LOCUS       NM_152996               6836 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ST6 N-acetylgalactosaminide
            alpha-2,6-sialyltransferase 3 (ST6GALNAC3), transcript variant 1,
            mRNA.
ACCESSION   NM_152996
VERSION     NM_152996.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6836)
  AUTHORS   Jung,S.Y., Lee,H.K., Kim,H., Kim,S., Kim,J.S., Kang,J.G., Kuh,H.J.,
            Yoo,J.S., Ko,J.H. and Lee,J.H.
  TITLE     Depletion of ST6GALNACIII retards A549 non-small cell lung cancer
            cell proliferation by downregulating transferrin receptor protein 1
            expression
  JOURNAL   Biochem Biophys Res Commun 575, 78-84 (2021)
   PUBMED   34461439
  REMARK    GeneRIF: Depletion of ST6GALNACIII retards A549 non-small cell lung
            cancer cell proliferation by downregulating transferrin receptor
            protein 1 expression.
REFERENCE   2  (bases 1 to 6836)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6836)
  AUTHORS   Haldrup,C., Pedersen,A.L., Ogaard,N., Strand,S.H., Hoyer,S.,
            Borre,M., Orntoft,T.F. and Sorensen,K.D.
  TITLE     Biomarker potential of ST6GALNAC3 and ZNF660 promoter
            hypermethylation in prostate cancer tissue and liquid biopsies
  JOURNAL   Mol Oncol 12 (4), 545-560 (2018)
   PUBMED   29465788
  REMARK    GeneRIF: Biomarker potential of ST6GALNAC3 and ZNF660 promoter
            hypermethylation in prostate cancer tissue and liquid biopsies.
REFERENCE   4  (bases 1 to 6836)
  AUTHORS   Moy,K.A., Mondul,A.M., Zhang,H., Weinstein,S.J., Wheeler,W.,
            Chung,C.C., Mannisto,S., Yu,K., Chanock,S.J. and Albanes,D.
  TITLE     Genome-wide association study of circulating vitamin D-binding
            protein
  JOURNAL   Am J Clin Nutr 99 (6), 1424-1431 (2014)
   PUBMED   24740207
  REMARK    GeneRIF: genome-wide association study in population in Finland:
            Data suggest that one SNP in ST6GALNAC3 (rs12144344) and two SNPs
            in VDBP (vitamin D binding protein; rs7041, rs705117) are
            associated with serum levels of VDBP in the male population
            studied.
REFERENCE   5  (bases 1 to 6836)
  AUTHORS   Park,T.J., Hwang,J.Y., Go,M.J., Lee,H.J., Jang,H.B., Choi,Y.,
            Kang,J.H., Park,K.H., Choi,M.G., Song,J., Kim,B.J. and Lee,J.Y.
  TITLE     Genome-wide association study of liver enzymes in korean children
  JOURNAL   Genomics Inform 11 (3), 149-154 (2013)
   PUBMED   24124411
REFERENCE   6  (bases 1 to 6836)
  AUTHORS   Hodgkinson,C.A., Enoch,M.A., Srivastava,V., Cummins-Oman,J.S.,
            Ferrier,C., Iarikova,P., Sankararaman,S., Yamini,G., Yuan,Q.,
            Zhou,Z., Albaugh,B., White,K.V., Shen,P.H. and Goldman,D.
  TITLE     Genome-wide association identifies candidate genes that influence
            the human electroencephalogram
  JOURNAL   Proc Natl Acad Sci U S A 107 (19), 8695-8700 (2010)
   PUBMED   20421487
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 6836)
  AUTHORS   Senda,M., Ito,A., Tsuchida,A., Hagiwara,T., Kaneda,T., Nakamura,Y.,
            Kasama,K., Kiso,M., Yoshikawa,K., Katagiri,Y., Ono,Y., Ogiso,M.,
            Urano,T., Furukawa,K., Oshima,S. and Furukawa,K.
