LOCUS       NM_013443               2410 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ST6 N-acetylgalactosaminide
            alpha-2,6-sialyltransferase 6 (ST6GALNAC6), transcript variant 1,
            mRNA.
ACCESSION   NM_013443 XM_005251953
VERSION     NM_013443.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2410)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2410)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2410)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 2410)
  AUTHORS   Senda,M., Ito,A., Tsuchida,A., Hagiwara,T., Kaneda,T., Nakamura,Y.,
            Kasama,K., Kiso,M., Yoshikawa,K., Katagiri,Y., Ono,Y., Ogiso,M.,
            Urano,T., Furukawa,K., Oshima,S. and Furukawa,K.
  TITLE     Identification and expression of a sialyltransferase responsible
            for the synthesis of disialylgalactosylgloboside in normal and
            malignant kidney cells: downregulation of ST6GalNAc VI in renal
            cancers
  JOURNAL   Biochem J 402 (3), 459-470 (2007)
   PUBMED   17123352
  REMARK    GeneRIF: ST6GalNAc-VI and disialylgalactosylgloboside were found in
            proximal tubule epithelial cells in normal kidney tissues
REFERENCE   5  (bases 1 to 2410)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   6  (bases 1 to 2410)
  AUTHORS   Tsuchida,A., Okajima,T., Furukawa,K., Ando,T., Ishida,H.,
            Yoshida,A., Nakamura,Y., Kannagi,R., Kiso,M. and Furukawa,K.
  TITLE     Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer
            cell lines by a sialyltransferase, ST6GalNAc VI, responsible for
            the synthesis of alpha-series gangliosides
  JOURNAL   J Biol Chem 278 (25), 22787-22794 (2003)
   PUBMED   12668675
  REMARK    GeneRIF: novel substrate specificity of ST6GalNAc VI, which is
            responsible for the synthesis of disialyl Lea but not for
            alpha-series gangliosides in human colon tissues
REFERENCE   7  (bases 1 to 2410)
  AUTHORS   Okajima,T., Chen,H.H., Ito,H., Kiso,M., Tai,T., Furukawa,K.,
            Urano,T. and Furukawa,K.
  TITLE     Molecular cloning and expression of mouse
            GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene
  JOURNAL   J Biol Chem 275 (10), 6717-6723 (2000)
   PUBMED   10702226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157935.28.
            
            On Aug 13, 2020 this sequence version replaced NM_013443.4.
            
            Summary: ST6GALNAC6 belongs to a family of sialyltransferases that
            modify proteins and ceramides on the cell surface to alter
            cell-cell or cell-extracellular matrix interactions (Tsuchida et
            al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006564.2, SRR11853566.28514.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373146.6/ ENSP00000362239.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL157935.28        72836-72936         c
            102-156             AL157935.28        71289-71343         c
            157-247             AL157935.28        69575-69665         c
            248-427             AL157935.28        67845-68024         c
            428-834             AL157935.28        63970-64376         c
            835-942             AL157935.28        60817-60924         c
            943-2410            AL157935.28        58654-60121         c
FEATURES             Location/Qualifiers
     source          1..2410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2410
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /note="ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 6"
                     /db_xref="GeneID:30815"
                     /db_xref="HGNC:HGNC:23364"
                     /db_xref="MIM:610135"
     exon            1..101
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /inference="alignment:Splign:2.1.0"
     exon            102..156
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1132
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /EC_number="2.4.99.-"
                     /note="isoform a is encoded by transcript variant 1;
                     CMP-NeuAC:(beta)-N-acetylgalactosaminide
                     (alpha)2,6-sialyltransferase member VI; sialytransferase 7
                     ((alpha-N-acetylneuraminyl
                     2,3-betagalactosyl-1,3)-N-acetyl galactosaminide
                     alpha-2,6-sialytransferase) F;
                     alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
                     6; ST6 -N-acetylgalactosaminide alpha-26-sialyltransferase
                     6; sialyltransferase 7F; galNAc
                     alpha-2,6-sialyltransferase VI; ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6;
