LOCUS       NM_001142351            6800 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ST6 beta-galactoside alpha-2,6-sialyltransferase 2
            (ST6GAL2), transcript variant 2, mRNA.
ACCESSION   NM_001142351
VERSION     NM_001142351.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6800)
  AUTHORS   Chandel,S., Joon,A., Kaur,S. and Ghosh,S.
  TITLE     Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling
            during enteroaggregative Escherichia coli infection of human
            intestinal epithelial cell lines
  JOURNAL   Appl Microbiol Biotechnol 107 (4), 1405-1420 (2023)
   PUBMED   36646912
  REMARK    GeneRIF: Role of ST6GAL1 and ST6GAL2 in subversion of cellular
            signaling during enteroaggregative Escherichia coli infection of
            human intestinal epithelial cell lines.
REFERENCE   2  (bases 1 to 6800)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6800)
  AUTHORS   Ikeda,M., Tomita,Y., Mouri,A., Koga,M., Okochi,T., Yoshimura,R.,
            Yamanouchi,Y., Kinoshita,Y., Hashimoto,R., Williams,H.J.,
            Takeda,M., Nakamura,J., Nabeshima,T., Owen,M.J., O'Donovan,M.C.,
            Honda,H., Arinami,T., Ozaki,N. and Iwata,N.
  TITLE     Identification of novel candidate genes for treatment response to
            risperidone and susceptibility for schizophrenia: integrated
            analysis among pharmacogenomics, mouse expression, and genetic
            case-control association approaches
  JOURNAL   Biol Psychiatry 67 (3), 263-269 (2010)
   PUBMED   19850283
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   4  (bases 1 to 6800)
  AUTHORS   Lehoux,S., Groux-Degroote,S., Cazet,A., Dhaenens,C.M.,
            Maurage,C.A., Caillet-Boudin,M.L., Delannoy,P. and
            Krzewinski-Recchi,M.A.
  TITLE     Transcriptional regulation of the human ST6GAL2 gene in cerebral
            cortex and neuronal cells
  JOURNAL   Glycoconj J 27 (1), 99-114 (2010)
   PUBMED   19768537
  REMARK    GeneRIF: This suggests that ST6GAL2 transcription could be
            potentially activated for specific neuronal functions.
REFERENCE   5  (bases 1 to 6800)
  AUTHORS   Krzewinski-Recchi,M.A., Julien,S., Juliant,S.,
            Teintenier-Lelievre,M., Samyn-Petit,B., Montiel,M.D., Mir,A.M.,
            Cerutti,M., Harduin-Lepers,A. and Delannoy,P.
  TITLE     Identification and functional expression of a second human
            beta-galactoside alpha2,6-sialyltransferase, ST6Gal II
  JOURNAL   Eur J Biochem 270 (5), 950-961 (2003)
   PUBMED   12603328
  REMARK    GeneRIF: identification and expression and localization in brain
REFERENCE   6  (bases 1 to 6800)
  AUTHORS   Takashima,S., Tsuji,S. and Tsujimoto,M.
  TITLE     Characterization of the second type of human beta-galactoside alpha
            2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta
            1,4GlcNAc structures on oligosaccharides preferentially. Genomic
            analysis of human sialyltransferase genes
  JOURNAL   J Biol Chem 277 (48), 45719-45728 (2002)
   PUBMED   12235148
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005040.2, AB058780.1,
            AB059555.1, CN365495.1, AC108049.5 and BQ016989.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001142351.1.
