LOCUS       NM_006011               5655 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 2 (ST8SIA2), transcript variant 1,
            mRNA.
ACCESSION   NM_006011
VERSION     NM_006011.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5655)
  AUTHORS   Hatanaka,R., Hane,M., Hayakawa,K., Morishita,S., Ohno,S.,
            Yamaguchi,Y., Wu,D., Kitajima,K. and Sato,C.
  TITLE     Identification of a buried beta-strand as a novel disease-related
            motif in the human polysialyltransferases
  JOURNAL   J Biol Chem 300 (1), 105564 (2024)
   PUBMED   38103644
  REMARK    GeneRIF: Identification of a buried beta-strand as a novel
            disease-related motif in the human polysialyltransferases.
REFERENCE   2  (bases 1 to 5655)
  AUTHORS   Moe,G.R., Steirer,L.M., Lee,J.A., Shivakumar,A. and Bolanos,A.D.
  TITLE     A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked
            to cell surface nucleolin depends on re-expression of the fetal
            polysialyltransferase ST8SIA2 gene
  JOURNAL   J Exp Clin Cancer Res 40 (1), 293 (2021)
   PUBMED   34544457
  REMARK    GeneRIF: A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA)
            linked to cell surface nucleolin depends on re-expression of the
            fetal polysialyltransferase ST8SIA2 gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5655)
  AUTHORS   Hao,J., Zeltz,C., Pintilie,M., Li,Q., Sakashita,S., Wang,T.,
            Cabanero,M., Martins-Filho,S.N., Wang,D.Y., Pasko,E., Venkat,K.,
            Joseph,J., Raghavan,V., Zhu,C.Q., Wang,Y.H., Moghal,N., Tsao,M.S.
            and Navab,R.
  TITLE     Characterization of Distinct Populations of Carcinoma-Associated
            Fibroblasts from Non-Small Cell Lung Carcinoma Reveals a Role for
            ST8SIA2 in Cancer Cell Invasion
  JOURNAL   Neoplasia 21 (5), 482-493 (2019)
   PUBMED   30978569
  REMARK    GeneRIF: High ST8SIA2 expression is associated with lung cancer
            Invasion.
REFERENCE   4  (bases 1 to 5655)
  AUTHORS   Yang,S.Y., Baek,J.H., Cho,Y., Cho,E.Y., Choi,Y., Kim,Y., Park,T.
            and Hong,K.S.
  TITLE     Effects of genetic variants of ST8SIA2 and NCAM1 genes on seasonal
            mood changes and circadian preference in the general population
  JOURNAL   Chronobiol Int 35 (3), 405-415 (2018)
   PUBMED   29215920
  REMARK    GeneRIF: 8 SNPs of ST8SIA2 and 2 SNPs of NCAM1 are associated with
            seasonality in mood changes and circadian preference
REFERENCE   5  (bases 1 to 5655)
  AUTHORS   Fullerton,J.M., Klauser,P., Lenroot,R.K., Shaw,A.D., Overs,B.,
            Heath,A., Cairns,M.J., Atkins,J., Scott,R., Schofield,P.R.,
            Weickert,C.S., Pantelis,C., Fornito,A., Whitford,T.J.,
            Weickert,T.W. and Zalesky,A.
  CONSRTM   Australian Schizophrenia Research Bank
  TITLE     Differential effect of disease-associated ST8SIA2 haplotype on
            cerebral white matter diffusion properties in schizophrenia and
            healthy controls
  JOURNAL   Transl Psychiatry 8 (1), 21 (2018)
   PUBMED   29353880
  REMARK    GeneRIF: The ST8SIA2 risk haplotype copy number did not show any
            differential effects on white matter in schizophrenia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5655)
  AUTHORS   Angata,K., Nakayama,J., Fredette,B., Chong,K., Ranscht,B. and
            Fukuda,M.
  TITLE     Human STX polysialyltransferase forms the embryonic form of the
            neural cell adhesion molecule. Tissue-specific expression, neurite
            outgrowth, and chromosomal localization in comparison with another
            polysialyltransferase, PST
  JOURNAL   J Biol Chem 272 (11), 7182-7190 (1997)
   PUBMED   9054414
REFERENCE   7  (bases 1 to 5655)
  AUTHORS   Kojima,N., Tachida,Y., Yoshida,Y. and Tsuji,S.
  TITLE     Characterization of mouse ST8Sia II (STX) as a neural cell adhesion
            molecule-specific polysialic acid synthase. Requirement of core
            alpha1,6-linked fucose and a polypeptide chain for polysialylation
  JOURNAL   J Biol Chem 271 (32), 19457-19463 (1996)
   PUBMED   8702635
REFERENCE   8  (bases 1 to 5655)
  AUTHORS   Munro,S.