  TITLE     Identification and expression of a sialyltransferase responsible
            for the synthesis of disialylgalactosylgloboside in normal and
            malignant kidney cells: downregulation of ST6GalNAc VI in renal
            cancers
  JOURNAL   Biochem J 402 (3), 459-470 (2007)
   PUBMED   17123352
REFERENCE   8  (bases 1 to 6836)
  AUTHORS   Tsuchida,A., Ogiso,M., Nakamura,Y., Kiso,M., Furukawa,K. and
            Furukawa,K.
  TITLE     Molecular cloning and expression of human ST6GalNAc III: restricted
            tissue distribution and substrate specificity
  JOURNAL   J Biochem 138 (3), 237-243 (2005)
   PUBMED   16169874
  REMARK    GeneRIF: Results describe the molecular cloning and expression of
            human ST6GalNAc III, including its tissue distribution and
            substrate specificity.
REFERENCE   9  (bases 1 to 6836)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059363.1, AC104458.2 and DA800675.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152996.3.
            
            Summary: ST6GALNAC3 belongs to a family of sialyltransferases that
            transfer sialic acids from CMP-sialic acid to terminal positions of
            carbohydrate groups in glycoproteins and glycolipids (Lee et al.,
            1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.246011.1,
                                           SRR1803611.83097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328299.4/ ENSP00000329214.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-787               BC059363.1         14-800
            788-788             AC104458.2         22878-22878
            789-1373            BC059363.1         802-1386
            1374-2123           AC104458.2         24524-25273
            2124-3184           BC059363.1         2137-3197
            3185-3217           DA800675.1         516-548
            3218-6836           AC104458.2         26368-29986
FEATURES             Location/Qualifiers
     source          1..6836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..6836
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /note="ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 3"
                     /db_xref="GeneID:256435"
                     /db_xref="HGNC:HGNC:19343"
                     /db_xref="MIM:610133"
     exon            1..139
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1039
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /EC_number="2.4.3.7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
                     III; sialyltransferase 7
                     ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)
                     C; ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3;
                     ST6 GalNAc alpha-2,6-sialyltransferase 3; GalNAc
                     alpha-2,6-sialyltransferase III; sialyltransferase 7C;
                     alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
                     3"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 3 isoform 1"
                     /protein_id="NP_694541.2"
                     /db_xref="CCDS:CCDS672.1"
                     /db_xref="GeneID:256435"
                     /db_xref="HGNC:HGNC:19343"
                     /db_xref="MIM:610133"
                     /translation="MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPG
                     TKWIPFSYTYRRPLRTHYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSS
                     CIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRN
                     MRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTG
                     WFTFLLAMDACYGIHVYGMINDTYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGG
                     HRFITEKKVFAKWAKKHRIIFTHPNWTLS"
     exon            140..334
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /inference="alignment:Splign:2.1.0"
     exon            335..744
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /inference="alignment:Splign:2.1.0"
     exon            745..852
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /inference="alignment:Splign:2.1.0"
     exon            853..6836
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3162..3167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /note="hexamer: AAGAAA"
     polyA_site      3181
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /note="major polyA site"
     regulatory      3927..3932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /note="hexamer: AATAAA"
     polyA_site      3947
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
     regulatory      6812..6817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
                     /note="hexamer: AATAAA"
     polyA_site      6836
                     /gene="ST6GALNAC3"
                     /gene_synonym="PRO7177; SIAT7C; ST6GALNACIII; STY"
ORIGIN      
        1 ggatctgcgg gaatgtgggc tggagaggtc ctgccgtggt accagcctcc agcctgcccc
       61 caggactgcc cctgacccag gcgcgcccgc tgctcggtgg caggagggcc ggcggagcgc
      121 catggcctgc atcctgaaga gaaagtctgt gattgctgtg agcttcatag cagcgttcct
      181 tttcctgctg gttgtgcgtc ttgtaaatga agtgaatttc ccattgctac taaactgctt
      241 tggacaacct ggtacaaagt ggataccatt ctcctacaca tacaggcggc cccttcgaac
      301 tcactatgga tacataaatg tgaagacaca agagcctttg caactggact gtgacctttg
      361 tgccatagtg tcaaactcag gtcagatggt tggccagaag gtgggaaatg agatagatcg
      421 atcctcctgc atttggagaa tgaacaatgc ccccaccaaa ggttatgaag aagatgtcgg
      481 ccgcatgacc atgattcgag ttgtgtccca taccagcgtt cctcttttgc taaaaaaccc
      541 tgattatttt ttcaaggaag cgaatactac tatttatgtt atttggggac ctttccgcaa
      601 tatgaggaaa gatggcaatg gcatcgttta caacatgttg aaaaagacag ttggtatcta
      661 tccgaatgcc caaatatacg tgaccacaga gaagcgcatg agttactgtg atggagtttt
      721 taagaaggaa actgggaagg acagagtcca gtctggctca tatctcagca cagggtggtt
      781 taccttcctt ctggccatgg acgcctgtta tggcattcac gtctacggga tgataaatga
      841 cacctactgc aagacagaag ggtatagaaa agtcccctac cattattatg aacaaggaag
      901 agatgagtgt gatgaatatt ttcttcatga acatgcccca tatgggggtc ataggtttat
      961 cactgaaaag aaagtgtttg ctaaatgggc caagaagcac aggataatat ttacacatcc
     1021 aaactggaca ttgtcttgat aatggttttc ctgatcttgc cgcatcactt aatgtgatcc
     1081 ccatactgca actgtgatgc tgatgatgct aatggagatg atggtaatga taaagacaac
     1141 aacaatgatt atcaagttcc tgtacactct cagatgtgga tggtgactct gctagtaatt
     1201 taaacttggc atttcatgga ggatggttgt gctcatgatg ttctttctgg aggttcaaca
     1261 ctacgtaccg cactttataa tttaactgga attgagatga aggccagtga catgacaact
     1321 gtgacctaag aaatgggaag attatctttc aagatagctg cctagaattg ttcaacagtg
     1381 agtaacttcc agaagccaaa agagtttggc ttcatgaggc aaggtgattg actcaatggc
     1441 ttgttgaatc tcagcagttc cgccatcttg aagaatgatt gattgtcaaa cactgaccca