            
            Summary: This locus encodes a sialyltransferase. The encoded type
            II transmembrane protein catalyzes the transfer of sialic acid from
            CMP to an oligosaccharide substrate. Polymorphisms at this locus
            may be associated with variations in risperidone response in
            schizophrenic patients. Alternatively spliced transcript variants
            have been described. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB058780.1, SRR14038192.3375621.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409382.8/ ENSP00000386942.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC005040.2         21708-21720         c
            14-91               AB058780.1         1-78
            92-1460             AB059555.1         135-1503
            1461-1734           CN365495.1         97-370
            1735-6138           AC108049.5         72246-76649         c
            6139-6800           BQ016989.1         15-676              c
FEATURES             Location/Qualifiers
     source          1..6800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.3"
     gene            1..6800
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /note="ST6 beta-galactoside alpha-2,6-sialyltransferase 2"
                     /db_xref="GeneID:84620"
                     /db_xref="HGNC:HGNC:10861"
                     /db_xref="MIM:608472"
     exon            1..75
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            76..1075
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1722
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /EC_number="2.4.3.1"
                     /note="isoform a is encoded by transcript variant 2;
                     beta-galactoside alpha-2,6-sialyltransferase II; alpha
                     2,6-ST 2; sialyltransferase 2 (monosialoganglioside
                     sialyltransferase); beta-galactoside
                     alpha-2,6-sialyltransferase 2; ST6 beta-galactosamide
                     alpha-2,6-sialyltranferase 2;
                     CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
                     6-sialyltransferase 2"
                     /codon_start=1
                     /product="beta-galactoside alpha-2,6-sialyltransferase 2
                     isoform a"
                     /protein_id="NP_001135823.1"
                     /db_xref="CCDS:CCDS2073.1"
                     /db_xref="GeneID:84620"
                     /db_xref="HGNC:HGNC:10861"
                     /db_xref="MIM:608472"
                     /translation="MKPHLKQWRQRMLFGIFAWGLLFLLIFIYFTDSNPAEPVPSSLS
                     FLETRRLLPVQGKQRAIMGAAHEPSPPGGLDARQALPRAHPAGSFHAGPGDLQKWAQS
                     QDGFEHKEFFSSQVGRKSQSAFYPEDDDYFFAAGQPGWHSHTQGTLGFPSPGEPGPRE
                     GAFPAAQVQRRRVKKRHRRQRRSHVLEEGDDGDRLYSSMSRAFLYRLWKGNVSSKMLN
                     PRLQKAMKDYLTANKHGVRFRGKREAGLSRAQLLCQLRSRARVRTLDGTEAPFSALGW
                     RRLVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKD
                     VGNKTTIRIINSQILTNPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFT
