LOCUS       NM_017744               4255 bp    mRNA    linear   PRI 04-MAR-2025
DEFINITION  Homo sapiens suppression of tumorigenicity 7 like (ST7L),
            transcript variant 1, mRNA.
ACCESSION   NM_017744 NM_139195 NM_139196
VERSION     NM_017744.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Zhan,T., Chen,X., Tian,X., Han,Z., Liu,M., Zou,Y., Huang,S.,
            Chen,A., Cheng,X., Deng,J., Tan,J. and Huang,X.
  TITLE     MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by
            Activating WNT/beta-Catenin Signal via ST7L
  JOURNAL   Technol Cancer Res Treat 19, 1533033820945801 (2020)
   PUBMED   32924881
  REMARK    GeneRIF: MiR-331-3p Links to Drug Resistance of Pancreatic Cancer
            Cells by Activating WNT/beta-Catenin Signal via ST7L.
REFERENCE   2  (bases 1 to 4255)
  AUTHORS   Wang,H., Sun,L., Jiang,J., Yu,S. and Zhou,Q.
  TITLE     Suppression of the proliferation and invasion of breast cancer
            cells by ST7L occurs through inhibition of activation of
            Wnt/GSK-3beta/beta-catenin signalling
  JOURNAL   Clin Exp Pharmacol Physiol 47 (1), 119-126 (2020)
   PUBMED   31429477
  REMARK    GeneRIF: Suppression of the proliferation and invasion of breast
            cancer cells by ST7L occurs through inhibition of activation of
            Wnt/GSK-3beta/beta-catenin signalling.
REFERENCE   3  (bases 1 to 4255)
  AUTHORS   Chen,X., Luo,H., Li,X., Tian,X., Peng,B., Liu,S., Zhan,T., Wan,Y.,
            Chen,W., Li,Y., Lu,Z. and Huang,X.
  TITLE     miR-331-3p functions as an oncogene by targeting ST7L in pancreatic
            cancer
  JOURNAL   Carcinogenesis 39 (8), 1006-1015 (2018)
   PUBMED   29850766
  REMARK    GeneRIF: Study found that miR-331-3p was significantly upregulated
            in tumor specimens of pancreatic cancer (PC) patients and cell
            lines. Downregulation of miR-331-3p inhibited PC cell proliferation
            and epithelial-mesenchymal transition-mediated metastasis in vitro.
            ST7L was identified as a novel target gene of miR-331-3p. Results
            demonstrate that miR-331-3p is a tumor-promoting microRNA and a
            promising biomarker for PC.
REFERENCE   4  (bases 1 to 4255)
  AUTHORS   Li,S., Yang,F., Wang,M., Cao,W. and Yang,Z.
  TITLE     miR-378 functions as an onco-miRNA by targeting the
            ST7L/Wnt/beta-catenin pathway in cervical cancer
  JOURNAL   Int J Mol Med 40 (4), 1047-1056 (2017)
   PUBMED   28902356
  REMARK    GeneRIF: miR-378 functions as an onco-miRNA by directly
            downregulating ST7L mRNA and protein level.
REFERENCE   5  (bases 1 to 4255)
  AUTHORS   Zhuang,L., Wang,X., Wang,Z., Ma,X., Han,B., Zou,H., Wu,Z., Dong,S.,
            Qu,Z., Zang,Y. and Wu,L.
  TITLE     MicroRNA-23b functions as an oncogene and activates
            AKT/GSK3beta/beta-catenin signaling by targeting ST7L in
            hepatocellular carcinoma
  JOURNAL   Cell Death Dis 8 (5), e2804 (2017)
   PUBMED   28518144
  REMARK    GeneRIF: This study revealed important roles of miR-23b and ST7L in
            progression of Hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4255)
  AUTHORS   Chen,L., Zhang,A., Li,Y., Zhang,K., Han,L., Du,W., Yan,W., Li,R.,
            Wang,Y., Wang,K., Pu,P., Jiang,T., Jiang,C. and Kang,C.
  TITLE     MiR-24 regulates the proliferation and invasion of glioma by ST7L
            via beta-catenin/Tcf-4 signaling
  JOURNAL   Cancer Lett 329 (2), 174-180 (2013)
   PUBMED   23142218
  REMARK    GeneRIF: miR-24 is a direct regulator of ST7L.