     1501 agaactgcta tcagggtgca agtatcttac tacttagcct aaggatggga aaatatctct
     1561 tcctaatata ccatctttct acagtatttc ctacagctaa agcctcaggc cattgcctaa
     1621 ttaacaatga agatttcatg gacatcctac acttcaggat tacttgacta tctcaaacac
     1681 ataaatcaaa atgggccaag tagcaaatct tgatgaattt ccactcttac catccattct
     1741 tactaccaac agtataactg aacatgtgat tagaatgatc tatattaatg tttagttatt
     1801 tttggttgag tgctaaatat ttcagaaggc tacttaacat gtaagatacc aacttcaaca
     1861 ctgtaataac atatactgtg aaaacattcc taaaaagtaa ccaaagggtt tgctaactct
     1921 gcttcaacat ccaacaacac aaaactatat gatttttaaa atcatgaaat agagacagca
     1981 aagcatattt ttacatcaat ttgtatccta tcatacttca taatatatat ttgtatattc
     2041 aaatttctat tttataggcc caaggtgtgt ttctccaaac attacattct cattgccaag
     2101 tgccagctgt tacacatgga gaggaaatga ttccttatat taaacctgac cagagctttt
     2161 tgccttctag ggatttattt ttcccatagt gtatcagttg ttatgccaca ataacaacaa
     2221 taataatgtt cttaatgtcc aaagtgcttt gtcatttaga gtcctttaac atctgttata
     2281 ccatgtgatg cccttgaaca ccccattggg ctattgtctg tgtattctgc tctctttagc
     2341 agatgatctg taatttggtc attgttctgt tatattccag attgctctac ttgctaatat
     2401 ttgtatagaa tagaatttat gtaaactagt aaccagttga tctctgtgcc aaatacatta
     2461 tatcaggatt acacaaaaag tatcacaaag gatggtcttg gccatatgct agggcccctg
     2521 tgaaaataag tagttttgag aagtttttct atatacgtat atatacacgt gtggttctat
     2581 ttaggtgggg aaaaaatgaa aaagcaggga caacaggagg aaatgaaggc agagaaatat
     2641 agtttccttt cctaggattg agacaattct atttttcata tactcgttgc tcattaaata
     2701 gtaaagggtt gatttgctgc aagagtagct gagaattcaa aaacatcctt gcagaatgat
     2761 tcaaaagaca aaagccaggc tcaacttata gaatgttttg gaaactggaa gtaatgatac
     2821 atttcacttc agaagcactt gtaggtcttt actagtgcta agtattatgg tgagctatca
     2881 ttaaagtgtg ccatcttgga taaaggcctt ttgcctactc tcttctgcaa ttttgacacc
     2941 tcaatattca cacccataaa cattactaag ccccagttct atcgttggaa ggagttgtta
     3001 ttcttttgtt gttcccttat gcaattttta attctatgaa tgttaagttt ttttgagcta
     3061 atgatagata gaaatgccca ctcaaagaaa aataaacaga gacaaatgtt aaaattgcca
     3121 tacagactgt ttttccccct gttgtttcac tttaaaataa aaagaaatcc ttgattaatc
     3181 agaatggctt gggacatgaa cttaatttat ttagttttct aataaatgaa gggccaactc
     3241 ttatttgttc tagcccctac tgatgagaaa catttgaaaa cttgcttgct ctcctgcctc
     3301 gttgtagctt tctctgatga agacttctgc agtatattgt atccctcact ctatagcaga
     3361 aggtgtgtgt ggaatatgta gactccagtg ttttcttagg aggggtggga aagggctttc
     3421 tttcctctcc tctcctctcg tctcctcttt ctttcctttc tttttgcaac taaactgcta
     3481 ctctacactt tttattgttg ttttctttgt ctttttcttt ctacaaacag gaaacaaaaa
     3541 aaaaaaaaaa caagtttttc tcaatttgga gactcaattg aataatttcc agtataatca
     3601 gcattttgat agaatctcac aacttatttt tctctgcttt tatttcctgt ttttctttgt
     3661 tccatctttc taattctagt gaaaatgcaa agtctaattt ctcccatgtt gagaataaat
     3721 ttttcatcta tgatttgctg atagagaaga gcttggtaag ggagcaattc aaggaaacta
     3781 ttttgccatg cacatttctg atcaattccc acagattctg gtcaaatgaa agatattcta
     3841 tccaacattt aaacattgaa aaatttaact gaacttactt atcactgatg tgtatttatc
     3901 ccagaaatta attaatatct gtgaaaaata aaaatatttc aatactatcc gtgcttcttg
     3961 gaaaatgaac tataaaaaag ggtcacaatt tttctgaaat tggcatgaaa acattcaaga
     4021 taaaaataat agactaaaca ttattttctg ttatgcataa ttctatgaaa aagcaaggta
     4081 atttaaaaag agttttaaaa tgtgtgtttg aatcttttcc aatttaacca agtgagaagt