                     PYIQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMCRE
                     VHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKLLVQRLNMGTQGDLHRKGK
                     VVLPGFQAVHCPAPSPVIPHS"
     exon            1076..1173
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1275
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1450
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..6800
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6773..6778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /note="hexamer: AATAAA"
     polyA_site      6800
                     /gene="ST6GAL2"
                     /gene_synonym="SIAT2; ST6GalII"
                     /note="major polyA site"
ORIGIN      
        1 agtgccgcgc tgccaggggg agcaccgagc accacggtgt cgtgcgcttc gaggcgcggc
       61 gtgggaagaa ggctggttca ttctgccacc catctgcatt aagacacaag gtgctgaccg
      121 cagagacctg ccatgaaacc acacttgaag caatggagac aacgaatgct tttcggaata
      181 ttcgcttggg ggctcctctt tttgctgatt ttcatctact tcaccgacag caaccccgct
      241 gagcctgtac ccagctccct ctccttcctg gagaccagga ggctcctgcc ggtgcagggg
      301 aagcagcggg ccatcatggg cgccgcacat gagccctccc cgcctggggg cctggacgca
      361 cgccaggcgc tgccccgcgc ccacccagcc ggttcctttc atgcggggcc tggagacctg
      421 cagaaatggg cccagtccca agatgggttt gaacataaag agtttttttc atcccaggtg
      481 gggagaaaat ctcaaagtgc tttctacccg gaggatgacg actacttttt tgctgctggt
      541 cagccagggt ggcacagcca cactcagggg acattgggat tcccttcccc cggggagcca
      601 ggcccacggg agggggcttt tccggctgca caggtccaga ggaggcgggt gaagaagagg
      661 caccggaggc agagaaggag ccacgtgttg gaggagggcg acgacggcga caggctgtac
      721 tcctccatgt ccagggcctt cctgtaccgg ctctggaagg ggaacgtctc ttccaaaatg
      781 ctgaacccgc gcctgcagaa ggcgatgaag gattacctga ccgccaacaa gcacggggtg
      841 cgcttccgcg ggaagcggga ggccgggctg agcagggcac agctgctgtg ccagctgcgg
      901 agccgcgcgc gcgtgcggac gctggacggc accgaggcgc ccttttctgc gctgggctgg
      961 cggcgcctgg tgcccgccgt gcccctgagc cagctgcacc cccgcggcct gcgcagctgc
     1021 gctgtcgtca tgtctgcagg cgcaatcctc aactcttcct tgggcgagga aatagattct
     1081 catgatgcgg ttttgagatt taactctgct cctacacgtg gttatgagaa agatgttggg
     1141 aataaaacca ccatacgcat cattaattcg cagattctga ccaaccccag ccatcacttc
     1201 attgacagtt cactgtataa agacgtcatt ttggtggcct gggaccctgc cccatattcc
     1261 gcaaatctta acctgtggta caaaaaaccg gattacaacc tgttcactcc atatattcag
     1321 catcgtcaga gaaacccaaa tcagccattt tacattcttc atcctaaatt tatatggcag
     1381 ctctgggata ttatccagga gaacactaaa gagaagattc aaccaaaccc accatcttct
     1441 ggtttcattg gaatcctcat aatgatgtcc atgtgcagag aggtgcacgt gtatgaatat
     1501 atcccatccg tgcggcagac ggagctgtgc cactaccacg agctgtacta cgacgcagcc
     1561 tgcaccctcg gggcgtacca cccactactc tatgagaagc tcctggtgca gcgcctgaac
     1621 atgggcacgc agggggattt gcatcgcaag ggcaaggtgg ttcttcccgg cttccaggcg
     1681 gtgcactgcc ctgcaccaag tccagtcatt ccacactctt aaaaagggtt tcttgggaat
     1741 caatgtgcaa taaggtacta ctgttgtact caaagtcaca aaagaatact tgaagataga
     1801 ttttagacag tgtagttttg agtctttaaa cagtaattta gtggtggtca tgataatcct