                     ST6 GalNAc alpha-2,6-sialyltransferase 6; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 6 isoform a"
                     /protein_id="NP_038471.2"
                     /db_xref="CCDS:CCDS6882.1"
                     /db_xref="GeneID:30815"
                     /db_xref="HGNC:HGNC:23364"
                     /db_xref="MIM:610135"
                     /translation="MACSRPPSQCEPTSLPPGPPAGRRHLPLSRRRREMSSNKEQRSA
                     VFVILFALITILILYSSNSANEVFHYGSLRGRSRRPVNLKKWSITDGYVPILGNKTLP
                     SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSS
                     VFRVLRRPQEFVNRTPETVFIFWGPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPG
                     RMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPNYCSQRPRL
                     QRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSWT"
     exon            157..247
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /inference="alignment:Splign:2.1.0"
     exon            248..427
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /inference="alignment:Splign:2.1.0"
     exon            428..834
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /inference="alignment:Splign:2.1.0"
     exon            835..942
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /inference="alignment:Splign:2.1.0"
     exon            943..2410
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /note="hexamer: AATAAA"
     polyA_site      2410
                     /gene="ST6GALNAC6"
                     /gene_synonym="SIAT7-F; SIAT7F; ST6GALNACVI"
                     /note="major polyA site"
ORIGIN      
        1 gaggcctggg cggcctgagg agcgcggacc ccggcgctcg gctcccggcg ccatgtgagg
       61 gggctcgggg gccgcggggg gccgggcgct ccccgccgga gatgaggaaa ctgaggctca
      121 gagaggtcac atggcttgct cgaggccccc cagccagtgt gaacccacat ccctgccccc
      181 agggccacct gcaggacgcc gacacctacc cctcagcaga cgccggagag aaatgagtag
      241 caacaaagag cagcggtcag cagtgttcgt gatcctcttt gccctcatca ccatcctcat
      301 cctctacagc tccaacagtg ccaatgaggt cttccattac ggctccctgc ggggccgtag
      361 ccgccgacct gtcaacctca agaagtggag catcactgac ggctatgtcc ccattctcgg
      421 caacaagaca ctgccctctc ggtgccacca gtgtgtgatt gtcagcagct ccagccacct
      481 gctgggcacc aagctgggcc ctgagatcga gcgggctgag tgtacaatcc gcatgaatga
      541 tgcacccacc actggctact cagctgatgt gggcaacaag accacctacc gcgtcgtggc
      601 ccattccagt gtgttccgcg tgctgaggag gccccaggag tttgtcaacc ggacccctga
      661 aaccgtgttc atcttctggg ggcccccgag caagatgcag aagccccagg gcagcctcgt
      721 gcgtgtgatc cagcgagcgg gcctggtgtt ccccaacatg gaagcatatg ccgtctctcc
      781 cggccgcatg cggcaatttg acgacctctt ccggggtgag acgggcaagg acagggagaa
      841 gtctcattcg tggttgagca caggctggtt taccatggtg atcgcggtgg agttgtgtga
      901 ccacgtgcat gtctatggca tggtcccccc caactactgc agccagcggc cccgcctcca
      961 gcgcatgccc taccactact acgagcccaa ggggccggac gaatgtgtca cctacatcca
     1021 gaatgagcac agtcgcaagg gcaaccacca ccgcttcatc accgagaaaa gggtcttctc
     1081 atcgtgggcc cagctgtatg gcatcacctt ctcccacccc tcctggacct aggccaccca
     1141 gcctgtggga cctcaggagg gtcagaggag aagcagcctc cgcccagccg ctaggccagg
     1201 gaccatcttc tggccaatca aggcttgctg gagtgtctcc cagccaatca gggccttgag
     1261 gaggatgtat cctccagcca atcagggcct ggggaatctg ttggcgaatc agggatttgg
     1321 gagtctatgc ggttaatcag gggtgtcttt cttgtgcagt cagggtctgc gcacagtcaa
     1381 tcagggtaga gggggtattt ctgagtcaat ctgaggctaa ggacatgtcc tttcccatga
     1441 ggccttggtt cagagcccca ggaatggacc ccccaatcac tccccactct cctgggataa
     1501 tggggtcctg tcccaaggag ctgggaactt ggtgttgccc cctcaatttc cagcaccaga
     1561 aagagagatt gtgtgggggt agaagctgtc tggaggcccg gccagagaat ttgtggggtt
     1621 gtggaggttg tgggggcggt ggggaggtcc cagaggtggg aggccggcat ccaggtcttg
     1681 gctctgccct gagaccttgg acaaaccctt ccccctctct gggcaccctt ctgcccacac
     1741 cagtttccag tgcggagtct gagacccttt ccacctcccc tacaagtgcc ctcgggtctg
     1801 tcctccccgt ctggaccctc ccagccacta tcccttgctg gaaggctcag ctctttgggg
     1861 ggtctggggt gacctcccca cctcctggaa aactttaggg tatttttgcg caaactcctt
     1921 cagggttggg ggactctgaa ggaaacggga caaaacctta agctgttttc ttagcccctc
     1981 agccagctgc cattagcttg gctcttaaag ggccaggcct ccttttctgc cctctagcag
     2041 ggaggttttc caactgttgg aggcgccttt ggggctgccc ctttgtctgg agtcactggg
     2101 ggcttccgag ggtctccctc gaccctctgt cgtcctggga tggctgtcgg gagctgtatc
     2161 acctgggttc tgtcccctgg ctctgtatca ggcactttat taaagctggg cctcagtggg
     2221 gtgtgtttgt ctcctgctct tctggagcct ggaaggaaag ggcttcagga ggaggctgtg
     2281 aggctggagg gaccagatgg aggaggccag cagctagcca ttgcacactg gggtgatggg
     2341 tgggggcggt gactgcccca gacttggttt tgtaatgatt tgtacaggaa taaacacacc
     2401 tacgctccgg
//
