LOCUS       NM_030965               5547 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ST6 N-acetylgalactosaminide
            alpha-2,6-sialyltransferase 5 (ST6GALNAC5), transcript variant 1,
            mRNA.
ACCESSION   NM_030965
VERSION     NM_030965.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5547)
  AUTHORS   InanlooRahatloo,K., Parsa,A.F., Huse,K., Rasooli,P., Davaran,S.,
            Platzer,M., Kramer,M., Fan,J.B., Turk,C., Amini,S., Steemers,F.,
            Gunderson,K., Ronaghi,M. and Elahi,E.
  TITLE     Mutation in ST6GALNAC5 identified in family with coronary artery
            disease
  JOURNAL   Sci Rep 4, 3595 (2014)
   PUBMED   24399302
  REMARK    GeneRIF: Sequence data from combined Iranian and US controls and
            CAD affected individuals provided evidence consistent with
            potential role of ST6GALNAC5 in coronary artery disease
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5547)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   3  (bases 1 to 5547)
  AUTHORS   Tsuchida,A., Okajima,T., Furukawa,K., Ando,T., Ishida,H.,
            Yoshida,A., Nakamura,Y., Kannagi,R., Kiso,M. and Furukawa,K.
  TITLE     Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer
            cell lines by a sialyltransferase, ST6GalNAc VI, responsible for
            the synthesis of alpha-series gangliosides
  JOURNAL   J Biol Chem 278 (25), 22787-22794 (2003)
   PUBMED   12668675
REFERENCE   4  (bases 1 to 5547)
  AUTHORS   Ikehara,Y., Shimizu,N., Kono,M., Nishihara,S., Nakanishi,H.,
            Kitamura,T., Narimatsu,H., Tsuji,S. and Tatematsu,M.
  TITLE     A novel glycosyltransferase with a polyglutamine repeat; a new
            candidate for GD1alpha synthase (ST6GalNAc V)(1)
  JOURNAL   FEBS Lett 463 (1-2), 92-96 (1999)
   PUBMED   10601645
REFERENCE   5  (bases 1 to 5547)
  AUTHORS   Okajima,T., Fukumoto,S., Ito,H., Kiso,M., Hirabayashi,Y., Urano,T.
            and Furukawa,K.
  TITLE     Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V)
            containing CAG/Glutamine repeats
  JOURNAL   J Biol Chem 274 (43), 30557-30562 (1999)
   PUBMED   10521438
  REMARK    Erratum:[J Biol Chem 2000 Jan 14;275(2):1520]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK056241.1, AL035409.15 and
            BU742124.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030965.2.
            
            Summary: The protein encoded by this gene is a Golgi type II
            transmembrane glycosyltransferase. The encoded protein catalyzes
            the transfer of sialic acid to cell surface proteins to modulate
            cell-cell interactions. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.11176.1,
                                           SRR1803612.99246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000477717.6/ ENSP00000417583.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2051              AK056241.1         40-2090
            2052-5100           AL035409.15        26137-29185         c
            5101-5539           BU742124.1         18-456              c
            5540-5547           AL035409.15        25690-25697         c
FEATURES             Location/Qualifiers
     source          1..5547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..5547
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 5"
                     /db_xref="GeneID:81849"
                     /db_xref="HGNC:HGNC:19342"
                     /db_xref="MIM:610134"