     1861 tctctttcta agccattgag tatgtattac tgctttgaac atagaaatgg tttttttaaa
     1921 aaaataaggc tcaagaaaga tgcaaaacca aggatagcta gaaagaaaac acatgtatga
     1981 ccatgggtat gatacctcca gaaatgttaa caacttattc ttctgccatg agtacccctc
     2041 atcagggttg gtttcaatga caggttttgg tgatgttcct gaccatatga agtggtttat
     2101 gtttagaaac attcaaattg agggacatca tttacagcat cgagtgtgtc agttatacat
     2161 gcattcatca ttaaatatcc taggttttat gacagacatt gaaattatca ctcagatgtg
     2221 tttaacagca aaaaattccc agcacatcct ggcaaaggct tttatttcca accgttgcat
     2281 tcttcatctc tgcctcccat tgcccactga atgctttgct ttctgtgcat caagacagag
     2341 ttctaaaacc agaaaacatc catcttgaaa ggtccaagaa aaagccaaat tccatatagc
     2401 accacagagg aggccctttg tttccctgca gtatttcaac caggaacatt agtatcacat
     2461 ccaccaggag gcacatcact ggcaagtaac atagaatcac agggctgcag gtgcccctgg
     2521 acactccccg gttctggctt ttctgccttg tacctcctca cctgcagatc taccctgcag
     2581 cttttgcata gtcagtgaca cacttgacaa ttggcacagc tgtgctgggg aagacgggag
     2641 acaccttgct ccttccaaac tagaaggaaa gattttggag ccatcaccct gtgcttctag
     2701 ggatgcacgc ctgtctttat tatacaggtt tcttgcaggt ttttatcagc cagtgggaac
     2761 tccacagtga tgagcactga atcttcacta aatcttccta cagacattta ggaatccagt
     2821 ccttgctttt gcagatatgt tttatgtcag cagcatgaca aagccatata attaaataat
     2881 ttatgtgaaa gcattgctta ttaacaagga aaatatgtag atgcttcaga gggaaaggca
     2941 gctagaggga aattttcatc ccaatatgtt agctatattc agggttgatt ttttctttaa
     3001 tctcaactgt cactgataca ttgaaaaatt tttgctatga atatagtgaa acagaaacat
     3061 tctgtaatac cttaattaaa catgctatta tttcaatgta taaccaaaac atatctccat
     3121 ggtacagtta agacttgttg caatgacaat agcagcttaa ttaaatgcgt tctcccttgc
     3181 aaaatgtatg aatgtcagga gagtttagtg gaaaagtttt ctttgtttca ggattggttt
     3241 cttctagact gttctcagga ctactttctt gagcaagaat ggcttacaga gactgaaggc
     3301 ttctgtttgg ttagtctatt cagcagatat ggagctggaa aacaagacat ctcctatagc
     3361 ttgctataat agtgaaggag aaattggaaa gttttaatca caataatatc caataaaagc
     3421 ccattttgag agttttgtta ttaagtcaat gagaagggat aggtaacttt gtcctatata
     3481 ttaacttatg tctaaataga catggttaag ccatgttcct ttctaatttc ttttcttttc
     3541 tttttttttt ttttttttga gacagtctct cgctctgtcg cccaggctag agtgcagtgg
     3601 tgcgatcttg gttcactgcc agctctgcct cccacgttca caccattctc ctgcctcagc
     3661 ctcctgagta gctggggact acaggcaccc gccaccacgc ccagctaatt ttttgtattt
     3721 ttagtagaga cagggtttca ccgtgttagc cagggtggtc tcgatctcct gaccttgtga
     3781 tctgcctgcc tcggcctccc aaagtgatgg gattataggc gtgagccacc accgcgcccg
     3841 gtcattcctt tctaatttct tgaaaaaact ttgtcttgtc cttatgttta catgtgtgta
     3901 ataatttcag caactctgga atgtgggtga ggtggctgtg gtggatgaat attactccct
     3961 accctccttg gatctttcta gatcttccag accattaaat gcccctgaag ctccttttat
     4021 agttttgcaa gtggatttac ttgtagacat ccttactatc cagcataatc ccccttggct
     4081 gacatgagaa cttggttaga ggagaattta ttggggtcag tgtaaatatt caagttcaaa
     4141 agcctcagaa cccaacactt taaagatttt taaatggaat tttgtcgtag tcattgtact
     4201 tttaaaatag tactttcagt ttcattgagg ttacaagaaa gactgaagag tacaaaggaa
     4261 atttagttac aatttttgca tttattatgg ccttaaagac tcttgggaat caggctctgt
