LOCUS       NM_175039               1706 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens ST6 N-acetylgalactosaminide
            alpha-2,6-sialyltransferase 4 (ST6GALNAC4), transcript variant 1,
            mRNA.
ACCESSION   NM_175039
VERSION     NM_175039.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Choi,H., Song,K.H., Kim,H.D., Park,J.Y., Lee,Y.C., Choi,H.J. and
            Kim,C.H.
  TITLE     Human ST3Gal II and ST6GalNAc IV genes increase human
            serum-mediated cytotoxicity to xenogeneic cells
  JOURNAL   Xenotransplantation 31 (2), exen12855 (2024)
   PUBMED   38602029
  REMARK    GeneRIF: Human ST3Gal II and ST6GalNAc IV genes increase human
            serum-mediated cytotoxicity to xenogeneic cells.
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Man,D., Jiang,Y., Zhang,D., Wu,J., Ding,B., Liu,H., Xu,G., Lu,J.,
            Ru,J., Tong,R., Zheng,S., Chen,D. and Wu,J.
  TITLE     ST6GALNAC4 promotes hepatocellular carcinogenesis by inducing
            abnormal glycosylation
  JOURNAL   J Transl Med 21 (1), 420 (2023)
   PUBMED   37381011
  REMARK    GeneRIF: ST6GALNAC4 promotes hepatocellular carcinogenesis by
            inducing abnormal glycosylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Miao,X., Jia,L., Zhou,H., Song,X., Zhou,M., Xu,J., Zhao,L., Feng,X.
            and Zhao,Y.
  TITLE     miR-4299 mediates the invasive properties and tumorigenicity of
            human follicular thyroid carcinoma by targeting ST6GALNAC4
  JOURNAL   IUBMB Life 68 (2), 136-144 (2016)
   PUBMED   26715099
  REMARK    GeneRIF: This study implies the potential therapeutic application
            of miR-4299 and ST6GALNAC4 in modulating the invasion and
            tumorigenicity of follicular thyroid carcinoma cell
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Yoshino,H., Ariga,T., Suzuki,A., Yu,R.K. and Miyatake,T.
  TITLE     Identification of gangliosides recognized by IgG anti-GalNAc-GD1a
            antibodies in bovine spinal motor neurons and motor nerves
  JOURNAL   Brain Res 1227, 216-220 (2008)
   PUBMED   18598683
  REMARK    GeneRIF: Data show that serum from a patient with axonal
            Guillain-Barre syndrome (GBS) with IgG anti-GalNAc-GD1a antibody
            yielded positive immunostaining with X1, X2, and X3.
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 1706)
  AUTHORS   Moody,A.M., North,S.J., Reinhold,B., Van Dyken,S.J., Rogers,M.E.,
            Panico,M., Dell,A., Morris,H.R., Marth,J.D. and Reinherz,E.L.
  TITLE     Sialic acid capping of CD8beta core 1-O-glycans controls
            thymocyte-major histocompatibility complex class I interaction
  JOURNAL   J Biol Chem 278 (9), 7240-7246 (2003)
   PUBMED   12459555
REFERENCE   7  (bases 1 to 1706)
  AUTHORS   Harduin-Lepers,A., Stokes,D.C., Steelant,W.F., Samyn-Petit,B.,
            Krzewinski-Recchi,M.A., Vallejo-Ruiz,V., Zanetta,J.P., Auge,C. and
            Delannoy,P.
  TITLE     Cloning, expression and gene organization of a human Neu5Ac alpha
            2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV
  JOURNAL   Biochem J 352 Pt 1 (Pt 1), 37-48 (2000)
   PUBMED   11062056
REFERENCE   8  (bases 1 to 1706)
  AUTHORS   Gilley,J. and Fried,M.
  TITLE     Extensive gene order differences within regions of conserved
            synteny between the Fugu and human genomes: implications for
            chromosomal evolution and the cloning of disease genes
  JOURNAL   Hum Mol Genet 8 (7), 1313-1320 (1999)
   PUBMED   10369878
REFERENCE   9  (bases 1 to 1706)
  AUTHORS   Lee,Y.C., Kaufmann,M., Kitazume-Kawaguchi,S., Kono,M.,
            Takashima,S., Kurosawa,N., Liu,H., Pircher,H. and Tsuji,S.
  TITLE     Molecular cloning and functional expression of two members of mouse
            NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase
            family, ST6GalNAc III and IV
  JOURNAL   J Biol Chem 274 (17), 11958-11967 (1999)
   PUBMED   10207017
REFERENCE   10 (bases 1 to 1706)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157935.28.
            
            On Nov 23, 2018 this sequence version replaced NM_175039.3.
            
            Summary: The protein encoded by this gene is a type II membrane
            protein that catalyzes the transfer of sialic acid from CMP-sialic
            acid to galactose-containing substrates. The encoded protein
            prefers glycoproteins rather than glycolipids as substrates and
            shows restricted substrate specificity, utilizing only the
            trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In
            addition, it is involved in the synthesis of ganglioside GD1A from
            GM1B. The encoded protein is normally found in the Golgi apparatus
            but can be proteolytically processed to a soluble form. This
            protein is a member of glycosyltransferase family 29. Transcript
            variants encoding different isoforms have been found for this gene.