     exon            1..211
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1207
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /EC_number="2.4.99.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sialyltransferase 7
                     ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)
                     E; GD1 alpha synthase; GalNAc alpha-2,6-sialyltransferase
                     V; alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase V; ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5;
                     ST6 GalNAc alpha-2,6-sialyltransferase 5;
                     alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
                     5; alpha-N-acetylneuraminyl
                     2,3-betagalactosyl-1,3)-N-acetyl galactosaminide
                     alpha-2,6-sialyltransferase E; ST6
                     neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5;
                     ST6GalNAc V; sialyltransferase 7E"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 5 isoform 1"
                     /protein_id="NP_112227.1"
                     /db_xref="CCDS:CCDS673.1"
                     /db_xref="GeneID:81849"
                     /db_xref="HGNC:HGNC:19342"
                     /db_xref="MIM:610134"
                     /translation="MKTLMRHGLAVCLALTTMCTSLLLVYSSLGGQKERPPQQQQQQQ
                     QQQQQASATGSSQPAAESSTQQRPGVPAGPRPLDGYLGVADHKPLKMHCRDCALVTSS
                     GHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLL
                     NVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQ
                     ETGKDRKISNTWLSTGWFTMTIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFG
                     PDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDWKPESLAINHPENKP
                     VF"
     exon            212..457
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /inference="alignment:Splign:2.1.0"
     exon            458..867
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /inference="alignment:Splign:2.1.0"
     exon            868..975
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /inference="alignment:Splign:2.1.0"
     exon            976..5547
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2033..2038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="hexamer: ATTAAA"
     regulatory      2038..2043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="hexamer: AACAAA"
     polyA_site      2053
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="major polyA site"
     polyA_site      2062
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="major polyA site"
     regulatory      3694..3699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="hexamer: TATAAA"
     regulatory      3706..3711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="hexamer: TATAAA"
     polyA_site      3712
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="major polyA site"
     polyA_site      3725
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
     regulatory      4657..4662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="hexamer: AATAAA"
     polyA_site      4677
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
     regulatory      5515..5520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
                     /note="hexamer: AATAAA"
     polyA_site      5547
                     /gene="ST6GALNAC5"
                     /gene_synonym="SIAT7-E; SIAT7E; ST6GalNAcV"
ORIGIN      