     4321 tcaacagtca ataaatgtaa tacacacatt aatatagtac tgactgggcg ttcttctata
     4381 aaagtttaag ttctttggct tctaagaaaa tgttgggcag ttacagttaa cttgatgact
     4441 acttctagta ttagccaaat gggtcctaag tggcagcatt ttgccagaca ttgactaaat
     4501 ccttacatgc cacatttact gaattccaat aaacatatag ttcttctgtg gagtagttaa
     4561 cagtaagtgg cagctcactg aatttctccc aggttctgtc tcttccaaaa tcctccatcc
     4621 tctcttatga agggaagctg ataaaaaaaa atcctcttgg tgcaagctga agctgttaag
     4681 gattcctttt ttcactctca ggaccaacag acgttctttt gtatttcaag ataatttcac
     4741 ctgttgttgt tgttgttgtt gttgttgttg ttgttgttgt tgttgttaca aagaaacaaa
     4801 ttttgagcag caatgacaat tcaaccatat ctagattctc cctaccttat ttctccagcc
     4861 agtcacacca ggcagacggg taacctttaa cagacctggt gttctcatgg aataccgatg
     4921 ctcgtcccag ggagctgacc tttctcacta tgtccttata gagctgctct tacagagaac
     4981 tttgtgctca ggaccaaggg atggtcaatt aaaagttgca tgtaagcatc aggcttggat
     5041 gggcaaggga gggcttttat acatctttga acgaccaggt ctttccttgt ctgcctgaag
     5101 gcagagcttc gagaaacagc acttcccatg tgtctggtcc tcttggtctc tcagccagac
     5161 acttaatcaa tcctggactc tccagtagtc ctcagtcatt gtagccatag catctgcaaa
     5221 aaaagaaatg ctaaaataat cattagcgtt ttcaaaatta ggaaatcaaa gtagctgggt
     5281 cactctctta catgtgtatg agccagttaa ttctgctgga cagatcatac ttacgctgct
     5341 gattgactct tctgagcagt aacacatctc ctgaattaat taggtaggtc ccgtttgggt
     5401 gctttaagtg ggatcagtct tagatgagtg ccagtatgtg attgaatttc atacgcacaa
     5461 atgccatgat tcaagttctc tctccagttt ttcttataga tcaacacaca gtacatgtgg
     5521 tcagttactt ggttgaattt ctgcttagct gtggtaagag acagagaaag ggagtgaggt
     5581 gggaccaggg gaattatcag aaagacatga gtgaacctat tggccaggta gcttccaagt
     5641 atgttctatt gtattgtctg ttttgattct gatagtttag aactctttct gatagtttag
     5701 aactcttacc cagtggttac atgactgatc aaggcaactc catctggaaa ttaattgctt
     5761 gggtaaaatg tccctgagtt tcaacttgtc ttttatctct ggatattctc ttatgagatt
     5821 attatgcatg tttctgtcac atgggcatta tttacacact tgataaatga aaggtatttc
     5881 tctgtccgtt caaggaaata aaatgtaagt tcttgtttta ttaaatgaat gaagcctttt
     5941 ggttaaaaaa aaagtaatgt aatatgtttc tgttcaaact tgagctaatg acatttaagg
     6001 aattaaagac attgatctag ttcttagtat gaaaagtgta catgtagata tagttatata
     6061 attgtgtata tacatatcta cacacatggt tggttttata ttgctttttc atcaatattt
     6121 ttgactgaaa cctttacaat aaattttatt ttaattatgt aaccactaat attttgagag
     6181 aaggaagcaa atgttatatg tccttctgtt aaaagaaaaa aaattcagtc ctccgccaac
     6241 cgcttcccac acactcatac tctgcacatc ttggctacat taaaatggac tgacagaatt
     6301 atttaaaagg cactatgaag gtagaacact accttaatat tttatcctag tcagaagcct
     6361 gatttaacac tgaactttga agggaagctt agctgtagct catggctttc aaagattaga
     6421 agaaacattt actggttcta tggaaaatag tcttcttgct aggtagattg gaaacaaaga
     6481 aattgcattg gtggtgttaa aatctaacat ttataacaaa tcctgtttta ttctagatga
     6541 aatacttaga caattcttcc agtggaaacc agtgaacttt tttaacagct ttgggaattc
     6601 ttttgtatga taatttttaa aatgaaatgt gtactcttca aactaattaa agcttgaagt
     6661 tttccaggag tcgcatttta aaagtgtttg tacacatttt aacacttgga tattttctat
     6721 tttggttttg tatattttta tgtatacaca atgtacagac ttttttcttg taaataaaac
     6781 atgttttcat ttgtctagaa
//