            Erratum:[Cancer Lett. 2013 Aug 28;337(1):145]
REFERENCE   7  (bases 1 to 4255)
  AUTHORS   Kato,N., Takeuchi,F., Tabara,Y., Kelly,T.N., Go,M.J., Sim,X.,
            Tay,W.T., Chen,C.H., Zhang,Y., Yamamoto,K., Katsuya,T., Yokota,M.,
            Kim,Y.J., Ong,R.T., Nabika,T., Gu,D., Chang,L.C., Kokubo,Y.,
            Huang,W., Ohnaka,K., Yamori,Y., Nakashima,E., Jaquish,C.E.,
            Lee,J.Y., Seielstad,M., Isono,M., Hixson,J.E., Chen,Y.T., Miki,T.,
            Zhou,X., Sugiyama,T., Jeon,J.P., Liu,J.J., Takayanagi,R., Kim,S.S.,
            Aung,T., Sung,Y.J., Zhang,X., Wong,T.Y., Han,B.G., Kobayashi,S.,
            Ogihara,T., Zhu,D., Iwai,N., Wu,J.Y., Teo,Y.Y., Tai,E.S., Cho,Y.S.
            and He,J.
  TITLE     Meta-analysis of genome-wide association studies identifies common
            variants associated with blood pressure variation in east Asians
  JOURNAL   Nat Genet 43 (6), 531-538 (2011)
   PUBMED   21572416
REFERENCE   8  (bases 1 to 4255)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 4255)
  AUTHORS   Kirikoshi,H. and Katoh,M.
  TITLE     Expression of ST7R (ST7-like, ST7L) in normal tissues and cancer
  JOURNAL   Int J Oncol 21 (1), 193-196 (2002)
   PUBMED   12063568
REFERENCE   10 (bases 1 to 4255)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of ST7R (ST7-like, ST7L) on
            human chromosome 1p13, a novel gene homologous to tumor suppressor
            gene ST7 on human chromosome 7q31
  JOURNAL   Int J Oncol 20 (6), 1247-1253 (2002)
   PUBMED   12012006
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB081317.1, AL109932.15 and
            BX538338.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017744.4.
            
            Summary: This gene was identified by its similarity to the ST7
            tumor suppressor gene found in the chromosome 7q31 region. This
            gene is clustered in a tail-to-tail manner with the WNT2B gene in a
            chromosomal region known to be deleted and rearranged in a variety
            of cancers. Several transcript variants encoding many different
            isoforms have been described, but some have not been fully
            characterized. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.206505.1,
                                           SRR1803617.16934.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358039.9/ ENSP00000350734.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1813              AB081317.1         49-1861
            1814-4206           AL109932.15        6381-8773           c
            4207-4251           BX538338.1         3415-3459
            4252-4255           AL109932.15        6332-6335           c
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..4255
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /note="suppression of tumorigenicity 7 like"
                     /db_xref="GeneID:54879"
                     /db_xref="HGNC:HGNC:18441"
                     /db_xref="MIM:617640"
     exon            1..233
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1756
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /note="isoform 1 is encoded by transcript variant 1; tumor
                     suppressor ST7 like; suppressor of tumorigenicity 7
                     protein-like; ST7-related protein"
                     /codon_start=1
                     /product="suppressor of tumorigenicity 7 protein-like
                     isoform 1"
                     /protein_id="NP_060214.2"
                     /db_xref="CCDS:CCDS848.1"
                     /db_xref="GeneID:54879"
                     /db_xref="HGNC:HGNC:18441"
                     /db_xref="MIM:617640"
                     /translation="MADRGGVGEAAAVGASPASVPGLNPTLGWRERLRAGLAGTGASL