     4141 agcaatgatt tacattgtta tgatgataat gtgaataaga aaccttttag agtatatgat
     4201 tttacattgc tatcaaacct atcaaagaaa aggcaattgg aatttggagg aatgtttgta
     4261 tatatgcaca tagagtctat ttgtgtgtgt gtgaacgcac atatatatac atctatatac
     4321 ttataactat atataaaagc atatatataa tcctatattc ttcactggtg catgtgaatc
     4381 acagaaagcc ctattttaga cttcatctga aattcgttgg gttacatttt gaatcctgat
     4441 gaaaaaagca aaaatccaaa ttaaatggac tgattgctaa gagtacgtaa aatcatattc
     4501 aaaagctggc cagaagaata aagctagaga agctgctaaa tctagaaaac acaatcagat
     4561 gccacagttg tcacaaatca gacttgtaag tatagcaatc tgtattgtag gttctgccga
     4621 ttgcaggctt agctaaagtc acattgaaaa acattgcatc aagcttcatt cacactgaag
     4681 taaatgaaca ttggtcctcc tattcaaata agccagtctt tagcataagc aaaatccaga
     4741 tttgcatgat ttttattata tagctacaga actgtgacca ctgtgaaaaa ggaaaattat
     4801 acaaggagat tgctcttgga ggatttggta tgaatcagct gaggtaggaa caagagtctg
     4861 aattggggac ctgctgacct tccaagaagt agaaggccat cagaagaaaa tcactgttac
     4921 ttagagaaga gacaacacta aagtacttca cctggtagtg ttaattggat gttaattatg
     4981 agctcggttt aatttcaata agcaagaaaa tataatcaga tgactgattt aaaaaaaaac
     5041 aacaacaatg tgcccatcta gcctttaatg tgacatgtca aatgcaaata ataaattatg
     5101 ttattcagta tcagttgttt gcatgtctta gcacaacaaa ggatttacag tctgagggcc
     5161 aagagagaaa aaatgctttt ttcttaaaac agcatattta aaagacaaga cctcatcatt
     5221 tcagtagtgt acatagatta gtgactgaag gagccagtgc tagccttttt aagtaggtca
     5281 ggcttttaga gctgaaagag attttaaaga ccagccaatt caactcctac accttggagc
     5341 tgaggaaaca gacagaggtg aagtgacttg cctgtagtta taaactggac taatggcagt
     5401 actgagactc aaattcttgt ctcatgtttt cttctctagt gctttttcca ctacactttt
     5461 tagacagaag agtagctgga aaaagaatgc ctaactgatt tactaaagag tctattcatg
     5521 gaatccaagg gctccaaatt gtgctaattc tgctcaggat gaaacaaatc cccacgctga
     5581 agtggagaaa tattttcata attgaaggaa catatcccat tgattgtcta cactttcttc
     5641 tctctgtttg ttgctattgg taaggctagg ctatgttctg ttatcacaaa attctaggac
     5701 ttgtttaaag aacttaaagg tcagtttctt agtttctctt tgtgattgag gatgagcaag
     5761 ccattgatac accaagagct gctgagtgtt ggaggttgcc tggtgaaact ggcaggccct
     5821 gttgttgaca tttccccaga gctaaaatgt cctcatactc aaaccaactg tgctgcccaa
     5881 gttagtgaaa ttatccatca gcactaacac caccctttgg gttcatgctc atccctgcac
     5941 tccatgtgac ctttgagccc agataccctt ctagaaggtg aatgaaagcc ccacatgtcc
     6001 cgcaagactt agtctgcata aaagatttaa aaggattttt ttttctctac agtccattta
     6061 tatgatactg ttagaagtga agaattttga aactacatac actggcctct gaaaatggtt
     6121 cttgtggctc agaaatagta tattgttctg ttgcttgttt ttgctgaact gtagagaaaa
     6181 caccagagta aaattccatg taaattgcta aggcatcgaa tcagaactgt ccttgggcgt
     6241 tgtaacagtg cagaaaatct catttagttt ttttcttttt ttttttcagt taactacttg
     6301 tttgtttctt ttcagaatag gcactttttt ttgagtagaa aacctcttct ttctccacag
     6361 atacatctct ttttgttcac gccttgaaga cttcagaaaa atagaagctc acttccttcc
     6421 ataaaggtga agaacatctt gatgaataaa cagtcaacta ccaagttcac atatttgcct
     6481 atgaagtgag agctatttct aagaaacttc aaaaagatca aaacgaggca attttatagc
     6541 tttttgttac ctaatctaca aagtactaat ttccttgtgt ttagctttgt tgtcactgtt
     6601 actgagtaaa tacccatttc tgttacatat ggtacatttt ttgcttcact tattttcctg
     6661 agttcccatg attttttttc tgtagtttct cattcatttt aaaacccata atcttcatct
     6721 atttttagaa gaaagtgtaa atgcacagtt gtacgtttgt tgagagtttt tatggcatta
     6781 tagtgcttta tttataagca ttgtgtctta gaataaagct tacaaaatgg caaaga
//