        1 agttttaatt ctgtctctaa tctctgcaac agccgcgctt cccgggtccc gcggctcccg
       61 cgcgcgatct gccgcggccg gctgctgggc aaaaatcaga gccgcctccg ccccattacc
      121 catcatggaa accctccagg aaaaagtggc cccggacgcg cgagcctgag gattctgcac
      181 aaaagaggtg cccaaaatga agaccctgat gcgccatggt ctggcagtgt gtttagcgct
      241 caccaccatg tgcaccagct tgttgctagt gtacagcagc ctcggcggcc agaaggagcg
      301 gcccccgcag cagcagcagc agcagcagca acagcagcag caggcgtcgg ccaccggcag
      361 ctcgcagccg gcggcggaga gcagcaccca gcagcgcccc ggggtccccg cgggaccgcg
      421 gccactggac ggatacctcg gagtggcgga ccacaagccc ctgaaaatgc actgcaggga
      481 ctgtgccctg gtgaccagct cagggcatct gctgcacagt cggcaaggct cccagattga
      541 ccagacagag tgtgtcatcc gcatgaatga cgcccccaca cgcggctatg ggcgtgacgt
      601 gggcaatcgc accagcctga gggtcatcgc gcattccagc atccagagga tcctccgcaa
      661 ccgccatgac ctgctcaacg tgagccaggg caccgtgttc atcttctggg gccccagcag
      721 ctacatgcgg cgggacggca agggccaggt ctacaacaac ctgcatctcc tgagccaggt
      781 gctgccccgg ctgaaggcct tcatgattac tcgccacaag atgctgcagt ttgatgagct
      841 cttcaagcag gagactggca aagacaggaa gatatccaac acttggctca gcactggctg
      901 gtttacaatg acaattgcac tggagctctg tgacaggatc aatgtttatg gcatggtgcc
      961 cccagacttc tgcagggatc ccaatcaccc ttcagtacct tatcattatt atgaaccttt
     1021 tggacctgat gaatgtacaa tgtacctctc ccatgagcga ggacgcaagg gcagtcatca
     1081 ccgctttatc acagagaaac gagtctttaa gaactgggca cggacattca atattcactt
     1141 ttttcaacca gactggaaac cagaatcact tgctataaat catcctgaga ataaacctgt
     1201 gttctaagga atgagcatgc cagactgtaa tcccaggtat tcactgcatc agacaccgag
     1261 acactgaact tcctgagcca ccagacagga aagggtagca gaaaacagct tcactcctca
     1321 ggaagtacca tggacagacg cctaccaggg gtgacaaagc agtgcagttg gattgtaagg
     1381 aaaaattccg gaattaatgc atcctaatga atgttgtccc cttcaatggt gttaccttag
     1441 gagctgaaca ttcaattcag ttacaccact atgactaaaa acagtttgga tctcttagta
     1501 ttgcctttga aactgcaaca taagcaactc aacaatatta gttgcattcc tttatagaca
     1561 taccatgtca aagacgtttt tctatcaagt tgtattcttt cctgttctat aacctttgtc
     1621 atctgttaga ctctgtatgt gtgatttgta aaaagcaggc tgaaactatg gacatgattt
     1681 ctgaagagca catctccact gactttcata aagcaaatgt ccaatattta tttattgaga
     1741 gttttttagt gcaatctggg ccagtatttt tatagattat gattatgtgg taatttatcc
     1801 ttcctaactc tttaatcctg aatgatggtt ggaaatggcc tagaattagg ttactctgtt
     1861 cacaatgctc attgttagca tgcaattggt atttgacttg gaagtgttgt gttgtatttt
     1921 ttgaacccct aggcttcagg aaaactgctc ttttgtaaaa agaatagcga tgacattttc
     1981 taatgtgcag aaatgttcca aaaggacaaa attgaaaacc aaaaactatg ttattaaaac
     2041 aaaaaaatgc taacaagaga aatttaaagg tagttttctt tagtaataat ttatgtaagt
     2101 gtcctctctt gagccctagt ttcctttttg gcagaatgat gtcactgtac cagacaacct
     2161 cttaggtttc atcccaaatc taaacttgtg gcctcttctt gacccatttg aagactctgc
     2221 acttggagtg atggggcccc aacagtagca ggaactttat tttggggagc cttatctaca
     2281 ttcatattac ttatatcact cttgtggtta aaactacact tcttcctgtg tccacatggg
     2341 ctaaaatcta ccccctgctt ctctcgaagc atcaccatcc gcctcttccc cagcctctca
     2401 acacaaaaac acaggataca cacacacaca cacacacaaa agacatagct ccaaggggtt
     2461 ccctggctac aatagcaaac agctgccctt ctgtgaggaa aagagactac aaggacatgc
     2521 cctatcattc aactcattta tgctatgaac tgtttagact cactacaaat cttcttagat
     2581 tatattcatt accattccct ggtctgaagg agtataaagg acttatttta ttcagagcca
     2641 agataaattc atattataga tttttattta aacaagtaat attgttcaaa aatagtctct
     2701 tataaatata ctagtgtttt ctttacacat gacttagaag gcattagttt ctctaatgcc
     2761 aaatttgaag gcaccagcaa atattatgta tgaagactga cattgtttta cagacatgac