  TITLE     An investigation of the role of transmembrane domains in Golgi
            protein retention
  JOURNAL   EMBO J 14 (19), 4695-4704 (1995)
   PUBMED   7588599
REFERENCE   9  (bases 1 to 5655)
  AUTHORS   Scheidegger,E.P., Sternberg,L.R., Roth,J. and Lowe,J.B.
  TITLE     A human STX cDNA confers polysialic acid expression in mammalian
            cells
  JOURNAL   J Biol Chem 270 (39), 22685-22688 (1995)
   PUBMED   7559389
REFERENCE   10 (bases 1 to 5655)
  AUTHORS   Kitagawa,H. and Paulson,J.C.
  TITLE     Differential expression of five sialyltransferase genes in human
            tissues
  JOURNAL   J Biol Chem 269 (27), 17872-17878 (1994)
   PUBMED   8027041
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC116162.5, AW163487.1,
            BC069584.1 and AC090985.6.
            
            On Nov 23, 2018 this sequence version replaced NM_006011.3.
            
            Summary: The protein encoded by this gene is a type II membrane
            protein that is thought to catalyze the transfer of sialic acid
            from CMP-sialic acid to N-linked oligosaccharides and
            glycoproteins. The encoded protein may be found in the Golgi
            apparatus and may be involved in the production of polysialic acid,
            a modulator of the adhesive properties of neural cell adhesion
            molecule (NCAM1). This protein is a member of glycosyltransferase
            family 29. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313924.1, BC096202.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268164.8/ ENSP00000268164.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC116162.5         1578-1606           c
            30-160              AW163487.1         1-131
            161-1311            BC069584.1         1-1151
            1312-5655           AC090985.6         36400-40743         c
FEATURES             Location/Qualifiers
     source          1..5655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..5655
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 2"
                     /db_xref="GeneID:8128"
                     /db_xref="HGNC:HGNC:10870"
                     /db_xref="MIM:602546"
     exon            1..282
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1312
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sialyltransferase 8 (alpha-2,
                     8-sialytransferase) B; sialyltransferase X;
                     sialyltransferase 8B; alpha-2,8-sialyltransferase 8B 1;
                     sialyltransferase St8Sia II; ST8 alpha-N-acetylneuraminate
                     alpha-2,8-sialyltransferase 2"
                     /codon_start=1
                     /product="alpha-2,8-sialyltransferase 8B isoform 1
                     precursor"
                     /protein_id="NP_006002.1"
                     /db_xref="CCDS:CCDS10372.1"
                     /db_xref="GeneID:8128"
                     /db_xref="HGNC:HGNC:10870"
                     /db_xref="MIM:602546"
                     /translation="MQLQFRSWMLAALTLLVVFLIFADISEIEEEIGNSGGRGTIRSA
                     VNSLHSKSNRAEVVINGSSSPAVVDRSNESIKHNIQPASSKWRHNQTLSLRIRKQILK
                     FLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIV
                     GNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLV
                     NATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLL
                     HAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDS
                     LKYGYTSQASPHTMPLEFKALKSLHEQGALKLTVGQCDGAT"
     exon            283..345
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /inference="alignment:Splign:2.1.0"
     exon            346..474
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /inference="alignment:Splign:2.1.0"