                     WFVAGLGLLYALRIPLRLCENLAAVTVFLNSLTPKFYVALTGTSSLISGLIFIFEWWY
                     FHKHGTSFIEQVSVSHLQPLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLN
                     LFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCDTDFLRPSDTVMQKAWRERNP
                     PARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALKAGETIYRQSQQCQH
                     QSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHEN
                     LLESLLELQAYPDVQAVLAKYDDISLPKSAAICYTAALLKTRTVSEKFSPETASRRGL
                     STAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWK
                     RIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKE
                     LPLFIHFTAGFCSSTAMIAILTHQFPEIMGIFAKAVLGLWCPQPWASSGFEENTQDLK
                     SEDLGLSSG"
     exon            234..316
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            317..479
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            480..534
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            535..650
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            651..729
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            730..884
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            885..982
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1097
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1170
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1273
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1424
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1517
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1657
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..4255
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /note="hexamer: ATTACA"
     polyA_site      1891
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /note="major polyA site"
     regulatory      4220..4225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
                     /note="hexamer: AATAAA"
     polyA_site      4255
                     /gene="ST7L"
                     /gene_synonym="FAM4B; ST7R; STLR"
ORIGIN      
        1 agctcctggc gcctgcgata gcggcaagat ggcggaccgt ggcggcgtgg gtgaagccgc
       61 agctgttgga gcgtctcctg catctgtccc tggcctaaac ccgacgctag gctggaggga
      121 gcgactgcgg gccgggctgg cggggactgg ggcctcgttg tggttcgtgg cggggctggg
      181 gctgctttac gccctgagga tccctttgag gctgtgtgag aatttggcag cggtgactgt
      241 atttttaaat tcattgacac ccaaattcta tgtggcactt acagggacct cttcattgat
      301 atcaggacta atatttatat ttgaatggtg gtacttccat aagcatggca catcttttat
      361 tgagcaagta tctgtaagcc atttgcaacc actgatggga ggaacagaga gcagcatttc
      421 agaaccaggt tctccttcga ggaacagaga aaatgaaacc agcagacaga atttgtcaga
      481 atgtaaggta tggagaaacc ctctaaatct tttcagagga gcagaatata ggagatacac
      541 ttgggtgact ggtaaagagc cacttacata ctatgacatg aacctgtcag ctcaggacca
      601 tcagaccttt ttcacctgtg acacagattt tttacgtcct tcagacacag ttatgcagaa
      661 ggcttggagg gaaagaaatc ctccagctcg aatcaaagca gcctatcaag ctttagaatt
      721 aaacaatgac tgtgccactg catatgttct actggctgag gaagaagcaa caactattgt
      781 agatgctgaa aggttattta aacaggcact caaggcagga gaaacaattt ataggcagtc
      841 acagcagtgc cagcaccaaa gtcctcagca tgaagctcaa ctgaggagag ataccaatgt
      901 actggtatat attaaaagaa gattggcaat gtgtgcaaga aaattaggaa gaataagaga
      961 agcagtaaaa ataatgagag atttgatgaa agaatttcct cctcttacca tgttgaacat
     1021 ccatgaaaat ctcttagaat cacttttaga attacaggcc tatccagatg ttcaggcagt
     1081 cctagcaaaa tatgatgata taagccttcc aaagtcagca gcaatctgtt acacagcagc
     1141 actgttgaag acaaggactg tttcagaaaa attctctcca gaaacagcct ccagaagagg
     1201 attaagcaca gcagaaatta atgccgtgga agcaattcat agagctgtgg aatttaatcc
