LOCUS       NM_001369598            2093 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens suppression of tumorigenicity 7 (ST7), transcript
            variant 3, mRNA.
ACCESSION   NM_001369598
VERSION     NM_001369598.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Liu,H., Lu,W., He,H., Wu,J., Zhang,C., Gong,H. and Yang,C.
  TITLE     Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4
            E3 ligase activity and promotes ubiquitination of ST7 in
            colitis-associated cancer
  JOURNAL   J Pathol 248 (4), 464-475 (2019)
   PUBMED   30945288
  REMARK    GeneRIF: Inflammation-dependent overexpression of c-Myc enhances
            CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7
            in colitis-associated cancer.
REFERENCE   2  (bases 1 to 2093)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2093)
  AUTHORS   Yan,F., Alinari,L., Lustberg,M.E., Martin,L.K.,
            Cordero-Nieves,H.M., Banasavadi-Siddegowda,Y., Virk,S.,
            Barnholtz-Sloan,J., Bell,E.H., Wojton,J., Jacob,N.K.,
            Chakravarti,A., Nowicki,M.O., Wu,X., Lapalombella,R., Datta,J.,
            Yu,B., Gordon,K., Haseley,A., Patton,J.T., Smith,P.L., Ryu,J.,
            Zhang,X., Mo,X., Marcucci,G., Nuovo,G., Kwon,C.H., Byrd,J.C.,
            Chiocca,E.A., Li,C., Sif,S., Jacob,S., Lawler,S., Kaur,B. and
            Baiocchi,R.A.
  TITLE     Genetic validation of the protein arginine methyltransferase PRMT5
            as a candidate therapeutic target in glioblastoma
  JOURNAL   Cancer Res 74 (6), 1752-1765 (2014)
   PUBMED   24453002
  REMARK    GeneRIF: The tumor suppressor ST7 is a key gene silenced by PRMT5.
REFERENCE   4  (bases 1 to 2093)
  AUTHORS   Hu,L., Wu,C., Zhao,X., Heist,R., Su,L., Zhao,Y., Han,B., Cao,S.,
            Chu,M., Dai,J., Dong,J., Shu,Y., Xu,L., Chen,Y., Wang,Y., Lu,F.,
            Jiang,Y., Yu,D., Chen,H., Tan,W., Ma,H., Chen,J., Jin,G., Wu,T.,
            Lu,D., Christiani,D.C., Lin,D., Hu,Z. and Shen,H.
  TITLE     Genome-wide association study of prognosis in advanced non-small
            cell lung cancer patients receiving platinum-based chemotherapy
  JOURNAL   Clin Cancer Res 18 (19), 5507-5514 (2012)
   PUBMED   22872573
REFERENCE   5  (bases 1 to 2093)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 2093)
  AUTHORS   Zenklusen,J.C., Rodriguez,L.V., LaCava,M., Wang,Z., Goldstein,L.S.
            and Conti,C.J.
  TITLE     Novel susceptibility locus for mouse hepatomas: evidence for a
            conserved tumor suppressor gene
  JOURNAL   Genome Res 6 (11), 1070-1076 (1996)
   PUBMED   8938430
REFERENCE   7  (bases 1 to 2093)
  AUTHORS   Zenklusen,J.C., Weitzel,J.N., Ball,H.G. and Conti,C.J.
  TITLE     Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests
            the existence of a tumor suppressor gene
  JOURNAL   Oncogene 11 (2), 359-363 (1995)
   PUBMED   7624150
REFERENCE   8  (bases 1 to 2093)
  AUTHORS   Zenklusen,J.C., Thompson,J.C., Troncoso,P., Kagan,J. and Conti,C.J.
  TITLE     Loss of heterozygosity in human primary prostate carcinomas: a
            possible tumor suppressor gene at 7q31.1
  JOURNAL   Cancer Res 54 (24), 6370-6373 (1994)
   PUBMED   7987830
REFERENCE   9  (bases 1 to 2093)
  AUTHORS   Zenklusen,J.C., Bieche,I., Lidereau,R. and Conti,C.J.
