LOCUS       NM_006456               1904 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ST6 N-acetylgalactosaminide
            alpha-2,6-sialyltransferase 2 (ST6GALNAC2), mRNA.
ACCESSION   NM_006456
VERSION     NM_006456.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1904)
  AUTHORS   Moremen,K.W., Ramiah,A., Stuart,M., Steel,J., Meng,L., Forouhar,F.,
            Moniz,H.A., Gahlay,G., Gao,Z., Chapla,D., Wang,S., Yang,J.Y.,
            Prabhakar,P.K., Johnson,R., Rosa,M.D., Geisler,C., Nairn,A.V.,
            Seetharaman,J., Wu,S.C., Tong,L., Gilbert,H.J., LaBaer,J. and
            Jarvis,D.L.
  TITLE     Expression system for structural and functional studies of human
            glycosylation enzymes
  JOURNAL   Nat Chem Biol 14 (2), 156-162 (2018)
   PUBMED   29251719
REFERENCE   2  (bases 1 to 1904)
  AUTHORS   Jia,L., Luo,S., Ren,X., Li,Y., Hu,J., Liu,B., Zhao,L., Shan,Y. and
            Zhou,H.
  TITLE     miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of
            Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT
            Pathway
  JOURNAL   Dig Dis Sci 62 (12), 3447-3459 (2017)
   PUBMED   29030743
  REMARK    GeneRIF: miR-182/-135b/ST6GALNAC2/PI3K/AKT axis could function as
            regulator of progression in colorectal cancer
REFERENCE   3  (bases 1 to 1904)
  AUTHORS   Liu,B., Liu,Y., Zhao,L., Pan,Y., Shan,Y., Li,Y. and Jia,L.
  TITLE     Upregulation of microRNA-135b and microRNA-182 promotes
            chemoresistance of colorectal cancer by targeting ST6GALNAC2 via
            PI3K/AKT pathway
  JOURNAL   Mol Carcinog 56 (12), 2669-2680 (2017)
   PUBMED   28767179
  REMARK    GeneRIF: MicroRNAs miR-135b and miR-182 may reverse the resistance
            to 5-fluorouracil (5-FU) in colorectal cancer (CRC) cells by
            targeting ST6GALNAC2 via PI3K/AKT pathway, which render potential
            chemotherapy targets for the treatment of CRC.
REFERENCE   4  (bases 1 to 1904)
  AUTHORS   Miao,X. and Zhao,Y.
  TITLE     ST6GalNAcII mediates tumor invasion through PI3K/Akt/NF-kappaB
            signaling pathway in follicular thyroid carcinoma
  JOURNAL   Oncol Rep 35 (4), 2131-2140 (2016)
   PUBMED   26820593
  REMARK    GeneRIF: Results provide evidence that ST6GalNAcII activated the
            invasion in follicular thyroid cancer cells through regulating the
            activity of PI3K/Akt pathway.
REFERENCE   5  (bases 1 to 1904)
  AUTHORS   Venkitachalam,S., Revoredo,L., Varadan,V., Fecteau,R.E., Ravi,L.,
            Lutterbaugh,J., Markowitz,S.D., Willis,J.E., Gerken,T.A. and
            Guda,K.
  TITLE     Biochemical and functional characterization of
            glycosylation-associated mutational landscapes in colon cancer
  JOURNAL   Sci Rep 6, 23642 (2016)
   PUBMED   27004849
  REMARK    GeneRIF: Study provides evidence that mutations in B3GNT2, B4GALT2,
            and ST6GALNAC2 underlie aberrant glycosylation, and contribute to
            the pathogenesis of molecular subsets of colon and other
            gastrointestinal malignancies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1904)
  AUTHORS   Li,G.S., Zhu,L., Zhang,H., Lv,J.C., Ding,J.X., Zhao,M.H., Shen,Y.
            and Wang,H.Y.