            Readthrough transcripts exist for this gene and the downstream
            ST6GALNAC6 gene. [provided by RefSeq, Jan 2022].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.530635.1,
                                           SRR1163655.182709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155770, SAMN03267755
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335791.10/ ENSP00000336733.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AL157935.28        90159-90374         c
            217-303             AL157935.28        89741-89827         c
            304-489             AL157935.28        87989-88174         c
            490-902             AL157935.28        85601-86013         c
            903-1010            AL157935.28        83284-83391         c
            1011-1706           AL157935.28        81219-81914         c
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..1706
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /note="ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 4"
                     /db_xref="GeneID:27090"
                     /db_xref="HGNC:HGNC:17846"
                     /db_xref="MIM:606378"
     exon            1..216
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /inference="alignment:Splign:2.1.0"
     exon            217..303
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1200
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /EC_number="2.4.3.7"
                     /note="isoform a is encoded by transcript variant 1;
                     sialyltransferase 7D
                     ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase);
                     NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,
                     6-sialyltransferase alpha2,6-sialyltransferase;
                     sialyltransferase 3C; ST6
                     neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminidealpha-2,6-sialyltransferase 4;
                     NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,
                     6-sialyltransferase IV;
                     alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase;
                     ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4;
                     ST6 GalNAc alpha-2,6-sialyltransferase 4"
                     /codon_start=1
                     /product="alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
                     isoform a"
                     /protein_id="NP_778204.1"
                     /db_xref="CCDS:CCDS6883.1"
                     /db_xref="GeneID:27090"
                     /db_xref="HGNC:HGNC:17846"
                     /db_xref="MIM:606378"
                     /translation="MKAPGRLVLIILCSVVFSAVYILLCCWAGLPLCLATCLDHHFPT
                     GSRPTVPGPLHFSGYSSVPDGKPLVREPCRSCAVVSSSGQMLGSGLGAEIDSAECVFR
                     MNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRV
                     LGGRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTM
                     ILALELCEEIVVYGMVSDSYCREKSHPSVPYHYFEKGRLDECQMYLAHEQAPRSAHRF
                     ITEKAVFSRWAKKRPIVFAHPSWRTE"
     exon            304..489
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /inference="alignment:Splign:2.1.0"
     exon            490..902
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1010
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1706
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1706
                     /gene="ST6GALNAC4"
                     /gene_synonym="IV; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D;
                     ST6GalNAc; ST6GALNACIV"
                     /note="major polyA site"
ORIGIN      
        1 cccctgcctc tggccgcgcg gatcagcttc cagcccagtc ggcccggccc gggggccatg
       61 gagctccgag cggcggatcg cgagcctcct gcgaacccca gcctgcacgc ccggttagca
      121 ttcggccggg agatgcggca gtggaatctg gaagggcggt gaaaaaccta cgtcctgccc
      181 tcgcccggcc tctccattcg tcccccgggt agagaggtgc ccggctccca ccccttccca
      241 gccccagccc tggagacagc agcccctaga ctactgaggg acagcgacag catgaaggct
      301 ccgggtcggc tcgtgctcat catcctgtgc tccgtggtct tctctgccgt ctacatcctc
      361 ctgtgctgct gggccggcct gcccctctgc ctggccacct gcctggacca ccacttcccc
      421 acaggctcca ggcccactgt gccgggaccc ctgcacttca gtggatatag cagtgtgcca
      481 gatgggaagc cgctggtccg cgagccctgc cgcagctgtg ccgtggtgtc cagctccggc
      541 caaatgctgg gctcaggcct gggtgctgag atcgacagtg ccgagtgcgt gttccgcatg
      601 aaccaggcgc ccaccgtggg ctttgaggcg gatgtgggcc agcgcagcac cctgcgtgtc
      661 gtctcacaca caagcgtgcc gctgctgctg cgcaactatt cacactactt ccagaaggcc
      721 cgagacacgc tctacatggt gtggggccag ggcaggcaca tggaccgggt gctcggcggc
      781 cgcacctacc gcacgctgct gcagctcacc aggatgtacc ccggcctgca ggtgtacacc
      841 ttcacggagc gcatgatggc ctactgcgac cagatcttcc aggacgagac gggcaagaac
      901 cggaggcagt cgggctcctt cctcagcacc ggctggttca ccatgatcct cgcgctggag
      961 ctgtgtgagg agatcgtggt ctatgggatg gtcagcgaca gctactgcag ggagaagagc
     1021 cacccctcag tgccttacca ctactttgag aagggccggc tagatgagtg tcagatgtac
     1081 ctggcacacg agcaggcgcc ccgaagcgcc caccgcttca tcactgagaa ggcggtcttc
     1141 tcccgctggg ccaagaagag gcccatcgtg ttcgcccatc cgtcctggag gactgagtag
     1201 cttccgtcgt cctgccagtc gccatgccgt tgcgaggcct ccgggatgtc ccatcccaag
     1261 ccatcacact ccacaaaaac atttaattta tggatcctgc ctcctgccac gtgctgggtg
     1321 gacctaaggt tccttcccgc cccattctgg cgacacttgg agccatctca ggcctcatga
     1381 cttgaagggg agtggagggg ggagccgtgt ctcccccctc cactccctga gtaattcacg
     1441 gcatttgggg gctcacccca cctccaggtc tgtcaagtgg cctttgtccc tggggctgat
     1501 ggcccccaac tcaccagcat catgaccttg tgccagtcct ggtcctccct ccccagccgc
     1561 tcctaccacc ttttggtgcc acacttctca ggctggccgc cctggttggg gcagccgaga
     1621 gcctggggtt cattggtgaa ggggccttgg agttgtgact gccggggccg tatcaggaac
     1681 gtacgggtaa acgtgtgttt tctgga
//