     exon            475..732
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1026
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..5655
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5627..5632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /note="hexamer: AATAAA"
     polyA_site      5655
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /note="major polyA site"
ORIGIN      
        1 gagcaacccc tgcctgtcgc tgccgctgcc gctgccgctg ccgccgccgg cccggactcg
       61 tccggagcgc agggtgtctg cccagctgcg cgcggcgcgc ggaggctccg gcgtccgccg
      121 ctgcgccctc cggcccctgc tcctcgcgcc ggcccgcgtg ggtcccggcg ggcgcgaacc
      181 caccatgcag ctgcagttcc ggagctggat gctggccgcg ctcacgctgc tcgtggtctt
      241 cctcatcttc gcagacatct cagagatcga agaagaaatc gggaattcgg gaggcagagg
      301 tacaatcaga tcagctgtga acagcttaca tagcaaatct aatagagctg aagttgtaat
      361 aaacggctcc tcatcaccag ctgttgttga cagaagtaat gaaagcatca agcacaacat
      421 ccagccagcc tcgtccaaat ggagacataa ccagacgctc tctctgagga tcaggaagca
      481 gattttaaag ttcttggatg ctgaaaagga catttctgtc ctaaagggaa ccctgaagcc
      541 tggagatatt attcattaca tcttcgatcg agacagcacc atgaatgtgt cccagaacct
      601 ctacgagctc ctccccagga cttcgccact gaagaataag cactttggga cttgtgccat
      661 cgtgggcaac tcgggggtct tgctgaacag cggctgtggg caggagattg acgcccacag
      721 cttcgtcatc aggtgcaacc tggccccagt acaggagtat gcccgggatg tggggctcaa
      781 gacagacctg gtaaccatga acccctcggt catccagcgg gcctttgagg acttggtcaa
      841 tgccacgtgg cgggagaagc tgctgcaacg gctgcacagc ctcaatggca gcatcctgtg
      901 gatccctgcc ttcatggccc ggggcggcaa ggagcgtgtt gagtgggtca acgagcttat
      961 cctgaagcac cacgtcaacg tgcgcactgc atacccctcg ctgcgcctgc tgcacgccgt
     1021 tcgcggatac tggctgacca acaaagtcca catcaaaaga cccaccaccg gcctcttgat
     1081 gtataccctg gccacacgtt tctgcaaaca aatctacctc tacggcttct ggccctttcc
     1141 gctggatcag aaccagaacc cagtcaagta ccactattat gacagcctca agtatggcta
     1201 cacctcccag gccagcccgc ataccatgcc cttggagttt aaggccctca agagcctaca
     1261 tgagcagggg gctttgaaac tgactgtcgg ccagtgcgat ggggccacgt agggtgggca
     1321 ccccatggga ctcagtggct cacatttcct gccagctaca ccacaggcag atgggagtcg
     1381 gggtggcaca aacaatagaa caagcaggct agtggttttc tttgttaaag tgtaaaacag
     1441 tgaccagaat atatatatct atacctgcat atatatattg acctgagtat ttataactgt
     1501 gtggtgttca tctagcatta ggcagatagg ccacaggaag aaggtgtgga gaacccacct
     1561 gaaccagatt gagactcaat ccatctttgg gggtggaagg acttgacatg aaaagaagcc
     1621 agtcccatga ctttggatga caaactgcct cctggcttgg agggatcttt gggctcatgg
     1681 atgaatggcg agccacctgt tgtcagctgc cccaagcctc tgggatatgt ggattcggag
     1741 aaagctgagg cccagagggg acactcgacc cagtctaaag tgggtgccat tcacggagga
     1801 gagggaggtt ggagacttca accgggcaaa ggagcacaag gaaaccaagc agcagaggcc
     1861 ccatcagcac agagggcctc gttccacgaa cgtagagttt gactgcctaa gggacagcac
     1921 gaatgactca catgtttcag acaggcctcc acggctatgg agagaaggct ggaggagaca
     1981 caatggatgg ttcatgttct ggcttagcaa gagccaccaa gaactttggg tgaagcaagc
     2041 agatgacaat gaagaggagt aatgttccga atcatgtttt tgaaaaatca agacctcctg
     2101 ttaagggccc acttgaccct agaataaggc aggagagtgt ctaaaatcta gctgctttgg
     2161 gtgtttttta aagcaatgtg agtccactga ggaggaagag accctgggat ttcaccctct
     2221 gggttagtct ctgtctcacc ctgttagaat gtcacgaggg actgtactgt cccctctgtc
     2281 accagggaag ccacaatgag agcttgaaag ggtgctgtca agataaatgt catccttctt
     2341 aaaatacata tgattgcctt tttgggtgcc tcacagagcc ccagagtgtg agacctgaaa
     2401 gaatgttcag catctagctc catgtccctg caaccactct ctgtttgcct tctgcattct
     2461 gcactctgcg gggcctttgc agccagactg ctgtgtcaat gttactttct tgtcactttc
     2521 ctaccctgat ggtcacacta gcccacccca agctccgaca ttgaggtttt catctctgca
     2581 gggagaggtt ccaatgtcca ccccaccccc aggtacccgc ctcttcccac agaagcaatt
     2641 ttagaatttt gcaaaattct tttcccctta ttgagattaa tatttaagat taaaaaaaaa