     2821 ctggcttatg ataaaagaag ttttatcgca ttaccacttc ttttcccttt tcttaattag
     2881 tacactaact agtactatta attacacgga gtattgttgt taaaatgcaa acacaatcag
     2941 ggtactcaca taacataaac aaagttgata ttgatgtgta tggcttgggc tgttcaaagc
     3001 cagtaagatt gaaatggccg tccaaaacat actggaatat gttctttaag ttttctcata
     3061 gtttttaaag ggactatgaa ttttattcca acacattgtc ttccacagca tggactctga
     3121 acacatcata ctttatcaac atatgaaaaa gtgtattaat tttatacaat ttacttatag
     3181 gccaccttta taatcacttg aagacgttat gttgctcaaa cataagtggc tcctttggca
     3241 atttctatat ttgtggaaat ttggaaaggc atagtttcaa catgcaagaa tgtaattata
     3301 ttgcttcatc taataatatc tcacatatct gtctatcttc agattttaga ttttctttat
     3361 taaaaaaacc atcatggtag ctccatctcg tttgtaactt ctccctctca aatactcaga
     3421 agaatgaaga ggccaaattc agaaaatcat ggcttcactg ggaaatgttt taaatctaca
     3481 tgtagctagg atatgtgatt tcatattttt taaaaatgtg gtgtaaataa gtgtaaaaaa
     3541 ttaccacttg caaagtggtt ttattacagc gttaaagaaa atgactagaa ttctgataga
     3601 ttgtgctgat gaacctggtt gtgggcaatt gaattcttgt cttcccacta ccatttcatg
     3661 actgtcgtct gaacactatt caacaccatt aaatataaac tctgatataa aagatgacta
     3721 cagaaccatg tttatagacc tcggtgattt cagtatctga ttgtgtttga tgcctaagtc
     3781 atactcgtta tgttacatgc ctttttcctc tctcccagct gtgtcatcag ctccctccta
     3841 gcttttaaga ccacagtaat acaatgccac agctggtcga tccatggctt ctgttatttc
     3901 aacacaagaa catttggcag aggccattac aatagatagc cattatgggc aaagatacgg
     3961 gaatttgcaa acaaaatcaa tcacttcaaa tggcccataa aaggaggaat ctcagattta
     4021 atattctacg gtaaatattc acccaagaaa gcatacatta aaagaacatt aggaggtaaa
     4081 tattcagcat gctgcatgga gacttagctg tgtgatttcc attaccgtta atgggcattt
     4141 ggcaactaag tccctgtgct ttgctaaccc tggtgtgtac tcctaagggc tacacataaa
     4201 acctgagcaa ttcagagact tctgaggtca tcagatttca gagtaagatc ttttctttaa
     4261 aaaaaaaaat agatgaaagc aaaacacaac gtattgtacc taaaagagaa atttgtgtgg
     4321 tctctcacaa tccttaggtt actaccagat ttgtgtatcc tttgttttct gaagttctct
     4381 ccattactga tctatttgaa tgacatgaga atggagggaa ataatctcat tttgaaataa
     4441 aaactcccct caaaaattaa aattaccgac ttagaagatg ataaatgcta agtaaaagta
     4501 gaaggagaaa gttgaaattc tattaggatt aagacagtgt tatttaaagg cacatgcacc
     4561 catttagtac ctgcctaaat atttgccctt gtgtaagagc aaactcattt cagaaatata
     4621 tcctgaattc caccagggtg atggttcaaa ttgttaaata aacctactct gaaagaaggg
     4681 tccatgttcc tattctctct ctgcagtgtt gggaggtgat gttaacactc tacatgtttt
     4741 gtatctgacc caatcatttc ttccattctc attgcttctc tcttaaacct cattgtatct
     4801 ctttactgtc attttctccc aattgtcttc ttttgtctac agtgtgctcc taaaccagca
     4861 gtctttggtg ctgttaaggt cttccttgta ggtttttaaa ctaaagatct atctgggaaa
     4921 cagatttggg gtaggtcctg ccagagtaat gaccatggta ggtgggagga atatatctgg
     4981 ctaccataca aggtacttca gaagtaccat tatggtttgc ccagggccaa gtggggagtg
     5041 aagaagaggg gtccccaaga cacagacttc agtgctaaaa ccagggaagt cctgggctcc
     5101 atgacagtgg ctcaccctat cagaaggcca cgtcaaagag aactataata ataagccctg
     5161 gggggcagga tgtgtgaacc aattgcctag gtgttagcac atgccagaag gtactttgga
     5221 atggaaagag gtgagagtgt ctcaaggttt aaaaatgagc aagtgtagcc cctcttttgt
     5281 agctcactca tcccaccttc tcagggtgtt gaaatgcaaa tgcaaaaagg ctgaaaccct
     5341 gtttctttct actcagtgcc ctaatattat atactacctt gaattgtgct tcgtcttttt
     5401 atgcatgtgt cctgttagtc taattagatt gtaagctcct tgagggcaga gactctttct
     5461 cctttgtctc tgcagcctat acctagtata gtgccttgca cacaataggt gctcaataaa
     5521 tgtctgttgt tgatcatgac ctcttaa
//