     1261 tcatgttcca aaatatttat tagagatgaa aagtttaatt ttacctccag aacacattct
     1321 gaaacggggt gatagtgaag caattgccta tgctttcttt catcttcagc actggaaacg
     1381 aatagaaggt gctcttaatc tgttacagtg tacatgggaa ggcactttta gaatgattcc
     1441 atacccgtta gagaaaggac atctatttta cccttatccc agctgcacag agacggctga
     1501 tagagagcta ttacctacct ttcatcatgt ttctgtttac ccaaaaaagg agcttccttt
     1561 gttcatccat ttcacagcag gattttgctc ttctacagca atgatagcca ttctcactca
     1621 ccagtttcct gaaatcatgg gtatttttgc taaagctgtg ctgggactct ggtgccccca
     1681 accctgggca tcctcaggct ttgaggagaa tacacaggat ttgaagtcag aagacctagg
     1741 tttgagttct ggctgagcca cgcactgttc atgtgacctt ggacaaatca ccaaattttt
     1801 ctgaacagca tctgtaaagt gacagtaacc cctacctcac agggttgttg tgaggattac
     1861 atatatgcta aagcattttg catatgaaaa agcttcttat gaatattgtt attcctaggc
     1921 aaacccccct tggaagctgt caaaaaggac aactgtagat gaaattgtct tccttttttc
     1981 ttcattcagc ttagcctttc tgtttggcca gggctactta caggggctgt tggggttgaa
     2041 gtcaagtcac cgcattttgg ctcctttggt caaagagaaa gaactctaat gtccagctgc
     2101 tccatcgata tactcataga atggaagtga gcaaaggaaa attttaagcc aggatagtta
     2161 accgttaggg ggccagtggg agaatgcttg ccttgcattt gcacatccag aatgactaaa
     2221 acatcttaag taaatgagga atagccaccg agatgctcag agataatata agccatgagt
     2281 gggaagtggg aaaatgagtt tgtcaacgcc ctctcttttc tatcccttta cctttgaggt
     2341 cagggacagg gcatattact gacaccccac tggctattgc cctatacctg ccaatcaccc
     2401 aaagaaaata atagcttctg agaaagctca attcactgta gcaactgtga tatatttacc
     2461 ctaataaagc caccacttgg tcttttccag tgcttctctc ttatggagat catccctgga
     2521 atccaaagct ctccagtttt ctaacccagt taagagttaa aaacaaccac aggtcatgag
     2581 cagtaggctt ggcagttata ccccatgcag tcataggaga ctgctccatc attctcagca
     2641 catagggtgc acatctcact atctctggca tgaaccagcc ttgcgaactt atacagtctc
     2701 agccactctg ctttgatggt aattcttcac cactgatctc tcctcaccat gcccttcctg
     2761 catccttccc ccaaccaccc accagaggag ttctggtccc caaaccaaag agttgcctgc
     2821 aggttggtaa tgtgactttg tagatattcc ttgattaaag ccagacccta ttggtatcct
     2881 ttttgaagta ctggatcgaa atctaattgc tttttttttt aattgttggg gagaggagga
     2941 tgagcagaac tcctatgcag cctgagagaa gttctctatg tgtctgtata tgtacacctc
     3001 tgtgtgtgtg tgtgtaacct catggttgtg ctcaggctga cagggagggc aaagagtgaa
     3061 aaggaagcat ctctttcttg ttatccaaca ttgcttcaaa gatgcccaac ccccgtagta
     3121 gcaggcagtt cccaagtgga gggtcggggc agaggcctcc accaaggcca tcaataacca
     3181 ggtgtgagct acaggtctct gtgtaatgtg aagctctccc gtatttcatt tctgcaccca
     3241 gggggcggct ctgcaggatt gcttacggag aactctgtgt ctggcacctc tctccacaag
     3301 gcccaggcgc ccagggtccc accgacctgc ccaggaatgc atcacattgt tctctggtgc
     3361 tgtaatttgg ctgcaggagc taggctgaat gcctcccagg gatgagaaac atactctccc
     3421 tggcgtcctc ccttcgcccc agctagcttg agcttctgcc ctatgaccac tgagtgcatt
     3481 taaataaaaa cctcagaaag actgaggaaa aaaaaatcct aattatctct cttctgttaa
     3541 gccatgtaga gactcgtgtc ctgagtgggt ctgagaattt ggcaaagact tactggttgg
     3601 tgttcttgat aagggaagtg agacaaagga gaagaaatta ctccctgcaa caggaggaat
     3661 agaaatgaag cagtgagtgt tcagaaatta gatctacaag aagttttgca aacagaccct
     3721 cagggccagg caatgtttgt ttttgttttt tgttttttgt tttttttttt aatctgaagc
     3781 ccctgatttt atttttccag catcactcta aggaagagtg tggattagtg ccattattca
     3841 gggctggtat taataaaagt tagcttttat ctgcagggct aggttaaggc tggcattctt
     3901 acttttacat taaaaaaact ggctacaggc tgcgcagctg aggtacttca gtcatgtgcc
     3961 ttctctaaag gattcttaga tccttaaaat atatagtatg ttttaagttt gtatctaaat
     4021 agcacttact gtaatgtatt atacctaaat gtttattaaa agttagaaga aatgagtacc
     4081 aacaggaagg aatggaagag aggagagggg ctaagacatt gctgatctga gggacagacc
     4141 tctatcaaat agaagagggc tgggagaagg ggtgattaga agcagagtga gggaactaaa
     4201 tggagccctg actgcaccaa ataaagttct cattttgctg cttgttccaa ataaa
//