     2701 atacccaaag ccaaatgcag ttccaaatag tggacataat ctcccaggga aatctgggct
     2761 cgaggcctac aacttagggg ctggaatcac aggtctcaca tagagaaata gccagcttga
     2821 atttgttagt cgtattcctt cacctgatga ataacagtgt tttaaaacat atttgaaagg
     2881 taagtaaaaa actaccatct tgaaggtgaa gggagttaag aaaagtaatc aagacctgct
     2941 cctaagcata tgagaccaga tgtaattaat caatggcaat gcagaacagg accttggctc
     3001 taaattaatg gttgaccgga agggattgga ggcggcagaa ccattaaccc tacacaagaa
     3061 cactccagcc caaaaccgtg aggaaggtga tatatctctg cattttccct tgttgttgct
     3121 tgaagtctgt gattggggat ttgcgttata aaatgaatat tttaaaaagc aacagcccta
     3181 atagcctctg tgggaactga gtggtttcgg actcctcaca ggcggtggaa ataattaata
     3241 ccatatttta tacatctcca gagcctttca tcttgaggat ctcaaagacc gtagaagaca
     3301 tttaatttct aaagcttgaa gtgccccgag gagcaggtag aatttccagc agggccttgg
     3361 tggattaacc aaggccttgg attccagaat gtttcatggt aagcactgtg gagaacctac
     3421 atgtcaggtt ctggagttgg ccctgagctc tatccaccaa gccagcaccc caccatccct
     3481 ttgcagggga gtcaaagggc cagaactcct tgggggacca gaacatggtt ttccttctgc
     3541 ctatcttagt catggctcct aaaattgaag ctgatatgag ctggagtgca aggagtcctt
     3601 ccaccctgcc ttcaggttct ctctggagaa aggttagaga ccccaggaca atcaacatgt
     3661 gcaccgttcc cctcctcggc ttgagtcctg cactaccaaa atggcctggc catttgatgg
     3721 cggagctcca ggggccttgg ctttctctgg ctcattgtcc ttctccatct gggccaattg
     3781 tccttccctg cccattcaga gttcaatttg agcctccact gcagttcctg gtgtgggcca
     3841 gctggtgttg ggtggcccca gggagtcaca cagtctgtac ccggccccga gatcctctgc
     3901 tgtaactgca gggtcacagg catcccggga gaatgggcct ccaccctcag ccagccctca
     3961 ctgctgacag gcacccctct gtcacctcct gccacctgtc agatacccag cctgcccgcc
     4021 atcagccacc cgagtggttc cgacctccat tcacctcaag ccccaacagg cccctgtcat
     4081 tccacttcat ggaagagacg gagccttctg aaatgagatc taccctgaaa atctcttctc
     4141 cttccccttt ctgagaaacg tcatccccac cagttaacgt ttcctgtaca ccctcaccct
     4201 ctctcgtcca tctctgttgc ctctgcacat cagcacacac tgactccacc tgggctggct
     4261 cctgccgcct cttccctacc tcctccacta gccgcaggaa gggcctccag cacccacaac
     4321 tgcccttcct cttgatgccc ctcggcttcc ccccagcctg gcagcagcgt cccagcgcct
     4381 ccacattgcc cctctcacct cccagctctc cacgccactt ggctctgcag cgacccctcc
     4441 tagacgctcc ctggcccctc ggcacccaga atgccacatt cttgtgtttt tttcctcctt
     4501 ctttcccaat ccctctcaac catgtattta tttatatatg tatgtatttt tttatttatt
     4561 atttatttat tgaaacccct actttgattg acaaaggaat caaggtagat ctgaccagta
     4621 ttcccctctc ttctccttgt cccaccacat ggacatgcct tacactggcg tcctctcctg
     4681 agtccctccg cactctccat cagcaacctc acacctgcct tcagacccgg ctgcaacttc
     4741 ctaagctgcc cctgccccag ctcctctctg caacccagcc ctctcctgag ctctaggctg
     4801 ggattacacc cgctggaggg acactcaccc catctgctcc cacggcagca ccatcaactc
     4861 aacaagtcag aagccaagtg gatcatctgt gtccccttcc cccacaatcc ctcctttttc
     4921 tagtaaaaga cccgtgatcc cgtcagccac ccagtctgag atgctgacgt tatcttcgac
     4981 tattcttccc tgtcctgcct tgctaattct tcccactagc actaatctcg actctttgtc
     5041 acttggacta tttcagcaac agtctcatct cccagattac ctctgtgcac actgacacgt
     5101 ggtcccgtcc atcctgaaca tgcacagtga ttttcctctc ccgttgcaca caaaccttta
     5161 aaagttcccc ggcccgtgaa caaatgtaca attctctatt ctgacattac agaccaccgg
     5221 ataaggcccc attcttcctt tacaccctcc cctggtcagc ctaggagagt tgtttttcct
     5281 ggaaagggtg cctgcgtttt actgtctctg tgcctttggt cttgctatcc ccatcccctg
     5341 gaatgctccc ttttcttccc ttcaaagccc atgcggaaac cacgtccttc atgaagccct
     5401 ccctgatgta ccaaccactg ggatctctcc ctctgctgaa ccaccgtagc actttatttg
     5461 tacctttctc atggcactta ccatattctg ccttgtatta tagttatttg tgcacttgtc
     5521 ctttgactgt tcttagactg taagcttgcc aagggcaggg actgtgtttt attcatctgt
     5581 atccatcaca gcactaggcg tggtgcatag cacacagcag ttgctcaata aatgtttgtt
     5641 ggattaaatc cttaa
//