  TITLE     (C-A)n microsatellite repeat D7S522 is the most commonly deleted
            region in human primary breast cancer
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 12155-12158 (1994)
   PUBMED   7991599
REFERENCE   10 (bases 1 to 2093)
  AUTHORS   Ogata,T., Ayusawa,D., Namba,M., Takahashi,E., Oshimura,M. and
            Oishi,M.
  TITLE     Chromosome 7 suppresses indefinite division of nontumorigenic
            immortalized human fibroblast cell lines KMST-6 and SUSM-1
  JOURNAL   Mol Cell Biol 13 (10), 6036-6043 (1993)
   PUBMED   8105370
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106873.3, AC002542.1 and
            AC003987.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The gene for this product maps to a region on chromosome 7
            identified as an autism-susceptibility locus. Mutation screening of
            the entire coding region in autistic individuals failed to identify
            phenotype-specific variants, suggesting that coding mutations for
            this gene are unlikely to be involved in the etiology of autism.
            The function of this gene product has not been determined.
            Transcript variants encoding different isoforms of this protein
            have been described. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138528.649671.1,
                                           SRR1803615.140084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323984.8/ ENSP00000325673.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC106873.3         14947-15137
            192-274             AC002542.1         63612-63694
            275-434             AC002542.1         83411-83570
            435-489             AC002542.1         93643-93697
            490-605             AC002542.1         94341-94456
            606-681             AC002542.1         95735-95810
            682-750             AC002542.1         97974-98042
            751-905             AC002542.1         99931-100085
            906-1003            AC002542.1         102285-102382
            1004-1118           AC002542.1         134712-134826
            1119-1191           AC002542.1         153171-153243
            1192-1294           AC002542.1         154684-154786
            1295-1445           AC002542.1         173637-173787
            1446-1538           AC002542.1         182934-183026
            1539-1678           AC002542.1         185773-185912
            1679-2093           AC003987.1         5071-5485
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.2"
     gene            1..2093
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /note="suppression of tumorigenicity 7"
                     /db_xref="GeneID:7982"
                     /db_xref="HGNC:HGNC:11351"
                     /db_xref="MIM:600833"
     exon            1..191
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1774
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /note="isoform 3 is encoded by transcript variant 3;
                     family with sequence similarity 4, subfamily A, member 1;
                     suppression of tumorigenicity 7 (breast); suppressor of
                     tumorigenicity 7 protein"
                     /codon_start=1
                     /product="suppressor of tumorigenicity 7 protein isoform
                     3"
                     /protein_id="NP_001356527.1"
                     /db_xref="CCDS:CCDS94182.1"
                     /db_xref="GeneID:7982"
                     /db_xref="HGNC:HGNC:11351"
                     /db_xref="MIM:600833"
                     /translation="MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKI
                     NDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLR
                     PLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPL
                     TYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSR
                     VEVPLIASSTIWEIKLLPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQ
                     LQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNI
                     HENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASR
                     RGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLA
                     HWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYP
                     KKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESIL
                     PSSLWHQLTRI"
     exon            192..274
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            275..434
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            435..489
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            490..605
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            606..681
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            682..750
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            751..905
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1003
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1118
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1191
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1294
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1445
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1538
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1678
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..2093
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1914..1919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /note="hexamer: ATTAAA"
     polyA_site      1940
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
     regulatory      1995..2000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /note="hexamer: AATAAA"
     polyA_site      2020
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /note="major polyA site"
     regulatory      2070..2075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
                     /note="hexamer: AATAAA"
     polyA_site      2093
                     /gene="ST7"
                     /gene_synonym="ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4;
                     TSG7"
ORIGIN      
        1 agacaccaag agccgcggca gcagagagga gcgctgaaac atggctgaag cggccacggg
       61 ctttctggag cagctcaagt cctgcatagt ttggtcttgg acgtatctgt ggaccgtgtg
      121 gttcttcatc gtgctattcc tggtctacat cctgcgggtg cctttgaaaa tcaacgacaa
      181 cttgagcaca gtgagcatgt ttttgaacac attaacaccg aagttctacg tggccctaac
      241 aggcacttcc tcactaatat cagggcttat tttgatattt gaatggtggt attttcgcaa
      301 atacggaact tcattcattg aacaagtctc agtaagccac ttgcgccccc ttctgggagg
      361 ggttgacaac aactcttcca acaattctaa ttccagtaac ggggactcag attccaatag
      421 gcaaagtgtc tcagaatgca aagtatggcg aaatccacta aatttattta ggggtgctga
      481 atacaatcgg tatacttggg tgacaggacg agagcctctt acttactatg acatgaatct
      541 ctctgcccaa gaccaccaga cattctttac ttgtgactcg gaccatctgc gtcccgcaga
      601 tgcaataatg cagaaagcct ggagagagag aaacccccaa gctaggattt ctgcagctca
      661 tgaagccttg gagataaatg aaattaggtc cagagttgaa gttcccctaa ttgcttcctc
      721 taccatctgg gagataaaat tgttaccaaa gtgtgcaact gcttatattc tcttggctga
      781 agaggaagca acaaccattg ctgaagcaga aaaattattt aagcaggccc tgaaggctgg
      841 agatggctgt taccgacgct ctcagcagct acaacatcat ggatcccagt atgaagccca
      901 acatagacga gacaccaatg tcttggtgta catcaaaaga aggctagcaa tgtgtgccag
      961 aagactcggg aggaccaggg aagcagtgaa aatgatgaga gatttaatga aggagttccc
     1021 ccttctgagt atgttcaata tccatgaaaa ccttttagaa gcccttctgg aactacaagc
     1081 atatgctgat gttcaggcag tcttagcaaa gtatgatgat ataagcttac caaagtcagc
     1141 aacaatatgc tacacagctg ctttgctcaa agcaagagct gtctctgaca aattctctcc
     1201 tgaggctgca tctcggcggg ggctgagcac agcagagatg aatgcagtag aggccattca
     1261 tagagctgtg gaattcaatc ctcatgtgcc aaaataccta ctagaaatga aaagcttaat
     1321 cctaccccca gaacatatcc tgaagagagg agacagtgaa gcaatagcat atgcattctt
     1381 tcatcttgca cactggaaga gagtggaagg ggctttgaat cttttgcatt gtacgtggga
     1441 aggcactttt cggatgatcc cttatccctt ggaaaagggg cacctatttt atccttaccc
     1501 aatctgtaca gaaacagcag accgagagct gcttccatct ttccatgaag tctcagttta
     1561 cccaaagaag gagcttccct tctttattct ctttactgct ggattatgtt ccttcacagc
     1621 catgctggcc ctcctgacac atcagttccc ggaacttatg ggggtcttcg caaaagcttt
     1681 cctcagcact ttgtttgccc ccttaaactt tgtcatggag aaagtggaga gcatcctccc
     1741 atccagtctg tggcaccagc taacacggat ctgagagaag ccctgtcctc cactcacctc
     1801 acccgccgct gccaccatct cctctgtgcc aactccttgt ggaccgcaag aaagcatgac
     1861 tttgaaaaag ggaagccatt ccgagatttt aaaatgttca tggactattc catattaaaa
     1921 gctgtttttg ttgtacaaaa ttcactgatg ttcagttcta ttttattttg ccttcagaaa
     1981 agaagaaagt caaaaataaa acttttgtgt attacagcaa tcatttgtat cctcctgtgt
     2041 cttccaaccc taaaattgtt gatgtcccaa ataaaccttt ggatttacct tga
//
