttcc aaacacagta ctgaatgcgt tgtttttaaa taaaccattt cgttttgctt
    10081 tgggaaa
//