  TITLE     Variants of the ST6GALNAC2 promoter influence transcriptional
            activity and contribute to genetic susceptibility to IgA
            nephropathy
  JOURNAL   Hum Mutat 28 (10), 950-957 (2007)
   PUBMED   17480010
  REMARK    GeneRIF: the ADG haplotype in the ST6GALNAC2 gene is a functional
            regulatory variant that may contribute to the genetic
            susceptibility in a subset of patients in whom the desialylation of
            IgA1 molecules was the main causative pathogenesis of IgAN
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1904)
  AUTHORS   Raska,M., Moldoveanu,Z., Suzuki,H., Brown,R., Kulhavy,R.,
            Andrasi,J., Hall,S., Vu,H.L., Carlsson,F., Lindahl,G., Tomana,M.,
            Julian,B.A., Wyatt,R.J., Mestecky,J. and Novak,J.
  TITLE     Identification and characterization of CMP-NeuAc:GalNAc-IgA1
            alpha2,6-sialyltransferase in IgA1-producing cells
  JOURNAL   J Mol Biol 369 (1), 69-78 (2007)
   PUBMED   17418236
  REMARK    GeneRIF: Expression of the ST6-GalNAcII gene and activity of the
            CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in
            immunoglobulinA1-producing cell lines.
REFERENCE   8  (bases 1 to 1904)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 1904)
  AUTHORS   Sotiropoulou,G., Kono,M., Anisowicz,A., Stenman,G., Tsuji,S. and
            Sager,R.
  TITLE     Identification and functional characterization of a human GalNAc
            [alpha]2,6-sialyltransferase with altered expression in breast
            cancer
  JOURNAL   Mol Med 8 (1), 42-55 (2002)
   PUBMED   11984005
REFERENCE   10 (bases 1 to 1904)
  AUTHORS   Samyn-Petit,B., Krzewinski-Recchi,M.A., Steelant,W.F., Delannoy,P.
            and Harduin-Lepers,A.
  TITLE     Molecular cloning and functional expression of human ST6GalNAc II.
            Molecular expression in various human cultured cells
  JOURNAL   Biochim Biophys Acta 1474 (2), 201-211 (2000)
   PUBMED   10742600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015802.21 and BT019972.1.
            
            On May 17, 2019 this sequence version replaced NM_006456.2.
            
            Summary: ST6GALNAC2 belongs to a family of sialyltransferases that
            add sialic acids to the nonreducing ends of glycoconjugates. At the
            cell surface, these modifications have roles in cell-cell and
            cell-substrate interactions, bacterial adhesion, and protein
            targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by
            OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.255230.1,
                                           SRR1660809.201916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162841 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225276.10/ ENSP00000225276.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC015802.21        33540-33591
            53-1175             BT019972.1         1-1123
            1176-1902           AC015802.21        53295-54021
            1903-1904           AC015802.21        54022-54023
FEATURES             Location/Qualifiers
     source          1..1904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1904
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /note="ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 2"
                     /db_xref="GeneID:10610"
                     /db_xref="HGNC:HGNC:10867"
                     /db_xref="MIM:610137"
     exon            1..177
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1177
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /EC_number="2.4.3.3"
                     /note="(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase;
                     sialyltransferase-like 1; sialyltransferase 7
                     ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)
                     B;
                     (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetyl galactosaminide B; sialyltransferase 7
                     ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetyl galactosaminide B; SIAT7-B; ST6GalNAcII;
                     ST6GalNAc II; sialyltransferase 7B; galNAc
                     alpha-2,6-sialyltransferase II; ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2;
                     ST6GALNAC2, alpha-2,6-sialyltransferase 2; ST6 GalNAc
                     alpha-2,6-sialyltransferase 2"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 2"
                     /protein_id="NP_006447.2"
                     /db_xref="CCDS:CCDS11747.1"
                     /db_xref="GeneID:10610"
                     /db_xref="HGNC:HGNC:10867"
                     /db_xref="MIM:610137"
                     /translation="MGLPRGSFFWLLLLLTAACSGLLFALYFSAVQRYPGPAAGARDT
                     TSFEAFFQSKASNSWTGKGQACRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALW
                     DRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGIL
                     NGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTS
                     VPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLH
                     PDFISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFS
                     DHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQR"
     exon            178..238
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     exon            239..413
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     exon            414..582
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     exon            583..721
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     exon            722..825
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     exon            826..909
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1009
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1904
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1630..1635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /note="hexamer: AATAAA"
     regulatory      1654..1659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /note="hexamer: AATATA"
     polyA_site      1660
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /note="major polyA site"
     polyA_site      1672
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
     regulatory      1885..1890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /note="hexamer: AATAAA"
     polyA_site      1904
                     /gene="ST6GALNAC2"
                     /gene_synonym="SAITL1; SIAT7; SIAT7B; SIATL1; ST6GalNAII;
                     STHM"
                     /note="major polyA site"
ORIGIN      
        1 ctcccttctg cctgggacgt cagcggacgg ggcgctcgcg ggccggggct gtatggggct
       61 cccgcgcggg tcgttcttct ggctgctgct cctgctcacg gctgcctgct cggggctcct
      121 ctttgccctg tacttctcgg cggtgcagcg gtacccgggg ccagcggccg gagccaggga
      181 caccacatca tttgaagcat tctttcaatc caaggcatcg aattcttgga caggaaaggg
      241 ccaggcctgc cgacacctgc ttcacctggc cattcagcgg cacccccact tccgtggcct
      301 gttcaatctc tccattccag tgctgctgtg gggggacctc ttcaccccag cgctctggga
      361 ccgcctgagc caacacaaag ccccgtatgg ctggcggggg ctctctcacc aagtcatcgc
      421 ctccaccctg agccttctga acggctcaga gagtgccaag ctgtttgccc cgcccaggga
      481 cacccctcca aagtgtatcc ggtgtgccgt ggtgggcaac ggaggcattc tgaatgggtc
      541 ccgccagggt cccaacatcg atgcccatga ctatgtattc agactcaatg gagctgtgat
      601 caaaggcttc gagcgcgatg tgggcaccaa gacttccttc tatggtttca ctgtgaacac
      661 gatgaagaac tccctcgtct cctactggaa tctgggcttc acctccgtgc cacaaggaca
      721 ggacctgcag tatatcttca tcccctcaga catccgcgac tatgtgatgc tgagatcggc
      781 cattctgggc gtgcctgtcc ctgagggcct agataaaggg gacaggccgc acgcctattt
      841 tggaccagaa gcctctgcca gtaaattcaa gctgctacat ccggacttca tcagctacct
      901 gacagaaagg ttcttgaaat caaagttgat taacacacat tttggagacc tatatatgcc
      961 tagtaccggg gctctcatgc tgctgacagc tttgcatacc tgtgaccagg tcagtgccta
     1021 tggattcatc acaagcaact actggaaatt ttccgaccac tatttcgaac gaaaaatgaa
     1081 gccattgata ttttatgcaa accacgatct gtccctggaa gctgccctgt ggagggacct
     1141 gcacaaggcc ggcatccttc agctgtacca gcgctgaccc caatgcactg agccctttgc
     1201 ttcttcaaga gttgcggccc tgatcctctc aagtggccaa aagctttttt aacttttcaa
     1261 tcttcacctt cccttgccaa cagagggcac tggggtgaat tcaagatttt catcgaggtc
     1321 tgttcaatat aggacacccc agcttgtcct tggctcatcc aagaactctt ctgtatctaa
     1381 aacaatacat ctcaatcttg gccaagggaa aatggactgc tttgctggat tggcactgag
     1441 caactttagg aaatgtcggt ggagtgttca gcaagatcag acagcagtcc aggtcaaagg
     1501 caaacacaca cgctccagcc caaatcctcc tggtggcaca tcctacccca gatgctaaag
     1561 tgattcaagg actccaggac acctcttaag agcctttcta agaacatgat aggcttactt
     1621 ctgctccata ataaagtggg agaaaaaagc cagaatataa cttaagacta gataactgcg
     1681 tacatgatgg accatttttt tttttttggc tgggtagaga aatcatataa aacgcaggct
     1741 gtttagcatg gagatgactc tcagaacact gggagggtct ggcacttgat gggggttagt
     1801 tgcttggcag cctgcctgcc actgagggaa gtcccattag agatgtatca ccaccttgtc
     1861 accaacagga tgatgtcacc aggtaataaa ccttcatcct cata
//
